NTPTH - SULSO - GREMLIN Contacts

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NTPTH - Nucleoside-triphosphatase THEP1

UniProt:	Q97WP0	Sequences: MLEESKNALRVFITGNPGVGKTTILLFLINKLSENNYKVAGFYCPEVRENGRRIGFRIVDITTNEGDWLAKENAPGRVKIGKYTVLEDSAKRITEITLSNINKADVLAIDEIGPMELKIPTIKKLIETILNNQKPLIAVLHRTQKPMGGRIYVITVENRDSIKYEILNYILSSLD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	175 (160)
Sequences:	346 (279)
Seq/√Len:	22.0

SULSO - NTPTH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
154_I	162_I	4.338	1.00
57_R	66_G	4.109	1.00
24_I	163_K	3.610	1.00
57_R	71_K	3.020	1.00
53_R	83_Y	2.449	0.98
86_L	89_S	2.303	0.97
90_A	94_T	2.209	0.96
114_P	118_K	2.135	0.95
12_F	144_Q	2.023	0.93
56_F	83_Y	2.003	0.93
53_R	115_M	1.981	0.92
131_N	149_G	1.910	0.91
12_F	140_L	1.910	0.91
67_D	89_S	1.862	0.90
44_C	122_I	1.856	0.90
18_G	116_E	1.851	0.90
80_I	85_V	1.831	0.89
48_R	80_I	1.789	0.88
12_F	138_A	1.788	0.88
46_E	83_Y	1.770	0.87
48_R	83_Y	1.765	0.87
72_E	82_K	1.745	0.87
150_R	169_Y	1.743	0.87
10_R	146_P	1.733	0.86
112_I	138_A	1.730	0.86
19_V	158_N	1.722	0.86
22_T	139_V	1.697	0.85
26_L	45_P	1.669	0.84
90_A	141_H	1.659	0.84
17_P	83_Y	1.584	0.81
53_R	81_G	1.547	0.79
98_L	129_I	1.543	0.79
23_T	81_G	1.538	0.79
12_F	149_G	1.538	0.79
46_E	115_M	1.528	0.78
13_I	154_I	1.507	0.77
40_A	134_K	1.497	0.77
133_Q	166_I	1.493	0.76
47_V	71_K	1.492	0.76
99_S	128_T	1.468	0.75
10_R	149_G	1.420	0.73
138_A	141_H	1.416	0.72
87_E	119_I	1.401	0.72
20_G	23_T	1.395	0.71
24_I	154_I	1.395	0.71
83_Y	115_M	1.392	0.71
48_R	115_M	1.376	0.70
114_P	141_H	1.373	0.70
18_G	69_L	1.372	0.70
44_C	139_V	1.366	0.70
25_L	29_I	1.363	0.70
54_I	71_K	1.341	0.68
59_V	66_G	1.337	0.68
47_V	57_R	1.334	0.68
60_D	93_I	1.333	0.68
10_R	148_G	1.331	0.68
42_F	113_G	1.319	0.67
28_L	166_I	1.294	0.65
17_P	115_M	1.292	0.65
114_P	139_V	1.285	0.65
131_N	148_G	1.260	0.63
53_R	56_F	1.227	0.61
48_R	56_F	1.217	0.61
90_A	119_I	1.201	0.59
17_P	81_G	1.199	0.59
48_R	53_R	1.194	0.59
45_P	57_R	1.189	0.59
17_P	53_R	1.187	0.59
22_T	42_F	1.187	0.59
23_T	56_F	1.178	0.58
46_E	53_R	1.168	0.57
69_L	81_G	1.153	0.56
106_V	137_I	1.145	0.56
56_F	115_M	1.128	0.55
109_I	112_I	1.120	0.54
29_I	108_A	1.106	0.53
25_L	108_A	1.104	0.53
81_G	115_M	1.091	0.52
106_V	113_G	1.091	0.52
74_A	84_T	1.084	0.52
44_C	113_G	1.084	0.52
58_I	86_L	1.081	0.51
68_W	71_K	1.076	0.51
17_P	46_E	1.073	0.51
107_L	134_K	1.053	0.50
24_I	106_V	1.047	0.49
45_P	114_P	1.033	0.48
44_C	55_G	1.027	0.48
91_K	95_E	1.017	0.47
10_R	13_I	1.016	0.47
104_A	135_P	1.014	0.47
42_F	46_E	1.010	0.47
42_F	94_T	0.986	0.45
122_I	126_I	0.984	0.45
22_T	138_A	0.983	0.45
88_D	92_R	0.979	0.44
56_F	81_G	0.979	0.44
90_A	95_E	0.976	0.44
22_T	43_Y	0.973	0.44
152_Y	166_I	0.967	0.44
46_E	80_I	0.960	0.43
127_E	142_R	0.946	0.42
65_E	124_K	0.915	0.40
17_P	48_R	0.897	0.39
61_I	103_K	0.889	0.39
48_R	85_V	0.887	0.38
33_S	154_I	0.882	0.38
76_G	84_T	0.877	0.38
58_I	151_I	0.866	0.37
15_G	21_K	0.862	0.37
53_R	117_L	0.862	0.37
136_L	157_E	0.857	0.37
23_T	53_R	0.857	0.37
68_W	89_S	0.833	0.35
16_N	156_V	0.830	0.35
113_G	158_N	0.815	0.34
100_N	103_K	0.803	0.33
77_R	133_Q	0.798	0.33
164_Y	167_L	0.793	0.33
53_R	80_I	0.792	0.33
137_I	169_Y	0.790	0.32
143_T	149_G	0.777	0.32
16_N	137_I	0.768	0.31
148_G	166_I	0.767	0.31
119_I	122_I	0.766	0.31
94_T	97_T	0.765	0.31
29_I	33_S	0.764	0.31
67_D	125_L	0.761	0.31
160_D	165_E	0.760	0.31
19_V	106_V	0.747	0.30
19_V	24_I	0.746	0.30
85_V	119_I	0.743	0.30
13_I	28_L	0.736	0.29
69_L	116_E	0.729	0.29
108_A	137_I	0.729	0.29
126_I	154_I	0.725	0.29
12_F	141_H	0.723	0.29
48_R	117_L	0.713	0.28
25_L	103_K	0.711	0.28
91_K	121_T	0.710	0.28
46_E	70_A	0.699	0.27
107_L	168_N	0.693	0.27
146_P	149_G	0.686	0.27
117_L	141_H	0.685	0.26
131_N	146_P	0.678	0.26
55_G	83_Y	0.678	0.26
147_M	151_I	0.676	0.26
13_I	61_I	0.675	0.26
43_Y	118_K	0.671	0.26
19_V	159_R	0.670	0.26
64_N	140_L	0.663	0.25
54_I	137_I	0.663	0.25
30_N	34_E	0.649	0.25
26_L	43_Y	0.649	0.25
28_L	137_I	0.648	0.25
46_E	81_G	0.647	0.25
73_N	162_I	0.645	0.24
17_P	80_I	0.640	0.24
43_Y	69_L	0.640	0.24
47_V	109_I	0.639	0.24
154_I	163_K	0.637	0.24
53_R	70_A	0.632	0.24
53_R	85_V	0.632	0.24
124_K	135_P	0.632	0.24
142_R	146_P	0.630	0.24
130_L	135_P	0.624	0.23
17_P	55_G	0.621	0.23
85_V	115_M	0.616	0.23
17_P	70_A	0.615	0.23
152_Y	169_Y	0.611	0.23
126_I	146_P	0.609	0.23
80_I	114_P	0.609	0.23
130_L	146_P	0.609	0.23
22_T	44_C	0.608	0.23
46_E	85_V	0.607	0.23
47_V	68_W	0.607	0.23
69_L	83_Y	0.605	0.22
88_D	131_N	0.605	0.22
93_I	97_T	0.603	0.22
87_E	121_T	0.599	0.22
11_V	93_I	0.594	0.22
101_I	170_I	0.590	0.22
48_R	81_G	0.587	0.22
51_G	97_T	0.583	0.21
42_F	158_N	0.582	0.21
98_L	153_V	0.581	0.21
100_N	124_K	0.579	0.21
27_F	54_I	0.577	0.21
160_D	163_K	0.577	0.21
28_L	164_Y	0.576	0.21
93_I	161_S	0.570	0.21
125_L	129_I	0.568	0.21
93_I	134_K	0.566	0.21
94_T	126_I	0.566	0.21
127_E	149_G	0.565	0.21
55_G	70_A	0.564	0.21
69_L	89_S	0.562	0.20
21_K	41_G	0.559	0.20
72_E	132_N	0.559	0.20
88_D	102_N	0.556	0.20
60_D	65_E	0.556	0.20
22_T	45_P	0.555	0.20
65_E	86_L	0.554	0.20
56_F	69_L	0.553	0.20
61_I	157_E	0.553	0.20
28_L	152_Y	0.549	0.20
41_G	110_D	0.548	0.20
18_G	85_V	0.546	0.20
161_S	165_E	0.542	0.20
106_V	147_M	0.541	0.20
30_N	144_Q	0.539	0.19
44_C	114_P	0.538	0.19
40_A	105_D	0.535	0.19
97_T	102_N	0.532	0.19
79_K	129_I	0.532	0.19
40_A	65_E	0.531	0.19
91_K	139_V	0.531	0.19
57_R	68_W	0.529	0.19
50_N	121_T	0.529	0.19
14_T	117_L	0.527	0.19
16_N	117_L	0.527	0.19
38_K	146_P	0.526	0.19
92_R	121_T	0.526	0.19
13_I	126_I	0.525	0.19
70_A	83_Y	0.525	0.19
60_D	114_P	0.522	0.19
65_E	88_D	0.521	0.19
15_G	20_G	0.520	0.19
28_L	109_I	0.520	0.19
145_K	152_Y	0.518	0.19
41_G	116_E	0.516	0.19
13_I	142_R	0.514	0.18
114_P	117_L	0.512	0.18
92_R	135_P	0.509	0.18
23_T	115_M	0.505	0.18
37_Y	143_T	0.504	0.18
17_P	56_F	0.503	0.18
40_A	101_I	0.503	0.18
120_P	164_Y	0.502	0.18
55_G	109_I	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ye8A	1	0.8914	99.7	0.702	Contact Map
2i3bA	1	0.9543	99.5	0.739	Contact Map
3bosA	2	0.7543	99	0.793	Contact Map
1fnnA	1	0.8971	98.8	0.804	Contact Map
1l8qA	1	0.8057	98.8	0.806	Contact Map
2w58A	2	0.7657	98.8	0.807	Contact Map
2j9rA	3	0.7429	98.8	0.807	Contact Map
2qgzA	1	0.6971	98.8	0.808	Contact Map
3te6A	1	0.88	98.8	0.808	Contact Map
2vhjA	3	0.7771	98.7	0.81	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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