GREMLIN Database
Q97WP2 - Uncharacterized protein
UniProt: Q97WP2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (208)
Sequences: 773 (439)
Seq/√Len: 30.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
119_L183_P5.3401.00
9_F166_T4.0741.00
157_K187_N3.6741.00
143_K199_K3.1291.00
151_T198_V3.0691.00
146_K150_E3.0301.00
69_D72_K2.9681.00
61_I88_G2.8851.00
80_L88_G2.6821.00
71_S120_R2.3840.99
42_F76_F2.3000.99
140_E143_K2.2560.99
121_Y214_E2.2200.99
135_L202_K2.2170.99
70_T95_F2.2130.99
41_Q79_T2.1980.98
35_I84_I2.1970.98
17_T89_Y2.1160.98
194_A197_E2.0860.98
110_I114_L2.0330.97
129_K145_M1.8770.96
173_D209_P1.8630.96
35_I38_V1.8340.95
123_V170_G1.8290.95
111_N115_S1.8220.95
168_S172_G1.7740.94
144_I204_I1.7690.94
192_V205_T1.7570.94
185_I212_V1.7400.94
176_F210_I1.7260.93
75_E79_T1.7240.93
33_N37_S1.6910.93
97_V186_E1.6900.93
38_V42_F1.6880.93
144_I200_A1.6460.92
143_K147_E1.6380.92
112_K115_S1.6370.92
154_T194_A1.6150.91
131_V208_E1.6120.91
36_E40_S1.5950.90
156_P194_A1.5550.89
8_Y186_E1.5480.89
20_W31_A1.5320.89
153_R156_P1.5160.88
161_I191_V1.5100.88
142_E146_K1.5070.88
147_E199_K1.4930.87
120_R214_E1.4860.87
11_I96_S1.4510.86
143_K146_K1.4460.85
45_N75_E1.4270.85
198_V204_I1.4210.84
136_L195_L1.4150.84
170_G195_L1.4010.84
142_E153_R1.3910.83
116_L162_R1.3910.83
70_T185_I1.3850.83
36_E218_L1.3760.82
62_I122_F1.3700.82
130_D205_T1.3680.82
29_R33_N1.3420.81
80_L85_R1.3400.81
94_L168_S1.3310.80
15_K89_Y1.3230.80
18_N22_S1.3160.79
131_V205_T1.3110.79
34_E83_K1.2950.78
71_S121_Y1.2630.77
217_G220_L1.2530.76
94_L172_G1.2410.75
187_N190_E1.2390.75
137_P143_K1.2350.75
147_E151_T1.2180.74
139_E142_E1.2100.73
144_I147_E1.2060.73
151_T194_A1.1790.71
41_Q44_N1.1720.71
96_S177_V1.1640.70
75_E217_G1.1630.70
130_D203_W1.1520.70
109_D112_K1.1470.69
49_L63_Y1.1460.69
147_E198_V1.1420.69
38_V80_L1.1390.69
18_N21_W1.1280.68
155_H194_A1.1170.67
39_E218_L1.1170.67
145_M171_V1.1140.67
111_N114_L1.1130.67
101_S129_K1.1120.67
123_V168_S1.1080.67
42_F83_K1.1070.66
109_D114_L1.1070.66
70_T171_V1.1030.66
51_R83_K1.1000.66
137_P140_E1.0900.65
171_V185_I1.0890.65
31_A87_L1.0850.65
149_I210_I1.0520.62
110_I113_V1.0420.62
94_L177_V1.0380.61
94_L211_L1.0350.61
193_E197_E1.0280.61
55_L168_S1.0150.60
150_E153_R1.0090.59
35_I69_D1.0020.59
9_F61_I0.9880.58
125_Y196_R0.9780.57
96_S167_Y0.9760.57
110_I115_S0.9750.57
35_I63_Y0.9740.56
39_E51_R0.9650.56
31_A78_Y0.9650.56
179_V188_W0.9640.56
43_R118_P0.9600.55
149_I176_F0.9580.55
98_Y164_Y0.9510.55
97_V171_V0.9500.55
10_Y77_K0.9490.54
64_W164_Y0.9440.54
161_I164_Y0.9310.53
188_W191_V0.9280.53
42_F63_Y0.9250.53
41_Q61_I0.9120.52
38_V41_Q0.9110.51
10_Y95_F0.9090.51
152_A188_W0.8960.50
144_I195_L0.8910.50
31_A34_E0.8830.49
32_I36_E0.8810.49
103_Y129_K0.8790.49
77_K90_E0.8710.48
156_P182_I0.8590.47
101_S138_F0.8560.47
13_S62_I0.8520.47
211_L214_E0.8520.47
57_N90_E0.8490.46
36_E219_D0.8340.45
41_Q86_D0.8300.45
12_S93_S0.8290.45
55_L95_F0.8280.45
124_A180_Y0.8240.44
31_A88_G0.8210.44
125_Y134_Y0.8160.44
125_Y175_E0.8130.44
65_V76_F0.8030.43
164_Y181_E0.8020.43
157_K182_I0.7910.42
17_T61_I0.7800.41
35_I39_E0.7800.41
168_S197_E0.7780.41
37_S40_S0.7710.40
26_E72_K0.7690.40
63_Y76_F0.7690.40
103_Y145_M0.7620.40
93_S123_V0.7590.39
147_E169_F0.7560.39
9_F64_W0.7540.39
53_I78_Y0.7530.39
108_F112_K0.7530.39
73_L82_S0.7520.39
62_I128_K0.7500.39
149_I213_G0.7470.39
71_S214_E0.7450.38
53_I63_Y0.7410.38
169_F193_E0.7400.38
68_S80_L0.7380.38
9_F215_L0.7350.38
175_E196_R0.7340.38
22_S26_E0.7330.37
54_S85_R0.7300.37
38_V218_L0.7290.37
131_V201_R0.7290.37
37_S79_T0.7290.37
62_I185_I0.7280.37
108_F111_N0.7260.37
131_V202_K0.7250.37
9_F65_V0.7250.37
178_V192_V0.7240.37
99_R189_V0.7210.37
17_T31_A0.7210.37
199_K202_K0.7190.36
189_V207_E0.7150.36
10_Y90_E0.7130.36
145_M193_E0.7080.36
174_Y211_L0.7080.36
38_V79_T0.7060.35
83_K161_I0.7060.35
99_R190_E0.7050.35
49_L65_V0.7010.35
75_E220_L0.7000.35
134_Y196_R0.6900.34
27_E107_N0.6880.34
34_E45_N0.6880.34
40_S44_N0.6870.34
6_L12_S0.6860.34
120_R217_G0.6850.34
90_E155_H0.6840.34
163_S207_E0.6800.34
140_E199_K0.6740.33
101_S145_M0.6730.33
74_L169_F0.6730.33
55_L74_L0.6720.33
16_L78_Y0.6680.33
163_S178_V0.6670.33
109_D113_V0.6650.33
10_Y73_L0.6640.32
30_S154_T0.6630.32
150_E154_T0.6590.32
152_A180_Y0.6590.32
153_R194_A0.6580.32
190_E195_L0.6470.31
42_F218_L0.6460.31
51_R63_Y0.6450.31
6_L10_Y0.6420.31
120_R183_P0.6400.31
31_A184_E0.6370.31
122_F143_K0.6360.31
130_D204_I0.6350.30
64_W74_L0.6330.30
36_E217_G0.6320.30
34_E86_D0.6310.30
19_R87_L0.6250.30
191_V198_V0.6250.30
91_S211_L0.6240.30
9_F137_P0.6210.30
153_R167_Y0.6210.30
16_L80_L0.6200.29
41_Q75_E0.6200.29
162_R191_V0.6190.29
107_N110_I0.6170.29
11_I179_V0.6170.29
182_I187_N0.6160.29
58_D195_L0.6150.29
108_F115_S0.6150.29
121_Y197_E0.6130.29
21_W31_A0.6120.29
40_S215_L0.6060.29
151_T156_P0.6040.28
19_R41_Q0.6030.28
33_N36_E0.6010.28
156_P179_V0.6010.28
13_S91_S0.6010.28
43_R143_K0.5960.28
61_I80_L0.5950.28
17_T44_N0.5910.28
135_L140_E0.5900.27
32_I51_R0.5900.27
193_E207_E0.5860.27
108_F113_V0.5860.27
16_L88_G0.5860.27
144_I169_F0.5830.27
44_N220_L0.5830.27
26_E36_E0.5740.26
19_R122_F0.5740.26
53_I88_G0.5730.26
11_I195_L0.5730.26
96_S138_F0.5720.26
124_A202_K0.5670.26
34_E84_I0.5640.26
101_S147_E0.5640.26
9_F119_L0.5600.26
35_I51_R0.5580.25
167_Y177_V0.5580.25
11_I117_E0.5560.25
121_Y188_W0.5550.25
163_S180_Y0.5540.25
47_I72_K0.5530.25
181_E209_P0.5530.25
9_F194_A0.5530.25
145_M163_S0.5510.25
51_R139_E0.5500.25
31_A168_S0.5500.25
83_K218_L0.5490.25
48_S200_A0.5470.25
101_S193_E0.5450.25
26_E41_Q0.5420.25
161_I205_T0.5400.24
132_E212_V0.5400.24
73_L95_F0.5380.24
31_A115_S0.5380.24
70_T121_Y0.5370.24
108_F169_F0.5360.24
15_K30_S0.5360.24
156_P195_L0.5340.24
130_D206_K0.5340.24
140_E182_I0.5340.24
57_N91_S0.5300.24
76_F120_R0.5300.24
75_E78_Y0.5290.24
125_Y148_H0.5290.24
104_T146_K0.5280.24
14_I85_R0.5260.24
102_P188_W0.5260.24
19_R31_A0.5260.24
78_Y214_E0.5240.23
124_A177_V0.5210.23
176_F195_L0.5200.23
14_I161_I0.5150.23
139_E143_K0.5150.23
102_P203_W0.5120.23
50_K64_W0.5120.23
165_T193_E0.5110.23
102_P200_A0.5100.23
114_L144_I0.5050.22
175_E200_A0.5050.22
191_V195_L0.5040.22
44_N219_D0.5040.22
34_E82_S0.5020.22
181_E185_I0.5020.22
104_T109_D0.5000.22
154_T168_S0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dtzA 3 0.9776 100 0.104 Contact Map
1t0tV 5 0.9821 100 0.128 Contact Map
1vdhA 3 0.991 100 0.129 Contact Map
4wwsA 3 0.9865 100 0.132 Contact Map
3nn1A 3 0.9776 100 0.151 Contact Map
2vxhA 3 0.9372 100 0.184 Contact Map
3qpiA 1 0.6951 100 0.454 Contact Map
4un1B 1 0.417 21.9 0.962 Contact Map
2csfA 1 0.4215 21 0.963 Contact Map
2zbcA 6 0.3587 18.6 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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