GREMLIN Database
NTPTH - Nucleoside-triphosphatase THEP1
UniProt: Q97WP0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (160)
Sequences: 346 (279)
Seq/√Len: 22.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_I162_I4.3381.00
57_R66_G4.1091.00
24_I163_K3.6101.00
57_R71_K3.0201.00
53_R83_Y2.4490.98
86_L89_S2.3030.97
90_A94_T2.2090.96
114_P118_K2.1350.95
12_F144_Q2.0230.93
56_F83_Y2.0030.93
53_R115_M1.9810.92
131_N149_G1.9100.91
12_F140_L1.9100.91
67_D89_S1.8620.90
44_C122_I1.8560.90
18_G116_E1.8510.90
80_I85_V1.8310.89
48_R80_I1.7890.88
12_F138_A1.7880.88
46_E83_Y1.7700.87
48_R83_Y1.7650.87
72_E82_K1.7450.87
150_R169_Y1.7430.87
10_R146_P1.7330.86
112_I138_A1.7300.86
19_V158_N1.7220.86
22_T139_V1.6970.85
26_L45_P1.6690.84
90_A141_H1.6590.84
17_P83_Y1.5840.81
53_R81_G1.5470.79
98_L129_I1.5430.79
23_T81_G1.5380.79
12_F149_G1.5380.79
46_E115_M1.5280.78
13_I154_I1.5070.77
40_A134_K1.4970.77
133_Q166_I1.4930.76
47_V71_K1.4920.76
99_S128_T1.4680.75
10_R149_G1.4200.73
138_A141_H1.4160.72
87_E119_I1.4010.72
20_G23_T1.3950.71
24_I154_I1.3950.71
83_Y115_M1.3920.71
48_R115_M1.3760.70
114_P141_H1.3730.70
18_G69_L1.3720.70
44_C139_V1.3660.70
25_L29_I1.3630.70
54_I71_K1.3410.68
59_V66_G1.3370.68
47_V57_R1.3340.68
60_D93_I1.3330.68
10_R148_G1.3310.68
42_F113_G1.3190.67
28_L166_I1.2940.65
17_P115_M1.2920.65
114_P139_V1.2850.65
131_N148_G1.2600.63
53_R56_F1.2270.61
48_R56_F1.2170.61
90_A119_I1.2010.59
17_P81_G1.1990.59
48_R53_R1.1940.59
45_P57_R1.1890.59
17_P53_R1.1870.59
22_T42_F1.1870.59
23_T56_F1.1780.58
46_E53_R1.1680.57
69_L81_G1.1530.56
106_V137_I1.1450.56
56_F115_M1.1280.55
109_I112_I1.1200.54
29_I108_A1.1060.53
25_L108_A1.1040.53
81_G115_M1.0910.52
106_V113_G1.0910.52
74_A84_T1.0840.52
44_C113_G1.0840.52
58_I86_L1.0810.51
68_W71_K1.0760.51
17_P46_E1.0730.51
107_L134_K1.0530.50
24_I106_V1.0470.49
45_P114_P1.0330.48
44_C55_G1.0270.48
91_K95_E1.0170.47
10_R13_I1.0160.47
104_A135_P1.0140.47
42_F46_E1.0100.47
42_F94_T0.9860.45
122_I126_I0.9840.45
22_T138_A0.9830.45
88_D92_R0.9790.44
56_F81_G0.9790.44
90_A95_E0.9760.44
22_T43_Y0.9730.44
152_Y166_I0.9670.44
46_E80_I0.9600.43
127_E142_R0.9460.42
65_E124_K0.9150.40
17_P48_R0.8970.39
61_I103_K0.8890.39
48_R85_V0.8870.38
33_S154_I0.8820.38
76_G84_T0.8770.38
58_I151_I0.8660.37
15_G21_K0.8620.37
53_R117_L0.8620.37
136_L157_E0.8570.37
23_T53_R0.8570.37
68_W89_S0.8330.35
16_N156_V0.8300.35
113_G158_N0.8150.34
100_N103_K0.8030.33
77_R133_Q0.7980.33
164_Y167_L0.7930.33
53_R80_I0.7920.33
137_I169_Y0.7900.32
143_T149_G0.7770.32
16_N137_I0.7680.31
148_G166_I0.7670.31
119_I122_I0.7660.31
94_T97_T0.7650.31
29_I33_S0.7640.31
67_D125_L0.7610.31
160_D165_E0.7600.31
19_V106_V0.7470.30
19_V24_I0.7460.30
85_V119_I0.7430.30
13_I28_L0.7360.29
69_L116_E0.7290.29
108_A137_I0.7290.29
126_I154_I0.7250.29
12_F141_H0.7230.29
48_R117_L0.7130.28
25_L103_K0.7110.28
91_K121_T0.7100.28
46_E70_A0.6990.27
107_L168_N0.6930.27
146_P149_G0.6860.27
117_L141_H0.6850.26
131_N146_P0.6780.26
55_G83_Y0.6780.26
147_M151_I0.6760.26
13_I61_I0.6750.26
43_Y118_K0.6710.26
19_V159_R0.6700.26
64_N140_L0.6630.25
54_I137_I0.6630.25
30_N34_E0.6490.25
26_L43_Y0.6490.25
28_L137_I0.6480.25
46_E81_G0.6470.25
73_N162_I0.6450.24
17_P80_I0.6400.24
43_Y69_L0.6400.24
47_V109_I0.6390.24
154_I163_K0.6370.24
53_R70_A0.6320.24
53_R85_V0.6320.24
124_K135_P0.6320.24
142_R146_P0.6300.24
130_L135_P0.6240.23
17_P55_G0.6210.23
85_V115_M0.6160.23
17_P70_A0.6150.23
152_Y169_Y0.6110.23
126_I146_P0.6090.23
80_I114_P0.6090.23
130_L146_P0.6090.23
22_T44_C0.6080.23
46_E85_V0.6070.23
47_V68_W0.6070.23
69_L83_Y0.6050.22
88_D131_N0.6050.22
93_I97_T0.6030.22
87_E121_T0.5990.22
11_V93_I0.5940.22
101_I170_I0.5900.22
48_R81_G0.5870.22
51_G97_T0.5830.21
42_F158_N0.5820.21
98_L153_V0.5810.21
100_N124_K0.5790.21
27_F54_I0.5770.21
160_D163_K0.5770.21
28_L164_Y0.5760.21
93_I161_S0.5700.21
125_L129_I0.5680.21
93_I134_K0.5660.21
94_T126_I0.5660.21
127_E149_G0.5650.21
55_G70_A0.5640.21
69_L89_S0.5620.20
21_K41_G0.5590.20
72_E132_N0.5590.20
88_D102_N0.5560.20
60_D65_E0.5560.20
22_T45_P0.5550.20
65_E86_L0.5540.20
56_F69_L0.5530.20
61_I157_E0.5530.20
28_L152_Y0.5490.20
41_G110_D0.5480.20
18_G85_V0.5460.20
161_S165_E0.5420.20
106_V147_M0.5410.20
30_N144_Q0.5390.19
44_C114_P0.5380.19
40_A105_D0.5350.19
97_T102_N0.5320.19
79_K129_I0.5320.19
40_A65_E0.5310.19
91_K139_V0.5310.19
57_R68_W0.5290.19
50_N121_T0.5290.19
14_T117_L0.5270.19
16_N117_L0.5270.19
38_K146_P0.5260.19
92_R121_T0.5260.19
13_I126_I0.5250.19
70_A83_Y0.5250.19
60_D114_P0.5220.19
65_E88_D0.5210.19
15_G20_G0.5200.19
28_L109_I0.5200.19
145_K152_Y0.5180.19
41_G116_E0.5160.19
13_I142_R0.5140.18
114_P117_L0.5120.18
92_R135_P0.5090.18
23_T115_M0.5050.18
37_Y143_T0.5040.18
17_P56_F0.5030.18
40_A101_I0.5030.18
120_P164_Y0.5020.18
55_G109_I0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ye8A 1 0.8914 99.7 0.702 Contact Map
2i3bA 1 0.9543 99.5 0.739 Contact Map
3bosA 2 0.7543 99 0.793 Contact Map
1fnnA 1 0.8971 98.8 0.804 Contact Map
1l8qA 1 0.8057 98.8 0.806 Contact Map
2w58A 2 0.7657 98.8 0.807 Contact Map
2j9rA 3 0.7429 98.8 0.807 Contact Map
2qgzA 1 0.6971 98.8 0.808 Contact Map
3te6A 1 0.88 98.8 0.808 Contact Map
2vhjA 3 0.7771 98.7 0.81 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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