GREMLIN Database
Q97WN6 - Uncharacterized protein
UniProt: Q97WN6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 299 (289)
Sequences: 384 (267)
Seq/√Len: 15.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_G260_A4.1131.00
260_A283_T4.0021.00
185_Y195_S3.7791.00
259_T264_T3.6551.00
115_I286_I3.2930.99
68_F180_L3.2720.99
212_V295_L3.1760.99
59_V247_F3.0200.98
205_Y240_P2.9110.98
68_F184_I2.7740.97
42_I225_F2.7030.96
234_L253_V2.6800.96
166_S170_L2.5860.95
208_V228_N2.5720.95
180_L184_I2.5520.95
77_G254_A2.4580.94
72_I183_V2.4000.93
172_I192_L2.3840.93
5_S142_L2.3580.92
121_G205_Y2.3550.92
283_T288_T2.3130.92
283_T287_L2.3080.92
218_P225_F2.2480.91
268_Y276_Y2.2440.90
146_L261_M2.2250.90
146_L255_V2.2120.90
73_T176_G2.1850.89
43_S207_Y2.1620.89
200_L207_Y2.1460.88
47_G136_D2.1390.88
84_N183_V2.1020.87
235_T256_G2.0980.87
37_L67_I2.0840.87
258_A291_I2.0350.85
200_L298_I1.9870.84
67_I71_I1.8860.81
141_A189_I1.8690.80
261_M288_T1.8240.78
76_S176_G1.7250.74
212_V220_L1.7040.73
27_A191_N1.6910.73
121_G240_P1.6910.73
44_Y75_F1.6860.72
179_I286_I1.6770.72
282_I288_T1.6410.70
66_S70_I1.6400.70
143_A288_T1.6290.70
39_I180_L1.6260.70
198_I291_I1.6260.70
40_L180_L1.5920.68
107_I205_Y1.5910.68
75_F183_V1.5770.67
150_M213_A1.5550.66
79_A179_I1.5540.66
62_S65_L1.5450.65
38_L176_G1.5450.65
269_V272_L1.5160.64
142_L297_L1.5160.64
110_Y113_P1.4950.63
115_I171_F1.4950.63
63_L171_F1.4540.61
220_L295_L1.4540.61
211_L238_L1.4380.60
110_Y229_F1.4310.59
173_T287_L1.4010.58
77_G218_P1.3980.57
225_F270_E1.3960.57
43_S200_L1.3680.56
42_I110_Y1.3630.55
93_T96_E1.3600.55
181_A195_S1.3560.55
208_V292_P1.3530.55
235_T278_L1.3530.55
262_D265_L1.3470.55
253_V276_Y1.3320.54
8_F31_V1.3310.54
42_I217_N1.3190.53
209_G288_T1.3100.52
244_R247_F1.3070.52
36_I225_F1.3070.52
82_S179_I1.3060.52
101_R141_A1.3010.52
64_I237_V1.2810.51
262_D284_G1.2800.51
178_I182_L1.2650.50
35_V210_P1.2520.49
149_T266_P1.2520.49
114_F233_Q1.2330.48
121_G225_F1.2250.48
114_F260_A1.2210.47
66_S230_L1.2200.47
126_I297_L1.2170.47
235_T295_L1.2130.47
120_F123_L1.2090.47
259_T273_G1.2000.46
167_L171_F1.1980.46
211_L289_L1.1860.45
40_L275_E1.1790.45
178_I294_I1.1790.45
151_G176_G1.1670.44
31_V213_A1.1580.44
34_V236_Y1.1480.43
131_V261_M1.1440.43
178_I199_A1.1300.42
193_T236_Y1.1270.42
71_I141_A1.1260.42
283_T296_P1.1240.42
67_I89_L1.1200.42
174_I290_I1.1130.41
213_A293_I1.1040.41
190_A288_T1.1020.41
115_I179_I1.0780.39
46_A272_L1.0750.39
196_F298_I1.0740.39
58_L206_S1.0740.39
269_V280_A1.0730.39
115_I120_F1.0700.39
182_L186_M1.0640.38
63_L119_I1.0630.38
38_L73_T1.0610.38
39_I229_F1.0600.38
145_V169_S1.0570.38
243_L276_Y1.0500.38
47_G122_L1.0480.38
66_S280_A1.0440.37
146_L180_L1.0430.37
49_E110_Y1.0370.37
9_I297_L1.0360.37
228_N291_I1.0340.37
17_I59_V1.0310.37
137_Y214_V1.0210.36
107_I110_Y1.0110.36
94_N112_L1.0100.36
243_L261_M1.0080.35
119_I175_L1.0060.35
265_L284_G1.0060.35
107_I240_P1.0060.35
209_G268_Y1.0030.35
173_T244_R1.0020.35
33_I112_L1.0020.35
27_A30_I1.0010.35
179_I182_L1.0000.35
29_R187_L1.0000.35
25_K29_R0.9970.35
70_I74_Y0.9940.35
38_L263_T0.9890.35
119_I179_I0.9850.34
110_Y225_F0.9830.34
222_T252_A0.9800.34
240_P243_L0.9790.34
282_I285_V0.9760.34
71_I75_F0.9710.34
160_L280_A0.9670.33
249_P253_V0.9660.33
13_L167_L0.9640.33
145_V236_Y0.9620.33
21_I171_F0.9580.33
62_S294_I0.9540.33
166_S273_G0.9510.33
71_I84_N0.9460.32
240_P269_V0.9450.32
143_A204_W0.9440.32
117_G265_L0.9430.32
13_L141_A0.9360.32
269_V277_A0.9310.32
151_G228_N0.9310.32
93_T241_F0.9310.32
31_V291_I0.9300.32
31_V253_V0.9290.31
151_G243_L0.9230.31
120_F179_I0.9200.31
194_I260_A0.9190.31
22_K183_V0.9190.31
243_L272_L0.9130.31
140_Y215_S0.9060.30
92_K95_K0.9030.30
37_L125_H0.9010.30
134_L172_I0.8990.30
156_R161_N0.8980.30
57_S144_S0.8950.30
194_I212_V0.8950.30
134_L187_L0.8950.30
174_I199_A0.8930.30
82_S105_Q0.8920.30
91_V119_I0.8820.29
209_G261_M0.8800.29
80_I172_I0.8720.29
6_I42_I0.8720.29
181_A217_N0.8700.29
224_A228_N0.8670.28
64_I184_I0.8610.28
175_L182_L0.8590.28
39_I208_V0.8540.28
181_A185_Y0.8510.28
116_S193_T0.8450.27
45_W170_L0.8410.27
115_I187_L0.8390.27
15_F211_L0.8370.27
43_S233_Q0.8360.27
173_T283_T0.8360.27
172_I297_L0.8340.27
67_I182_L0.8340.27
236_Y271_V0.8330.27
119_I123_L0.8330.27
122_L233_Q0.8240.26
272_L278_L0.8230.26
58_L81_R0.8220.26
208_V224_A0.8220.26
17_I83_F0.8190.26
39_I264_T0.8180.26
53_N175_L0.8180.26
116_S187_L0.8140.26
91_V94_N0.8120.26
184_I191_N0.8110.26
77_G150_M0.8100.26
73_T151_G0.8090.26
141_A175_L0.8080.26
268_Y283_T0.8080.26
166_S181_A0.8080.26
79_A182_L0.8070.26
213_A253_V0.8060.26
224_A227_I0.8040.26
194_I216_S0.8010.25
15_F298_I0.7970.25
23_Y94_N0.7910.25
129_N175_L0.7900.25
101_R133_N0.7900.25
41_T197_A0.7850.25
72_I179_I0.7850.25
30_I93_T0.7840.25
116_S127_N0.7810.25
141_A268_Y0.7790.25
257_G262_D0.7790.25
13_L112_L0.7790.25
220_L224_A0.7780.24
8_F228_N0.7760.24
137_Y258_A0.7740.24
144_S183_V0.7720.24
222_T276_Y0.7720.24
261_M268_Y0.7720.24
15_F51_T0.7710.24
164_K230_L0.7630.24
15_F280_A0.7600.24
31_V236_Y0.7590.24
60_I95_K0.7550.24
102_S174_I0.7540.23
15_F238_L0.7510.23
132_I137_Y0.7500.23
188_H210_P0.7350.23
16_L68_F0.7330.23
63_L137_Y0.7330.23
253_V283_T0.7320.23
43_S77_G0.7300.23
114_F254_A0.7300.23
72_I171_F0.7290.22
91_V175_L0.7290.22
51_T263_T0.7280.22
258_A287_L0.7270.22
94_N127_N0.7240.22
183_V237_V0.7240.22
226_L264_T0.7210.22
110_Y240_P0.7210.22
30_I132_I0.7200.22
146_L165_D0.7180.22
202_S207_Y0.7170.22
81_R236_Y0.7170.22
209_G221_G0.7110.22
77_G176_G0.7100.22
280_A287_L0.7090.22
103_N167_L0.7080.22
226_L230_L0.7070.22
151_G170_L0.7050.22
107_I149_T0.6970.21
178_I202_S0.6970.21
255_V260_A0.6940.21
156_R228_N0.6940.21
14_I207_Y0.6920.21
179_I183_V0.6910.21
222_T243_L0.6900.21
75_F171_F0.6860.21
265_L292_P0.6860.21
34_V200_L0.6860.21
221_G259_T0.6850.21
116_S290_I0.6850.21
186_M241_F0.6800.21
79_A124_F0.6780.20
66_S192_L0.6780.20
70_I253_V0.6780.20
186_M192_L0.6750.20
58_L191_N0.6740.20
141_A191_N0.6730.20
204_W226_L0.6730.20
58_L209_G0.6720.20
222_T227_I0.6710.20
55_V240_P0.6670.20
20_K115_I0.6670.20
78_V119_I0.6670.20
12_Y37_L0.6650.20
37_L187_L0.6630.20
115_I133_N0.6630.20
198_I235_T0.6620.20
147_G232_E0.6620.20
112_L171_F0.6620.20
213_A222_T0.6610.20
75_F116_S0.6600.20
77_G166_S0.6550.20
65_L184_I0.6530.20
205_Y273_G0.6520.20
247_F289_L0.6510.19
22_K120_F0.6510.19
51_T109_K0.6480.19
27_A75_F0.6440.19
12_Y48_E0.6410.19
30_I35_V0.6400.19
41_T275_E0.6400.19
168_I171_F0.6380.19
9_I30_I0.6360.19
55_V205_Y0.6350.19
166_S285_V0.6340.19
112_L116_S0.6320.19
243_L248_E0.6280.19
228_N278_L0.6280.19
146_L283_T0.6280.19
205_Y263_T0.6260.19
194_I263_T0.6260.19
36_I46_A0.6250.19
30_I293_I0.6240.19
261_M283_T0.6230.19
11_L14_I0.6230.19
5_S297_L0.6230.19
172_I182_L0.6220.18
31_V36_I0.6210.18
60_I223_L0.6210.18
21_I234_L0.6160.18
89_L234_L0.6160.18
117_G221_G0.6150.18
145_V150_M0.6140.18
282_I287_L0.6140.18
171_F183_V0.6120.18
169_S255_V0.6110.18
50_I240_P0.6110.18
98_V191_N0.6100.18
82_S241_F0.6090.18
242_L290_I0.6080.18
100_N226_L0.6060.18
151_G240_P0.6040.18
94_N101_R0.6040.18
11_L285_V0.6040.18
210_P235_T0.6020.18
209_G264_T0.6020.18
225_F247_F0.6010.18
116_S179_I0.6010.18
147_G206_S0.6010.18
17_I91_V0.6010.18
163_S228_N0.6010.18
6_I141_A0.5980.18
63_L167_L0.5960.18
167_L288_T0.5950.18
53_N64_I0.5940.18
174_I287_L0.5930.17
212_V224_A0.5920.17
75_F175_L0.5900.17
101_R119_I0.5880.17
223_L256_G0.5870.17
163_S278_L0.5840.17
133_N267_L0.5830.17
114_F229_F0.5820.17
80_I112_L0.5800.17
148_Y289_L0.5770.17
95_K179_I0.5700.17
64_I146_L0.5700.17
110_Y170_L0.5690.17
140_Y250_R0.5680.17
182_L192_L0.5680.17
151_G225_F0.5660.17
272_L288_T0.5650.17
25_K89_L0.5620.16
78_V123_L0.5620.16
45_W218_P0.5600.16
37_L116_S0.5600.16
8_F80_I0.5590.16
212_V279_S0.5580.16
42_I233_Q0.5580.16
56_F126_I0.5560.16
41_T230_L0.5550.16
154_V239_V0.5510.16
155_N228_N0.5510.16
210_P263_T0.5500.16
17_I27_A0.5470.16
258_A283_T0.5450.16
65_L234_L0.5450.16
248_E295_L0.5440.16
31_V263_T0.5430.16
67_I234_L0.5430.16
8_F291_I0.5410.16
9_I56_F0.5410.16
109_K200_L0.5410.16
56_F223_L0.5400.16
13_L97_K0.5380.16
175_L186_M0.5370.16
98_V167_L0.5340.16
225_F240_P0.5330.16
40_L115_I0.5330.16
236_Y289_L0.5310.16
17_I92_K0.5310.16
58_L252_A0.5300.15
187_L252_A0.5270.15
175_L275_E0.5260.15
10_V166_S0.5260.15
63_L89_L0.5230.15
74_Y251_S0.5220.15
119_I237_V0.5200.15
183_V192_L0.5200.15
13_L37_L0.5200.15
46_A77_G0.5190.15
286_I298_I0.5190.15
52_S240_P0.5190.15
44_Y271_V0.5190.15
175_L184_I0.5160.15
152_K212_V0.5140.15
170_L243_L0.5120.15
67_I174_I0.5110.15
38_L181_A0.5100.15
38_L151_G0.5060.15
18_I111_M0.5050.15
266_P277_A0.5030.15
92_K123_L0.5030.15
131_V242_L0.5030.15
268_Y279_S0.5010.15
144_S148_Y0.5010.15
35_V263_T0.5010.15
110_Y272_L0.5010.15
127_N179_I0.5000.15
176_G228_N0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.5518 71.6 0.95 Contact Map
4bwzA 2 0.6555 70.6 0.95 Contact Map
4cz8A 2 0.6957 70.4 0.95 Contact Map
4n7wA 2 0.5585 50.8 0.956 Contact Map
4czbA 2 0.6522 45.3 0.958 Contact Map
3dh4A 3 0.3579 15.7 0.966 Contact Map
3giaA 1 0.2943 13.7 0.967 Contact Map
2xq2A 2 0.4716 9.2 0.97 Contact Map
3qnqA 2 0.2943 8.8 0.97 Contact Map
3l1lA 2 0.2709 8.3 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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