GREMLIN Database
Q97WN3 - Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (Asd-2)
UniProt: Q97WN3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (302)
Sequences: 7227 (3844)
Seq/√Len: 221.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_I323_I3.8261.00
160_A164_M3.7751.00
6_K31_K3.6531.00
8_A77_V3.4201.00
151_T177_Q3.2251.00
147_T343_A2.9301.00
286_L311_V2.7691.00
44_P63_D2.7431.00
102_P347_L2.7291.00
257_T260_K2.5991.00
196_V238_V2.5771.00
263_E267_S2.5461.00
170_S251_T2.5291.00
79_I344_T2.4251.00
30_I344_T2.3921.00
155_A173_I2.3331.00
158_P248_I2.2641.00
44_P65_E2.2591.00
154_G246_E2.2041.00
19_E22_R2.0661.00
38_K68_P2.0521.00
169_D253_K2.0461.00
23_M341_I2.0431.00
46_G63_D2.0261.00
155_A246_E2.0221.00
81_F344_T2.0011.00
334_R342_L1.9991.00
286_L309_S1.9971.00
169_D251_T1.9901.00
164_M268_F1.9891.00
174_T247_V1.9861.00
69_T92_V1.9651.00
154_G329_I1.9601.00
5_L348_I1.9431.00
158_P325_L1.9351.00
145_V347_L1.9161.00
20_Y81_F1.8821.00
262_G266_D1.8811.00
260_K263_E1.8791.00
90_G109_D1.8711.00
287_L290_Q1.8661.00
151_T175_T1.8661.00
6_K33_G1.8551.00
165_N264_T1.8201.00
294_P313_G1.7811.00
156_A214_I1.7791.00
167_K253_K1.7781.00
24_L30_I1.7641.00
162_I252_F1.7351.00
159_L171_S1.7211.00
19_E242_H1.7051.00
284_P308_M1.6811.00
184_Y188_P1.6691.00
283_K309_S1.6441.00
205_N212_S1.6411.00
240_T296_V1.6391.00
258_V262_G1.6381.00
158_P327_S1.6241.00
12_S35_L1.5981.00
7_A79_I1.5951.00
172_L249_Y1.5901.00
175_T246_E1.5891.00
302_A309_S1.5741.00
333_V338_G1.5671.00
21_V32_V1.5611.00
97_A144_I1.5571.00
91_P95_E1.5371.00
248_I327_S1.5311.00
75_D99_H1.5271.00
6_K78_D1.5211.00
16_V337_A1.4811.00
102_P143_F1.4741.00
126_H143_F1.4591.00
74_M96_F1.4591.00
162_I323_I1.4581.00
194_D300_R1.4501.00
252_F323_I1.4411.00
266_D289_N1.4401.00
7_A30_I1.4381.00
162_I265_L1.4341.00
165_N260_K1.4231.00
308_M333_V1.4211.00
265_L325_L1.4031.00
87_G109_D1.4011.00
201_D209_K1.3751.00
263_E266_D1.3701.00
10_L82_S1.3601.00
79_I348_I1.3571.00
82_S93_E1.3511.00
193_I241_I1.3321.00
155_A248_I1.3281.00
80_V101_F1.3251.00
262_G290_Q1.3131.00
95_E98_K1.3081.00
199_L291_D1.3081.00
25_A60_E1.3041.00
94_E98_K1.2951.00
255_D317_Q1.2841.00
251_T322_T1.2631.00
40_S43_K1.2561.00
8_A80_V1.2511.00
92_V95_E1.2431.00
173_I248_I1.2381.00
248_I325_L1.2351.00
155_A211_I1.2231.00
310_V329_I1.1981.00
259_E263_E1.1941.00
295_Q298_F1.1931.00
308_M338_G1.1871.00
170_S322_T1.1761.00
159_L250_I1.1711.00
182_A186_G1.1691.00
258_V315_L1.1681.00
33_G67_K1.1651.00
13_T66_V1.1591.00
95_E99_H1.1571.00
154_G175_T1.1561.00
174_T249_Y1.1551.00
180_S241_I1.1491.00
250_I323_I1.1481.00
160_A218_T1.1481.00
245_Y328_V1.1441.00
33_G77_V1.1381.00
102_P145_V1.1371.00
90_G119_L1.1301.00
333_V341_I1.1301.00
158_P265_L1.1221.00
262_G289_N1.1211.00
113_D217_E1.1211.00
93_E103_V1.1171.00
188_P191_D1.1091.00
310_V327_S1.1001.00
238_V296_V1.0931.00
166_F256_V1.0771.00
252_F316_G1.0761.00
176_I238_V1.0761.00
125_P346_L1.0691.00
171_S250_I1.0681.00
13_T37_G1.0611.00
250_I325_L1.0551.00
230_S320_R1.0541.00
186_G190_L1.0391.00
77_V80_V1.0331.00
243_G331_N1.0301.00
23_M338_G1.0271.00
5_L79_I1.0251.00
158_P161_P1.0251.00
157_I310_V1.0231.00
21_V45_Y1.0211.00
319_N322_T1.0211.00
16_V336_A1.0151.00
41_V68_P1.0031.00
254_E260_K1.0021.00
162_I261_I0.9861.00
252_F256_V0.9851.00
6_K30_I0.9821.00
232_G249_Y0.9821.00
245_Y326_V0.9801.00
176_I249_Y0.9781.00
115_D142_G0.9721.00
165_N254_E0.9711.00
302_A311_V0.9701.00
226_D229_L0.9671.00
212_S319_N0.9481.00
249_Y324_R0.9461.00
195_N295_Q0.9441.00
110_H120_I0.9431.00
165_N267_S0.9391.00
129_S350_K0.9371.00
30_I348_I0.9361.00
32_V64_M0.9341.00
96_F103_V0.9311.00
118_L124_N0.9240.99
10_L69_T0.9240.99
71_P95_E0.9230.99
120_I156_A0.9210.99
71_P99_H0.9210.99
93_E144_I0.9200.99
236_H247_V0.9170.99
268_F282_D0.9150.99
8_A34_Y0.9120.99
81_F340_G0.9100.99
118_L121_P0.9070.99
154_G327_S0.9030.99
267_S270_G0.8990.99
163_Y226_D0.8940.99
59_T62_A0.8930.99
126_H129_S0.8910.99
293_R326_V0.8900.99
159_L248_I0.8790.99
104_I344_T0.8780.99
258_V317_Q0.8780.99
212_S216_S0.8680.99
259_E262_G0.8660.99
79_I102_P0.8650.99
182_A197_L0.8650.99
22_R26_N0.8640.99
80_V96_F0.8630.99
262_G287_L0.8600.99
152_A200_G0.8570.99
84_L107_S0.8550.99
88_A91_P0.8490.99
317_Q320_R0.8440.99
197_L295_Q0.8400.99
288_I298_F0.8390.99
45_Y66_V0.8340.99
25_A62_A0.8320.99
150_C181_G0.8280.99
70_D73_L0.8260.99
196_V236_H0.8260.99
187_I190_L0.8250.99
219_K229_L0.8250.99
147_T336_A0.8230.99
242_H332_T0.8220.99
262_G315_L0.8210.99
87_G90_G0.8130.99
202_N209_K0.8130.99
72_K75_D0.8120.99
94_E97_A0.8110.99
23_M333_V0.8090.99
312_V325_L0.8070.99
139_D347_L0.8050.99
200_G205_N0.8040.99
84_L89_A0.8030.99
287_L292_A0.8010.99
174_T236_H0.7980.99
344_T348_I0.7940.98
40_S66_V0.7900.98
61_I64_M0.7860.98
157_I268_F0.7830.98
255_D264_T0.7810.98
84_L88_A0.7790.98
200_G203_Y0.7750.98
288_I311_V0.7750.98
179_L192_V0.7740.98
255_D321_R0.7700.98
219_K226_D0.7680.98
112_F146_T0.7660.98
196_V296_V0.7660.98
230_S319_N0.7660.98
5_L350_K0.7660.98
153_Q339_G0.7650.98
296_V301_W0.7630.98
168_I250_I0.7620.98
293_R315_L0.7600.98
112_F209_K0.7590.98
167_K170_S0.7570.98
293_R313_G0.7570.98
154_G328_V0.7570.98
36_A40_S0.7560.98
27_H30_I0.7550.98
252_F255_D0.7500.98
128_I346_L0.7500.98
37_G40_S0.7500.98
212_S230_S0.7490.98
247_V324_R0.7470.98
67_K73_L0.7450.98
294_P301_W0.7410.98
245_Y296_V0.7400.98
198_P326_V0.7380.98
12_S17_G0.7350.97
173_I211_I0.7350.97
258_V261_I0.7330.97
166_F257_T0.7330.97
176_I236_H0.7320.97
256_V264_T0.7310.97
293_R296_V0.7290.97
79_I104_I0.7260.97
122_E334_R0.7250.97
106_N147_T0.7200.97
102_P348_I0.7190.97
173_I246_E0.7180.97
256_V261_I0.7170.97
247_V326_V0.7160.97
152_A156_A0.7160.97
219_K227_N0.7130.97
33_G76_D0.7120.97
106_N339_G0.7110.97
7_A27_H0.7090.97
258_V316_G0.7070.97
5_L78_D0.7060.97
252_F261_I0.7060.97
104_I347_L0.7040.97
198_P236_H0.7030.97
198_P245_Y0.7020.97
346_L350_K0.7010.97
29_Y350_K0.6990.97
94_E110_H0.6990.97
243_G300_R0.6980.97
159_L173_I0.6960.96
67_K76_D0.6950.96
35_L64_M0.6950.96
113_D213_R0.6920.96
265_L287_L0.6870.96
163_Y167_K0.6860.96
261_I314_R0.6850.96
163_Y168_I0.6810.96
160_A163_Y0.6750.96
216_S219_K0.6750.96
259_E290_Q0.6730.96
108_P209_K0.6730.96
112_F213_R0.6690.96
139_D346_L0.6690.96
176_I196_V0.6690.96
73_L76_D0.6680.96
94_E103_V0.6660.95
26_N333_V0.6660.95
189_S197_L0.6610.95
9_I24_L0.6610.95
346_L349_E0.6600.95
82_S103_V0.6580.95
125_P129_S0.6570.95
9_I20_Y0.6570.95
111_R210_E0.6560.95
22_R25_A0.6560.95
32_V62_A0.6550.95
12_S66_V0.6550.95
13_T40_S0.6520.95
46_G62_A0.6510.95
96_F107_S0.6510.95
214_I217_E0.6500.95
208_V212_S0.6490.95
218_T229_L0.6490.95
261_I316_G0.6470.95
66_V69_T0.6450.95
162_I250_I0.6410.94
163_Y171_S0.6390.94
142_G145_V0.6380.94
154_G310_V0.6380.94
117_P124_N0.6340.94
24_L341_I0.6330.94
173_I233_A0.6320.94
34_Y45_Y0.6270.94
158_P310_V0.6270.94
288_I292_A0.6260.94
124_N127_T0.6250.94
27_H345_E0.6250.94
82_S89_A0.6240.94
86_Q108_P0.6230.94
166_F260_K0.6220.94
296_V300_R0.6200.93
166_F253_K0.6190.93
232_G324_R0.6180.93
29_Y59_T0.6180.93
199_L203_Y0.6150.93
166_F264_T0.6140.93
9_I21_V0.6130.93
285_I298_F0.6130.93
298_F311_V0.6110.93
242_H331_N0.6100.93
232_G322_T0.6080.93
154_G244_H0.6060.93
297_Y300_R0.6050.93
194_D241_I0.6050.93
299_D302_A0.6040.93
168_I253_K0.6040.93
154_G331_N0.6010.92
148_P153_Q0.6010.92
158_P312_V0.6010.92
21_V34_Y0.6000.92
15_L187_I0.6000.92
29_Y32_V0.5980.92
246_E327_S0.5980.92
285_I292_A0.5970.92
123_V157_I0.5970.92
128_I139_D0.5950.92
24_L32_V0.5950.92
241_I300_R0.5930.92
75_D98_K0.5920.92
64_M67_K0.5900.92
87_G107_S0.5900.92
311_V328_V0.5890.92
160_A268_F0.5880.92
294_P302_A0.5870.91
93_E96_F0.5860.91
46_G61_I0.5830.91
96_F101_F0.5790.91
167_K251_T0.5790.91
152_A246_E0.5780.91
155_A175_T0.5780.91
77_V101_F0.5760.91
81_F341_I0.5740.91
172_L247_V0.5730.90
11_G14_G0.5720.90
178_S242_H0.5720.90
150_C210_E0.5720.90
71_P74_M0.5710.90
97_A100_G0.5700.90
257_T317_Q0.5650.90
117_P142_G0.5650.90
7_A81_F0.5640.90
164_M267_S0.5630.90
299_D311_V0.5630.90
255_D320_R0.5620.90
243_G299_D0.5620.90
121_P125_P0.5620.90
24_L344_T0.5600.89
153_Q329_I0.5580.89
198_P295_Q0.5570.89
70_D91_P0.5560.89
111_R181_G0.5550.89
294_P298_F0.5550.89
81_F104_I0.5530.89
323_I326_V0.5520.89
91_P94_E0.5510.89
89_A110_H0.5500.89
172_L251_T0.5490.89
29_Y64_M0.5480.88
339_G343_A0.5460.88
181_G210_E0.5460.88
265_L282_D0.5440.88
13_T36_A0.5430.88
6_K77_V0.5420.88
288_I313_G0.5420.88
7_A344_T0.5420.88
65_E68_P0.5400.88
345_E349_E0.5340.87
128_I145_V0.5340.87
90_G113_D0.5340.87
96_F100_G0.5340.87
85_P108_P0.5330.87
186_G189_S0.5320.87
127_T144_I0.5310.87
20_Y341_I0.5310.87
122_E125_P0.5290.87
18_I45_Y0.5280.87
120_I123_V0.5270.86
242_H300_R0.5250.86
187_I241_I0.5240.86
186_G197_L0.5230.86
34_Y77_V0.5220.86
111_R150_C0.5220.86
155_A327_S0.5210.86
258_V314_R0.5200.86
216_S229_L0.5180.86
169_D321_R0.5150.85
266_D270_G0.5140.85
88_A107_S0.5130.85
73_L96_F0.5130.85
196_V240_T0.5120.85
254_E321_R0.5110.85
23_M26_N0.5100.85
316_G321_R0.5100.85
269_R285_I0.5090.85
227_N230_S0.5080.84
122_E342_L0.5070.84
107_S340_G0.5040.84
21_V25_A0.5040.84
62_A65_E0.5030.84
284_P288_I0.5010.84
292_A295_Q0.5000.83
173_I231_L0.5000.83
265_L314_R0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vknA 4 0.8961 100 0.241 Contact Map
3hskA 4 0.9691 100 0.246 Contact Map
1xygA 4 0.9101 100 0.257 Contact Map
4dplA 4 0.9888 100 0.261 Contact Map
2ep5A 4 0.9719 100 0.266 Contact Map
1ys4A 4 0.9579 100 0.282 Contact Map
2nqtA 4 0.8848 100 0.3 Contact Map
2yv3A 2 0.8427 100 0.3 Contact Map
3uw3A 2 0.8708 100 0.306 Contact Map
3tz6A 2 0.8427 100 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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