GREMLIN Database
Q97WN8 - Amidohydrolase, putative
UniProt: Q97WN8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (241)
Sequences: 13694 (9337)
Seq/√Len: 601.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_K241_E3.0771.00
132_E137_K3.0541.00
16_D19_R2.6821.00
78_T92_A2.4901.00
219_V240_I2.4331.00
231_K236_D2.3801.00
23_K235_E2.3381.00
191_H194_M2.3201.00
24_H42_S2.3191.00
221_S225_D2.2911.00
6_E239_T2.2721.00
141_V152_I2.2151.00
6_E33_A2.2121.00
185_D229_K2.2001.00
139_G155_L2.1261.00
73_C95_I2.0811.00
7_L202_T2.0051.00
7_L200_V1.9981.00
25_L62_A1.9981.00
161_D248_L1.9961.00
37_I164_F1.9941.00
29_E70_V1.9341.00
36_V72_K1.9231.00
230_L238_G1.9191.00
25_L66_I1.8941.00
186_S189_K1.8891.00
29_E69_K1.8851.00
34_D134_K1.8811.00
230_L236_D1.8611.00
86_I120_Q1.8441.00
25_L29_E1.8371.00
23_K26_E1.8191.00
5_V200_V1.8001.00
137_K161_D1.7231.00
163_I197_V1.7201.00
198_W222_P1.7031.00
91_A140_V1.6931.00
65_K69_K1.6891.00
95_I134_K1.6891.00
73_C93_V1.6841.00
133_Y136_L1.6521.00
8_A36_V1.6421.00
33_A239_T1.6241.00
220_V226_V1.6121.00
73_C100_D1.6101.00
228_L238_G1.5901.00
93_V140_V1.5841.00
138_F162_A1.5661.00
75_V91_A1.5631.00
75_V93_V1.5431.00
66_I70_V1.5341.00
64_Q94_I1.5201.00
114_E117_R1.5161.00
75_V164_F1.5031.00
90_S102_I1.5031.00
246_E249_R1.4931.00
26_E30_S1.4921.00
188_L201_F1.4841.00
27_I30_S1.4831.00
37_I202_T1.4831.00
80_R90_S1.4791.00
24_H38_F1.4721.00
67_A74_V1.4701.00
28_I74_V1.4601.00
56_Y60_E1.4541.00
73_C133_Y1.4491.00
63_T76_F1.4451.00
35_C164_F1.4421.00
109_T116_R1.4411.00
141_V165_I1.4331.00
28_I36_V1.4121.00
22_K26_E1.3981.00
200_V219_V1.3881.00
152_I163_I1.3781.00
185_D189_K1.3761.00
75_V140_V1.3691.00
141_V151_P1.3641.00
198_W227_K1.3611.00
94_I99_L1.3551.00
8_A38_F1.3331.00
19_R22_K1.3281.00
91_A166_P1.3221.00
25_L69_K1.3201.00
60_E92_A1.3151.00
150_E153_E1.3021.00
29_E66_I1.2901.00
221_S227_K1.2821.00
249_R253_F1.2741.00
21_Y62_A1.2631.00
152_I165_I1.2631.00
216_G229_K1.2611.00
8_A237_R1.2491.00
138_F164_F1.2441.00
28_I66_I1.2411.00
31_S237_R1.2341.00
78_T102_I1.2251.00
154_A158_M1.2151.00
34_D95_I1.2141.00
207_S212_Y1.2011.00
231_K234_Y1.2001.00
28_I72_K1.1881.00
18_Y22_K1.1851.00
19_R23_K1.1831.00
61_E64_Q1.1811.00
186_S193_L1.1701.00
221_S246_E1.1481.00
62_A65_K1.1411.00
88_R120_Q1.1331.00
162_A200_V1.1311.00
23_K27_I1.1271.00
43_L59_A1.1181.00
101_Y129_K1.1141.00
144_E148_H1.1101.00
185_D218_R1.0931.00
8_A27_I1.0921.00
10_I27_I1.0901.00
204_V208_Q1.0851.00
192_S199_T1.0841.00
92_A102_I1.0831.00
156_S197_V1.0791.00
21_Y25_L1.0661.00
160_A163_I1.0631.00
4_K239_T1.0601.00
61_E65_K1.0591.00
136_L161_D1.0571.00
25_L65_K1.0561.00
71_N95_I1.0441.00
76_F94_I1.0421.00
60_E94_I1.0281.00
171_M212_Y1.0251.00
33_A36_V1.0201.00
27_I237_R1.0191.00
188_L199_T1.0161.00
65_K68_E1.0151.00
55_I60_E1.0131.00
139_G160_A1.0101.00
216_G232_L0.9971.00
57_K60_E0.9961.00
248_L252_F0.9961.00
18_Y58_D0.9841.00
22_K62_A0.9841.00
80_R88_R0.9821.00
130_I137_K0.9801.00
136_L162_A0.9731.00
192_S220_V0.9721.00
101_Y131_F0.9701.00
93_V131_F0.9681.00
245_N248_L0.9661.00
9_Q217_S0.9591.00
63_T74_V0.9591.00
186_S190_A0.9581.00
188_L218_R0.9561.00
103_Y129_K0.9541.00
62_A66_I0.9411.00
73_C134_K0.9341.00
66_I69_K0.9331.00
10_I24_H0.9271.00
133_Y138_F0.9261.00
188_L220_V0.9191.00
56_Y61_E0.9141.00
7_L238_G0.9081.00
184_W201_F0.9061.00
205_V234_Y0.9031.00
227_K240_I0.8991.00
130_I160_A0.8961.00
243_T246_E0.8961.00
7_L219_V0.8931.00
41_L119_F0.8931.00
80_R102_I0.8871.00
17_V21_Y0.8811.00
198_W247_L0.8801.00
6_E237_R0.8751.00
161_D244_E0.8741.00
228_L240_I0.8711.00
245_N249_R0.8681.00
18_Y62_A0.8661.00
153_E195_N0.8651.00
124_P129_K0.8571.00
218_R226_V0.8521.00
67_A70_V0.8501.00
226_V229_K0.8481.00
103_Y145_D0.8401.00
109_T114_E0.8361.00
26_E29_E0.8341.00
198_W242_I0.8281.00
10_I42_S0.8171.00
11_R205_V0.8161.00
153_E157_L0.8141.00
22_K25_L0.8121.00
6_E31_S0.8081.00
132_E135_D0.8001.00
12_S204_V0.7941.00
57_K61_E0.7871.00
9_Q215_G0.7861.00
5_V242_I0.7851.00
60_E64_Q0.7811.00
11_R235_E0.7801.00
41_L46_Y0.7771.00
24_H63_T0.7751.00
105_F151_P0.7731.00
24_H76_F0.7691.00
48_I52_T0.7671.00
38_F42_S0.7661.00
106_Y145_D0.7581.00
6_E36_V0.7561.00
244_E248_L0.7551.00
104_K143_C0.7541.00
3_I135_D0.7531.00
7_L217_S0.7481.00
37_I75_V0.7481.00
146_A165_I0.7461.00
28_I38_F0.7451.00
246_E250_A0.7391.00
28_I70_V0.7281.00
31_S36_V0.7281.00
128_L131_F0.7251.00
31_S72_K0.7241.00
165_I199_T0.7231.00
136_L244_E0.7201.00
247_L251_R0.7151.00
10_I23_K0.7151.00
205_V235_E0.7141.00
89_N104_K0.7131.00
35_C75_V0.7121.00
141_V155_L0.7101.00
35_C135_D0.7091.00
92_A99_L0.7091.00
64_Q67_A0.7061.00
3_I136_L0.7001.00
60_E99_L0.7001.00
218_R229_K0.6991.00
198_W246_E0.6961.00
128_L151_P0.6941.00
146_A188_L0.6921.00
155_L160_A0.6921.00
35_C73_C0.6871.00
156_S195_N0.6831.00
225_D246_E0.6811.00
3_I242_I0.6791.00
223_L250_A0.6771.00
73_C135_D0.6751.00
64_Q98_K0.6741.00
59_A62_A0.6731.00
24_H28_I0.6731.00
163_I199_T0.6701.00
99_L102_I0.6671.00
106_Y148_H0.6671.00
168_A204_V0.6661.00
131_F138_F0.6641.00
204_V213_F0.6631.00
255_S258_D0.6611.00
34_D135_D0.6581.00
105_F128_L0.6551.00
168_A213_F0.6551.00
83_R86_I0.6541.00
21_Y63_T0.6521.00
16_D20_N0.6501.00
42_S76_F0.6441.00
37_I200_V0.6411.00
17_V59_A0.6361.00
47_I50_D0.6311.00
48_I51_L0.6281.00
252_F258_D0.6281.00
71_N96_N0.6241.00
128_L155_L0.6241.00
151_P155_L0.6221.00
185_D216_G0.6201.00
41_L79_I0.6201.00
58_D62_A0.6191.00
154_A157_L0.6161.00
81_Q87_L0.6161.00
33_A72_K0.6161.00
64_Q99_L0.6141.00
203_N217_S0.6111.00
108_P144_E0.6111.00
80_R92_A0.6101.00
18_Y21_Y0.6091.00
89_N143_C0.6071.00
30_S237_R0.6021.00
25_L70_V0.6011.00
147_W169_S0.6001.00
172_R175_R0.5981.00
55_I58_D0.5981.00
64_Q68_E0.5971.00
191_H195_N0.5971.00
108_P147_W0.5941.00
137_K158_M0.5921.00
7_L228_L0.5851.00
95_I100_D0.5851.00
11_R204_V0.5791.00
187_L190_A0.5791.00
105_F154_A0.5761.00
83_R88_R0.5751.00
79_I119_F0.5751.00
147_W187_L0.5721.00
24_H27_I0.5651.00
21_Y66_I0.5641.00
108_P170_P0.5631.00
139_G163_I0.5611.00
41_L89_N0.5601.00
77_G89_N0.5581.00
45_G48_I0.5581.00
11_R23_K0.5571.00
129_K158_M0.5571.00
144_E147_W0.5561.00
51_L54_E0.5550.99
93_V138_F0.5550.99
171_M214_W0.5530.99
30_S236_D0.5530.99
174_L214_W0.5520.99
184_W188_L0.5510.99
89_N142_I0.5490.99
101_Y140_V0.5480.99
156_S257_R0.5460.99
189_K226_V0.5450.99
40_E143_C0.5440.99
78_T90_S0.5430.99
203_N214_W0.5420.99
27_I31_S0.5410.99
25_L28_I0.5390.99
185_D226_V0.5390.99
30_S239_T0.5380.99
190_A193_L0.5350.99
124_P128_L0.5350.99
55_I61_E0.5340.99
37_I166_P0.5310.99
56_Y59_A0.5290.99
185_D220_V0.5270.99
3_I35_C0.5270.99
128_L154_A0.5270.99
103_Y122_G0.5270.99
169_S184_W0.5260.99
38_F76_F0.5260.99
80_R83_R0.5260.99
155_L163_I0.5220.99
244_E247_L0.5210.99
183_S223_L0.5210.99
196_T250_A0.5210.99
162_A198_W0.5190.99
183_S187_L0.5190.99
96_N100_D0.5190.99
34_D71_N0.5180.99
91_A142_I0.5170.99
78_T142_I0.5160.99
60_E66_I0.5160.99
150_E154_A0.5140.99
66_I74_V0.5120.99
41_L44_T0.5110.99
27_I235_E0.5100.99
165_I188_L0.5090.99
76_F92_A0.5080.99
153_E257_R0.5080.99
174_L216_G0.5080.99
38_F74_V0.5070.99
161_D247_L0.5070.99
207_S210_E0.5070.99
43_L63_T0.5040.99
21_Y59_A0.5030.99
189_K193_L0.5020.99
169_S201_F0.5010.99
17_V20_N0.5010.99
190_A194_M0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4izuA 2 0.9074 100 0.226 Contact Map
2vhhA 5 0.9667 100 0.226 Contact Map
2w1vA 2 0.9519 100 0.231 Contact Map
2e11A 2 0.9333 100 0.232 Contact Map
3ivzA 2 0.9111 100 0.236 Contact Map
3p8kA 2 0.937 100 0.238 Contact Map
3wuyA 2 0.9148 100 0.239 Contact Map
1uf5A 4 0.9852 100 0.241 Contact Map
3ilvA 2 0.8778 100 0.242 Contact Map
3n05A 2 0.9704 100 0.249 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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