GREMLIN Database
Q97WN4 - SAM-dependent methyltransferase, putative
UniProt: Q97WN4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (211)
Sequences: 5098 (4146)
Seq/√Len: 285.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
106_D135_R3.8611.00
76_I90_V3.3691.00
67_T105_Y3.3661.00
73_E90_V3.2181.00
44_K65_K3.1101.00
49_P114_S3.1091.00
46_L105_Y3.0901.00
130_L138_V2.7531.00
48_I130_L2.7041.00
79_A88_F2.6651.00
94_R123_D2.5891.00
56_S66_V2.4941.00
33_D62_R2.4611.00
76_I88_F2.4351.00
50_C68_G2.3891.00
129_S132_D2.2981.00
69_I91_G2.2261.00
17_E52_I2.1071.00
57_Y82_N2.0531.00
78_M81_S2.0211.00
118_Y126_I1.9751.00
26_E58_F1.9741.00
73_E77_S1.9641.00
57_Y83_I1.8641.00
129_S133_S1.8261.00
56_S68_G1.8211.00
96_I129_S1.8201.00
131_R215_L1.8201.00
49_P110_N1.8171.00
83_I88_F1.7901.00
120_E123_D1.7881.00
70_D76_I1.7641.00
36_V107_L1.7451.00
44_K106_D1.7141.00
65_K87_K1.6921.00
108_V130_L1.6901.00
67_T89_I1.6651.00
45_V64_Y1.6621.00
45_V59_L1.6381.00
126_I130_L1.6341.00
119_S123_D1.5781.00
101_G133_S1.5731.00
74_R77_S1.5591.00
44_K135_R1.5591.00
207_L211_K1.5481.00
208_A212_K1.5371.00
48_I93_M1.5251.00
130_L134_T1.5141.00
50_C79_A1.4971.00
108_V133_S1.4731.00
104_K135_R1.4711.00
68_G79_A1.4691.00
45_V107_L1.4581.00
30_N62_R1.4501.00
117_Y196_Y1.4481.00
202_S205_E1.4481.00
58_F61_N1.4381.00
50_C56_S1.4331.00
44_K103_E1.4201.00
108_V134_T1.4041.00
49_P93_M1.3821.00
32_I111_I1.3801.00
203_I207_L1.3601.00
93_M114_S1.3501.00
142_L206_I1.3381.00
54_R82_N1.3121.00
48_I126_I1.3011.00
100_I132_D1.2911.00
57_Y61_N1.2741.00
100_I105_Y1.2671.00
17_E82_N1.2651.00
55_V111_I1.2641.00
45_V109_I1.2561.00
52_I75_M1.2551.00
205_E208_A1.2451.00
71_I92_D1.2251.00
121_E205_E1.2201.00
125_K128_E1.2181.00
96_I100_I1.2111.00
48_I69_I1.2001.00
147_Y151_N1.1961.00
40_K43_K1.1871.00
69_I96_I1.1791.00
101_G105_Y1.1771.00
203_I220_V1.1711.00
100_I129_S1.1701.00
148_I152_R1.1381.00
68_G88_F1.1361.00
83_I86_G1.1351.00
100_I133_S1.1301.00
101_G104_K1.1221.00
207_L220_V1.1211.00
67_T87_K1.1001.00
128_E132_D1.0951.00
44_K67_T1.0791.00
56_S88_F1.0791.00
92_D95_K1.0751.00
112_Y116_G1.0701.00
72_S75_M1.0651.00
44_K104_K1.0631.00
17_E20_K1.0571.00
30_N34_E1.0541.00
181_Y195_I1.0541.00
47_D109_I1.0451.00
104_K133_S1.0231.00
48_I108_V1.0181.00
148_I151_N1.0171.00
60_A86_G1.0131.00
105_Y133_S1.0051.00
54_R58_F1.0011.00
102_N133_S1.0001.00
39_Y43_K0.9991.00
50_C70_D0.9841.00
172_E175_T0.9821.00
16_R20_K0.9801.00
46_L108_V0.9381.00
116_G143_D0.9331.00
137_I218_I0.9291.00
125_K129_S0.9201.00
115_L127_L0.9161.00
39_Y42_E0.9161.00
43_K106_D0.9051.00
28_W55_V0.9011.00
26_E30_N0.9011.00
44_K105_Y0.8881.00
165_V169_V0.8851.00
13_F16_R0.8841.00
56_S60_A0.8841.00
80_R84_Q0.8721.00
102_N132_D0.8651.00
47_D111_I0.8591.00
77_S81_S0.8561.00
93_M118_Y0.8551.00
119_S177_R0.8521.00
110_N114_S0.8511.00
57_Y84_Q0.8501.00
115_L118_Y0.8461.00
56_S86_G0.8431.00
205_E209_L0.8431.00
113_N116_G0.8351.00
93_M110_N0.8351.00
47_D50_C0.8311.00
112_Y117_Y0.8291.00
96_I133_S0.8251.00
25_G28_W0.8161.00
167_S170_E0.8070.99
31_W221_L0.8060.99
45_V63_G0.8040.99
13_F17_E0.8010.99
208_A211_K0.7990.99
60_A85_N0.7990.99
94_R126_I0.7960.99
57_Y88_F0.7930.99
221_L224_Y0.7820.99
69_I89_I0.7800.99
145_R202_S0.7780.99
149_I152_R0.7770.99
100_I104_K0.7770.99
71_I93_M0.7740.99
65_K103_E0.7710.99
29_A62_R0.7580.99
153_P157_Y0.7500.99
112_Y143_D0.7490.99
153_P159_Y0.7360.99
147_Y150_Y0.7360.99
91_G129_S0.7360.99
16_R19_I0.7340.99
43_K64_Y0.7340.99
28_W32_I0.7310.99
115_L126_I0.7300.99
70_D75_M0.7240.99
113_N117_Y0.7230.99
55_V58_F0.7230.99
209_L213_A0.7220.99
20_K25_G0.7210.99
31_W34_E0.7200.99
80_R83_I0.7150.99
52_I82_N0.7140.99
29_A55_V0.7090.99
118_Y123_D0.7080.99
127_L131_R0.7080.99
12_D20_K0.7080.99
13_F75_M0.7070.99
29_A32_I0.7060.99
104_K132_D0.7040.99
91_G96_I0.6970.98
29_A33_D0.6950.98
124_L209_L0.6950.98
121_E209_L0.6890.98
95_K125_K0.6880.98
49_P71_I0.6850.98
116_G141_N0.6830.98
76_I80_R0.6810.98
45_V66_V0.6760.98
42_E64_Y0.6750.98
171_F176_S0.6750.98
52_I78_M0.6730.98
96_I101_G0.6720.98
177_R197_E0.6710.98
210_L213_A0.6690.98
163_Y168_K0.6670.98
95_K129_S0.6670.98
22_W25_G0.6640.98
162_P165_V0.6610.98
24_E28_W0.6600.98
20_K112_Y0.6560.98
31_W35_V0.6510.98
206_I220_V0.6510.98
55_V59_L0.6510.98
78_M82_N0.6510.98
14_Y78_M0.6500.98
173_Q178_L0.6490.98
77_S80_R0.6480.98
111_I116_G0.6460.97
93_M126_I0.6410.97
156_Y159_Y0.6340.97
146_D150_Y0.6330.97
28_W31_W0.6330.97
118_Y124_L0.6250.97
157_Y160_I0.6240.97
32_I36_V0.6210.97
47_D55_V0.6200.97
31_W224_Y0.6190.97
14_Y17_E0.6190.97
38_K41_L0.6170.97
58_F62_R0.6170.97
75_M194_M0.6120.97
155_E159_Y0.6120.97
15_V18_M0.6110.96
201_Y209_L0.6100.96
50_C76_I0.6100.96
59_L109_I0.6090.96
17_E78_M0.6070.96
204_H207_L0.6060.96
70_D88_F0.6030.96
131_R213_A0.6010.96
127_L210_L0.5980.96
116_G142_L0.5970.96
172_E176_S0.5960.96
114_S117_Y0.5940.96
140_I210_L0.5930.96
165_V170_E0.5910.96
113_N198_Q0.5910.96
116_G201_Y0.5880.96
71_I90_V0.5860.96
179_K197_E0.5840.95
47_D110_N0.5840.95
12_D15_V0.5750.95
162_P167_S0.5750.95
29_A58_F0.5740.95
179_K195_I0.5720.95
14_Y74_R0.5710.95
156_Y160_I0.5700.95
187_N190_E0.5680.95
171_F175_T0.5680.95
87_K103_E0.5670.95
170_E179_K0.5660.95
80_R87_K0.5660.95
147_Y152_R0.5650.95
53_G66_V0.5640.95
76_I79_A0.5640.95
39_Y64_Y0.5620.94
15_V20_K0.5610.94
211_K216_Q0.5610.94
121_E124_L0.5600.94
47_D68_G0.5590.94
166_Y169_V0.5590.94
127_L138_V0.5590.94
56_S83_I0.5580.94
16_R75_M0.5550.94
116_G198_Q0.5530.94
80_R88_F0.5510.94
153_P156_Y0.5510.94
23_D26_E0.5500.94
210_L215_L0.5500.94
148_I153_P0.5470.94
124_L127_L0.5470.94
126_I129_S0.5440.93
33_D64_Y0.5440.93
27_K30_N0.5440.93
172_E179_K0.5410.93
164_L167_S0.5400.93
175_T178_L0.5400.93
25_G29_A0.5400.93
134_T138_V0.5400.93
173_Q176_S0.5390.93
113_N144_N0.5380.93
111_I114_S0.5370.93
21_V24_E0.5370.93
43_K107_L0.5350.93
161_P164_L0.5330.93
47_D79_A0.5320.93
163_Y179_K0.5310.93
183_K193_E0.5280.92
134_T215_L0.5280.92
121_E199_R0.5250.92
209_L212_K0.5220.92
166_Y185_Y0.5220.92
54_R57_Y0.5210.92
113_N145_R0.5210.92
103_E133_S0.5200.92
138_V215_L0.5200.92
176_S180_I0.5190.92
21_V28_W0.5140.91
181_Y186_L0.5130.91
132_D135_R0.5120.91
163_Y166_Y0.5090.91
40_K64_Y0.5090.91
217_P220_V0.5080.91
11_S14_Y0.5080.91
186_L190_E0.5080.91
104_K136_K0.5080.91
94_R125_K0.5040.91
115_L124_L0.5020.90
180_I183_K0.5020.90
196_Y201_Y0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y8cA 1 0.9506 100 0.387 Contact Map
4hgzA 4 0.9259 100 0.395 Contact Map
3d2lA 1 0.9465 100 0.421 Contact Map
1wznA 4 0.93 100 0.425 Contact Map
3thrA 3 0.9671 100 0.427 Contact Map
5bszA 3 0.9588 100 0.461 Contact Map
3bxoA 2 0.9218 100 0.464 Contact Map
2avnA 3 0.8971 100 0.483 Contact Map
3g2mA 2 0.8807 100 0.485 Contact Map
3pfgA 2 0.9383 99.9 0.487 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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