GREMLIN Database
Q97WQ4 - Uncharacterized protein
UniProt: Q97WQ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (121)
Sequences: 590 (347)
Seq/√Len: 31.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_K75_E3.9551.00
52_C66_C3.9181.00
49_C63_C3.5701.00
52_C63_C3.3181.00
49_C52_C3.0681.00
44_I57_V2.9561.00
83_V130_A2.5761.00
38_G45_I2.5301.00
80_E131_K2.4050.99
110_P129_K2.4030.99
83_V105_A2.3720.99
63_C66_C2.2870.99
83_V124_V2.2180.99
77_N80_E2.2160.99
84_D108_R2.1010.98
45_I75_E2.0460.98
49_C66_C1.9900.97
107_I132_I1.9840.97
34_Q73_Y1.9660.97
34_Q37_N1.9070.97
38_G43_K1.7510.95
33_E37_N1.7280.94
28_V36_F1.6620.93
81_A130_A1.6290.92
48_K74_V1.4690.87
120_A124_V1.4560.87
80_E129_K1.4080.85
109_F112_I1.3980.85
42_N136_Q1.3940.84
50_S68_V1.3850.84
88_I103_Y1.3630.83
72_N122_G1.3530.83
35_F39_L1.2630.78
118_C132_I1.2380.76
107_I120_A1.2200.75
92_D101_P1.2000.74
43_K136_Q1.1960.74
109_F132_I1.1900.74
37_N41_Q1.1780.73
86_Y103_Y1.1640.72
48_K53_G1.1590.72
76_I109_F1.1440.71
55_I74_V1.1310.70
16_Y19_M1.1070.68
46_G74_V1.0920.67
107_I118_C1.0910.67
14_R18_V1.0530.64
82_Y129_K1.0470.64
105_A130_A1.0450.63
34_Q38_G1.0430.63
93_D102_V1.0420.63
46_G57_V1.0410.63
48_K72_N1.0310.62
34_Q131_K1.0140.61
80_E110_P0.9870.59
121_E128_A0.9820.59
41_Q75_E0.9780.58
108_R126_V0.9770.58
35_F38_G0.9410.55
41_Q45_I0.9400.55
51_K70_I0.9330.55
48_K55_I0.9290.54
76_I112_I0.9280.54
16_Y20_E0.9210.54
47_S73_Y0.9140.53
85_S93_D0.9140.53
67_F132_I0.9040.52
109_F114_G0.9010.52
52_C68_V0.8930.51
57_V112_I0.8860.51
46_G58_P0.8800.50
60_R88_I0.8580.48
55_I111_N0.8570.48
53_G123_N0.8470.48
46_G90_Y0.8450.47
43_K51_K0.8390.47
47_S56_F0.8350.47
28_V116_L0.8350.47
46_G76_I0.8220.46
29_G107_I0.8190.45
57_V76_I0.8180.45
14_R23_R0.8180.45
22_E102_V0.8160.45
105_A124_V0.8130.45
63_C104_I0.8060.44
44_I109_F0.8010.44
59_A73_Y0.7980.44
32_G36_F0.7950.43
39_L118_C0.7870.43
87_T120_A0.7740.42
87_T104_I0.7630.41
18_V70_I0.7590.41
29_G62_Y0.7590.41
81_A110_P0.7550.40
93_D100_Q0.7520.40
38_G41_Q0.7450.39
66_C136_Q0.7390.39
45_I73_Y0.7370.39
107_I124_V0.7330.39
38_G42_N0.7320.38
103_Y124_V0.7250.38
19_M42_N0.7200.38
33_E110_P0.7170.37
14_R17_D0.7000.36
47_S63_C0.6900.35
70_I135_F0.6850.35
49_C73_Y0.6730.34
76_I117_L0.6720.34
35_F57_V0.6710.34
74_V131_K0.6700.34
46_G55_I0.6700.34
20_E87_T0.6690.34
49_C60_R0.6660.33
61_S70_I0.6650.33
31_A61_S0.6630.33
84_D128_A0.6540.33
33_E107_I0.6510.32
23_R59_A0.6500.32
36_F42_N0.6440.32
48_K100_Q0.6410.32
56_F60_R0.6390.32
82_Y110_P0.6380.31
106_L130_A0.6360.31
89_I102_V0.6330.31
87_T127_G0.6300.31
15_W18_V0.6280.31
37_N131_K0.6240.31
38_G89_I0.6210.30
132_I135_F0.6200.30
47_S52_C0.6200.30
48_K123_N0.6190.30
53_G127_G0.6170.30
29_G97_K0.6140.30
26_Y32_G0.6070.29
50_S72_N0.5970.29
35_F132_I0.5970.29
28_V33_E0.5950.29
97_K135_F0.5950.29
27_T92_D0.5930.28
30_P72_N0.5900.28
45_I77_N0.5900.28
14_R19_M0.5890.28
42_N135_F0.5880.28
87_T90_Y0.5860.28
42_N59_A0.5840.28
108_R115_G0.5780.27
50_S70_I0.5760.27
27_T64_E0.5720.27
32_G56_F0.5710.27
77_N109_F0.5680.27
97_K103_Y0.5670.27
86_Y135_F0.5640.27
114_G117_L0.5600.26
50_S53_G0.5590.26
15_W26_Y0.5570.26
95_G129_K0.5550.26
36_F47_S0.5480.26
97_K137_W0.5480.26
102_V119_Y0.5450.25
27_T39_L0.5450.25
80_E128_A0.5440.25
18_V83_V0.5430.25
26_Y102_V0.5420.25
81_A107_I0.5390.25
19_M22_E0.5370.25
104_I116_L0.5310.24
101_P105_A0.5290.24
58_P76_I0.5270.24
18_V59_A0.5250.24
43_K137_W0.5240.24
44_I83_V0.5240.24
47_S70_I0.5240.24
18_V38_G0.5220.24
63_C68_V0.5190.24
108_R113_E0.5180.24
88_I121_E0.5180.24
60_R80_E0.5140.23
48_K113_E0.5090.23
54_R116_L0.5030.23
85_S91_N0.5020.23
17_D117_L0.5020.23
63_C73_Y0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3irbA 3 0.9514 100 0.248 Contact Map
3pwfA 4 0.4931 83.3 0.906 Contact Map
2lcqA 1 0.5347 80.3 0.909 Contact Map
1lkoA 3 0.5208 80.2 0.909 Contact Map
1s24A 1 0.2569 74.1 0.913 Contact Map
1yuzA 2 0.4931 72.8 0.914 Contact Map
4d02A 2 0.1597 67.3 0.918 Contact Map
4tpuA 3 0.5208 64.9 0.919 Contact Map
1yk4A 1 0.2292 61.3 0.921 Contact Map
6rxnA 1 0.2292 58 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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