GREMLIN Database
Q97WP5 - Uncharacterized protein
UniProt: Q97WP5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (238)
Sequences: 22933 (15886)
Seq/√Len: 1029.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
182_A250_V5.1311.00
20_S24_K3.7951.00
14_G136_N3.1201.00
196_M279_I3.1161.00
19_A147_I3.0251.00
186_M247_S3.0131.00
18_L140_G2.9831.00
15_L143_L2.9041.00
16_W20_S2.7501.00
22_E141_K2.7041.00
154_T180_Y2.5811.00
133_P136_N2.5291.00
233_Y237_P2.5151.00
19_A143_L2.4711.00
185_L270_G2.3541.00
189_G273_A2.3241.00
188_F273_A2.3101.00
263_A267_L2.1641.00
24_K27_Y2.1251.00
90_D93_S2.1211.00
264_I268_Y1.9671.00
15_L19_A1.9451.00
15_L136_N1.8811.00
27_Y30_P1.8751.00
189_G276_L1.8591.00
267_L271_L1.8041.00
278_T282_V1.7771.00
178_G254_M1.7761.00
268_Y271_L1.7471.00
118_D141_K1.7361.00
233_Y236_K1.7361.00
203_S206_S1.7141.00
239_A245_T1.7031.00
236_K240_Y1.6931.00
234_W237_P1.6491.00
192_S277_S1.6391.00
192_S273_A1.6341.00
272_F276_L1.6101.00
201_A210_I1.5941.00
268_Y272_F1.5911.00
228_V239_A1.5911.00
246_Y265_D1.5881.00
196_M276_L1.5541.00
150_L184_F1.5361.00
264_I267_L1.5171.00
196_M283_L1.5111.00
182_A266_F1.5091.00
186_M190_L1.4701.00
275_I279_I1.4681.00
15_L139_I1.4281.00
178_G262_L1.3811.00
240_Y246_Y1.3771.00
182_A254_M1.3671.00
183_L247_S1.3601.00
158_V161_V1.3601.00
15_L140_G1.3571.00
146_V184_F1.3571.00
249_G265_D1.3561.00
185_L273_A1.3481.00
159_V162_L1.3471.00
91_Y94_F1.3461.00
177_L181_A1.3381.00
122_G125_D1.3271.00
140_G144_S1.3261.00
273_A277_S1.3251.00
237_P241_I1.3231.00
49_K52_N1.3211.00
266_F270_G1.3121.00
21_R118_D1.3101.00
271_L275_I1.3001.00
197_L201_A1.2951.00
123_V126_R1.2901.00
234_W238_V1.2841.00
149_S187_S1.2821.00
16_W19_A1.2631.00
185_L266_F1.2621.00
199_L283_L1.2611.00
112_G207_Q1.2521.00
237_P240_Y1.2421.00
96_A99_M1.2371.00
189_G272_F1.2361.00
212_N216_L1.2281.00
112_G115_I1.2271.00
249_G253_G1.2141.00
231_M236_K1.2081.00
270_G274_I1.1981.00
120_R204_W1.1881.00
146_V188_F1.1851.00
19_A140_G1.1821.00
52_N55_S1.1801.00
23_L27_Y1.1591.00
178_G181_A1.1551.00
192_S276_L1.1441.00
261_N264_I1.1421.00
189_G269_L1.1361.00
240_Y245_T1.1321.00
246_Y268_Y1.1321.00
23_L144_S1.1311.00
123_V127_I1.1251.00
279_I283_L1.1221.00
24_K28_K1.1211.00
135_G139_I1.1211.00
19_A144_S1.1151.00
110_Q113_M1.1141.00
17_T20_S1.1101.00
157_L179_V1.1101.00
34_L38_I1.0951.00
224_A248_N1.0941.00
127_I132_V1.0761.00
213_L217_P1.0741.00
249_G261_N1.0721.00
275_I278_T1.0721.00
14_G133_P1.0631.00
19_A23_L1.0511.00
40_P46_I1.0461.00
201_A206_S1.0441.00
218_L242_N1.0391.00
13_H16_W1.0371.00
260_T263_A1.0351.00
192_S280_G1.0291.00
111_S115_I1.0201.00
200_R283_L1.0171.00
22_E144_S1.0071.00
48_G52_N0.9971.00
228_V245_T0.9941.00
117_W120_R0.9871.00
97_A100_L0.9841.00
246_Y250_V0.9781.00
196_M280_G0.9611.00
127_I131_P0.9501.00
202_T206_S0.9421.00
100_L103_I0.9401.00
177_L180_Y0.9331.00
39_Q43_W0.9311.00
111_S114_S0.9301.00
141_K145_A0.9251.00
138_I280_G0.9241.00
124_L127_I0.9231.00
263_A266_F0.9231.00
138_I281_I0.9231.00
236_K239_A0.9221.00
242_N245_T0.9211.00
97_A101_S0.9201.00
23_L147_I0.9191.00
187_S191_S0.9181.00
90_D94_F0.9151.00
193_L214_L0.9041.00
166_T175_D0.9021.00
193_L276_L0.8991.00
246_Y272_F0.8931.00
174_L177_L0.8781.00
181_A185_L0.8711.00
181_A266_F0.8701.00
261_N265_D0.8681.00
245_T249_G0.8591.00
40_P43_W0.8591.00
105_L108_S0.8591.00
99_M103_I0.8581.00
232_P236_K0.8571.00
176_F180_Y0.8571.00
175_D178_G0.8541.00
185_L269_L0.8531.00
13_H17_T0.8531.00
116_V207_Q0.8481.00
121_L125_D0.8461.00
262_L265_D0.8451.00
22_E145_A0.8441.00
265_D269_L0.8441.00
228_V236_K0.8391.00
48_G163_L0.8331.00
116_V120_R0.8301.00
30_P33_L0.8291.00
136_N140_G0.8231.00
126_R131_P0.8221.00
164_G167_F0.8171.00
212_N217_P0.8161.00
126_R132_V0.8151.00
276_L280_G0.8141.00
279_I282_V0.8141.00
135_G281_I0.8141.00
270_G273_A0.8111.00
41_I159_V0.8101.00
110_Q115_I0.8101.00
228_V240_Y0.8091.00
98_G101_S0.8081.00
45_G49_K0.8051.00
267_L270_G0.8031.00
183_L251_A0.8021.00
132_V137_I0.8021.00
246_Y249_G0.8011.00
150_L154_T0.8001.00
99_M102_F0.8001.00
180_Y184_F0.7991.00
265_D268_Y0.7971.00
274_I278_T0.7941.00
253_G258_I0.7911.00
93_S96_A0.7901.00
269_L272_F0.7881.00
26_W36_S0.7871.00
250_V265_D0.7821.00
124_L137_I0.7781.00
95_L99_M0.7781.00
97_A102_F0.7781.00
116_V119_R0.7741.00
41_I45_G0.7721.00
142_V192_S0.7711.00
254_M262_L0.7701.00
22_E25_K0.7641.00
262_L266_F0.7621.00
29_A32_I0.7531.00
101_S104_V0.7511.00
208_M212_N0.7511.00
274_I277_S0.7501.00
157_L183_L0.7471.00
128_L134_R0.7461.00
48_G162_L0.7391.00
21_R25_K0.7391.00
153_A183_L0.7381.00
95_L98_G0.7381.00
87_G90_D0.7371.00
154_T158_V0.7351.00
264_I271_L0.7341.00
160_A179_V0.7331.00
118_D123_V0.7321.00
243_P247_S0.7241.00
211_M215_N0.7211.00
206_S209_A0.7131.00
155_I158_V0.7121.00
209_A212_N0.7111.00
158_V176_F0.7071.00
122_G132_V0.7041.00
139_I143_L0.7031.00
142_V277_S0.7011.00
97_A108_S0.7001.00
183_L187_S0.6991.00
91_Y96_A0.6991.00
154_T157_L0.6881.00
145_A149_S0.6871.00
147_I151_V0.6871.00
195_L280_G0.6841.00
215_N219_L0.6691.00
222_S245_T0.6671.00
96_A107_T0.6661.00
217_P220_F0.6651.00
122_G126_R0.6641.00
120_R124_L0.6631.00
18_L136_N0.6621.00
44_I156_V0.6591.00
277_S281_I0.6591.00
146_V191_S0.6581.00
127_I130_T0.6521.00
182_A247_S0.6521.00
35_L39_Q0.6521.00
26_W148_R0.6511.00
247_S269_L0.6491.00
223_N227_P0.6491.00
110_Q114_S0.6491.00
91_Y95_L0.6481.00
195_L199_L0.6421.00
23_L151_V0.6421.00
179_V251_A0.6411.00
214_L218_L0.6331.00
44_I160_A0.6251.00
45_G159_V0.6251.00
231_M235_L0.6231.00
257_G260_T0.6201.00
15_L135_G0.6201.00
241_I246_Y0.6191.00
124_L128_L0.6181.00
269_L273_A0.6171.00
143_L147_I0.6171.00
194_F198_A0.6141.00
153_A184_F0.6141.00
43_W46_I0.6121.00
216_L219_L0.6111.00
119_R202_T0.6091.00
178_G266_F0.6081.00
101_S109_M0.6061.00
226_Y230_S0.6041.00
248_N252_R0.6021.00
100_L108_S0.6011.00
174_L178_G0.5991.00
253_G261_N0.5991.00
31_V35_L0.5971.00
27_Y33_L0.5961.00
125_D128_L0.5961.00
145_A195_L0.5961.00
240_Y249_G0.5941.00
43_W47_F0.5931.00
98_G107_T0.5891.00
193_L196_M0.5891.00
105_L190_L0.5871.00
195_L198_A0.5851.00
142_V191_S0.5831.00
98_G102_F0.5801.00
239_A242_N0.5801.00
117_W121_L0.5791.00
212_N215_N0.5791.00
278_T281_I0.5791.00
98_G103_I0.5791.00
96_A100_L0.5771.00
199_L280_G0.5701.00
26_W144_S0.5691.00
126_R130_T0.5661.00
49_K162_L0.5641.00
17_T24_K0.5631.00
210_I214_L0.5621.00
253_G265_D0.5571.00
272_F275_I0.5571.00
89_T93_S0.5541.00
197_L214_L0.5531.00
219_L222_S0.5521.00
196_M199_L0.5501.00
92_F96_A0.5501.00
161_V167_F0.5491.00
147_I150_L0.5441.00
105_L109_M0.5431.00
146_V150_L0.5401.00
112_G211_M0.5401.00
188_F192_S0.5391.00
122_G131_P0.5391.00
116_V204_W0.5391.00
197_L211_M0.5381.00
227_P230_S0.5371.00
51_M56_I0.5371.00
108_S194_F0.5341.00
36_S148_R0.5331.00
230_S233_Y0.5301.00
102_F108_S0.5281.00
14_G17_T0.5281.00
41_I155_I0.5271.00
268_Y276_L0.5261.00
252_R256_L0.5261.00
178_G182_A0.5241.00
92_F97_A0.5221.00
125_D131_P0.5211.00
85_T88_T0.5211.00
101_S244_L0.5191.00
106_F109_M0.5191.00
110_Q116_V0.5181.00
250_V262_L0.5181.00
148_R152_Q0.5181.00
197_L200_R0.5161.00
38_I41_I0.5131.00
22_E137_I0.5131.00
84_Q88_T0.5121.00
103_I108_S0.5091.00
228_V231_M0.5071.00
87_G91_Y0.5061.00
281_I284_S0.5051.00
151_V154_T0.5031.00
276_L279_I0.5011.00
128_L131_P0.5011.00
47_F52_N0.5011.00
112_G118_D0.5011.00
21_R126_R0.5001.00
101_S248_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rh1A 1 0.6172 10.5 0.941 Contact Map
2z73A 2 0.7069 9.7 0.942 Contact Map
2wswA 3 0.5448 7.7 0.944 Contact Map
4ib4A 1 0.6241 7.7 0.944 Contact Map
2rddB 1 0.1034 6.6 0.946 Contact Map
2ks9A 1 0.7034 5.9 0.947 Contact Map
3j9pD 4 0.7828 5.1 0.949 Contact Map
4grvA 1 0.6517 5 0.949 Contact Map
4hfiA 3 0.5069 4.8 0.949 Contact Map
2r4rA 1 0.4138 4.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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