GREMLIN Database
Q97WP7 - Uncharacterized protein
UniProt: Q97WP7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (245)
Sequences: 206 (113)
Seq/√Len: 7.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
180_S183_E5.6111.00
135_S156_I4.8130.99
243_Q263_E4.2260.97
182_R185_P4.0080.96
243_Q262_G3.2740.89
170_S208_N3.1600.87
180_S185_P3.0550.86
182_R186_D3.0470.85
238_L242_F2.5100.72
183_E186_D2.5080.72
174_G184_I2.3810.67
180_S186_D2.3030.65
184_I192_K2.2450.63
185_P188_E2.1680.60
135_S155_L2.1490.59
194_K241_E2.1390.59
236_L240_T2.1360.59
190_Y238_L2.0920.57
20_L26_S2.0740.56
163_L168_I2.0600.56
193_G238_L2.0140.54
196_L211_M1.9810.53
99_S263_E1.8610.48
174_G211_M1.8460.47
187_S191_I1.8380.47
153_S273_Y1.8160.46
179_N183_E1.8030.46
109_I143_Q1.7990.45
86_I267_I1.7210.42
134_W149_K1.7100.42
115_Q120_V1.6970.42
94_I257_S1.6940.41
162_N165_E1.6810.41
61_G90_K1.6770.41
178_G182_R1.6750.41
132_V152_G1.6650.40
77_E195_S1.6570.40
47_G137_A1.6530.40
61_G114_E1.6310.39
30_S123_A1.6090.38
163_L188_E1.5850.37
177_I230_V1.5670.37
20_L40_D1.5640.37
113_S117_S1.5360.36
106_K237_D1.5100.35
13_K92_E1.5070.35
178_G183_E1.4680.33
175_S211_M1.4650.33
49_I85_Y1.4580.33
177_I183_E1.4530.33
171_L209_F1.4530.33
79_A134_W1.4280.32
229_H266_A1.4140.31
139_G271_S1.4100.31
177_I180_S1.3830.30
209_F235_V1.3620.30
80_L197_L1.3410.29
108_V123_A1.3370.29
97_I165_E1.3370.29
133_F163_L1.3170.28
102_S112_A1.3020.28
17_F39_V1.2930.27
44_I136_P1.2860.27
17_F30_S1.2830.27
232_S276_G1.2820.27
188_E191_I1.2780.27
113_S123_A1.2770.27
85_Y186_D1.2730.27
94_I247_S1.2690.27
54_L66_N1.2590.26
20_L48_L1.2550.26
43_I49_I1.2510.26
131_K144_L1.2510.26
106_K186_D1.2510.26
186_D230_V1.2490.26
112_A124_E1.2470.26
45_S116_M1.2190.25
18_T163_L1.2180.25
103_K260_K1.2100.25
118_R277_D1.2070.25
131_K164_E1.2020.25
180_S230_V1.1940.25
235_V275_L1.1860.24
171_L247_S1.1810.24
77_E248_L1.1770.24
101_K125_E1.1760.24
87_V267_I1.1760.24
43_I103_K1.1680.24
180_S184_I1.1630.24
69_K107_I1.1600.24
193_G196_L1.1580.24
54_L78_D1.1580.24
58_D80_L1.1540.23
47_G138_H1.1510.23
164_E206_I1.1430.23
20_L79_A1.1410.23
82_S97_I1.1290.23
118_R238_L1.1280.23
232_S251_H1.1240.23
174_G257_S1.1230.23
42_L265_I1.1190.22
181_Y185_P1.1110.22
85_Y276_G1.1050.22
43_I243_Q1.0840.21
93_V177_I1.0770.21
77_E233_K1.0720.21
121_K188_E1.0680.21
23_S93_V1.0610.21
43_I80_L1.0590.21
213_P270_G1.0420.20
116_M158_E1.0390.20
108_V252_V1.0300.20
61_G160_V1.0290.20
219_D250_G1.0240.20
212_P219_D1.0240.20
210_H250_G1.0240.20
212_P250_G1.0240.20
19_D46_G1.0240.20
210_H219_D1.0240.20
46_G210_H1.0240.20
46_G212_P1.0240.20
46_G219_D1.0240.20
46_G250_G1.0240.20
19_D250_G1.0240.20
19_D219_D1.0240.20
19_D212_P1.0240.20
19_D210_H1.0240.20
260_K265_I1.0060.20
57_E273_Y1.0000.19
195_S234_A0.9880.19
13_K39_V0.9820.19
31_L269_P0.9790.19
163_L266_A0.9770.19
258_M267_I0.9760.19
107_I233_K0.9750.19
234_A275_L0.9730.19
141_I175_S0.9720.19
68_K114_E0.9690.19
90_K247_S0.9680.19
73_N189_L0.9640.19
155_L206_I0.9610.18
49_I89_D0.9600.18
59_I133_F0.9490.18
178_G186_D0.9490.18
162_N191_I0.9490.18
154_N258_M0.9420.18
60_G153_S0.9400.18
168_I206_I0.9380.18
243_Q264_T0.9320.18
114_E144_L0.9310.18
57_E75_L0.9310.18
61_G187_S0.9280.18
237_D259_D0.9230.18
181_Y238_L0.9210.18
189_L234_A0.9110.17
69_K94_I0.9100.17
118_R162_N0.9040.17
84_K267_I0.8980.17
59_I231_G0.8980.17
81_R165_E0.8970.17
181_Y186_D0.8920.17
25_Y122_I0.8870.17
67_G75_L0.8820.17
13_K18_T0.8780.17
237_D240_T0.8690.16
177_I276_G0.8650.16
107_I134_W0.8640.16
177_I240_T0.8630.16
53_I57_E0.8630.16
39_V170_S0.8570.16
181_Y230_V0.8560.16
85_Y160_V0.8460.16
174_G230_V0.8390.16
156_I160_V0.8370.16
80_L238_L0.8310.16
116_M122_I0.8230.15
161_I242_F0.8220.15
173_F272_L0.8200.15
80_L106_K0.8160.15
14_L39_V0.8110.15
39_V136_P0.8070.15
38_R142_P0.8010.15
123_A276_G0.7990.15
96_D190_Y0.7970.15
188_E192_K0.7960.15
178_G181_Y0.7940.15
85_Y88_V0.7900.15
166_I267_I0.7890.15
76_N111_K0.7860.15
84_K258_M0.7840.15
54_L107_I0.7820.15
74_N93_V0.7810.15
73_N96_D0.7810.15
43_I265_I0.7810.15
77_E276_G0.7800.15
108_V125_E0.7780.15
247_S266_A0.7770.15
21_H140_D0.7760.14
248_L277_D0.7740.14
40_D215_N0.7700.14
88_V258_M0.7680.14
91_K233_K0.7680.14
118_R133_F0.7670.14
22_G270_G0.7580.14
69_K211_M0.7540.14
171_L218_L0.7510.14
116_M120_V0.7450.14
215_N238_L0.7450.14
22_G251_H0.7440.14
75_L79_A0.7440.14
57_E94_I0.7420.14
179_N185_P0.7410.14
252_V279_S0.7410.14
133_F168_I0.7400.14
181_Y193_G0.7390.14
174_G183_E0.7360.14
58_D158_E0.7350.14
83_G273_Y0.7340.14
43_I154_N0.7340.14
66_N179_N0.7330.14
106_K188_E0.7290.14
24_E263_E0.7270.14
178_G273_Y0.7240.14
190_Y267_I0.7210.13
66_N78_D0.7170.13
177_I186_D0.7110.13
47_G250_G0.7100.13
47_G212_P0.7100.13
47_G219_D0.7100.13
47_G210_H0.7100.13
19_D47_G0.7100.13
19_D253_H0.7090.13
46_G253_H0.7090.13
210_H253_H0.7090.13
219_D253_H0.7090.13
212_P253_H0.7090.13
250_G253_H0.7090.13
239_I242_F0.7090.13
179_N186_D0.7030.13
177_I211_M0.7000.13
42_L213_P0.6990.13
159_N191_I0.6990.13
146_S194_K0.6970.13
139_G252_V0.6890.13
149_K196_L0.6880.13
61_G189_L0.6880.13
105_E112_A0.6840.13
99_S176_P0.6830.13
101_K231_G0.6830.13
115_Q122_I0.6810.13
25_Y110_E0.6770.13
87_V90_K0.6750.13
41_F144_L0.6730.13
155_L259_D0.6690.13
26_S151_Y0.6670.13
14_L72_L0.6670.13
198_K259_D0.6660.12
183_E230_V0.6640.12
100_D252_V0.6620.12
42_L79_A0.6620.12
106_K109_I0.6600.12
77_E162_N0.6600.12
179_N182_R0.6590.12
197_L238_L0.6570.12
121_K234_A0.6520.12
58_D133_F0.6510.12
16_F42_L0.6450.12
28_K61_G0.6370.12
173_F252_V0.6360.12
21_H219_D0.6340.12
21_H212_P0.6340.12
21_H210_H0.6340.12
21_H46_G0.6340.12
21_H250_G0.6340.12
146_S261_V0.6340.12
95_E105_E0.6330.12
67_G79_A0.6320.12
19_D268_N0.6270.12
250_G268_N0.6270.12
46_G268_N0.6270.12
219_D268_N0.6270.12
212_P268_N0.6270.12
210_H268_N0.6270.12
140_D270_G0.6250.12
96_D185_P0.6240.12
97_I234_A0.6200.12
137_A212_P0.6180.12
46_G137_A0.6180.12
137_A210_H0.6180.12
137_A250_G0.6180.12
137_A219_D0.6180.12
19_D137_A0.6180.12
163_L237_D0.6170.12
45_S48_L0.6160.12
55_F272_L0.6150.12
69_K84_K0.6120.12
114_E154_N0.6110.12
228_S267_I0.6060.12
208_N255_S0.6050.11
76_N88_V0.6050.11
93_V242_F0.6030.11
199_D237_D0.6020.11
79_A82_S0.6000.11
233_K261_V0.5960.11
18_T116_M0.5960.11
142_P206_I0.5950.11
235_V261_V0.5940.11
229_H259_D0.5940.11
86_I174_G0.5940.11
58_D131_K0.5930.11
20_L111_K0.5920.11
41_F142_P0.5890.11
197_L236_L0.5870.11
154_N189_L0.5860.11
22_G232_S0.5840.11
85_Y267_I0.5820.11
85_Y107_I0.5790.11
192_K274_Q0.5780.11
68_K153_S0.5780.11
119_W208_N0.5770.11
49_I136_P0.5770.11
188_E194_K0.5760.11
154_N159_N0.5750.11
42_L260_K0.5740.11
183_E257_S0.5730.11
99_S234_A0.5730.11
193_G229_H0.5720.11
136_P157_N0.5670.11
18_T135_S0.5640.11
262_G265_I0.5600.11
102_S196_L0.5570.11
99_S206_I0.5570.11
187_S236_L0.5560.11
92_E113_S0.5550.11
109_I277_D0.5540.11
31_L52_E0.5490.11
48_L61_G0.5480.11
70_V82_S0.5480.11
111_K163_L0.5450.11
176_P183_E0.5440.11
54_L192_K0.5430.11
191_I195_S0.5420.11
260_K269_P0.5370.10
102_S247_S0.5370.10
92_E99_S0.5350.10
49_I145_D0.5330.10
155_L168_I0.5320.10
87_V197_L0.5300.10
38_R214_L0.5260.10
198_K241_E0.5240.10
52_E136_P0.5220.10
120_V124_E0.5210.10
152_G194_K0.5210.10
131_K142_P0.5210.10
49_I121_K0.5200.10
124_E192_K0.5190.10
24_E216_T0.5180.10
66_N112_A0.5180.10
101_K206_I0.5160.10
133_F231_G0.5160.10
49_I258_M0.5150.10
14_L159_N0.5130.10
60_G141_I0.5100.10
40_D131_K0.5050.10
96_D233_K0.5050.10
17_F27_F0.5020.10
239_I270_G0.5020.10
77_E181_Y0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yvtA 1 0.769 100 0.755 Contact Map
1uf3A 6 0.6677 100 0.758 Contact Map
4peiA 2 0.7911 99.9 0.784 Contact Map
3rl5A 1 0.6646 99.9 0.789 Contact Map
3qfmA 2 0.7057 99.9 0.811 Contact Map
3ib7A 2 0.788 99.9 0.815 Contact Map
3d03A 5 0.7468 99.9 0.815 Contact Map
3rqzA 1 0.6772 99.9 0.819 Contact Map
4ykeA 2 0.8481 99.8 0.821 Contact Map
1nnwA 2 0.7152 99.8 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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