Q97WN3 - SULSO - GREMLIN Contacts

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Q97WN3 - Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (Asd-2)

UniProt:	Q97WN3	Sequences: MRRTLKAAILGSTGLVGIEYVRMLANHPYIKVGYLAGKGSVGKPYGEVVRWQTIGQVPTEIADMEVKPTDPKLMDDVDIVFSPLPQGAAGPVEEEFAKHGFPVISNSPDHRFDPDVPLLIPEVNPHTISLIDKQRERRDWRGFIVTTPLCTAQGAAIPLAPIYMNFKIDSSLITTIQSLSGAGYPGIPSLDVIDNVLPLGDNYDNKTVKEISRILSETKRMVDDDDNNLSLGATTHRVATIHGHYEVIYITFKEDVTVEKIGETLDSFRGEPQNLKLPTAPDKPILLINQDARPQVYFDRWAGNPPGMSVVVGRLGQINRRTIRLVSVIHNTVRGAAGGGILATELLIEKGYIDKR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	356 (302)
Sequences:	7227 (3844)
Seq/√Len:	221.2

ECOLI - USG ARGC DHAS
BACSU - ARGC DHAS
HALSA - Q9HPX0
SULSO - Q97WN3 Q97ZL8 ARGC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
261_I	323_I	3.826	1.00
160_A	164_M	3.775	1.00
6_K	31_K	3.653	1.00
8_A	77_V	3.420	1.00
151_T	177_Q	3.225	1.00
147_T	343_A	2.930	1.00
286_L	311_V	2.769	1.00
44_P	63_D	2.743	1.00
102_P	347_L	2.729	1.00
257_T	260_K	2.599	1.00
196_V	238_V	2.577	1.00
263_E	267_S	2.546	1.00
170_S	251_T	2.529	1.00
79_I	344_T	2.425	1.00
30_I	344_T	2.392	1.00
155_A	173_I	2.333	1.00
158_P	248_I	2.264	1.00
44_P	65_E	2.259	1.00
154_G	246_E	2.204	1.00
19_E	22_R	2.066	1.00
38_K	68_P	2.052	1.00
169_D	253_K	2.046	1.00
23_M	341_I	2.043	1.00
46_G	63_D	2.026	1.00
155_A	246_E	2.022	1.00
81_F	344_T	2.001	1.00
334_R	342_L	1.999	1.00
286_L	309_S	1.997	1.00
169_D	251_T	1.990	1.00
164_M	268_F	1.989	1.00
174_T	247_V	1.986	1.00
69_T	92_V	1.965	1.00
154_G	329_I	1.960	1.00
5_L	348_I	1.943	1.00
158_P	325_L	1.935	1.00
145_V	347_L	1.916	1.00
20_Y	81_F	1.882	1.00
262_G	266_D	1.881	1.00
260_K	263_E	1.879	1.00
90_G	109_D	1.871	1.00
287_L	290_Q	1.866	1.00
151_T	175_T	1.866	1.00
6_K	33_G	1.855	1.00
165_N	264_T	1.820	1.00
294_P	313_G	1.781	1.00
156_A	214_I	1.779	1.00
167_K	253_K	1.778	1.00
24_L	30_I	1.764	1.00
162_I	252_F	1.735	1.00
159_L	171_S	1.721	1.00
19_E	242_H	1.705	1.00
284_P	308_M	1.681	1.00
184_Y	188_P	1.669	1.00
283_K	309_S	1.644	1.00
205_N	212_S	1.641	1.00
240_T	296_V	1.639	1.00
258_V	262_G	1.638	1.00
158_P	327_S	1.624	1.00
12_S	35_L	1.598	1.00
7_A	79_I	1.595	1.00
172_L	249_Y	1.590	1.00
175_T	246_E	1.589	1.00
302_A	309_S	1.574	1.00
333_V	338_G	1.567	1.00
21_V	32_V	1.561	1.00
97_A	144_I	1.557	1.00
91_P	95_E	1.537	1.00
248_I	327_S	1.531	1.00
75_D	99_H	1.527	1.00
6_K	78_D	1.521	1.00
16_V	337_A	1.481	1.00
102_P	143_F	1.474	1.00
126_H	143_F	1.459	1.00
74_M	96_F	1.459	1.00
162_I	323_I	1.458	1.00
194_D	300_R	1.450	1.00
252_F	323_I	1.441	1.00
266_D	289_N	1.440	1.00
7_A	30_I	1.438	1.00
162_I	265_L	1.434	1.00
165_N	260_K	1.423	1.00
308_M	333_V	1.421	1.00
265_L	325_L	1.403	1.00
87_G	109_D	1.401	1.00
201_D	209_K	1.375	1.00
263_E	266_D	1.370	1.00
10_L	82_S	1.360	1.00
79_I	348_I	1.357	1.00
82_S	93_E	1.351	1.00
193_I	241_I	1.332	1.00
155_A	248_I	1.328	1.00
80_V	101_F	1.325	1.00
262_G	290_Q	1.313	1.00
95_E	98_K	1.308	1.00
199_L	291_D	1.308	1.00
25_A	60_E	1.304	1.00
94_E	98_K	1.295	1.00
255_D	317_Q	1.284	1.00
251_T	322_T	1.263	1.00
40_S	43_K	1.256	1.00
8_A	80_V	1.251	1.00
92_V	95_E	1.243	1.00
173_I	248_I	1.238	1.00
248_I	325_L	1.235	1.00
155_A	211_I	1.223	1.00
310_V	329_I	1.198	1.00
259_E	263_E	1.194	1.00
295_Q	298_F	1.193	1.00
308_M	338_G	1.187	1.00
170_S	322_T	1.176	1.00
159_L	250_I	1.171	1.00
182_A	186_G	1.169	1.00
258_V	315_L	1.168	1.00
33_G	67_K	1.165	1.00
13_T	66_V	1.159	1.00
95_E	99_H	1.157	1.00
154_G	175_T	1.156	1.00
174_T	249_Y	1.155	1.00
180_S	241_I	1.149	1.00
250_I	323_I	1.148	1.00
160_A	218_T	1.148	1.00
245_Y	328_V	1.144	1.00
33_G	77_V	1.138	1.00
102_P	145_V	1.137	1.00
90_G	119_L	1.130	1.00
333_V	341_I	1.130	1.00
158_P	265_L	1.122	1.00
262_G	289_N	1.121	1.00
113_D	217_E	1.121	1.00
93_E	103_V	1.117	1.00
188_P	191_D	1.109	1.00
310_V	327_S	1.100	1.00
238_V	296_V	1.093	1.00
166_F	256_V	1.077	1.00
252_F	316_G	1.076	1.00
176_I	238_V	1.076	1.00
125_P	346_L	1.069	1.00
171_S	250_I	1.068	1.00
13_T	37_G	1.061	1.00
250_I	325_L	1.055	1.00
230_S	320_R	1.054	1.00
186_G	190_L	1.039	1.00
77_V	80_V	1.033	1.00
243_G	331_N	1.030	1.00
23_M	338_G	1.027	1.00
5_L	79_I	1.025	1.00
158_P	161_P	1.025	1.00
157_I	310_V	1.023	1.00
21_V	45_Y	1.021	1.00
319_N	322_T	1.021	1.00
16_V	336_A	1.015	1.00
41_V	68_P	1.003	1.00
254_E	260_K	1.002	1.00
162_I	261_I	0.986	1.00
252_F	256_V	0.985	1.00
6_K	30_I	0.982	1.00
232_G	249_Y	0.982	1.00
245_Y	326_V	0.980	1.00
176_I	249_Y	0.978	1.00
115_D	142_G	0.972	1.00
165_N	254_E	0.971	1.00
302_A	311_V	0.970	1.00
226_D	229_L	0.967	1.00
212_S	319_N	0.948	1.00
249_Y	324_R	0.946	1.00
195_N	295_Q	0.944	1.00
110_H	120_I	0.943	1.00
165_N	267_S	0.939	1.00
129_S	350_K	0.937	1.00
30_I	348_I	0.936	1.00
32_V	64_M	0.934	1.00
96_F	103_V	0.931	1.00
118_L	124_N	0.924	0.99
10_L	69_T	0.924	0.99
71_P	95_E	0.923	0.99
120_I	156_A	0.921	0.99
71_P	99_H	0.921	0.99
93_E	144_I	0.920	0.99
236_H	247_V	0.917	0.99
268_F	282_D	0.915	0.99
8_A	34_Y	0.912	0.99
81_F	340_G	0.910	0.99
118_L	121_P	0.907	0.99
154_G	327_S	0.903	0.99
267_S	270_G	0.899	0.99
163_Y	226_D	0.894	0.99
59_T	62_A	0.893	0.99
126_H	129_S	0.891	0.99
293_R	326_V	0.890	0.99
159_L	248_I	0.879	0.99
104_I	344_T	0.878	0.99
258_V	317_Q	0.878	0.99
212_S	216_S	0.868	0.99
259_E	262_G	0.866	0.99
79_I	102_P	0.865	0.99
182_A	197_L	0.865	0.99
22_R	26_N	0.864	0.99
80_V	96_F	0.863	0.99
262_G	287_L	0.860	0.99
152_A	200_G	0.857	0.99
84_L	107_S	0.855	0.99
88_A	91_P	0.849	0.99
317_Q	320_R	0.844	0.99
197_L	295_Q	0.840	0.99
288_I	298_F	0.839	0.99
45_Y	66_V	0.834	0.99
25_A	62_A	0.832	0.99
150_C	181_G	0.828	0.99
70_D	73_L	0.826	0.99
196_V	236_H	0.826	0.99
187_I	190_L	0.825	0.99
219_K	229_L	0.825	0.99
147_T	336_A	0.823	0.99
242_H	332_T	0.822	0.99
262_G	315_L	0.821	0.99
87_G	90_G	0.813	0.99
202_N	209_K	0.813	0.99
72_K	75_D	0.812	0.99
94_E	97_A	0.811	0.99
23_M	333_V	0.809	0.99
312_V	325_L	0.807	0.99
139_D	347_L	0.805	0.99
200_G	205_N	0.804	0.99
84_L	89_A	0.803	0.99
287_L	292_A	0.801	0.99
174_T	236_H	0.798	0.99
344_T	348_I	0.794	0.98
40_S	66_V	0.790	0.98
61_I	64_M	0.786	0.98
157_I	268_F	0.783	0.98
255_D	264_T	0.781	0.98
84_L	88_A	0.779	0.98
200_G	203_Y	0.775	0.98
288_I	311_V	0.775	0.98
179_L	192_V	0.774	0.98
255_D	321_R	0.770	0.98
219_K	226_D	0.768	0.98
112_F	146_T	0.766	0.98
196_V	296_V	0.766	0.98
230_S	319_N	0.766	0.98
5_L	350_K	0.766	0.98
153_Q	339_G	0.765	0.98
296_V	301_W	0.763	0.98
168_I	250_I	0.762	0.98
293_R	315_L	0.760	0.98
112_F	209_K	0.759	0.98
167_K	170_S	0.757	0.98
293_R	313_G	0.757	0.98
154_G	328_V	0.757	0.98
36_A	40_S	0.756	0.98
27_H	30_I	0.755	0.98
252_F	255_D	0.750	0.98
128_I	346_L	0.750	0.98
37_G	40_S	0.750	0.98
212_S	230_S	0.749	0.98
247_V	324_R	0.747	0.98
67_K	73_L	0.745	0.98
294_P	301_W	0.741	0.98
245_Y	296_V	0.740	0.98
198_P	326_V	0.738	0.98
12_S	17_G	0.735	0.97
173_I	211_I	0.735	0.97
258_V	261_I	0.733	0.97
166_F	257_T	0.733	0.97
176_I	236_H	0.732	0.97
256_V	264_T	0.731	0.97
293_R	296_V	0.729	0.97
79_I	104_I	0.726	0.97
122_E	334_R	0.725	0.97
106_N	147_T	0.720	0.97
102_P	348_I	0.719	0.97
173_I	246_E	0.718	0.97
256_V	261_I	0.717	0.97
247_V	326_V	0.716	0.97
152_A	156_A	0.716	0.97
219_K	227_N	0.713	0.97
33_G	76_D	0.712	0.97
106_N	339_G	0.711	0.97
7_A	27_H	0.709	0.97
258_V	316_G	0.707	0.97
5_L	78_D	0.706	0.97
252_F	261_I	0.706	0.97
104_I	347_L	0.704	0.97
198_P	236_H	0.703	0.97
198_P	245_Y	0.702	0.97
346_L	350_K	0.701	0.97
29_Y	350_K	0.699	0.97
94_E	110_H	0.699	0.97
243_G	300_R	0.698	0.97
159_L	173_I	0.696	0.96
67_K	76_D	0.695	0.96
35_L	64_M	0.695	0.96
113_D	213_R	0.692	0.96
265_L	287_L	0.687	0.96
163_Y	167_K	0.686	0.96
261_I	314_R	0.685	0.96
163_Y	168_I	0.681	0.96
160_A	163_Y	0.675	0.96
216_S	219_K	0.675	0.96
259_E	290_Q	0.673	0.96
108_P	209_K	0.673	0.96
112_F	213_R	0.669	0.96
139_D	346_L	0.669	0.96
176_I	196_V	0.669	0.96
73_L	76_D	0.668	0.96
94_E	103_V	0.666	0.95
26_N	333_V	0.666	0.95
189_S	197_L	0.661	0.95
9_I	24_L	0.661	0.95
346_L	349_E	0.660	0.95
82_S	103_V	0.658	0.95
125_P	129_S	0.657	0.95
9_I	20_Y	0.657	0.95
111_R	210_E	0.656	0.95
22_R	25_A	0.656	0.95
32_V	62_A	0.655	0.95
12_S	66_V	0.655	0.95
13_T	40_S	0.652	0.95
46_G	62_A	0.651	0.95
96_F	107_S	0.651	0.95
214_I	217_E	0.650	0.95
208_V	212_S	0.649	0.95
218_T	229_L	0.649	0.95
261_I	316_G	0.647	0.95
66_V	69_T	0.645	0.95
162_I	250_I	0.641	0.94
163_Y	171_S	0.639	0.94
142_G	145_V	0.638	0.94
154_G	310_V	0.638	0.94
117_P	124_N	0.634	0.94
24_L	341_I	0.633	0.94
173_I	233_A	0.632	0.94
34_Y	45_Y	0.627	0.94
158_P	310_V	0.627	0.94
288_I	292_A	0.626	0.94
124_N	127_T	0.625	0.94
27_H	345_E	0.625	0.94
82_S	89_A	0.624	0.94
86_Q	108_P	0.623	0.94
166_F	260_K	0.622	0.94
296_V	300_R	0.620	0.93
166_F	253_K	0.619	0.93
232_G	324_R	0.618	0.93
29_Y	59_T	0.618	0.93
199_L	203_Y	0.615	0.93
166_F	264_T	0.614	0.93
9_I	21_V	0.613	0.93
285_I	298_F	0.613	0.93
298_F	311_V	0.611	0.93
242_H	331_N	0.610	0.93
232_G	322_T	0.608	0.93
154_G	244_H	0.606	0.93
297_Y	300_R	0.605	0.93
194_D	241_I	0.605	0.93
299_D	302_A	0.604	0.93
168_I	253_K	0.604	0.93
154_G	331_N	0.601	0.92
148_P	153_Q	0.601	0.92
158_P	312_V	0.601	0.92
21_V	34_Y	0.600	0.92
15_L	187_I	0.600	0.92
29_Y	32_V	0.598	0.92
246_E	327_S	0.598	0.92
285_I	292_A	0.597	0.92
123_V	157_I	0.597	0.92
128_I	139_D	0.595	0.92
24_L	32_V	0.595	0.92
241_I	300_R	0.593	0.92
75_D	98_K	0.592	0.92
64_M	67_K	0.590	0.92
87_G	107_S	0.590	0.92
311_V	328_V	0.589	0.92
160_A	268_F	0.588	0.92
294_P	302_A	0.587	0.91
93_E	96_F	0.586	0.91
46_G	61_I	0.583	0.91
96_F	101_F	0.579	0.91
167_K	251_T	0.579	0.91
152_A	246_E	0.578	0.91
155_A	175_T	0.578	0.91
77_V	101_F	0.576	0.91
81_F	341_I	0.574	0.91
172_L	247_V	0.573	0.90
11_G	14_G	0.572	0.90
178_S	242_H	0.572	0.90
150_C	210_E	0.572	0.90
71_P	74_M	0.571	0.90
97_A	100_G	0.570	0.90
257_T	317_Q	0.565	0.90
117_P	142_G	0.565	0.90
7_A	81_F	0.564	0.90
164_M	267_S	0.563	0.90
299_D	311_V	0.563	0.90
255_D	320_R	0.562	0.90
243_G	299_D	0.562	0.90
121_P	125_P	0.562	0.90
24_L	344_T	0.560	0.89
153_Q	329_I	0.558	0.89
198_P	295_Q	0.557	0.89
70_D	91_P	0.556	0.89
111_R	181_G	0.555	0.89
294_P	298_F	0.555	0.89
81_F	104_I	0.553	0.89
323_I	326_V	0.552	0.89
91_P	94_E	0.551	0.89
89_A	110_H	0.550	0.89
172_L	251_T	0.549	0.89
29_Y	64_M	0.548	0.88
339_G	343_A	0.546	0.88
181_G	210_E	0.546	0.88
265_L	282_D	0.544	0.88
13_T	36_A	0.543	0.88
6_K	77_V	0.542	0.88
288_I	313_G	0.542	0.88
7_A	344_T	0.542	0.88
65_E	68_P	0.540	0.88
345_E	349_E	0.534	0.87
128_I	145_V	0.534	0.87
90_G	113_D	0.534	0.87
96_F	100_G	0.534	0.87
85_P	108_P	0.533	0.87
186_G	189_S	0.532	0.87
127_T	144_I	0.531	0.87
20_Y	341_I	0.531	0.87
122_E	125_P	0.529	0.87
18_I	45_Y	0.528	0.87
120_I	123_V	0.527	0.86
242_H	300_R	0.525	0.86
187_I	241_I	0.524	0.86
186_G	197_L	0.523	0.86
34_Y	77_V	0.522	0.86
111_R	150_C	0.522	0.86
155_A	327_S	0.521	0.86
258_V	314_R	0.520	0.86
216_S	229_L	0.518	0.86
169_D	321_R	0.515	0.85
266_D	270_G	0.514	0.85
88_A	107_S	0.513	0.85
73_L	96_F	0.513	0.85
196_V	240_T	0.512	0.85
254_E	321_R	0.511	0.85
23_M	26_N	0.510	0.85
316_G	321_R	0.510	0.85
269_R	285_I	0.509	0.85
227_N	230_S	0.508	0.84
122_E	342_L	0.507	0.84
107_S	340_G	0.504	0.84
21_V	25_A	0.504	0.84
62_A	65_E	0.503	0.84
284_P	288_I	0.501	0.84
292_A	295_Q	0.500	0.83
173_I	231_L	0.500	0.83
265_L	314_R	0.500	0.83

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vknA	4	0.8961	100	0.241	Contact Map
3hskA	4	0.9691	100	0.246	Contact Map
1xygA	4	0.9101	100	0.257	Contact Map
4dplA	4	0.9888	100	0.261	Contact Map
2ep5A	4	0.9719	100	0.266	Contact Map
1ys4A	4	0.9579	100	0.282	Contact Map
2nqtA	4	0.8848	100	0.3	Contact Map
2yv3A	2	0.8427	100	0.3	Contact Map
3uw3A	2	0.8708	100	0.306	Contact Map
3tz6A	2	0.8427	100	0.313	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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