Q97WQ6 - SULSO - GREMLIN Contacts

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Q97WQ6 - Acetyl-CoA C-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-3)

UniProt:	Q97WQ6	Sequences: MAWNSHAYWISRGGGKAMKVNIHLNKRVAIIGAGLTLFRRRLLETPQEIAWEAASKALDEAGLELKDIDCVVIGSAPDAFDGVNLKGEYLSHGAGGIKKPVSRVYVGGATGVMTAITGWYHVASGLCQKVLAVAEEKMSPARPHPQSIFRYIWDPILEKPLNPNLIWIFAMEMHRYMATYGIKKEEIALVSVKNKRNAINNPYAQLGSNITVEDVLKSEVLVWPVQLLDVSPVSDGGAAIVLASEDVARRYTDTPVWVEGVGWTLDNTEWPARDLAYARYVEFAARMAYKMAGIERPNKEIDVAEPYDPFDYKELHHLEALQLAKRGEAPKLLKEGVFDIDGDIPSSPSGGLLGVGNPIAAAGLMKVISIYWQLKGIAGKMQVKRPVHTGVAQAWGDLMQAGTVIVLRN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	409 (347)
Sequences:	15324 (8389)
Seq/√Len:	450.4

ECOLI - PAAJ ATOB YQEF FADA FADI
BACSU - THL YHFS FADA
HALSA - Q9HRI8 Q9HQZ8 Q9HNK4
SULSO - Q97WQ6 Q97VJ9 Q97UW8 Q97VD4 Q97VU9 Q97UA5 Q97WQ7 Q7LXW2 Q97VV9 Q97W61

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
193_K	197_N	3.541	1.00
247_V	251_Y	3.435	1.00
27_R	245_E	3.393	1.00
186_E	319_E	3.383	1.00
127_C	130_V	3.138	1.00
192_V	212_V	3.002	1.00
115_A	367_V	2.918	1.00
26_K	246_D	2.911	1.00
56_K	59_D	2.897	1.00
370_I	382_Q	2.860	1.00
295_E	299_K	2.727	1.00
245_E	249_R	2.725	1.00
247_V	250_R	2.705	1.00
193_K	196_R	2.702	1.00
200_N	204_A	2.673	1.00
178_A	223_W	2.651	1.00
54_A	131_L	2.549	1.00
288_A	292_A	2.514	1.00
29_A	248_A	2.499	1.00
33_A	368_I	2.477	1.00
122_V	242_L	2.464	1.00
34_G	60_E	2.314	1.00
57_A	241_V	2.286	1.00
129_K	243_A	2.232	1.00
183_K	186_E	2.143	1.00
118_G	130_V	2.132	1.00
256_V	371_Y	2.132	1.00
374_L	379_G	2.093	1.00
27_R	257_W	2.086	1.00
122_V	244_S	2.080	1.00
50_A	73_I	2.059	1.00
203_Y	208_S	2.054	1.00
260_G	292_A	2.053	1.00
31_I	243_A	2.025	1.00
64_E	67_D	1.999	1.00
303_V	348_P	1.963	1.00
294_I	381_M	1.919	1.00
185_E	189_L	1.897	1.00
238_A	364_L	1.867	1.00
176_Y	182_I	1.822	1.00
67_D	251_Y	1.817	1.00
349_S	373_Q	1.803	1.00
202_P	206_L	1.789	1.00
260_G	288_A	1.786	1.00
215_V	228_L	1.773	1.00
128_Q	244_S	1.769	1.00
288_A	398_L	1.755	1.00
373_Q	377_I	1.742	1.00
199_I	206_L	1.731	1.00
318_L	346_S	1.726	1.00
318_L	325_K	1.724	1.00
179_T	275_L	1.699	1.00
302_D	379_G	1.694	1.00
301_I	304_A	1.691	1.00
286_R	290_K	1.689	1.00
243_A	247_V	1.689	1.00
57_A	61_A	1.686	1.00
205_Q	232_P	1.675	1.00
285_A	385_R	1.671	1.00
128_Q	247_V	1.659	1.00
243_A	248_A	1.646	1.00
170_A	222_V	1.634	1.00
244_S	247_V	1.623	1.00
73_I	133_V	1.619	1.00
32_G	61_A	1.603	1.00
294_I	301_I	1.600	1.00
120_Y	126_L	1.595	1.00
214_D	217_K	1.591	1.00
199_I	203_Y	1.588	1.00
102_S	117_T	1.586	1.00
240_I	364_L	1.583	1.00
121_H	127_C	1.564	1.00
50_A	90_L	1.562	1.00
29_A	257_W	1.561	1.00
283_F	286_R	1.551	1.00
192_V	196_R	1.549	1.00
118_G	242_L	1.535	1.00
189_L	193_K	1.533	1.00
48_E	93_G	1.523	1.00
296_R	304_A	1.507	1.00
303_V	373_Q	1.491	1.00
54_A	90_L	1.487	1.00
137_K	140_P	1.486	1.00
55_S	59_D	1.482	1.00
129_K	247_V	1.474	1.00
53_A	239_A	1.455	1.00
193_K	325_K	1.453	1.00
56_K	60_E	1.448	1.00
26_K	244_S	1.445	1.00
196_R	209_N	1.443	1.00
189_L	212_V	1.438	1.00
373_Q	376_G	1.423	1.00
371_Y	375_K	1.404	1.00
32_G	57_A	1.395	1.00
196_R	200_N	1.393	1.00
304_A	383_V	1.369	1.00
53_A	237_G	1.341	1.00
287_M	290_K	1.340	1.00
262_G	287_M	1.337	1.00
38_F	361_A	1.332	1.00
44_E	52_E	1.314	1.00
262_G	288_A	1.290	1.00
324_A	345_P	1.279	1.00
174_H	223_W	1.274	1.00
199_I	209_N	1.272	1.00
86_K	135_E	1.269	1.00
69_D	127_C	1.267	1.00
51_W	93_G	1.262	1.00
286_R	320_A	1.261	1.00
116_I	261_V	1.260	1.00
182_I	187_I	1.245	1.00
115_A	240_I	1.243	1.00
348_P	373_Q	1.238	1.00
294_I	398_L	1.236	1.00
116_I	397_D	1.232	1.00
246_D	250_R	1.226	1.00
109_A	395_W	1.217	1.00
73_I	239_A	1.215	1.00
28_V	242_L	1.214	1.00
368_I	372_W	1.213	1.00
186_E	189_L	1.212	1.00
131_L	241_V	1.211	1.00
75_S	78_D	1.207	1.00
184_K	226_Q	1.198	1.00
301_I	398_L	1.188	1.00
301_I	381_M	1.177	1.00
98_K	272_A	1.173	1.00
52_E	56_K	1.169	1.00
68_I	129_K	1.169	1.00
171_M	223_W	1.158	1.00
264_T	283_F	1.149	1.00
29_A	245_E	1.146	1.00
38_F	355_V	1.146	1.00
285_A	383_V	1.142	1.00
112_V	367_V	1.141	1.00
72_V	130_V	1.137	1.00
33_A	372_W	1.135	1.00
67_D	247_V	1.130	1.00
383_V	398_L	1.130	1.00
179_T	274_D	1.124	1.00
295_E	300_E	1.119	1.00
190_V	314_E	1.112	1.00
296_R	299_K	1.100	1.00
126_L	291_M	1.099	1.00
69_D	128_Q	1.098	1.00
296_R	301_I	1.093	1.00
190_V	315_L	1.091	1.00
118_G	132_A	1.088	1.00
275_L	278_A	1.083	1.00
199_I	208_S	1.081	1.00
29_A	243_A	1.080	1.00
26_K	128_Q	1.075	1.00
284_A	396_G	1.070	1.00
192_V	215_V	1.065	1.00
302_D	345_P	1.058	1.00
175_R	179_T	1.057	1.00
212_V	216_L	1.056	1.00
74_G	110_T	1.055	1.00
260_G	291_M	1.053	1.00
278_A	281_V	1.053	1.00
303_V	377_I	1.051	1.00
33_A	371_Y	1.049	1.00
266_D	278_A	1.048	1.00
123_A	126_L	1.045	1.00
54_A	96_G	1.042	1.00
109_A	389_T	1.042	1.00
34_G	56_K	1.042	1.00
71_V	91_S	1.040	1.00
170_A	221_L	1.032	1.00
115_A	242_L	1.031	1.00
113_M	117_T	1.029	1.00
67_D	250_R	1.017	1.00
211_T	214_D	1.015	1.00
365_M	369_S	1.011	1.00
182_I	315_L	1.011	1.00
302_D	374_L	1.010	1.00
157_L	162_N	1.006	1.00
210_I	215_V	1.003	1.00
51_W	55_S	0.996	1.00
218_S	228_L	0.995	1.00
155_P	159_K	0.992	1.00
120_Y	124_S	0.989	1.00
264_T	287_M	0.983	1.00
32_G	60_E	0.982	1.00
258_V	397_D	0.980	1.00
348_P	377_I	0.980	1.00
156_I	159_K	0.966	1.00
245_E	257_W	0.961	1.00
38_F	234_S	0.961	1.00
174_H	178_A	0.957	1.00
180_Y	278_A	0.956	1.00
301_I	389_T	0.956	1.00
349_S	376_G	0.949	1.00
185_E	216_L	0.948	1.00
195_K	206_L	0.948	1.00
31_I	253_D	0.947	1.00
149_F	153_W	0.947	1.00
287_M	291_M	0.939	1.00
304_A	323_L	0.932	1.00
196_R	199_I	0.930	1.00
259_E	381_M	0.926	1.00
370_I	390_G	0.924	1.00
58_L	96_G	0.924	1.00
205_Q	208_S	0.924	1.00
96_G	99_K	0.921	1.00
119_W	258_V	0.920	1.00
145_P	150_R	0.919	1.00
323_L	346_S	0.916	1.00
370_I	384_K	0.916	1.00
238_A	361_A	0.914	1.00
367_V	399_M	0.912	1.00
53_A	56_K	0.911	1.00
45_T	48_E	0.911	1.00
37_L	52_E	0.910	1.00
278_A	320_A	0.909	1.00
192_V	209_N	0.901	1.00
58_L	63_L	0.900	1.00
204_A	376_G	0.895	1.00
177_M	312_Y	0.895	1.00
36_T	52_E	0.889	1.00
281_V	320_A	0.886	1.00
289_Y	296_R	0.885	1.00
199_I	207_G	0.884	1.00
285_A	321_L	0.884	1.00
27_R	123_A	0.882	1.00
57_A	131_L	0.877	1.00
218_S	226_Q	0.875	1.00
38_F	365_M	0.875	1.00
219_E	227_L	0.873	1.00
294_I	389_T	0.872	1.00
72_V	114_T	0.868	1.00
157_L	160_P	0.865	1.00
81_D	140_P	0.862	1.00
303_V	370_I	0.860	1.00
238_A	368_I	0.857	1.00
36_T	53_A	0.856	1.00
301_I	383_V	0.852	1.00
278_A	316_H	0.849	1.00
366_K	384_K	0.846	1.00
72_V	118_G	0.846	1.00
119_W	123_A	0.845	1.00
243_A	253_D	0.844	1.00
155_P	158_E	0.840	1.00
132_A	240_I	0.839	1.00
148_I	154_D	0.838	1.00
311_D	353_L	0.838	1.00
306_P	385_R	0.836	1.00
175_R	178_A	0.836	1.00
36_T	49_I	0.835	1.00
28_V	244_S	0.835	1.00
260_G	398_L	0.835	1.00
72_V	102_S	0.834	1.00
180_Y	320_A	0.832	1.00
352_L	362_A	0.831	1.00
193_K	326_R	0.831	1.00
53_A	57_A	0.830	1.00
160_P	163_P	0.820	1.00
258_V	261_V	0.819	1.00
33_A	240_I	0.818	1.00
245_E	248_A	0.815	1.00
246_D	249_R	0.815	1.00
188_A	229_D	0.813	1.00
176_Y	278_A	0.811	1.00
121_H	126_L	0.809	1.00
106_V	113_M	0.807	1.00
176_Y	316_H	0.806	1.00
50_A	133_V	0.805	1.00
92_H	98_K	0.804	1.00
254_T	375_K	0.803	1.00
67_D	129_K	0.802	1.00
69_D	287_M	0.796	1.00
318_L	323_L	0.795	1.00
198_A	206_L	0.793	1.00
266_D	283_F	0.792	1.00
272_A	275_L	0.791	1.00
71_V	99_K	0.789	1.00
114_T	364_L	0.787	1.00
197_N	200_N	0.786	1.00
370_I	392_A	0.783	1.00
46_P	135_E	0.782	1.00
185_E	212_V	0.782	1.00
220_V	223_W	0.779	1.00
349_S	377_I	0.778	1.00
126_L	261_V	0.776	1.00
70_C	121_H	0.776	1.00
57_A	239_A	0.773	1.00
314_E	318_L	0.769	1.00
149_F	152_I	0.763	1.00
285_A	396_G	0.760	1.00
151_Y	154_D	0.759	1.00
149_F	154_D	0.759	1.00
117_T	120_Y	0.758	1.00
112_V	397_D	0.757	1.00
229_D	311_D	0.756	1.00
34_G	53_A	0.753	1.00
44_E	48_E	0.752	1.00
58_L	68_I	0.751	1.00
202_P	208_S	0.749	1.00
292_A	398_L	0.749	1.00
150_R	154_D	0.741	1.00
173_M	312_Y	0.741	1.00
186_E	315_L	0.737	1.00
210_I	214_D	0.737	1.00
68_I	131_L	0.732	1.00
289_Y	294_I	0.731	1.00
28_V	119_W	0.728	1.00
286_R	321_L	0.725	1.00
28_V	123_A	0.725	1.00
131_L	239_A	0.724	1.00
75_S	81_D	0.723	1.00
213_E	217_K	0.723	1.00
30_I	371_Y	0.723	1.00
55_S	65_L	0.715	1.00
389_T	395_W	0.715	1.00
266_D	279_R	0.713	1.00
294_I	300_E	0.712	1.00
198_A	202_P	0.711	1.00
47_Q	81_D	0.710	1.00
147_S	154_D	0.710	1.00
158_E	162_N	0.705	1.00
146_Q	149_F	0.701	1.00
210_I	228_L	0.697	1.00
139_S	235_D	0.696	1.00
200_N	203_Y	0.694	1.00
117_T	121_H	0.694	1.00
73_I	87_G	0.692	1.00
69_D	130_V	0.690	1.00
45_T	140_P	0.689	1.00
157_L	168_I	0.685	1.00
75_S	86_K	0.682	1.00
367_V	397_D	0.681	1.00
299_K	345_P	0.680	1.00
316_H	320_A	0.679	1.00
192_V	210_I	0.678	1.00
70_C	263_W	0.678	1.00
259_E	292_A	0.676	1.00
288_A	383_V	0.675	1.00
28_V	122_V	0.674	1.00
52_E	55_S	0.673	1.00
192_V	211_T	0.673	1.00
306_P	317_H	0.673	1.00
76_A	359_I	0.673	1.00
150_R	153_W	0.672	1.00
96_G	131_L	0.668	1.00
192_V	214_D	0.668	1.00
128_Q	291_M	0.665	1.00
58_L	65_L	0.659	1.00
147_S	150_R	0.657	1.00
168_I	171_M	0.655	1.00
302_D	381_M	0.655	1.00
72_V	117_T	0.654	1.00
378_A	381_M	0.654	1.00
221_L	227_L	0.652	1.00
299_K	322_Q	0.650	1.00
34_G	57_A	0.650	1.00
285_A	306_P	0.650	1.00
198_A	354_G	0.649	1.00
68_I	96_G	0.649	1.00
31_I	248_A	0.647	1.00
120_Y	123_A	0.646	1.00
176_Y	180_Y	0.646	1.00
188_A	216_L	0.645	1.00
374_L	382_Q	0.644	0.99
121_H	130_V	0.644	0.99
281_V	286_R	0.643	0.99
173_M	177_M	0.642	0.99
162_N	166_I	0.642	0.99
172_E	276_A	0.641	0.99
29_A	247_V	0.640	0.99
54_A	94_A	0.638	0.99
115_A	132_A	0.637	0.99
240_I	368_I	0.637	0.99
61_A	241_V	0.636	0.99
158_E	161_L	0.635	0.99
100_P	263_W	0.631	0.99
118_G	127_C	0.630	0.99
54_A	239_A	0.629	0.99
155_P	162_N	0.629	0.99
40_R	205_Q	0.628	0.99
47_Q	93_G	0.627	0.99
171_M	175_R	0.626	0.99
296_R	323_L	0.626	0.99
242_L	258_V	0.623	0.99
144_H	148_I	0.623	0.99
225_V	230_V	0.623	0.99
195_K	199_I	0.621	0.99
58_L	62_G	0.621	0.99
182_I	186_E	0.620	0.99
55_S	95_G	0.620	0.99
383_V	387_V	0.620	0.99
44_E	140_P	0.620	0.99
26_K	123_A	0.619	0.99
106_V	263_W	0.618	0.99
128_Q	250_R	0.617	0.99
205_Q	234_S	0.617	0.99
206_L	232_P	0.615	0.99
382_Q	399_M	0.615	0.99
198_A	355_V	0.614	0.99
104_V	117_T	0.614	0.99
286_R	322_Q	0.612	0.99
304_A	385_R	0.610	0.99
129_K	251_Y	0.609	0.99
195_K	353_L	0.606	0.99
50_A	135_E	0.606	0.99
51_W	94_A	0.606	0.99
147_S	156_I	0.605	0.99
205_Q	209_N	0.605	0.99
262_G	291_M	0.604	0.99
375_K	378_A	0.604	0.99
309_P	357_N	0.596	0.99
55_S	94_A	0.594	0.99
73_I	90_L	0.592	0.99
191_S	311_D	0.591	0.99
156_I	160_P	0.591	0.99
188_A	212_V	0.589	0.99
48_E	51_W	0.588	0.99
314_E	346_S	0.588	0.99
170_A	224_P	0.588	0.99
31_I	247_V	0.587	0.99
167_W	171_M	0.584	0.99
243_A	251_Y	0.584	0.99
195_K	205_Q	0.584	0.99
58_L	61_A	0.584	0.99
159_K	162_N	0.582	0.99
102_S	113_M	0.582	0.99
385_R	388_H	0.582	0.99
199_I	202_P	0.581	0.99
138_M	359_I	0.580	0.99
290_K	295_E	0.579	0.99
112_V	384_K	0.578	0.99
29_A	244_S	0.578	0.99
259_E	294_I	0.577	0.99
355_V	365_M	0.576	0.99
284_A	288_A	0.576	0.99
206_L	209_N	0.574	0.99
70_C	106_V	0.574	0.99
69_D	99_K	0.573	0.99
252_T	255_P	0.573	0.99
296_R	300_E	0.572	0.99
44_E	137_K	0.572	0.99
78_D	103_R	0.572	0.99
173_M	225_V	0.572	0.99
362_A	366_K	0.571	0.99
197_N	325_K	0.570	0.99
156_I	162_N	0.570	0.99
54_A	58_L	0.569	0.99
313_K	317_H	0.569	0.99
71_V	131_L	0.568	0.99
160_P	359_I	0.567	0.99
182_I	319_E	0.566	0.99
30_I	399_M	0.566	0.99
285_A	317_H	0.566	0.99
143_P	146_Q	0.566	0.99
389_T	393_Q	0.565	0.99
167_W	274_D	0.564	0.99
367_V	384_K	0.563	0.99
116_I	395_W	0.563	0.99
90_L	94_A	0.563	0.99
153_W	158_E	0.561	0.99
195_K	209_N	0.561	0.99
91_S	101_V	0.560	0.99
123_A	261_V	0.560	0.99
151_Y	155_P	0.558	0.99
157_L	161_L	0.558	0.99
90_L	135_E	0.558	0.99
289_Y	292_A	0.557	0.99
285_A	296_R	0.553	0.98
371_Y	399_M	0.552	0.98
381_M	398_L	0.552	0.98
133_V	239_A	0.551	0.98
155_P	160_P	0.551	0.98
34_G	61_A	0.550	0.98
200_N	380_K	0.548	0.98
283_F	287_M	0.548	0.98
114_T	132_A	0.547	0.98
302_D	380_K	0.547	0.98
209_N	214_D	0.546	0.98
189_L	325_K	0.545	0.98
355_V	369_S	0.544	0.98
318_L	324_A	0.544	0.98
180_Y	316_H	0.543	0.98
361_A	364_L	0.542	0.98
63_L	241_V	0.542	0.98
144_H	149_F	0.542	0.98
30_I	242_L	0.539	0.98
77_P	141_A	0.537	0.98
193_K	314_E	0.537	0.98
91_S	96_G	0.536	0.98
256_V	374_L	0.533	0.98
315_L	319_E	0.533	0.98
174_H	225_V	0.529	0.98
147_S	157_L	0.529	0.98
132_A	364_L	0.525	0.98
112_V	395_W	0.524	0.98
312_Y	316_H	0.523	0.98
289_Y	301_I	0.521	0.98
29_A	251_Y	0.521	0.98
212_V	215_V	0.521	0.98
306_P	314_E	0.521	0.98
70_C	127_C	0.520	0.98
41_R	44_E	0.520	0.98
148_I	151_Y	0.519	0.98
113_M	121_H	0.519	0.98
146_Q	154_D	0.518	0.98
115_A	364_L	0.518	0.98
70_C	130_V	0.517	0.98
113_M	116_I	0.516	0.98
285_A	289_Y	0.515	0.98
65_L	97_I	0.512	0.98
319_E	322_Q	0.511	0.97
146_Q	150_R	0.510	0.97
180_Y	319_E	0.509	0.97
191_S	195_K	0.508	0.97
204_A	349_S	0.508	0.97
84_N	107_G	0.507	0.97
244_S	248_A	0.504	0.97
121_H	124_S	0.502	0.97
113_M	263_W	0.501	0.97
148_I	152_I	0.501	0.97
189_L	192_V	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbgA	2	0.934	100	0.295	Contact Map
4u4eA	1	0.8606	100	0.339	Contact Map
1wdkC	2	0.8606	100	0.388	Contact Map
2wu9A	2	0.8631	100	0.397	Contact Map
1ulqA	4	0.8533	100	0.4	Contact Map
3goaA	2	0.8386	100	0.407	Contact Map
1afwA	2	0.8704	100	0.408	Contact Map
2vu1A	4	0.8582	100	0.41	Contact Map
3svkA	2	0.7726	100	0.413	Contact Map
4nzsA	4	0.8557	100	0.416	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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