Q97WN4 - SULSO - GREMLIN Contacts

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Q97WN4 - SAM-dependent methyltransferase, putative

UniProt:	Q97WN4	Sequences: MSDEWIKIFESDFYVREMIKVWDEGEKWANWIDEVVSKYKLEKKVLDIPCGIGRVSYFLANRGYKVTGIDISERMISMARSNIQNGKFIVGDMRKIKEIIGNEKYDLVINIYNSLGYYSEEDDLKILESLRDSTRKIVVINLDNRDYIIYNRPNEYYTYIPPYLVYSKVEFEQETSRLKIYRKYYLNDKEVGEMIYEQRLYSIHEILALLKKAGLQPIEVLSGYSWKKFSIMDPEMTIIATPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	243 (211)
Sequences:	5098 (4146)
Seq/√Len:	285.4

ECOLI - UBIE UBIG CMOA BIOC TAM SMTA YJHP TEHB
BACSU - YQEM YBAJ YRRT MENG YXBB YCGJ YODH YRHH YDAC
HALSA - Q9HR81 Q9HND6 Q9HMT2 Q9HRX3 Q9HQ85 Q9HSK6 Q9HR63 ARSM
SULSO - Q97WN4 Q7LXN7 Q97ZU8 Q97XD7 Q97X57 Q97WT7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
106_D	135_R	3.861	1.00
76_I	90_V	3.369	1.00
67_T	105_Y	3.366	1.00
73_E	90_V	3.218	1.00
44_K	65_K	3.110	1.00
49_P	114_S	3.109	1.00
46_L	105_Y	3.090	1.00
130_L	138_V	2.753	1.00
48_I	130_L	2.704	1.00
79_A	88_F	2.665	1.00
94_R	123_D	2.589	1.00
56_S	66_V	2.494	1.00
33_D	62_R	2.461	1.00
76_I	88_F	2.435	1.00
50_C	68_G	2.389	1.00
129_S	132_D	2.298	1.00
69_I	91_G	2.226	1.00
17_E	52_I	2.107	1.00
57_Y	82_N	2.053	1.00
78_M	81_S	2.021	1.00
118_Y	126_I	1.975	1.00
26_E	58_F	1.974	1.00
73_E	77_S	1.964	1.00
57_Y	83_I	1.864	1.00
129_S	133_S	1.826	1.00
56_S	68_G	1.821	1.00
96_I	129_S	1.820	1.00
131_R	215_L	1.820	1.00
49_P	110_N	1.817	1.00
83_I	88_F	1.790	1.00
120_E	123_D	1.788	1.00
70_D	76_I	1.764	1.00
36_V	107_L	1.745	1.00
44_K	106_D	1.714	1.00
65_K	87_K	1.692	1.00
108_V	130_L	1.690	1.00
67_T	89_I	1.665	1.00
45_V	64_Y	1.662	1.00
45_V	59_L	1.638	1.00
126_I	130_L	1.634	1.00
119_S	123_D	1.578	1.00
101_G	133_S	1.573	1.00
74_R	77_S	1.559	1.00
44_K	135_R	1.559	1.00
207_L	211_K	1.548	1.00
208_A	212_K	1.537	1.00
48_I	93_M	1.525	1.00
130_L	134_T	1.514	1.00
50_C	79_A	1.497	1.00
108_V	133_S	1.473	1.00
104_K	135_R	1.471	1.00
68_G	79_A	1.469	1.00
45_V	107_L	1.458	1.00
30_N	62_R	1.450	1.00
117_Y	196_Y	1.448	1.00
202_S	205_E	1.448	1.00
58_F	61_N	1.438	1.00
50_C	56_S	1.433	1.00
44_K	103_E	1.420	1.00
108_V	134_T	1.404	1.00
49_P	93_M	1.382	1.00
32_I	111_I	1.380	1.00
203_I	207_L	1.360	1.00
93_M	114_S	1.350	1.00
142_L	206_I	1.338	1.00
54_R	82_N	1.312	1.00
48_I	126_I	1.301	1.00
100_I	132_D	1.291	1.00
57_Y	61_N	1.274	1.00
100_I	105_Y	1.267	1.00
17_E	82_N	1.265	1.00
55_V	111_I	1.264	1.00
45_V	109_I	1.256	1.00
52_I	75_M	1.255	1.00
205_E	208_A	1.245	1.00
71_I	92_D	1.225	1.00
121_E	205_E	1.220	1.00
125_K	128_E	1.218	1.00
96_I	100_I	1.211	1.00
48_I	69_I	1.200	1.00
147_Y	151_N	1.196	1.00
40_K	43_K	1.187	1.00
69_I	96_I	1.179	1.00
101_G	105_Y	1.177	1.00
203_I	220_V	1.171	1.00
100_I	129_S	1.170	1.00
148_I	152_R	1.138	1.00
68_G	88_F	1.136	1.00
83_I	86_G	1.135	1.00
100_I	133_S	1.130	1.00
101_G	104_K	1.122	1.00
207_L	220_V	1.121	1.00
67_T	87_K	1.100	1.00
128_E	132_D	1.095	1.00
44_K	67_T	1.079	1.00
56_S	88_F	1.079	1.00
92_D	95_K	1.075	1.00
112_Y	116_G	1.070	1.00
72_S	75_M	1.065	1.00
44_K	104_K	1.063	1.00
17_E	20_K	1.057	1.00
30_N	34_E	1.054	1.00
181_Y	195_I	1.054	1.00
47_D	109_I	1.045	1.00
104_K	133_S	1.023	1.00
48_I	108_V	1.018	1.00
148_I	151_N	1.017	1.00
60_A	86_G	1.013	1.00
105_Y	133_S	1.005	1.00
54_R	58_F	1.001	1.00
102_N	133_S	1.000	1.00
39_Y	43_K	0.999	1.00
50_C	70_D	0.984	1.00
172_E	175_T	0.982	1.00
16_R	20_K	0.980	1.00
46_L	108_V	0.938	1.00
116_G	143_D	0.933	1.00
137_I	218_I	0.929	1.00
125_K	129_S	0.920	1.00
115_L	127_L	0.916	1.00
39_Y	42_E	0.916	1.00
43_K	106_D	0.905	1.00
28_W	55_V	0.901	1.00
26_E	30_N	0.901	1.00
44_K	105_Y	0.888	1.00
165_V	169_V	0.885	1.00
13_F	16_R	0.884	1.00
56_S	60_A	0.884	1.00
80_R	84_Q	0.872	1.00
102_N	132_D	0.865	1.00
47_D	111_I	0.859	1.00
77_S	81_S	0.856	1.00
93_M	118_Y	0.855	1.00
119_S	177_R	0.852	1.00
110_N	114_S	0.851	1.00
57_Y	84_Q	0.850	1.00
115_L	118_Y	0.846	1.00
56_S	86_G	0.843	1.00
205_E	209_L	0.843	1.00
113_N	116_G	0.835	1.00
93_M	110_N	0.835	1.00
47_D	50_C	0.831	1.00
112_Y	117_Y	0.829	1.00
96_I	133_S	0.825	1.00
25_G	28_W	0.816	1.00
167_S	170_E	0.807	0.99
31_W	221_L	0.806	0.99
45_V	63_G	0.804	0.99
13_F	17_E	0.801	0.99
208_A	211_K	0.799	0.99
60_A	85_N	0.799	0.99
94_R	126_I	0.796	0.99
57_Y	88_F	0.793	0.99
221_L	224_Y	0.782	0.99
69_I	89_I	0.780	0.99
145_R	202_S	0.778	0.99
149_I	152_R	0.777	0.99
100_I	104_K	0.777	0.99
71_I	93_M	0.774	0.99
65_K	103_E	0.771	0.99
29_A	62_R	0.758	0.99
153_P	157_Y	0.750	0.99
112_Y	143_D	0.749	0.99
153_P	159_Y	0.736	0.99
147_Y	150_Y	0.736	0.99
91_G	129_S	0.736	0.99
16_R	19_I	0.734	0.99
43_K	64_Y	0.734	0.99
28_W	32_I	0.731	0.99
115_L	126_I	0.730	0.99
70_D	75_M	0.724	0.99
113_N	117_Y	0.723	0.99
55_V	58_F	0.723	0.99
209_L	213_A	0.722	0.99
20_K	25_G	0.721	0.99
31_W	34_E	0.720	0.99
80_R	83_I	0.715	0.99
52_I	82_N	0.714	0.99
29_A	55_V	0.709	0.99
118_Y	123_D	0.708	0.99
127_L	131_R	0.708	0.99
12_D	20_K	0.708	0.99
13_F	75_M	0.707	0.99
29_A	32_I	0.706	0.99
104_K	132_D	0.704	0.99
91_G	96_I	0.697	0.98
29_A	33_D	0.695	0.98
124_L	209_L	0.695	0.98
121_E	209_L	0.689	0.98
95_K	125_K	0.688	0.98
49_P	71_I	0.685	0.98
116_G	141_N	0.683	0.98
76_I	80_R	0.681	0.98
45_V	66_V	0.676	0.98
42_E	64_Y	0.675	0.98
171_F	176_S	0.675	0.98
52_I	78_M	0.673	0.98
96_I	101_G	0.672	0.98
177_R	197_E	0.671	0.98
210_L	213_A	0.669	0.98
163_Y	168_K	0.667	0.98
95_K	129_S	0.667	0.98
22_W	25_G	0.664	0.98
162_P	165_V	0.661	0.98
24_E	28_W	0.660	0.98
20_K	112_Y	0.656	0.98
31_W	35_V	0.651	0.98
206_I	220_V	0.651	0.98
55_V	59_L	0.651	0.98
78_M	82_N	0.651	0.98
14_Y	78_M	0.650	0.98
173_Q	178_L	0.649	0.98
77_S	80_R	0.648	0.98
111_I	116_G	0.646	0.97
93_M	126_I	0.641	0.97
156_Y	159_Y	0.634	0.97
146_D	150_Y	0.633	0.97
28_W	31_W	0.633	0.97
118_Y	124_L	0.625	0.97
157_Y	160_I	0.624	0.97
32_I	36_V	0.621	0.97
47_D	55_V	0.620	0.97
31_W	224_Y	0.619	0.97
14_Y	17_E	0.619	0.97
38_K	41_L	0.617	0.97
58_F	62_R	0.617	0.97
75_M	194_M	0.612	0.97
155_E	159_Y	0.612	0.97
15_V	18_M	0.611	0.96
201_Y	209_L	0.610	0.96
50_C	76_I	0.610	0.96
59_L	109_I	0.609	0.96
17_E	78_M	0.607	0.96
204_H	207_L	0.606	0.96
70_D	88_F	0.603	0.96
131_R	213_A	0.601	0.96
127_L	210_L	0.598	0.96
116_G	142_L	0.597	0.96
172_E	176_S	0.596	0.96
114_S	117_Y	0.594	0.96
140_I	210_L	0.593	0.96
165_V	170_E	0.591	0.96
113_N	198_Q	0.591	0.96
116_G	201_Y	0.588	0.96
71_I	90_V	0.586	0.96
179_K	197_E	0.584	0.95
47_D	110_N	0.584	0.95
12_D	15_V	0.575	0.95
162_P	167_S	0.575	0.95
29_A	58_F	0.574	0.95
179_K	195_I	0.572	0.95
14_Y	74_R	0.571	0.95
156_Y	160_I	0.570	0.95
187_N	190_E	0.568	0.95
171_F	175_T	0.568	0.95
87_K	103_E	0.567	0.95
170_E	179_K	0.566	0.95
80_R	87_K	0.566	0.95
147_Y	152_R	0.565	0.95
53_G	66_V	0.564	0.95
76_I	79_A	0.564	0.95
39_Y	64_Y	0.562	0.94
15_V	20_K	0.561	0.94
211_K	216_Q	0.561	0.94
121_E	124_L	0.560	0.94
47_D	68_G	0.559	0.94
166_Y	169_V	0.559	0.94
127_L	138_V	0.559	0.94
56_S	83_I	0.558	0.94
16_R	75_M	0.555	0.94
116_G	198_Q	0.553	0.94
80_R	88_F	0.551	0.94
153_P	156_Y	0.551	0.94
23_D	26_E	0.550	0.94
210_L	215_L	0.550	0.94
148_I	153_P	0.547	0.94
124_L	127_L	0.547	0.94
126_I	129_S	0.544	0.93
33_D	64_Y	0.544	0.93
27_K	30_N	0.544	0.93
172_E	179_K	0.541	0.93
164_L	167_S	0.540	0.93
175_T	178_L	0.540	0.93
25_G	29_A	0.540	0.93
134_T	138_V	0.540	0.93
173_Q	176_S	0.539	0.93
113_N	144_N	0.538	0.93
111_I	114_S	0.537	0.93
21_V	24_E	0.537	0.93
43_K	107_L	0.535	0.93
161_P	164_L	0.533	0.93
47_D	79_A	0.532	0.93
163_Y	179_K	0.531	0.93
183_K	193_E	0.528	0.92
134_T	215_L	0.528	0.92
121_E	199_R	0.525	0.92
209_L	212_K	0.522	0.92
166_Y	185_Y	0.522	0.92
54_R	57_Y	0.521	0.92
113_N	145_R	0.521	0.92
103_E	133_S	0.520	0.92
138_V	215_L	0.520	0.92
176_S	180_I	0.519	0.92
21_V	28_W	0.514	0.91
181_Y	186_L	0.513	0.91
132_D	135_R	0.512	0.91
163_Y	166_Y	0.509	0.91
40_K	64_Y	0.509	0.91
217_P	220_V	0.508	0.91
11_S	14_Y	0.508	0.91
186_L	190_E	0.508	0.91
104_K	136_K	0.508	0.91
94_R	125_K	0.504	0.91
115_L	124_L	0.502	0.90
180_I	183_K	0.502	0.90
196_Y	201_Y	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1y8cA	1	0.9506	100	0.387	Contact Map
4hgzA	4	0.9259	100	0.395	Contact Map
3d2lA	1	0.9465	100	0.421	Contact Map
1wznA	4	0.93	100	0.425	Contact Map
3thrA	3	0.9671	100	0.427	Contact Map
5bszA	3	0.9588	100	0.461	Contact Map
3bxoA	2	0.9218	100	0.464	Contact Map
2avnA	3	0.8971	100	0.483	Contact Map
3g2mA	2	0.8807	100	0.485	Contact Map
3pfgA	2	0.9383	99.9	0.487	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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