Q97WN8 - SULSO - GREMLIN Contacts

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Q97WN8 - Amidohydrolase, putative

UniProt:	Q97WN8	Sequences: MGIKVELAQIRSYPGDVYRNYKKHLEIIESSSADCVIFPELSLTGYIIKDLTYEIYKDAEEATQKIAEKVNKCVVFGTIRQVRKGILRNSAAVIINGKLDYIYKFYLPTYGLFEERRYFQRGDPLKDLKIFEYKDLKFGVVICEDAWHPEPIEALSLMGADAIFIPSASPMRKLRENLAIEESWDSLLKAHSLMNTVWTVFTNVVGSQEEEYFWGGSRVVSPLGDVKLKLKLFYEDRGTIEITENELLRARFFSSYRDHIREFHSILDKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	270 (241)
Sequences:	13694 (9337)
Seq/√Len:	601.4

ECOLI - YAFV YBEM YOBB
BACSU - MTNU YHCX
HALSA - Q9HQZ3
SULSO - Q97WN8 Q97ZZ7 Q981B6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
4_K	241_E	3.077	1.00
132_E	137_K	3.054	1.00
16_D	19_R	2.682	1.00
78_T	92_A	2.490	1.00
219_V	240_I	2.433	1.00
231_K	236_D	2.380	1.00
23_K	235_E	2.338	1.00
191_H	194_M	2.320	1.00
24_H	42_S	2.319	1.00
221_S	225_D	2.291	1.00
6_E	239_T	2.272	1.00
141_V	152_I	2.215	1.00
6_E	33_A	2.212	1.00
185_D	229_K	2.200	1.00
139_G	155_L	2.126	1.00
73_C	95_I	2.081	1.00
7_L	202_T	2.005	1.00
7_L	200_V	1.998	1.00
25_L	62_A	1.998	1.00
161_D	248_L	1.996	1.00
37_I	164_F	1.994	1.00
29_E	70_V	1.934	1.00
36_V	72_K	1.923	1.00
230_L	238_G	1.919	1.00
25_L	66_I	1.894	1.00
186_S	189_K	1.889	1.00
29_E	69_K	1.885	1.00
34_D	134_K	1.881	1.00
230_L	236_D	1.861	1.00
86_I	120_Q	1.844	1.00
25_L	29_E	1.837	1.00
23_K	26_E	1.819	1.00
5_V	200_V	1.800	1.00
137_K	161_D	1.723	1.00
163_I	197_V	1.720	1.00
198_W	222_P	1.703	1.00
91_A	140_V	1.693	1.00
65_K	69_K	1.689	1.00
95_I	134_K	1.689	1.00
73_C	93_V	1.684	1.00
133_Y	136_L	1.652	1.00
8_A	36_V	1.642	1.00
33_A	239_T	1.624	1.00
220_V	226_V	1.612	1.00
73_C	100_D	1.610	1.00
228_L	238_G	1.590	1.00
93_V	140_V	1.584	1.00
138_F	162_A	1.566	1.00
75_V	91_A	1.563	1.00
75_V	93_V	1.543	1.00
66_I	70_V	1.534	1.00
64_Q	94_I	1.520	1.00
114_E	117_R	1.516	1.00
75_V	164_F	1.503	1.00
90_S	102_I	1.503	1.00
246_E	249_R	1.493	1.00
26_E	30_S	1.492	1.00
188_L	201_F	1.484	1.00
27_I	30_S	1.483	1.00
37_I	202_T	1.483	1.00
80_R	90_S	1.479	1.00
24_H	38_F	1.472	1.00
67_A	74_V	1.470	1.00
28_I	74_V	1.460	1.00
56_Y	60_E	1.454	1.00
73_C	133_Y	1.449	1.00
63_T	76_F	1.445	1.00
35_C	164_F	1.442	1.00
109_T	116_R	1.441	1.00
141_V	165_I	1.433	1.00
28_I	36_V	1.412	1.00
22_K	26_E	1.398	1.00
200_V	219_V	1.388	1.00
152_I	163_I	1.378	1.00
185_D	189_K	1.376	1.00
75_V	140_V	1.369	1.00
141_V	151_P	1.364	1.00
198_W	227_K	1.361	1.00
94_I	99_L	1.355	1.00
8_A	38_F	1.333	1.00
19_R	22_K	1.328	1.00
91_A	166_P	1.322	1.00
25_L	69_K	1.320	1.00
60_E	92_A	1.315	1.00
150_E	153_E	1.302	1.00
29_E	66_I	1.290	1.00
221_S	227_K	1.282	1.00
249_R	253_F	1.274	1.00
21_Y	62_A	1.263	1.00
152_I	165_I	1.263	1.00
216_G	229_K	1.261	1.00
8_A	237_R	1.249	1.00
138_F	164_F	1.244	1.00
28_I	66_I	1.241	1.00
31_S	237_R	1.234	1.00
78_T	102_I	1.225	1.00
154_A	158_M	1.215	1.00
34_D	95_I	1.214	1.00
207_S	212_Y	1.201	1.00
231_K	234_Y	1.200	1.00
28_I	72_K	1.188	1.00
18_Y	22_K	1.185	1.00
19_R	23_K	1.183	1.00
61_E	64_Q	1.181	1.00
186_S	193_L	1.170	1.00
221_S	246_E	1.148	1.00
62_A	65_K	1.141	1.00
88_R	120_Q	1.133	1.00
162_A	200_V	1.131	1.00
23_K	27_I	1.127	1.00
43_L	59_A	1.118	1.00
101_Y	129_K	1.114	1.00
144_E	148_H	1.110	1.00
185_D	218_R	1.093	1.00
8_A	27_I	1.092	1.00
10_I	27_I	1.090	1.00
204_V	208_Q	1.085	1.00
192_S	199_T	1.084	1.00
92_A	102_I	1.083	1.00
156_S	197_V	1.079	1.00
21_Y	25_L	1.066	1.00
160_A	163_I	1.063	1.00
4_K	239_T	1.060	1.00
61_E	65_K	1.059	1.00
136_L	161_D	1.057	1.00
25_L	65_K	1.056	1.00
71_N	95_I	1.044	1.00
76_F	94_I	1.042	1.00
60_E	94_I	1.028	1.00
171_M	212_Y	1.025	1.00
33_A	36_V	1.020	1.00
27_I	237_R	1.019	1.00
188_L	199_T	1.016	1.00
65_K	68_E	1.015	1.00
55_I	60_E	1.013	1.00
139_G	160_A	1.010	1.00
216_G	232_L	0.997	1.00
57_K	60_E	0.996	1.00
248_L	252_F	0.996	1.00
18_Y	58_D	0.984	1.00
22_K	62_A	0.984	1.00
80_R	88_R	0.982	1.00
130_I	137_K	0.980	1.00
136_L	162_A	0.973	1.00
192_S	220_V	0.972	1.00
101_Y	131_F	0.970	1.00
93_V	131_F	0.968	1.00
245_N	248_L	0.966	1.00
9_Q	217_S	0.959	1.00
63_T	74_V	0.959	1.00
186_S	190_A	0.958	1.00
188_L	218_R	0.956	1.00
103_Y	129_K	0.954	1.00
62_A	66_I	0.941	1.00
73_C	134_K	0.934	1.00
66_I	69_K	0.933	1.00
10_I	24_H	0.927	1.00
133_Y	138_F	0.926	1.00
188_L	220_V	0.919	1.00
56_Y	61_E	0.914	1.00
7_L	238_G	0.908	1.00
184_W	201_F	0.906	1.00
205_V	234_Y	0.903	1.00
227_K	240_I	0.899	1.00
130_I	160_A	0.896	1.00
243_T	246_E	0.896	1.00
7_L	219_V	0.893	1.00
41_L	119_F	0.893	1.00
80_R	102_I	0.887	1.00
17_V	21_Y	0.881	1.00
198_W	247_L	0.880	1.00
6_E	237_R	0.875	1.00
161_D	244_E	0.874	1.00
228_L	240_I	0.871	1.00
245_N	249_R	0.868	1.00
18_Y	62_A	0.866	1.00
153_E	195_N	0.865	1.00
124_P	129_K	0.857	1.00
218_R	226_V	0.852	1.00
67_A	70_V	0.850	1.00
226_V	229_K	0.848	1.00
103_Y	145_D	0.840	1.00
109_T	114_E	0.836	1.00
26_E	29_E	0.834	1.00
198_W	242_I	0.828	1.00
10_I	42_S	0.817	1.00
11_R	205_V	0.816	1.00
153_E	157_L	0.814	1.00
22_K	25_L	0.812	1.00
6_E	31_S	0.808	1.00
132_E	135_D	0.800	1.00
12_S	204_V	0.794	1.00
57_K	61_E	0.787	1.00
9_Q	215_G	0.786	1.00
5_V	242_I	0.785	1.00
60_E	64_Q	0.781	1.00
11_R	235_E	0.780	1.00
41_L	46_Y	0.777	1.00
24_H	63_T	0.775	1.00
105_F	151_P	0.773	1.00
24_H	76_F	0.769	1.00
48_I	52_T	0.767	1.00
38_F	42_S	0.766	1.00
106_Y	145_D	0.758	1.00
6_E	36_V	0.756	1.00
244_E	248_L	0.755	1.00
104_K	143_C	0.754	1.00
3_I	135_D	0.753	1.00
7_L	217_S	0.748	1.00
37_I	75_V	0.748	1.00
146_A	165_I	0.746	1.00
28_I	38_F	0.745	1.00
246_E	250_A	0.739	1.00
28_I	70_V	0.728	1.00
31_S	36_V	0.728	1.00
128_L	131_F	0.725	1.00
31_S	72_K	0.724	1.00
165_I	199_T	0.723	1.00
136_L	244_E	0.720	1.00
247_L	251_R	0.715	1.00
10_I	23_K	0.715	1.00
205_V	235_E	0.714	1.00
89_N	104_K	0.713	1.00
35_C	75_V	0.712	1.00
141_V	155_L	0.710	1.00
35_C	135_D	0.709	1.00
92_A	99_L	0.709	1.00
64_Q	67_A	0.706	1.00
3_I	136_L	0.700	1.00
60_E	99_L	0.700	1.00
218_R	229_K	0.699	1.00
198_W	246_E	0.696	1.00
128_L	151_P	0.694	1.00
146_A	188_L	0.692	1.00
155_L	160_A	0.692	1.00
35_C	73_C	0.687	1.00
156_S	195_N	0.683	1.00
225_D	246_E	0.681	1.00
3_I	242_I	0.679	1.00
223_L	250_A	0.677	1.00
73_C	135_D	0.675	1.00
64_Q	98_K	0.674	1.00
59_A	62_A	0.673	1.00
24_H	28_I	0.673	1.00
163_I	199_T	0.670	1.00
99_L	102_I	0.667	1.00
106_Y	148_H	0.667	1.00
168_A	204_V	0.666	1.00
131_F	138_F	0.664	1.00
204_V	213_F	0.663	1.00
255_S	258_D	0.661	1.00
34_D	135_D	0.658	1.00
105_F	128_L	0.655	1.00
168_A	213_F	0.655	1.00
83_R	86_I	0.654	1.00
21_Y	63_T	0.652	1.00
16_D	20_N	0.650	1.00
42_S	76_F	0.644	1.00
37_I	200_V	0.641	1.00
17_V	59_A	0.636	1.00
47_I	50_D	0.631	1.00
48_I	51_L	0.628	1.00
252_F	258_D	0.628	1.00
71_N	96_N	0.624	1.00
128_L	155_L	0.624	1.00
151_P	155_L	0.622	1.00
185_D	216_G	0.620	1.00
41_L	79_I	0.620	1.00
58_D	62_A	0.619	1.00
154_A	157_L	0.616	1.00
81_Q	87_L	0.616	1.00
33_A	72_K	0.616	1.00
64_Q	99_L	0.614	1.00
203_N	217_S	0.611	1.00
108_P	144_E	0.611	1.00
80_R	92_A	0.610	1.00
18_Y	21_Y	0.609	1.00
89_N	143_C	0.607	1.00
30_S	237_R	0.602	1.00
25_L	70_V	0.601	1.00
147_W	169_S	0.600	1.00
172_R	175_R	0.598	1.00
55_I	58_D	0.598	1.00
64_Q	68_E	0.597	1.00
191_H	195_N	0.597	1.00
108_P	147_W	0.594	1.00
137_K	158_M	0.592	1.00
7_L	228_L	0.585	1.00
95_I	100_D	0.585	1.00
11_R	204_V	0.579	1.00
187_L	190_A	0.579	1.00
105_F	154_A	0.576	1.00
83_R	88_R	0.575	1.00
79_I	119_F	0.575	1.00
147_W	187_L	0.572	1.00
24_H	27_I	0.565	1.00
21_Y	66_I	0.564	1.00
108_P	170_P	0.563	1.00
139_G	163_I	0.561	1.00
41_L	89_N	0.560	1.00
77_G	89_N	0.558	1.00
45_G	48_I	0.558	1.00
11_R	23_K	0.557	1.00
129_K	158_M	0.557	1.00
144_E	147_W	0.556	1.00
51_L	54_E	0.555	0.99
93_V	138_F	0.555	0.99
171_M	214_W	0.553	0.99
30_S	236_D	0.553	0.99
174_L	214_W	0.552	0.99
184_W	188_L	0.551	0.99
89_N	142_I	0.549	0.99
101_Y	140_V	0.548	0.99
156_S	257_R	0.546	0.99
189_K	226_V	0.545	0.99
40_E	143_C	0.544	0.99
78_T	90_S	0.543	0.99
203_N	214_W	0.542	0.99
27_I	31_S	0.541	0.99
25_L	28_I	0.539	0.99
185_D	226_V	0.539	0.99
30_S	239_T	0.538	0.99
190_A	193_L	0.535	0.99
124_P	128_L	0.535	0.99
55_I	61_E	0.534	0.99
37_I	166_P	0.531	0.99
56_Y	59_A	0.529	0.99
185_D	220_V	0.527	0.99
3_I	35_C	0.527	0.99
128_L	154_A	0.527	0.99
103_Y	122_G	0.527	0.99
169_S	184_W	0.526	0.99
38_F	76_F	0.526	0.99
80_R	83_R	0.526	0.99
155_L	163_I	0.522	0.99
244_E	247_L	0.521	0.99
183_S	223_L	0.521	0.99
196_T	250_A	0.521	0.99
162_A	198_W	0.519	0.99
183_S	187_L	0.519	0.99
96_N	100_D	0.519	0.99
34_D	71_N	0.518	0.99
91_A	142_I	0.517	0.99
78_T	142_I	0.516	0.99
60_E	66_I	0.516	0.99
150_E	154_A	0.514	0.99
66_I	74_V	0.512	0.99
41_L	44_T	0.511	0.99
27_I	235_E	0.510	0.99
165_I	188_L	0.509	0.99
76_F	92_A	0.508	0.99
153_E	257_R	0.508	0.99
174_L	216_G	0.508	0.99
38_F	74_V	0.507	0.99
161_D	247_L	0.507	0.99
207_S	210_E	0.507	0.99
43_L	63_T	0.504	0.99
21_Y	59_A	0.503	0.99
189_K	193_L	0.502	0.99
169_S	201_F	0.501	0.99
17_V	20_N	0.501	0.99
190_A	194_M	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4izuA	2	0.9074	100	0.226	Contact Map
2vhhA	5	0.9667	100	0.226	Contact Map
2w1vA	2	0.9519	100	0.231	Contact Map
2e11A	2	0.9333	100	0.232	Contact Map
3ivzA	2	0.9111	100	0.236	Contact Map
3p8kA	2	0.937	100	0.238	Contact Map
3wuyA	2	0.9148	100	0.239	Contact Map
1uf5A	4	0.9852	100	0.241	Contact Map
3ilvA	2	0.8778	100	0.242	Contact Map
3n05A	2	0.9704	100	0.249	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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