GREMLIN Database
Q97WQ7 - Acetyl-CoA C-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-2)
UniProt: Q97WQ7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 381 (346)
Sequences: 15355 (8330)
Seq/√Len: 447.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_K176_A3.4721.00
7_R224_E3.4371.00
226_V230_L3.3801.00
165_D299_E3.3101.00
106_A109_V3.0411.00
348_A360_A2.9771.00
94_L345_L2.9321.00
171_E191_A2.9121.00
37_R40_K2.8631.00
6_N225_E2.8431.00
275_E279_R2.7021.00
172_K175_K2.6761.00
226_V229_K2.6691.00
224_E228_K2.6561.00
179_S183_A2.6301.00
157_H202_Y2.5681.00
268_A272_A2.5511.00
35_A110_S2.5241.00
9_A227_A2.4921.00
101_I221_V2.4611.00
13_L346_L2.4521.00
38_A220_V2.3431.00
14_G41_D2.3051.00
268_A375_V2.2531.00
108_V222_A2.1821.00
352_I357_G2.1141.00
101_I223_D2.1141.00
236_L349_I2.1081.00
97_A109_V2.1041.00
162_T165_D2.0721.00
240_G272_A2.0621.00
31_V55_I2.0371.00
11_I222_A2.0261.00
283_A326_P2.0181.00
46_N49_S1.9941.00
235_Y353_K1.9711.00
7_R237_V1.9521.00
164_E168_L1.8911.00
237_V377_V1.8761.00
182_R187_S1.8671.00
217_I342_F1.8651.00
155_F161_I1.8501.00
194_V207_L1.7941.00
327_L351_Y1.7921.00
282_D357_G1.7891.00
274_V359_R1.7651.00
49_S230_L1.7421.00
298_L324_V1.7411.00
240_G268_A1.7401.00
38_A42_A1.7221.00
265_S363_A1.7141.00
107_N223_D1.7071.00
298_L305_E1.6981.00
266_D270_K1.6881.00
351_Y355_G1.6881.00
222_A226_V1.6881.00
222_A227_A1.6741.00
149_G201_V1.6711.00
107_N226_V1.6411.00
281_F284_V1.6271.00
223_D226_V1.6191.00
193_D196_K1.6071.00
158_R255_L1.5961.00
274_V281_F1.5931.00
31_V72_A1.5841.00
219_I342_F1.5711.00
97_A221_V1.5631.00
99_M105_V1.5601.00
81_R96_H1.5551.00
100_H106_A1.5521.00
35_A72_A1.5471.00
168_L172_K1.5411.00
12_G42_A1.5381.00
178_L182_R1.5381.00
29_E75_Q1.5361.00
9_A237_V1.5221.00
116_K119_D1.5171.00
55_I112_E1.5151.00
171_E175_K1.5151.00
284_V361_V1.4941.00
263_I266_D1.4891.00
281_F375_V1.4861.00
108_V226_V1.4741.00
34_A218_V1.4721.00
175_K188_N1.4671.00
37_R41_D1.4671.00
283_A351_Y1.4611.00
274_V375_V1.4501.00
172_K305_E1.4501.00
351_Y354_Q1.4461.00
36_S40_K1.4331.00
6_N223_D1.4271.00
168_L191_A1.4021.00
95_A374_S1.3931.00
175_K179_S1.3851.00
345_L376_V1.3811.00
12_G38_A1.3751.00
242_G268_A1.3681.00
242_G267_M1.3651.00
267_M270_K1.3631.00
358_E377_V1.3441.00
34_A216_A1.3431.00
18_F339_A1.3291.00
153_V202_Y1.3191.00
239_K377_V1.3131.00
361_V375_V1.2981.00
25_V33_E1.2961.00
88_G372_T1.2911.00
178_L188_N1.2841.00
349_I353_K1.2701.00
264_A373_G1.2591.00
304_S323_P1.2581.00
165_D168_L1.2561.00
161_I166_L1.2521.00
94_L219_I1.2371.00
225_E229_K1.2361.00
266_D300_G1.2361.00
8_I221_V1.2311.00
95_A241_I1.2251.00
51_V106_A1.2161.00
110_S220_V1.2141.00
346_L350_E1.2131.00
326_P351_Y1.2111.00
57_C60_D1.2081.00
32_F75_Q1.2011.00
55_I218_V1.1991.00
88_G366_R1.1711.00
255_L258_A1.1671.00
163_R205_S1.1661.00
150_L202_Y1.1621.00
244_A263_I1.1611.00
9_A224_E1.1561.00
18_F333_K1.1541.00
33_E37_R1.1431.00
13_L350_E1.1401.00
50_D108_V1.1391.00
169_V294_E1.1371.00
91_L345_L1.1311.00
178_L187_S1.1311.00
275_E280_Y1.1311.00
189_I194_V1.1301.00
149_G200_V1.1081.00
265_S361_V1.1041.00
56_S89_D1.1021.00
281_F359_R1.1021.00
240_G271_M1.0991.00
169_V295_L1.0961.00
181_P186_A1.0951.00
9_A222_A1.0931.00
123_F133_P1.0931.00
42_A45_I1.0911.00
13_L349_I1.0871.00
135_Y140_N1.0811.00
190_S193_D1.0781.00
282_D323_P1.0721.00
154_K158_R1.0691.00
54_F109_V1.0691.00
97_A111_I1.0681.00
6_N107_N1.0661.00
94_L221_V1.0661.00
283_A355_G1.0621.00
238_V374_S1.0621.00
49_S226_V1.0621.00
35_A78_G1.0541.00
343_S347_D1.0531.00
105_V271_M1.0531.00
12_G41_D1.0531.00
246_D258_A1.0521.00
272_A375_V1.0471.00
92_Q96_H1.0451.00
51_V107_N1.0391.00
282_D352_I1.0361.00
14_G37_R1.0361.00
171_E194_V1.0361.00
102_N105_V1.0251.00
10_I376_V1.0241.00
191_A195_M1.0171.00
161_I295_L1.0161.00
348_A362_V1.0141.00
258_A261_M1.0101.00
197_K207_L1.0001.00
326_P355_G0.9861.00
359_R377_V0.9831.00
39_Y78_G0.9831.00
303_V324_V0.9771.00
99_M103_S0.9751.00
175_K178_L0.9731.00
34_A37_R0.9651.00
49_S229_K0.9631.00
159_K258_A0.9621.00
11_I232_K0.9561.00
244_A267_M0.9551.00
53_S73_P0.9551.00
18_F213_V0.9531.00
153_V157_H0.9521.00
281_F361_V0.9501.00
16_Y34_A0.9491.00
239_K359_R0.9471.00
284_V303_V0.9341.00
222_A232_K0.9341.00
26_S29_E0.9331.00
261_M300_G0.9301.00
217_I339_A0.9281.00
32_F36_S0.9241.00
7_R102_N0.9191.00
164_E195_M0.9171.00
16_Y33_E0.9131.00
240_G375_V0.9101.00
197_K205_S0.9091.00
198_N206_E0.9071.00
17_G33_E0.9061.00
224_E237_V0.9051.00
171_E188_N0.9021.00
38_A110_S0.9021.00
158_R249_N0.9011.00
98_A238_V0.8901.00
258_A300_G0.8891.00
283_A348_A0.8801.00
235_Y349_I0.8791.00
327_L354_Q0.8741.00
286_V363_A0.8701.00
265_S301_L0.8671.00
172_K306_E0.8671.00
267_M271_M0.8671.00
217_I346_L0.8671.00
156_M292_Y0.8661.00
8_I223_D0.8641.00
16_Y30_M0.8621.00
135_Y138_S0.8611.00
155_F258_A0.8591.00
18_F343_S0.8581.00
167_A208_D0.8561.00
183_A354_Q0.8511.00
39_Y45_I0.8451.00
344_L362_V0.8441.00
98_A102_N0.8441.00
291_S331_M0.8421.00
133_P136_I0.8381.00
136_I140_N0.8371.00
54_F93_G0.8371.00
73_P78_G0.8361.00
34_A38_A0.8331.00
258_A296_Q0.8331.00
330_H340_S0.8311.00
224_E227_A0.8301.00
298_L303_V0.8301.00
111_I219_I0.8271.00
345_L374_S0.8261.00
13_L219_I0.8241.00
93_G342_F0.8231.00
85_T92_Q0.8231.00
238_V241_I0.8221.00
159_K300_G0.8211.00
54_F81_R0.8191.00
51_V267_M0.8181.00
154_K157_H0.8151.00
189_I193_D0.8131.00
265_S373_G0.8131.00
100_H105_V0.8101.00
31_V112_E0.8091.00
152_A292_Y0.8061.00
133_P138_S0.8041.00
199_Y202_Y0.8021.00
281_F366_R0.8011.00
155_F296_Q0.8011.00
225_E228_K0.8001.00
54_F97_A0.7991.00
110_S218_V0.7991.00
134_I138_S0.7941.00
105_V241_I0.7931.00
359_R375_V0.7901.00
294_E298_L0.7881.00
14_G34_A0.7861.00
8_I98_A0.7861.00
246_D263_I0.7851.00
348_A367_G0.7821.00
208_D291_S0.7801.00
274_V280_Y0.7791.00
150_L154_K0.7781.00
52_D100_H0.7721.00
349_I376_V0.7721.00
181_P187_S0.7711.00
91_L374_S0.7681.00
327_L355_G0.7681.00
27_F114_H0.7631.00
269_Y274_V0.7561.00
366_R372_T0.7541.00
39_Y50_D0.7501.00
25_V29_E0.7491.00
49_S108_V0.7461.00
164_E191_A0.7461.00
176_A179_S0.7441.00
52_D243_F0.7421.00
233_D353_K0.7401.00
266_D301_L0.7391.00
134_I137_R0.7371.00
38_A218_V0.7361.00
8_I102_N0.7361.00
165_D295_L0.7351.00
174_K188_N0.7341.00
96_H100_H0.7341.00
68_A114_H0.7321.00
286_V297_H0.7291.00
274_V366_R0.7291.00
63_E119_D0.7291.00
28_R63_E0.7261.00
51_V109_V0.7261.00
189_I207_L0.7251.00
67_I70_E0.7201.00
36_S47_P0.7191.00
171_E193_D0.7181.00
246_D259_N0.7161.00
127_E130_A0.7161.00
177_G332_A0.7151.00
96_H99_M0.7141.00
131_M136_I0.7131.00
10_I349_I0.7121.00
50_D110_S0.7111.00
122_T127_E0.7111.00
118_S214_D0.7111.00
151_D256_G0.7091.00
268_A361_V0.7081.00
356_K359_R0.7081.00
8_I101_I0.7061.00
265_S286_V0.7061.00
192_V196_K0.7051.00
78_G110_S0.7031.00
26_S119_D0.7031.00
235_Y350_E0.7011.00
177_G181_P0.6961.00
279_R323_P0.6941.00
171_E190_S0.6901.00
171_E189_I0.6871.00
6_N102_N0.6861.00
33_E36_S0.6831.00
239_K272_A0.6831.00
179_S182_R0.6801.00
14_G38_A0.6781.00
174_K331_M0.6781.00
25_V119_D0.6761.00
296_Q300_G0.6751.00
19_K22_T0.6731.00
126_L130_A0.6721.00
99_M102_N0.6701.00
35_A76_M0.6671.00
35_A218_V0.6631.00
167_A195_M0.6631.00
279_R302_R0.6621.00
135_Y147_I0.6611.00
58_Q337_L0.6601.00
55_I72_A0.6601.00
352_I360_A0.6571.00
249_N255_L0.6551.00
55_I69_D0.6531.00
235_Y239_K0.6531.00
42_A220_V0.6531.00
107_N271_M0.6531.00
9_A226_V0.6521.00
95_A372_T0.6521.00
247_S255_L0.6501.00
222_A230_L0.6471.00
85_T243_F0.6460.99
100_H109_V0.6440.99
52_D85_T0.6430.99
54_F96_H0.6430.99
147_I150_L0.6430.99
219_I346_L0.6420.99
57_C63_E0.6420.99
11_I227_A0.6420.99
200_V206_E0.6390.99
333_K343_S0.6390.99
270_K275_E0.6380.99
256_G259_N0.6380.99
97_A106_A0.6370.99
188_N193_D0.6350.99
67_I114_H0.6350.99
152_A156_M0.6350.99
108_V230_L0.6340.99
366_R370_T0.6310.99
294_E324_V0.6310.99
107_N229_K0.6300.99
161_I165_D0.6300.99
31_V114_H0.6290.99
261_M266_D0.6260.99
39_Y43_G0.6240.99
9_A223_D0.6240.99
167_A191_A0.6230.99
149_G203_P0.6220.99
137_R140_N0.6220.99
152_A204_L0.6200.99
155_F159_K0.6200.99
133_P137_R0.6200.99
178_L181_P0.6200.99
29_E32_F0.6190.99
72_A114_H0.6190.99
53_S110_S0.6170.99
131_M134_I0.6150.99
204_L209_I0.6140.99
340_S344_L0.6140.99
242_G271_M0.6140.99
191_A194_V0.6120.99
36_S77_G0.6100.99
47_P79_A0.6100.99
39_Y47_P0.6090.99
289_R335_V0.6080.99
168_L305_E0.6080.99
28_R75_Q0.6070.99
91_L362_V0.6060.99
293_K297_H0.6060.99
146_F150_L0.6060.99
83_T96_H0.6040.99
81_R92_Q0.6010.99
117_V337_L0.5990.99
76_M79_A0.5990.99
282_D359_R0.5980.99
25_V116_K0.5980.99
284_V363_A0.5970.99
122_T126_L0.5970.99
174_K178_L0.5960.99
348_A369_P0.5960.99
339_A342_F0.5960.99
12_G235_Y0.5920.99
112_E218_V0.5910.99
265_S269_Y0.5900.99
170_V291_S0.5890.99
177_G333_K0.5880.99
266_D302_R0.5860.99
10_I221_V0.5850.99
333_K347_D0.5850.99
94_L342_F0.5850.99
11_I226_V0.5840.99
102_N241_I0.5810.99
94_L111_I0.5810.99
264_A268_A0.5810.99
221_V238_V0.5800.99
239_K274_V0.5780.99
35_A39_Y0.5780.99
269_Y272_A0.5770.99
238_V376_V0.5770.99
146_F249_N0.5760.99
172_K294_E0.5750.99
265_S297_H0.5740.99
298_L304_S0.5720.99
243_F372_T0.5720.99
131_M140_N0.5700.99
50_D78_G0.5690.99
140_N145_H0.5690.99
132_D137_R0.5670.99
39_Y42_A0.5650.99
132_D138_S0.5630.99
282_D358_E0.5630.99
176_A305_E0.5610.99
360_A376_V0.5610.99
32_F76_M0.5580.99
36_S76_M0.5560.99
9_A230_L0.5550.98
146_F154_K0.5530.98
52_D106_A0.5530.98
361_V364_S0.5530.98
236_L352_I0.5520.98
268_A281_F0.5520.98
295_L299_E0.5520.98
89_D338_E0.5510.98
292_Y296_Q0.5510.98
60_D82_P0.5500.98
161_I299_E0.5500.98
174_K211_P0.5470.98
93_G111_I0.5460.98
92_Q95_A0.5460.98
329_G332_A0.5450.98
45_I220_V0.5440.98
66_S69_D0.5420.98
263_I267_M0.5420.98
132_D139_I0.5410.98
159_K296_Q0.5410.98
345_L362_V0.5410.98
183_A327_L0.5400.98
14_G42_A0.5400.98
70_E74_D0.5380.98
342_F346_L0.5380.98
289_R293_K0.5380.98
92_Q243_F0.5370.98
24_E119_D0.5370.98
35_A53_S0.5350.98
159_K255_L0.5330.98
92_Q100_H0.5330.98
353_K356_K0.5330.98
111_I342_F0.5330.98
192_V195_M0.5300.98
61_F65_I0.5300.98
73_P76_M0.5290.98
255_L259_N0.5280.98
170_V194_V0.5250.98
22_T25_V0.5240.98
52_D109_V0.5240.98
156_M161_I0.5200.98
357_G360_A0.5200.98
170_V174_K0.5190.98
286_V294_E0.5180.98
100_H103_S0.5170.98
7_R377_V0.5170.98
339_A343_S0.5170.98
169_V329_G0.5140.98
11_I108_V0.5130.97
107_N225_E0.5110.97
284_V323_P0.5100.97
58_Q86_V0.5100.97
269_Y281_F0.5090.97
155_F292_Y0.5080.97
184_S213_V0.5080.97
23_H129_F0.5060.97
189_I192_V0.5050.97
132_D136_I0.5050.97
178_L186_A0.5040.97
72_A76_M0.5040.97
242_G272_A0.5030.97
132_D135_Y0.5030.97
148_A151_D0.5020.97
280_Y359_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.9711 100 0.248 Contact Map
4u4eA 1 0.895 100 0.3 Contact Map
2wu9A 2 0.9239 100 0.312 Contact Map
1wdkC 2 0.9213 100 0.315 Contact Map
1ulqA 4 0.9213 100 0.316 Contact Map
1wl4A 4 0.916 100 0.32 Contact Map
3svkA 2 0.8268 100 0.323 Contact Map
1afwA 2 0.9186 100 0.325 Contact Map
4e1lA 4 0.9081 100 0.326 Contact Map
2vu1A 4 0.916 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.012 seconds.