GREMLIN Database
Q97WQ5 - Uncharacterized protein
UniProt: Q97WQ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (140)
Sequences: 488 (284)
Seq/√Len: 24.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_K163_K4.9921.00
49_C52_C4.3171.00
49_C63_C4.2171.00
52_C63_C3.9761.00
52_C66_C3.8541.00
44_I57_V3.4541.00
82_V104_G3.1431.00
42_G152_R2.9961.00
43_K75_E2.7520.99
78_D144_A2.7160.99
38_G45_Y2.6660.99
28_A36_L2.3540.98
79_E143_K2.2120.97
63_C66_C2.2050.97
106_I144_A2.1100.96
49_C66_C2.0830.95
125_I132_V2.0730.95
108_L162_F2.0380.95
145_V161_C2.0350.95
83_M107_R1.9920.94
140_K164_V1.9350.93
82_V142_V1.9030.93
80_G142_V1.8430.91
34_K73_W1.6410.86
46_G57_V1.6300.85
154_G158_D1.5390.82
108_L112_N1.5360.81
145_V163_K1.5070.80
128_S131_Q1.5010.80
45_Y75_E1.4920.80
34_K37_L1.4860.79
152_R158_D1.4750.79
33_S37_L1.3560.73
77_K108_L1.3440.72
94_R126_C1.3270.71
41_E133_K1.2820.68
34_K143_K1.2800.68
124_R127_A1.2120.64
47_R73_W1.1600.60
15_I23_K1.1550.60
99_E126_C1.1340.58
104_G142_V1.1260.58
126_C161_C1.1170.57
46_G112_N1.1130.57
34_K38_G1.0840.55
48_K141_R1.0600.53
60_K87_A1.0590.53
120_G124_R1.0580.53
44_I108_L1.0560.53
76_V108_L1.0430.52
52_C68_R1.0290.51
110_P141_R0.9940.49
38_G43_K0.9900.48
63_C103_V0.9810.48
108_L144_A0.9810.48
45_Y73_W0.9770.47
59_P73_W0.9760.47
42_G147_R0.9750.47
28_A33_S0.9720.47
30_Q72_E0.9620.46
37_L143_K0.9420.45
36_L155_S0.9370.45
47_R68_R0.9320.44
46_G74_V0.9250.44
106_I132_V0.9220.44
145_V160_Q0.9110.43
129_Y164_V0.9060.42
26_Y101_E0.9030.42
42_G59_P0.9010.42
35_Y73_W0.8950.42
68_R71_D0.8900.41
92_W99_E0.8870.41
147_R151_E0.8870.41
57_V76_V0.8860.41
55_I110_P0.8810.41
42_G151_E0.8790.41
92_W101_E0.8790.41
67_F144_A0.8740.40
18_Y122_F0.8610.39
29_G96_K0.8510.39
12_K54_R0.8370.38
47_R63_C0.8360.38
132_V140_K0.8360.38
48_K99_E0.8360.38
123_H162_F0.8350.38
37_L41_E0.8330.37
108_L119_P0.8320.37
47_R70_T0.8310.37
69_P125_I0.8300.37
147_R152_R0.8290.37
140_K150_E0.8130.36
61_M70_T0.8120.36
32_Q146_W0.8020.35
53_G68_R0.8010.35
24_Y68_R0.8000.35
61_M104_G0.7970.35
13_H145_V0.7830.34
38_G161_C0.7810.34
33_S39_L0.7770.34
64_E88_S0.7770.34
32_Q36_L0.7690.33
20_P27_T0.7610.33
29_G158_D0.7570.33
71_D156_I0.7520.32
89_F145_V0.7460.32
79_E144_A0.7370.31
48_K74_V0.7220.30
63_C68_R0.7220.30
95_A141_R0.7180.30
83_M140_K0.7180.30
106_I125_I0.7170.30
48_K53_G0.7160.30
120_G123_H0.7150.30
65_E87_A0.7090.30
127_A131_Q0.7060.29
80_G111_S0.6960.29
45_Y153_K0.6960.29
13_H38_G0.6940.29
41_E152_R0.6940.29
14_Y17_S0.6890.28
121_I147_R0.6890.28
74_V111_S0.6880.28
147_R158_D0.6860.28
106_I123_H0.6810.28
35_Y103_V0.6780.28
59_P88_S0.6760.28
84_T129_Y0.6740.28
32_Q56_H0.6730.28
55_I74_V0.6720.27
81_I141_R0.6660.27
42_G131_Q0.6650.27
36_L47_R0.6620.27
99_E161_C0.6600.27
87_A102_I0.6600.27
123_H127_A0.6580.27
126_C130_E0.6570.27
81_I108_L0.6530.26
35_Y38_G0.6520.26
45_Y88_S0.6510.26
36_L93_T0.6500.26
35_Y156_I0.6470.26
44_I76_V0.6470.26
38_G77_K0.6380.26
31_A61_M0.6340.25
67_F147_R0.6330.25
31_A77_K0.6290.25
28_A121_I0.6260.25
31_A93_T0.6230.25
91_S95_A0.6200.25
35_Y90_I0.6190.25
156_I159_I0.6130.24
70_T147_R0.6100.24
12_K75_E0.6060.24
86_V103_V0.6020.24
85_A102_I0.5970.23
58_P154_G0.5950.23
55_I112_N0.5930.23
16_I22_A0.5920.23
55_I111_S0.5920.23
44_I106_I0.5870.23
92_W95_A0.5860.23
133_K140_K0.5850.23
59_P62_Y0.5830.23
38_G41_E0.5790.23
32_Q122_F0.5770.22
79_E83_M0.5760.22
38_G146_W0.5740.22
96_K101_E0.5740.22
22_A60_K0.5740.22
69_P131_Q0.5740.22
58_P159_I0.5720.22
22_A101_E0.5670.22
49_C60_K0.5670.22
26_Y32_Q0.5650.22
19_K133_K0.5620.22
55_I141_R0.5610.22
119_P123_H0.5590.22
101_E124_R0.5580.22
43_K161_C0.5530.21
78_D132_V0.5500.21
14_Y21_N0.5470.21
153_K161_C0.5470.21
38_G88_S0.5470.21
92_W103_V0.5460.21
52_C138_I0.5430.21
24_Y42_G0.5420.21
28_A133_K0.5390.21
154_G157_E0.5390.21
41_E128_S0.5380.21
82_V132_V0.5370.21
72_E131_Q0.5360.20
72_E130_E0.5360.20
129_Y132_V0.5350.20
106_I162_F0.5320.20
102_I127_A0.5290.20
47_R56_H0.5270.20
123_H144_A0.5270.20
28_A32_Q0.5270.20
91_S100_P0.5260.20
79_E107_R0.5240.20
80_G107_R0.5200.20
84_T92_W0.5200.20
43_K155_S0.5120.19
98_E125_I0.5110.19
43_K51_K0.5100.19
81_I110_P0.5070.19
55_I87_A0.5060.19
45_Y81_I0.5040.19
31_A71_D0.5000.19
88_S140_K0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irbA 3 0.8182 100 0.463 Contact Map
1lkoA 3 0.4848 88.4 0.907 Contact Map
3pwfA 4 0.3636 86.2 0.91 Contact Map
1s24A 1 0.2182 79.5 0.916 Contact Map
1yuzA 2 0.3636 77 0.918 Contact Map
2lcqA 1 0.4606 76.5 0.919 Contact Map
4d02A 2 0.103 72.6 0.921 Contact Map
1yk4A 1 0.2 68.4 0.923 Contact Map
2v3bB 1 0.2061 65.1 0.925 Contact Map
2kn9A 1 0.3636 61.9 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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