GREMLIN Database
Q97WP3 - Uncharacterized protein
UniProt: Q97WP3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (157)
Sequences: 5910 (4104)
Seq/√Len: 327.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_V62_L2.9721.00
74_L78_N2.5741.00
41_I44_E2.5511.00
91_K115_E2.5111.00
82_I88_E2.4331.00
44_E134_R2.3641.00
44_E136_S2.2541.00
140_A158_I2.2541.00
41_I134_R2.1891.00
60_Y133_I2.1861.00
5_S10_E2.1651.00
142_K146_E2.1381.00
93_K115_E2.1061.00
46_I134_R2.0671.00
72_D75_N2.0621.00
94_E110_R2.0601.00
90_G116_D2.0421.00
49_R131_E2.0141.00
97_S108_Y1.9761.00
30_K106_T1.9501.00
12_H30_K1.9381.00
71_E79_R1.9221.00
143_M148_K1.8751.00
67_I76_T1.8671.00
78_N92_M1.8351.00
15_K23_E1.8151.00
17_K23_E1.8011.00
37_I77_A1.7761.00
49_R133_I1.7691.00
94_E97_S1.7541.00
135_L143_M1.7351.00
73_P110_R1.7221.00
50_Q61_E1.6751.00
90_G118_R1.6661.00
13_I25_E1.6651.00
136_S139_E1.6351.00
88_E118_R1.6011.00
97_S110_R1.5981.00
14_D53_P1.5581.00
81_L89_A1.5381.00
15_K25_E1.5271.00
91_K116_D1.4961.00
139_E142_K1.4891.00
75_N78_N1.4751.00
99_Y150_E1.4681.00
38_I157_G1.4381.00
74_L92_M1.4291.00
62_L157_G1.4001.00
76_T79_R1.3911.00
57_K150_E1.3891.00
67_I73_P1.3881.00
46_I87_Y1.3271.00
13_I27_E1.3201.00
98_F156_I1.2911.00
88_E120_V1.2911.00
73_P112_Y1.2571.00
78_N82_I1.2341.00
53_P56_D1.2281.00
82_I120_V1.2151.00
82_I123_K1.1911.00
55_I99_Y1.1831.00
55_I59_I1.1811.00
135_L140_A1.1751.00
144_I155_I1.1691.00
94_E112_Y1.1621.00
63_P85_I1.1611.00
87_Y119_Y1.1611.00
6_G27_E1.1591.00
98_F111_L1.1561.00
39_P81_L1.1531.00
141_I145_R1.1231.00
43_N137_I1.1191.00
49_R58_W1.1071.00
101_S107_E1.1051.00
46_I132_P1.0971.00
142_K145_R1.0951.00
19_P129_I1.0821.00
38_I161_L1.0761.00
139_E143_M1.0721.00
71_E76_T1.0491.00
111_L157_G1.0401.00
33_G67_I1.0401.00
14_D28_F1.0271.00
35_V77_A1.0081.00
51_F56_D1.0081.00
95_I113_L0.9841.00
38_I45_I0.9651.00
116_D121_G0.9581.00
151_D154_T0.9561.00
156_I159_F0.9441.00
141_I158_I0.9371.00
59_I102_P0.9311.00
34_S109_M0.9241.00
92_M112_Y0.9021.00
89_A92_M0.8991.00
77_A92_M0.8851.00
33_G108_Y0.8731.00
40_K137_I0.8621.00
41_I87_Y0.8601.00
52_R61_E0.8561.00
116_D120_V0.8511.00
31_H107_E0.8431.00
29_V104_I0.8391.00
40_K113_L0.8341.00
74_L94_E0.8311.00
37_I114_A0.8301.00
47_L60_Y0.8281.00
124_P127_Y0.8241.00
62_L158_I0.8231.00
123_K128_E0.8201.00
36_V109_M0.8191.00
10_E30_K0.8111.00
45_I62_L0.8111.00
99_Y108_Y0.8071.00
58_W129_I0.7961.00
45_I158_I0.7931.00
124_P130_I0.7921.00
117_L120_V0.7901.00
100_A104_I0.7831.00
28_F53_P0.7761.00
92_M114_A0.7751.00
38_I62_L0.7731.00
82_I121_G0.7731.00
89_A114_A0.7701.00
78_N88_E0.7671.00
45_I161_L0.7661.00
63_P81_L0.7570.99
36_V153_K0.7560.99
36_V111_L0.7540.99
117_L121_G0.7420.99
47_L133_I0.7410.99
43_N138_E0.7390.99
33_G110_R0.7380.99
35_V73_P0.7370.99
60_Y135_L0.7300.99
47_L135_L0.7290.99
40_K45_I0.7290.99
144_I149_I0.7240.99
125_E128_E0.7220.99
93_K113_L0.7190.99
40_K43_N0.7170.99
143_M146_E0.7140.99
42_N134_R0.7080.99
96_I156_I0.7070.99
17_K21_G0.6920.99
39_P113_L0.6920.99
122_A132_P0.6730.99
16_V53_P0.6700.99
108_Y150_E0.6690.99
101_S105_T0.6680.99
109_M153_K0.6680.99
122_A125_E0.6680.99
98_F152_A0.6680.99
45_I137_I0.6650.99
40_K161_L0.6610.99
140_A144_I0.6600.99
48_I130_I0.6550.99
40_K115_E0.6490.98
89_A117_L0.6410.98
97_S150_E0.6400.98
16_V24_R0.6380.98
49_R60_Y0.6380.98
37_I63_P0.6350.98
18_L22_Y0.6330.98
20_N129_I0.6320.98
137_I141_I0.6320.98
74_L112_Y0.6320.98
39_P48_I0.6260.98
39_P89_A0.6250.98
133_I143_M0.6190.98
60_Y143_M0.6170.98
91_K94_E0.6150.98
156_I160_T0.6140.98
100_A152_A0.6130.98
47_L140_A0.6120.98
39_P62_L0.6100.98
139_E148_K0.6040.98
96_I160_T0.6030.98
7_K13_I0.5920.97
11_V29_V0.5890.97
45_I140_A0.5880.97
37_I81_L0.5860.97
67_I110_R0.5850.97
6_G13_I0.5830.97
34_S66_T0.5810.97
64_A153_K0.5800.97
36_V64_A0.5800.97
89_A116_D0.5800.97
59_I99_Y0.5790.97
41_I46_I0.5760.97
32_R66_T0.5750.97
77_A81_L0.5740.97
123_K127_Y0.5730.97
31_H104_I0.5730.97
138_E141_I0.5710.97
77_A112_Y0.5700.97
136_S141_I0.5690.96
64_A103_G0.5660.96
122_A128_E0.5630.96
135_L139_E0.5600.96
52_R103_G0.5590.96
140_A149_I0.5550.96
14_D56_D0.5550.96
104_I109_M0.5540.96
72_D112_Y0.5520.96
33_G66_T0.5520.96
28_F54_V0.5510.96
98_F155_I0.5500.96
149_I154_T0.5480.96
96_I147_R0.5450.96
96_I155_I0.5440.95
31_H105_T0.5430.95
143_M149_I0.5410.95
124_P128_E0.5390.95
118_R121_G0.5370.95
144_I158_I0.5330.95
93_K96_I0.5300.95
100_A105_T0.5290.95
6_G26_L0.5270.95
11_V27_E0.5240.94
138_E142_K0.5240.94
80_E84_E0.5230.94
31_H64_A0.5220.94
155_I159_F0.5210.94
64_A101_S0.5190.94
48_I59_I0.5180.94
68_E76_T0.5170.94
96_I111_L0.5150.94
20_N127_Y0.5100.94
7_K25_E0.5090.94
116_D119_Y0.5090.94
18_L24_R0.5080.94
24_R127_Y0.5070.93
144_I159_F0.5060.93
154_T158_I0.5020.93
34_S107_E0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vhzA 2 1 100 0.291 Contact Map
1g0sA 2 0.994 100 0.299 Contact Map
2dscA 2 0.994 100 0.319 Contact Map
1mk1A 2 0.9217 100 0.358 Contact Map
3o6zA 2 0.988 100 0.39 Contact Map
2yvpA 2 0.9819 100 0.403 Contact Map
1v8yA 2 0.8916 100 0.424 Contact Map
3q91A 2 0.759 100 0.437 Contact Map
2w4eA 2 0.7892 99.9 0.488 Contact Map
2fvvA 1 0.8012 99.9 0.554 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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