GREMLIN Database
Q97WQ6 - Acetyl-CoA C-acetyltransferase (Acetoacetyl-CoA thiolase) (AcaB-3)
UniProt: Q97WQ6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (347)
Sequences: 15324 (8389)
Seq/√Len: 450.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
193_K197_N3.5411.00
247_V251_Y3.4351.00
27_R245_E3.3931.00
186_E319_E3.3831.00
127_C130_V3.1381.00
192_V212_V3.0021.00
115_A367_V2.9181.00
26_K246_D2.9111.00
56_K59_D2.8971.00
370_I382_Q2.8601.00
295_E299_K2.7271.00
245_E249_R2.7251.00
247_V250_R2.7051.00
193_K196_R2.7021.00
200_N204_A2.6731.00
178_A223_W2.6511.00
54_A131_L2.5491.00
288_A292_A2.5141.00
29_A248_A2.4991.00
33_A368_I2.4771.00
122_V242_L2.4641.00
34_G60_E2.3141.00
57_A241_V2.2861.00
129_K243_A2.2321.00
183_K186_E2.1431.00
118_G130_V2.1321.00
256_V371_Y2.1321.00
374_L379_G2.0931.00
27_R257_W2.0861.00
122_V244_S2.0801.00
50_A73_I2.0591.00
203_Y208_S2.0541.00
260_G292_A2.0531.00
31_I243_A2.0251.00
64_E67_D1.9991.00
303_V348_P1.9631.00
294_I381_M1.9191.00
185_E189_L1.8971.00
238_A364_L1.8671.00
176_Y182_I1.8221.00
67_D251_Y1.8171.00
349_S373_Q1.8031.00
202_P206_L1.7891.00
260_G288_A1.7861.00
215_V228_L1.7731.00
128_Q244_S1.7691.00
288_A398_L1.7551.00
373_Q377_I1.7421.00
199_I206_L1.7311.00
318_L346_S1.7261.00
318_L325_K1.7241.00
179_T275_L1.6991.00
302_D379_G1.6941.00
301_I304_A1.6911.00
286_R290_K1.6891.00
243_A247_V1.6891.00
57_A61_A1.6861.00
205_Q232_P1.6751.00
285_A385_R1.6711.00
128_Q247_V1.6591.00
243_A248_A1.6461.00
170_A222_V1.6341.00
244_S247_V1.6231.00
73_I133_V1.6191.00
32_G61_A1.6031.00
294_I301_I1.6001.00
120_Y126_L1.5951.00
214_D217_K1.5911.00
199_I203_Y1.5881.00
102_S117_T1.5861.00
240_I364_L1.5831.00
121_H127_C1.5641.00
50_A90_L1.5621.00
29_A257_W1.5611.00
283_F286_R1.5511.00
192_V196_R1.5491.00
118_G242_L1.5351.00
189_L193_K1.5331.00
48_E93_G1.5231.00
296_R304_A1.5071.00
303_V373_Q1.4911.00
54_A90_L1.4871.00
137_K140_P1.4861.00
55_S59_D1.4821.00
129_K247_V1.4741.00
53_A239_A1.4551.00
193_K325_K1.4531.00
56_K60_E1.4481.00
26_K244_S1.4451.00
196_R209_N1.4431.00
189_L212_V1.4381.00
373_Q376_G1.4231.00
371_Y375_K1.4041.00
32_G57_A1.3951.00
196_R200_N1.3931.00
304_A383_V1.3691.00
53_A237_G1.3411.00
287_M290_K1.3401.00
262_G287_M1.3371.00
38_F361_A1.3321.00
44_E52_E1.3141.00
262_G288_A1.2901.00
324_A345_P1.2791.00
174_H223_W1.2741.00
199_I209_N1.2721.00
86_K135_E1.2691.00
69_D127_C1.2671.00
51_W93_G1.2621.00
286_R320_A1.2611.00
116_I261_V1.2601.00
182_I187_I1.2451.00
115_A240_I1.2431.00
348_P373_Q1.2381.00
294_I398_L1.2361.00
116_I397_D1.2321.00
246_D250_R1.2261.00
109_A395_W1.2171.00
73_I239_A1.2151.00
28_V242_L1.2141.00
368_I372_W1.2131.00
186_E189_L1.2121.00
131_L241_V1.2111.00
75_S78_D1.2071.00
184_K226_Q1.1981.00
301_I398_L1.1881.00
301_I381_M1.1771.00
98_K272_A1.1731.00
52_E56_K1.1691.00
68_I129_K1.1691.00
171_M223_W1.1581.00
264_T283_F1.1491.00
29_A245_E1.1461.00
38_F355_V1.1461.00
285_A383_V1.1421.00
112_V367_V1.1411.00
72_V130_V1.1371.00
33_A372_W1.1351.00
67_D247_V1.1301.00
383_V398_L1.1301.00
179_T274_D1.1241.00
295_E300_E1.1191.00
190_V314_E1.1121.00
296_R299_K1.1001.00
126_L291_M1.0991.00
69_D128_Q1.0981.00
296_R301_I1.0931.00
190_V315_L1.0911.00
118_G132_A1.0881.00
275_L278_A1.0831.00
199_I208_S1.0811.00
29_A243_A1.0801.00
26_K128_Q1.0751.00
284_A396_G1.0701.00
192_V215_V1.0651.00
302_D345_P1.0581.00
175_R179_T1.0571.00
212_V216_L1.0561.00
74_G110_T1.0551.00
260_G291_M1.0531.00
278_A281_V1.0531.00
303_V377_I1.0511.00
33_A371_Y1.0491.00
266_D278_A1.0481.00
123_A126_L1.0451.00
54_A96_G1.0421.00
109_A389_T1.0421.00
34_G56_K1.0421.00
71_V91_S1.0401.00
170_A221_L1.0321.00
115_A242_L1.0311.00
113_M117_T1.0291.00
67_D250_R1.0171.00
211_T214_D1.0151.00
365_M369_S1.0111.00
182_I315_L1.0111.00
302_D374_L1.0101.00
157_L162_N1.0061.00
210_I215_V1.0031.00
51_W55_S0.9961.00
218_S228_L0.9951.00
155_P159_K0.9921.00
120_Y124_S0.9891.00
264_T287_M0.9831.00
32_G60_E0.9821.00
258_V397_D0.9801.00
348_P377_I0.9801.00
156_I159_K0.9661.00
245_E257_W0.9611.00
38_F234_S0.9611.00
174_H178_A0.9571.00
180_Y278_A0.9561.00
301_I389_T0.9561.00
349_S376_G0.9491.00
185_E216_L0.9481.00
195_K206_L0.9481.00
31_I253_D0.9471.00
149_F153_W0.9471.00
287_M291_M0.9391.00
304_A323_L0.9321.00
196_R199_I0.9301.00
259_E381_M0.9261.00
370_I390_G0.9241.00
58_L96_G0.9241.00
205_Q208_S0.9241.00
96_G99_K0.9211.00
119_W258_V0.9201.00
145_P150_R0.9191.00
323_L346_S0.9161.00
370_I384_K0.9161.00
238_A361_A0.9141.00
367_V399_M0.9121.00
53_A56_K0.9111.00
45_T48_E0.9111.00
37_L52_E0.9101.00
278_A320_A0.9091.00
192_V209_N0.9011.00
58_L63_L0.9001.00
204_A376_G0.8951.00
177_M312_Y0.8951.00
36_T52_E0.8891.00
281_V320_A0.8861.00
289_Y296_R0.8851.00
199_I207_G0.8841.00
285_A321_L0.8841.00
27_R123_A0.8821.00
57_A131_L0.8771.00
218_S226_Q0.8751.00
38_F365_M0.8751.00
219_E227_L0.8731.00
294_I389_T0.8721.00
72_V114_T0.8681.00
157_L160_P0.8651.00
81_D140_P0.8621.00
303_V370_I0.8601.00
238_A368_I0.8571.00
36_T53_A0.8561.00
301_I383_V0.8521.00
278_A316_H0.8491.00
366_K384_K0.8461.00
72_V118_G0.8461.00
119_W123_A0.8451.00
243_A253_D0.8441.00
155_P158_E0.8401.00
132_A240_I0.8391.00
148_I154_D0.8381.00
311_D353_L0.8381.00
306_P385_R0.8361.00
175_R178_A0.8361.00
36_T49_I0.8351.00
28_V244_S0.8351.00
260_G398_L0.8351.00
72_V102_S0.8341.00
180_Y320_A0.8321.00
352_L362_A0.8311.00
193_K326_R0.8311.00
53_A57_A0.8301.00
160_P163_P0.8201.00
258_V261_V0.8191.00
33_A240_I0.8181.00
245_E248_A0.8151.00
246_D249_R0.8151.00
188_A229_D0.8131.00
176_Y278_A0.8111.00
121_H126_L0.8091.00
106_V113_M0.8071.00
176_Y316_H0.8061.00
50_A133_V0.8051.00
92_H98_K0.8041.00
254_T375_K0.8031.00
67_D129_K0.8021.00
69_D287_M0.7961.00
318_L323_L0.7951.00
198_A206_L0.7931.00
266_D283_F0.7921.00
272_A275_L0.7911.00
71_V99_K0.7891.00
114_T364_L0.7871.00
197_N200_N0.7861.00
370_I392_A0.7831.00
46_P135_E0.7821.00
185_E212_V0.7821.00
220_V223_W0.7791.00
349_S377_I0.7781.00
126_L261_V0.7761.00
70_C121_H0.7761.00
57_A239_A0.7731.00
314_E318_L0.7691.00
149_F152_I0.7631.00
285_A396_G0.7601.00
151_Y154_D0.7591.00
149_F154_D0.7591.00
117_T120_Y0.7581.00
112_V397_D0.7571.00
229_D311_D0.7561.00
34_G53_A0.7531.00
44_E48_E0.7521.00
58_L68_I0.7511.00
202_P208_S0.7491.00
292_A398_L0.7491.00
150_R154_D0.7411.00
173_M312_Y0.7411.00
186_E315_L0.7371.00
210_I214_D0.7371.00
68_I131_L0.7321.00
289_Y294_I0.7311.00
28_V119_W0.7281.00
286_R321_L0.7251.00
28_V123_A0.7251.00
131_L239_A0.7241.00
75_S81_D0.7231.00
213_E217_K0.7231.00
30_I371_Y0.7231.00
55_S65_L0.7151.00
389_T395_W0.7151.00
266_D279_R0.7131.00
294_I300_E0.7121.00
198_A202_P0.7111.00
47_Q81_D0.7101.00
147_S154_D0.7101.00
158_E162_N0.7051.00
146_Q149_F0.7011.00
210_I228_L0.6971.00
139_S235_D0.6961.00
200_N203_Y0.6941.00
117_T121_H0.6941.00
73_I87_G0.6921.00
69_D130_V0.6901.00
45_T140_P0.6891.00
157_L168_I0.6851.00
75_S86_K0.6821.00
367_V397_D0.6811.00
299_K345_P0.6801.00
316_H320_A0.6791.00
192_V210_I0.6781.00
70_C263_W0.6781.00
259_E292_A0.6761.00
288_A383_V0.6751.00
28_V122_V0.6741.00
52_E55_S0.6731.00
192_V211_T0.6731.00
306_P317_H0.6731.00
76_A359_I0.6731.00
150_R153_W0.6721.00
96_G131_L0.6681.00
192_V214_D0.6681.00
128_Q291_M0.6651.00
58_L65_L0.6591.00
147_S150_R0.6571.00
168_I171_M0.6551.00
302_D381_M0.6551.00
72_V117_T0.6541.00
378_A381_M0.6541.00
221_L227_L0.6521.00
299_K322_Q0.6501.00
34_G57_A0.6501.00
285_A306_P0.6501.00
198_A354_G0.6491.00
68_I96_G0.6491.00
31_I248_A0.6471.00
120_Y123_A0.6461.00
176_Y180_Y0.6461.00
188_A216_L0.6451.00
374_L382_Q0.6440.99
121_H130_V0.6440.99
281_V286_R0.6430.99
173_M177_M0.6420.99
162_N166_I0.6420.99
172_E276_A0.6410.99
29_A247_V0.6400.99
54_A94_A0.6380.99
115_A132_A0.6370.99
240_I368_I0.6370.99
61_A241_V0.6360.99
158_E161_L0.6350.99
100_P263_W0.6310.99
118_G127_C0.6300.99
54_A239_A0.6290.99
155_P162_N0.6290.99
40_R205_Q0.6280.99
47_Q93_G0.6270.99
171_M175_R0.6260.99
296_R323_L0.6260.99
242_L258_V0.6230.99
144_H148_I0.6230.99
225_V230_V0.6230.99
195_K199_I0.6210.99
58_L62_G0.6210.99
182_I186_E0.6200.99
55_S95_G0.6200.99
383_V387_V0.6200.99
44_E140_P0.6200.99
26_K123_A0.6190.99
106_V263_W0.6180.99
128_Q250_R0.6170.99
205_Q234_S0.6170.99
206_L232_P0.6150.99
382_Q399_M0.6150.99
198_A355_V0.6140.99
104_V117_T0.6140.99
286_R322_Q0.6120.99
304_A385_R0.6100.99
129_K251_Y0.6090.99
195_K353_L0.6060.99
50_A135_E0.6060.99
51_W94_A0.6060.99
147_S156_I0.6050.99
205_Q209_N0.6050.99
262_G291_M0.6040.99
375_K378_A0.6040.99
309_P357_N0.5960.99
55_S94_A0.5940.99
73_I90_L0.5920.99
191_S311_D0.5910.99
156_I160_P0.5910.99
188_A212_V0.5890.99
48_E51_W0.5880.99
314_E346_S0.5880.99
170_A224_P0.5880.99
31_I247_V0.5870.99
167_W171_M0.5840.99
243_A251_Y0.5840.99
195_K205_Q0.5840.99
58_L61_A0.5840.99
159_K162_N0.5820.99
102_S113_M0.5820.99
385_R388_H0.5820.99
199_I202_P0.5810.99
138_M359_I0.5800.99
290_K295_E0.5790.99
112_V384_K0.5780.99
29_A244_S0.5780.99
259_E294_I0.5770.99
355_V365_M0.5760.99
284_A288_A0.5760.99
206_L209_N0.5740.99
70_C106_V0.5740.99
69_D99_K0.5730.99
252_T255_P0.5730.99
296_R300_E0.5720.99
44_E137_K0.5720.99
78_D103_R0.5720.99
173_M225_V0.5720.99
362_A366_K0.5710.99
197_N325_K0.5700.99
156_I162_N0.5700.99
54_A58_L0.5690.99
313_K317_H0.5690.99
71_V131_L0.5680.99
160_P359_I0.5670.99
182_I319_E0.5660.99
30_I399_M0.5660.99
285_A317_H0.5660.99
143_P146_Q0.5660.99
389_T393_Q0.5650.99
167_W274_D0.5640.99
367_V384_K0.5630.99
116_I395_W0.5630.99
90_L94_A0.5630.99
153_W158_E0.5610.99
195_K209_N0.5610.99
91_S101_V0.5600.99
123_A261_V0.5600.99
151_Y155_P0.5580.99
157_L161_L0.5580.99
90_L135_E0.5580.99
289_Y292_A0.5570.99
285_A296_R0.5530.98
371_Y399_M0.5520.98
381_M398_L0.5520.98
133_V239_A0.5510.98
155_P160_P0.5510.98
34_G61_A0.5500.98
200_N380_K0.5480.98
283_F287_M0.5480.98
114_T132_A0.5470.98
302_D380_K0.5470.98
209_N214_D0.5460.98
189_L325_K0.5450.98
355_V369_S0.5440.98
318_L324_A0.5440.98
180_Y316_H0.5430.98
361_A364_L0.5420.98
63_L241_V0.5420.98
144_H149_F0.5420.98
30_I242_L0.5390.98
77_P141_A0.5370.98
193_K314_E0.5370.98
91_S96_G0.5360.98
256_V374_L0.5330.98
315_L319_E0.5330.98
174_H225_V0.5290.98
147_S157_L0.5290.98
132_A364_L0.5250.98
112_V395_W0.5240.98
312_Y316_H0.5230.98
289_Y301_I0.5210.98
29_A251_Y0.5210.98
212_V215_V0.5210.98
306_P314_E0.5210.98
70_C127_C0.5200.98
41_R44_E0.5200.98
148_I151_Y0.5190.98
113_M121_H0.5190.98
146_Q154_D0.5180.98
115_A364_L0.5180.98
70_C130_V0.5170.98
113_M116_I0.5160.98
285_A289_Y0.5150.98
65_L97_I0.5120.98
319_E322_Q0.5110.97
146_Q150_R0.5100.97
180_Y319_E0.5090.97
191_S195_K0.5080.97
204_A349_S0.5080.97
84_N107_G0.5070.97
244_S248_A0.5040.97
121_H124_S0.5020.97
113_M263_W0.5010.97
148_I152_I0.5010.97
189_L192_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbgA 2 0.934 100 0.295 Contact Map
4u4eA 1 0.8606 100 0.339 Contact Map
1wdkC 2 0.8606 100 0.388 Contact Map
2wu9A 2 0.8631 100 0.397 Contact Map
1ulqA 4 0.8533 100 0.4 Contact Map
3goaA 2 0.8386 100 0.407 Contact Map
1afwA 2 0.8704 100 0.408 Contact Map
2vu1A 4 0.8582 100 0.41 Contact Map
3svkA 2 0.7726 100 0.413 Contact Map
4nzsA 4 0.8557 100 0.416 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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