Q97WN0 - SULSO - GREMLIN Contacts

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Q97WN0 - Isocitrate dehydrogenase, probable (Idh)

UniProt:	Q97WN0	Sequences: MMQKIPEDGEVIKFENGKWIVPKKPIILYVEGDGIGHEITHAAMKVINKAVEKAYGSDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPIGKGWKSINVAIRLMLDLYANIRPVKYIPGIESPIKNADKIDLIIFRENTDDLYRGIEYPYDSEQAKKIRDFLRKELGVEVEDDTGIGIKLISRFKTQRIARMAIKYAIDHKRKKVTIMHKGNVMKYTEGAFREWSYEVATKEFRDYIVTEEEVTKNYNGVPPSGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGGMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDKAAELIDSAIMESIRQKKVTQDLARFMGVRALSTTEYTDELIAIIDTLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	413 (336)
Sequences:	7065 (3003)
Seq/√Len:	163.8

ECOLI - IDH DMLA LEU3
BACSU - IDH TTUC LEU3
HALSA - Q9HNZ7
SULSO - Q97WN0 LEU3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
211_I	262_G	4.167	1.00
204_R	259_N	3.465	1.00
203_A	238_S	3.063	1.00
42_A	402_T	3.018	1.00
204_R	208_K	2.834	1.00
26_I	62_K	2.760	1.00
45_K	403_D	2.717	1.00
278_N	282_Q	2.688	1.00
359_R	371_D	2.637	1.00
380_Q	408_I	2.630	1.00
48_N	63_W	2.429	1.00
82_K	86_E	2.415	1.00
376_E	408_I	2.360	1.00
404_E	407_A	2.313	1.00
196_R	200_Q	2.288	1.00
40_T	350_I	2.276	1.00
42_A	45_K	2.200	1.00
29_Y	44_M	2.178	1.00
359_R	368_E	2.177	1.00
219_T	272_N	2.090	1.00
78_N	82_K	2.068	1.00
377_S	408_I	2.053	1.00
66_V	87_L	2.032	1.00
238_S	271_I	2.018	1.00
388_A	395_A	2.016	1.00
217_K	272_N	2.010	1.00
28_L	87_L	1.988	1.00
146_I	209_Y	1.978	1.00
89_E	118_L	1.967	1.00
44_M	65_E	1.950	1.00
67_L	75_L	1.942	1.00
200_Q	240_E	1.939	1.00
348_T	405_L	1.937	1.00
203_A	294_L	1.907	1.00
352_K	374_I	1.902	1.00
351_I	405_L	1.884	1.00
200_Q	237_W	1.882	1.00
363_W	366_A	1.872	1.00
286_R	289_E	1.835	1.00
72_A	81_P	1.835	1.00
217_K	270_I	1.831	1.00
343_N	397_S	1.828	1.00
343_N	399_T	1.800	1.00
35_I	345_A	1.785	1.00
37_H	41_H	1.763	1.00
368_E	372_S	1.744	1.00
239_Y	273_D	1.734	1.00
240_E	258_K	1.724	1.00
402_T	406_I	1.720	1.00
86_E	90_K	1.719	1.00
355_E	371_D	1.706	1.00
196_R	240_E	1.687	1.00
382_K	404_E	1.665	1.00
221_M	279_M	1.651	1.00
128_K	375_M	1.650	1.00
186_D	196_R	1.620	1.00
89_E	117_M	1.608	1.00
237_W	240_E	1.602	1.00
200_Q	204_R	1.593	1.00
403_D	407_A	1.584	1.00
382_K	396_L	1.582	1.00
364_D	368_E	1.577	1.00
24_K	62_K	1.575	1.00
162_P	236_E	1.567	1.00
50_A	370_I	1.565	1.00
131_P	379_R	1.556	1.00
192_K	296_P	1.544	1.00
121_Y	324_D	1.541	1.00
124_I	146_I	1.540	1.00
204_R	260_Y	1.528	1.00
28_L	91_Y	1.522	1.00
208_K	260_Y	1.491	1.00
397_S	400_E	1.491	1.00
64_V	90_K	1.487	1.00
207_I	242_A	1.486	1.00
86_E	89_E	1.484	1.00
24_K	60_E	1.477	1.00
43_A	354_G	1.477	1.00
85_E	117_M	1.473	1.00
59_R	363_W	1.467	1.00
343_N	398_T	1.461	1.00
25_P	363_W	1.456	1.00
284_I	306_A	1.452	1.00
220_I	238_S	1.451	1.00
359_R	367_A	1.451	1.00
71_K	75_L	1.448	1.00
204_R	241_V	1.420	1.00
28_L	66_V	1.407	1.00
148_F	205_M	1.404	1.00
63_W	354_G	1.403	1.00
47_I	61_I	1.402	1.00
208_K	212_D	1.401	1.00
185_D	197_F	1.400	1.00
59_R	366_A	1.399	1.00
45_K	406_I	1.397	1.00
113_A	117_M	1.387	1.00
49_K	406_I	1.385	1.00
30_V	68_A	1.376	1.00
64_V	91_Y	1.374	1.00
147_I	304_S	1.368	1.00
44_M	48_N	1.362	1.00
101_T	104_G	1.355	1.00
241_V	259_N	1.342	1.00
43_A	95_L	1.336	1.00
215_R	291_D	1.334	1.00
31_E	65_E	1.321	1.00
132_G	379_R	1.318	1.00
80_F	85_E	1.299	1.00
148_F	209_Y	1.290	1.00
67_L	76_T	1.289	1.00
344_V	385_Q	1.289	1.00
406_I	409_I	1.274	1.00
348_T	401_Y	1.265	1.00
280_F	303_I	1.251	1.00
25_P	361_M	1.250	1.00
208_K	211_I	1.244	1.00
396_L	404_E	1.242	1.00
233_A	237_W	1.241	1.00
359_R	364_D	1.238	1.00
377_S	404_E	1.234	1.00
216_K	291_D	1.232	1.00
274_R	282_Q	1.220	1.00
190_G	229_Y	1.220	1.00
44_M	63_W	1.217	1.00
43_A	350_I	1.216	1.00
220_I	273_D	1.216	1.00
357_M	361_M	1.213	1.00
203_A	241_V	1.212	1.00
401_Y	405_L	1.203	1.00
67_L	72_A	1.202	1.00
64_V	87_L	1.200	1.00
207_I	260_Y	1.183	1.00
372_S	376_E	1.172	1.00
274_R	290_Y	1.167	1.00
26_I	64_V	1.164	1.00
358_L	366_A	1.157	1.00
236_E	240_E	1.156	1.00
274_R	278_N	1.151	1.00
396_L	400_E	1.143	1.00
88_I	94_L	1.138	1.00
192_K	229_Y	1.135	1.00
283_I	293_I	1.133	1.00
147_I	307_A	1.128	1.00
200_Q	241_V	1.127	1.00
119_D	201_R	1.119	1.00
145_L	283_I	1.113	1.00
274_R	279_M	1.111	1.00
196_R	237_W	1.099	1.00
29_Y	65_E	1.096	1.00
339_Y	345_A	1.094	1.00
128_K	144_D	1.091	1.00
46_V	370_I	1.088	1.00
400_E	403_D	1.086	1.00
72_A	76_T	1.084	1.00
369_L	409_I	1.082	1.00
47_I	354_G	1.080	1.00
28_L	88_I	1.077	0.99
95_L	354_G	1.074	0.99
199_T	203_A	1.067	0.99
50_A	366_A	1.066	0.99
404_E	408_I	1.065	0.99
280_F	306_A	1.064	0.99
207_I	269_V	1.060	0.99
124_I	148_F	1.054	0.99
276_A	302_Y	1.042	0.99
142_K	288_D	1.039	0.99
211_I	216_K	1.038	0.99
218_V	271_I	1.031	0.99
76_T	83_E	1.020	0.99
42_A	399_T	1.016	0.99
224_G	235_R	1.016	0.99
348_T	378_I	1.015	0.99
96_K	111_N	1.012	0.99
194_I	296_P	1.008	0.99
343_N	400_E	1.006	0.99
188_G	233_A	1.006	0.99
376_E	380_Q	1.003	0.99
218_V	241_V	1.002	0.99
45_K	402_T	1.000	0.99
155_L	192_K	0.999	0.99
43_A	351_I	0.996	0.99
160_E	191_I	0.992	0.99
41_H	45_K	0.991	0.99
122_A	202_I	0.985	0.99
155_L	296_P	0.983	0.99
238_S	294_L	0.977	0.99
221_M	276_A	0.975	0.99
45_K	399_T	0.973	0.99
151_N	321_N	0.969	0.99
282_Q	289_E	0.964	0.99
81_P	84_S	0.963	0.99
46_V	406_I	0.962	0.99
72_A	84_S	0.958	0.99
211_I	269_V	0.955	0.99
83_E	86_E	0.953	0.99
154_D	192_K	0.947	0.99
74_K	103_I	0.944	0.99
272_N	289_E	0.944	0.99
187_T	193_L	0.942	0.99
285_I	309_A	0.936	0.99
50_A	354_G	0.935	0.99
46_V	409_I	0.929	0.98
131_P	141_D	0.927	0.98
128_K	371_D	0.924	0.98
206_A	218_V	0.923	0.98
145_L	307_A	0.923	0.98
197_F	200_Q	0.922	0.98
352_K	371_D	0.919	0.98
218_V	292_I	0.917	0.98
42_A	343_N	0.915	0.98
194_I	199_T	0.915	0.98
207_I	218_V	0.914	0.98
385_Q	395_A	0.913	0.98
355_E	359_R	0.912	0.98
344_V	395_A	0.912	0.98
39_I	350_I	0.911	0.98
39_I	97_G	0.911	0.98
222_H	235_R	0.908	0.98
29_Y	40_T	0.908	0.98
348_T	374_I	0.907	0.98
231_E	299_N	0.904	0.98
68_A	114_I	0.897	0.98
339_Y	344_V	0.897	0.98
366_A	369_L	0.897	0.98
323_G	326_G	0.896	0.98
214_K	269_V	0.895	0.98
368_E	371_D	0.894	0.98
26_I	90_K	0.893	0.98
388_A	396_L	0.890	0.98
242_A	271_I	0.886	0.98
211_I	260_Y	0.886	0.98
31_E	41_H	0.885	0.98
46_V	351_I	0.883	0.98
132_G	375_M	0.882	0.98
130_I	375_M	0.880	0.98
78_N	113_A	0.877	0.98
331_A	350_I	0.875	0.98
66_V	91_Y	0.873	0.98
83_E	87_L	0.865	0.98
42_A	403_D	0.862	0.98
154_D	296_P	0.859	0.97
389_R	395_A	0.859	0.97
68_A	110_I	0.858	0.97
282_Q	286_R	0.857	0.97
87_L	91_Y	0.857	0.97
339_Y	385_Q	0.857	0.97
220_I	271_I	0.856	0.97
351_I	374_I	0.855	0.97
218_V	294_L	0.854	0.97
377_S	382_K	0.852	0.97
66_V	84_S	0.850	0.97
127_V	307_A	0.837	0.97
187_T	195_S	0.832	0.97
376_E	379_R	0.832	0.97
50_A	59_R	0.831	0.97
124_I	205_M	0.827	0.97
93_V	361_M	0.823	0.97
68_A	96_K	0.821	0.97
222_H	273_D	0.819	0.97
354_G	357_M	0.817	0.97
98_P	333_H	0.816	0.97
40_T	97_G	0.814	0.97
29_Y	63_W	0.809	0.96
219_T	274_R	0.808	0.96
338_K	385_Q	0.808	0.96
276_A	296_P	0.804	0.96
74_K	101_T	0.801	0.96
25_P	59_R	0.801	0.96
119_D	152_T	0.800	0.96
218_V	242_A	0.798	0.96
214_K	291_D	0.796	0.96
38_E	341_G	0.791	0.96
224_G	275_I	0.790	0.96
123_N	332_I	0.788	0.96
377_S	405_L	0.788	0.96
342_K	385_Q	0.786	0.96
384_T	401_Y	0.786	0.96
155_L	298_V	0.786	0.96
373_A	377_S	0.786	0.96
30_V	88_I	0.784	0.96
161_Y	189_I	0.780	0.96
43_A	47_I	0.777	0.95
203_A	271_I	0.776	0.95
206_A	294_L	0.776	0.95
147_I	303_I	0.775	0.95
237_W	241_V	0.771	0.95
47_I	358_L	0.767	0.95
122_A	205_M	0.767	0.95
42_A	406_I	0.767	0.95
61_I	354_G	0.766	0.95
320_A	329_F	0.765	0.95
372_S	375_M	0.763	0.95
221_M	293_I	0.761	0.95
396_L	401_Y	0.760	0.95
242_A	261_N	0.759	0.95
131_P	375_M	0.757	0.95
85_E	89_E	0.756	0.95
221_M	303_I	0.755	0.95
205_M	209_Y	0.754	0.95
389_R	396_L	0.753	0.95
67_L	71_K	0.752	0.95
212_D	362_G	0.751	0.95
192_K	298_V	0.750	0.95
283_I	307_A	0.750	0.95
127_V	311_V	0.750	0.95
73_E	79_R	0.747	0.94
279_M	290_Y	0.744	0.94
70_D	101_T	0.738	0.94
276_A	280_F	0.737	0.94
70_D	74_K	0.736	0.94
41_H	399_T	0.735	0.94
239_Y	271_I	0.733	0.94
354_G	358_L	0.733	0.94
218_V	269_V	0.730	0.94
144_D	291_D	0.730	0.94
105_K	109_S	0.729	0.94
95_L	350_I	0.726	0.94
162_P	188_G	0.720	0.93
196_R	233_A	0.718	0.93
338_K	345_A	0.716	0.93
279_M	293_I	0.715	0.93
241_V	260_Y	0.715	0.93
120_L	328_M	0.711	0.93
384_T	387_L	0.708	0.93
318_G	356_L	0.705	0.93
100_E	335_T	0.702	0.92
207_I	271_I	0.701	0.92
318_G	352_K	0.701	0.92
192_K	299_N	0.699	0.92
399_T	403_D	0.698	0.92
41_H	65_E	0.697	0.92
87_L	90_K	0.696	0.92
399_T	402_T	0.696	0.92
127_V	145_L	0.695	0.92
98_P	350_I	0.694	0.92
385_Q	397_S	0.694	0.92
239_Y	242_A	0.693	0.92
336_A	339_Y	0.692	0.92
148_F	202_I	0.691	0.92
42_A	351_I	0.688	0.92
278_N	314_I	0.685	0.91
403_D	406_I	0.685	0.91
66_V	83_E	0.682	0.91
320_A	356_L	0.682	0.91
184_E	187_T	0.681	0.91
365_K	368_E	0.678	0.91
160_E	189_I	0.677	0.91
153_D	198_K	0.677	0.91
377_S	401_Y	0.676	0.91
145_L	310_L	0.675	0.91
202_I	294_L	0.674	0.91
139_N	142_K	0.673	0.91
94_L	328_M	0.670	0.91
78_N	83_E	0.670	0.91
235_R	239_Y	0.669	0.90
367_A	371_D	0.664	0.90
70_D	100_E	0.660	0.90
80_F	114_I	0.658	0.90
284_I	310_L	0.654	0.89
222_H	275_I	0.653	0.89
108_K	113_A	0.653	0.89
129_Y	143_I	0.652	0.89
106_G	109_S	0.651	0.89
47_I	63_W	0.650	0.89
199_T	237_W	0.649	0.89
205_M	324_D	0.648	0.89
282_Q	285_I	0.648	0.89
242_A	258_K	0.647	0.89
40_T	43_A	0.645	0.89
190_G	232_G	0.635	0.88
313_N	349_G	0.635	0.88
71_K	74_K	0.634	0.88
318_G	349_G	0.631	0.88
192_K	231_E	0.630	0.88
375_M	379_R	0.630	0.88
140_A	288_D	0.629	0.88
316_M	387_L	0.625	0.87
186_D	236_E	0.625	0.87
72_A	80_F	0.625	0.87
50_A	58_D	0.624	0.87
134_E	138_K	0.624	0.87
45_K	48_N	0.622	0.87
221_M	295_A	0.621	0.87
47_I	370_I	0.620	0.87
332_I	349_G	0.618	0.87
82_K	113_A	0.617	0.87
358_L	370_I	0.615	0.86
205_M	208_K	0.615	0.86
199_T	296_P	0.615	0.86
97_G	350_I	0.614	0.86
147_I	293_I	0.612	0.86
74_K	104_G	0.611	0.86
159_I	193_L	0.609	0.86
160_E	163_Y	0.609	0.86
27_I	61_I	0.609	0.86
369_L	373_A	0.609	0.86
67_L	83_E	0.606	0.86
119_D	153_D	0.605	0.85
351_I	370_I	0.605	0.85
361_M	364_D	0.601	0.85
119_D	197_F	0.597	0.85
382_K	408_I	0.596	0.85
110_I	113_A	0.595	0.85
345_A	385_Q	0.594	0.84
40_T	44_M	0.593	0.84
220_I	234_F	0.592	0.84
130_I	352_K	0.588	0.84
208_K	259_N	0.588	0.84
27_I	63_W	0.588	0.84
50_A	369_L	0.588	0.84
216_K	262_G	0.587	0.84
329_F	360_F	0.586	0.84
164_D	182_E	0.585	0.84
146_I	292_I	0.584	0.83
327_G	360_F	0.582	0.83
27_I	357_M	0.581	0.83
144_D	215_R	0.580	0.83
322_I	360_F	0.580	0.83
68_A	80_F	0.577	0.83
70_D	104_G	0.577	0.83
186_D	197_F	0.577	0.83
88_I	91_Y	0.576	0.83
162_P	228_K	0.576	0.83
278_N	289_E	0.575	0.83
156_Y	330_E	0.574	0.82
184_E	196_R	0.574	0.82
101_T	109_S	0.572	0.82
242_A	269_V	0.572	0.82
100_E	107_W	0.571	0.82
99_L	335_T	0.571	0.82
236_E	258_K	0.570	0.82
119_D	323_G	0.569	0.82
164_D	187_T	0.569	0.82
121_Y	202_I	0.568	0.82
184_E	197_F	0.567	0.82
198_K	201_R	0.565	0.81
351_I	402_T	0.564	0.81
80_F	113_A	0.563	0.81
159_I	191_I	0.563	0.81
146_I	215_R	0.562	0.81
203_A	237_W	0.562	0.81
84_S	110_I	0.561	0.81
322_I	327_G	0.556	0.80
223_K	277_D	0.556	0.80
65_E	71_K	0.556	0.80
358_L	367_A	0.555	0.80
211_I	242_A	0.555	0.80
61_I	363_W	0.554	0.80
30_V	66_V	0.552	0.80
88_I	114_I	0.552	0.80
365_K	369_L	0.551	0.80
313_N	316_M	0.550	0.80
183_V	186_D	0.548	0.79
163_Y	236_E	0.548	0.79
78_N	105_K	0.546	0.79
40_T	95_L	0.545	0.79
61_I	366_A	0.544	0.79
143_I	288_D	0.540	0.78
208_K	241_V	0.539	0.78
68_A	84_S	0.539	0.78
230_T	296_P	0.537	0.78
190_G	227_M	0.537	0.78
227_M	230_T	0.536	0.78
28_L	64_V	0.533	0.78
118_L	328_M	0.532	0.77
278_N	290_Y	0.530	0.77
96_K	114_I	0.530	0.77
323_G	327_G	0.529	0.77
80_F	84_S	0.529	0.77
43_A	46_V	0.527	0.77
187_T	196_R	0.527	0.77
41_H	44_M	0.527	0.77
296_P	299_N	0.526	0.77
210_A	218_V	0.526	0.77
369_L	406_I	0.525	0.76
181_V	184_E	0.525	0.76
153_D	195_S	0.525	0.76
385_Q	389_R	0.524	0.76
164_D	185_D	0.523	0.76
242_A	260_Y	0.522	0.76
279_M	303_I	0.521	0.76
37_H	71_K	0.519	0.76
239_Y	258_K	0.518	0.76
189_I	193_L	0.518	0.76
88_I	118_L	0.517	0.75
301_D	305_D	0.516	0.75
31_E	44_M	0.513	0.75
205_M	322_I	0.513	0.75
382_K	395_A	0.513	0.75
79_R	83_E	0.512	0.75
326_G	360_F	0.512	0.75
398_T	402_T	0.510	0.74
109_S	113_A	0.510	0.74
334_G	337_P	0.509	0.74
163_Y	196_R	0.509	0.74
69_G	72_A	0.507	0.74
102_P	332_I	0.505	0.74
125_R	301_D	0.504	0.74
34_G	345_A	0.502	0.73
50_A	351_I	0.501	0.73
50_A	61_I	0.501	0.73
355_E	367_A	0.500	0.73
31_E	37_H	0.500	0.73
47_I	50_A	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2e0cA	2	0.9637	100	0.076	Contact Map
1tyoA	2	0.9976	100	0.081	Contact Map
2d4vA	2	0.9758	100	0.086	Contact Map
2iv0A	2	0.9903	100	0.087	Contact Map
3dmsA	2	0.9685	100	0.093	Contact Map
1hqsA	2	0.9661	100	0.104	Contact Map
2d1cA	2	0.862	100	0.142	Contact Map
3flkA	3	0.8329	100	0.144	Contact Map
1x0lA	4	0.8015	100	0.15	Contact Map
3ty4A	2	0.8184	100	0.153	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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