GREMLIN Database
Q97WN0 - Isocitrate dehydrogenase, probable (Idh)
UniProt: Q97WN0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (336)
Sequences: 7065 (3003)
Seq/√Len: 163.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
211_I262_G4.1671.00
204_R259_N3.4651.00
203_A238_S3.0631.00
42_A402_T3.0181.00
204_R208_K2.8341.00
26_I62_K2.7601.00
45_K403_D2.7171.00
278_N282_Q2.6881.00
359_R371_D2.6371.00
380_Q408_I2.6301.00
48_N63_W2.4291.00
82_K86_E2.4151.00
376_E408_I2.3601.00
404_E407_A2.3131.00
196_R200_Q2.2881.00
40_T350_I2.2761.00
42_A45_K2.2001.00
29_Y44_M2.1781.00
359_R368_E2.1771.00
219_T272_N2.0901.00
78_N82_K2.0681.00
377_S408_I2.0531.00
66_V87_L2.0321.00
238_S271_I2.0181.00
388_A395_A2.0161.00
217_K272_N2.0101.00
28_L87_L1.9881.00
146_I209_Y1.9781.00
89_E118_L1.9671.00
44_M65_E1.9501.00
67_L75_L1.9421.00
200_Q240_E1.9391.00
348_T405_L1.9371.00
203_A294_L1.9071.00
352_K374_I1.9021.00
351_I405_L1.8841.00
200_Q237_W1.8821.00
363_W366_A1.8721.00
286_R289_E1.8351.00
72_A81_P1.8351.00
217_K270_I1.8311.00
343_N397_S1.8281.00
343_N399_T1.8001.00
35_I345_A1.7851.00
37_H41_H1.7631.00
368_E372_S1.7441.00
239_Y273_D1.7341.00
240_E258_K1.7241.00
402_T406_I1.7201.00
86_E90_K1.7191.00
355_E371_D1.7061.00
196_R240_E1.6871.00
382_K404_E1.6651.00
221_M279_M1.6511.00
128_K375_M1.6501.00
186_D196_R1.6201.00
89_E117_M1.6081.00
237_W240_E1.6021.00
200_Q204_R1.5931.00
403_D407_A1.5841.00
382_K396_L1.5821.00
364_D368_E1.5771.00
24_K62_K1.5751.00
162_P236_E1.5671.00
50_A370_I1.5651.00
131_P379_R1.5561.00
192_K296_P1.5441.00
121_Y324_D1.5411.00
124_I146_I1.5401.00
204_R260_Y1.5281.00
28_L91_Y1.5221.00
208_K260_Y1.4911.00
397_S400_E1.4911.00
64_V90_K1.4871.00
207_I242_A1.4861.00
86_E89_E1.4841.00
24_K60_E1.4771.00
43_A354_G1.4771.00
85_E117_M1.4731.00
59_R363_W1.4671.00
343_N398_T1.4611.00
25_P363_W1.4561.00
284_I306_A1.4521.00
220_I238_S1.4511.00
359_R367_A1.4511.00
71_K75_L1.4481.00
204_R241_V1.4201.00
28_L66_V1.4071.00
148_F205_M1.4041.00
63_W354_G1.4031.00
47_I61_I1.4021.00
208_K212_D1.4011.00
185_D197_F1.4001.00
59_R366_A1.3991.00
45_K406_I1.3971.00
113_A117_M1.3871.00
49_K406_I1.3851.00
30_V68_A1.3761.00
64_V91_Y1.3741.00
147_I304_S1.3681.00
44_M48_N1.3621.00
101_T104_G1.3551.00
241_V259_N1.3421.00
43_A95_L1.3361.00
215_R291_D1.3341.00
31_E65_E1.3211.00
132_G379_R1.3181.00
80_F85_E1.2991.00
148_F209_Y1.2901.00
67_L76_T1.2891.00
344_V385_Q1.2891.00
406_I409_I1.2741.00
348_T401_Y1.2651.00
280_F303_I1.2511.00
25_P361_M1.2501.00
208_K211_I1.2441.00
396_L404_E1.2421.00
233_A237_W1.2411.00
359_R364_D1.2381.00
377_S404_E1.2341.00
216_K291_D1.2321.00
274_R282_Q1.2201.00
190_G229_Y1.2201.00
44_M63_W1.2171.00
43_A350_I1.2161.00
220_I273_D1.2161.00
357_M361_M1.2131.00
203_A241_V1.2121.00
401_Y405_L1.2031.00
67_L72_A1.2021.00
64_V87_L1.2001.00
207_I260_Y1.1831.00
372_S376_E1.1721.00
274_R290_Y1.1671.00
26_I64_V1.1641.00
358_L366_A1.1571.00
236_E240_E1.1561.00
274_R278_N1.1511.00
396_L400_E1.1431.00
88_I94_L1.1381.00
192_K229_Y1.1351.00
283_I293_I1.1331.00
147_I307_A1.1281.00
200_Q241_V1.1271.00
119_D201_R1.1191.00
145_L283_I1.1131.00
274_R279_M1.1111.00
196_R237_W1.0991.00
29_Y65_E1.0961.00
339_Y345_A1.0941.00
128_K144_D1.0911.00
46_V370_I1.0881.00
400_E403_D1.0861.00
72_A76_T1.0841.00
369_L409_I1.0821.00
47_I354_G1.0801.00
28_L88_I1.0770.99
95_L354_G1.0740.99
199_T203_A1.0670.99
50_A366_A1.0660.99
404_E408_I1.0650.99
280_F306_A1.0640.99
207_I269_V1.0600.99
124_I148_F1.0540.99
276_A302_Y1.0420.99
142_K288_D1.0390.99
211_I216_K1.0380.99
218_V271_I1.0310.99
76_T83_E1.0200.99
42_A399_T1.0160.99
224_G235_R1.0160.99
348_T378_I1.0150.99
96_K111_N1.0120.99
194_I296_P1.0080.99
343_N400_E1.0060.99
188_G233_A1.0060.99
376_E380_Q1.0030.99
218_V241_V1.0020.99
45_K402_T1.0000.99
155_L192_K0.9990.99
43_A351_I0.9960.99
160_E191_I0.9920.99
41_H45_K0.9910.99
122_A202_I0.9850.99
155_L296_P0.9830.99
238_S294_L0.9770.99
221_M276_A0.9750.99
45_K399_T0.9730.99
151_N321_N0.9690.99
282_Q289_E0.9640.99
81_P84_S0.9630.99
46_V406_I0.9620.99
72_A84_S0.9580.99
211_I269_V0.9550.99
83_E86_E0.9530.99
154_D192_K0.9470.99
74_K103_I0.9440.99
272_N289_E0.9440.99
187_T193_L0.9420.99
285_I309_A0.9360.99
50_A354_G0.9350.99
46_V409_I0.9290.98
131_P141_D0.9270.98
128_K371_D0.9240.98
206_A218_V0.9230.98
145_L307_A0.9230.98
197_F200_Q0.9220.98
352_K371_D0.9190.98
218_V292_I0.9170.98
42_A343_N0.9150.98
194_I199_T0.9150.98
207_I218_V0.9140.98
385_Q395_A0.9130.98
355_E359_R0.9120.98
344_V395_A0.9120.98
39_I350_I0.9110.98
39_I97_G0.9110.98
222_H235_R0.9080.98
29_Y40_T0.9080.98
348_T374_I0.9070.98
231_E299_N0.9040.98
68_A114_I0.8970.98
339_Y344_V0.8970.98
366_A369_L0.8970.98
323_G326_G0.8960.98
214_K269_V0.8950.98
368_E371_D0.8940.98
26_I90_K0.8930.98
388_A396_L0.8900.98
242_A271_I0.8860.98
211_I260_Y0.8860.98
31_E41_H0.8850.98
46_V351_I0.8830.98
132_G375_M0.8820.98
130_I375_M0.8800.98
78_N113_A0.8770.98
331_A350_I0.8750.98
66_V91_Y0.8730.98
83_E87_L0.8650.98
42_A403_D0.8620.98
154_D296_P0.8590.97
389_R395_A0.8590.97
68_A110_I0.8580.97
282_Q286_R0.8570.97
87_L91_Y0.8570.97
339_Y385_Q0.8570.97
220_I271_I0.8560.97
351_I374_I0.8550.97
218_V294_L0.8540.97
377_S382_K0.8520.97
66_V84_S0.8500.97
127_V307_A0.8370.97
187_T195_S0.8320.97
376_E379_R0.8320.97
50_A59_R0.8310.97
124_I205_M0.8270.97
93_V361_M0.8230.97
68_A96_K0.8210.97
222_H273_D0.8190.97
354_G357_M0.8170.97
98_P333_H0.8160.97
40_T97_G0.8140.97
29_Y63_W0.8090.96
219_T274_R0.8080.96
338_K385_Q0.8080.96
276_A296_P0.8040.96
74_K101_T0.8010.96
25_P59_R0.8010.96
119_D152_T0.8000.96
218_V242_A0.7980.96
214_K291_D0.7960.96
38_E341_G0.7910.96
224_G275_I0.7900.96
123_N332_I0.7880.96
377_S405_L0.7880.96
342_K385_Q0.7860.96
384_T401_Y0.7860.96
155_L298_V0.7860.96
373_A377_S0.7860.96
30_V88_I0.7840.96
161_Y189_I0.7800.96
43_A47_I0.7770.95
203_A271_I0.7760.95
206_A294_L0.7760.95
147_I303_I0.7750.95
237_W241_V0.7710.95
47_I358_L0.7670.95
122_A205_M0.7670.95
42_A406_I0.7670.95
61_I354_G0.7660.95
320_A329_F0.7650.95
372_S375_M0.7630.95
221_M293_I0.7610.95
396_L401_Y0.7600.95
242_A261_N0.7590.95
131_P375_M0.7570.95
85_E89_E0.7560.95
221_M303_I0.7550.95
205_M209_Y0.7540.95
389_R396_L0.7530.95
67_L71_K0.7520.95
212_D362_G0.7510.95
192_K298_V0.7500.95
283_I307_A0.7500.95
127_V311_V0.7500.95
73_E79_R0.7470.94
279_M290_Y0.7440.94
70_D101_T0.7380.94
276_A280_F0.7370.94
70_D74_K0.7360.94
41_H399_T0.7350.94
239_Y271_I0.7330.94
354_G358_L0.7330.94
218_V269_V0.7300.94
144_D291_D0.7300.94
105_K109_S0.7290.94
95_L350_I0.7260.94
162_P188_G0.7200.93
196_R233_A0.7180.93
338_K345_A0.7160.93
279_M293_I0.7150.93
241_V260_Y0.7150.93
120_L328_M0.7110.93
384_T387_L0.7080.93
318_G356_L0.7050.93
100_E335_T0.7020.92
207_I271_I0.7010.92
318_G352_K0.7010.92
192_K299_N0.6990.92
399_T403_D0.6980.92
41_H65_E0.6970.92
87_L90_K0.6960.92
399_T402_T0.6960.92
127_V145_L0.6950.92
98_P350_I0.6940.92
385_Q397_S0.6940.92
239_Y242_A0.6930.92
336_A339_Y0.6920.92
148_F202_I0.6910.92
42_A351_I0.6880.92
278_N314_I0.6850.91
403_D406_I0.6850.91
66_V83_E0.6820.91
320_A356_L0.6820.91
184_E187_T0.6810.91
365_K368_E0.6780.91
160_E189_I0.6770.91
153_D198_K0.6770.91
377_S401_Y0.6760.91
145_L310_L0.6750.91
202_I294_L0.6740.91
139_N142_K0.6730.91
94_L328_M0.6700.91
78_N83_E0.6700.91
235_R239_Y0.6690.90
367_A371_D0.6640.90
70_D100_E0.6600.90
80_F114_I0.6580.90
284_I310_L0.6540.89
222_H275_I0.6530.89
108_K113_A0.6530.89
129_Y143_I0.6520.89
106_G109_S0.6510.89
47_I63_W0.6500.89
199_T237_W0.6490.89
205_M324_D0.6480.89
282_Q285_I0.6480.89
242_A258_K0.6470.89
40_T43_A0.6450.89
190_G232_G0.6350.88
313_N349_G0.6350.88
71_K74_K0.6340.88
318_G349_G0.6310.88
192_K231_E0.6300.88
375_M379_R0.6300.88
140_A288_D0.6290.88
316_M387_L0.6250.87
186_D236_E0.6250.87
72_A80_F0.6250.87
50_A58_D0.6240.87
134_E138_K0.6240.87
45_K48_N0.6220.87
221_M295_A0.6210.87
47_I370_I0.6200.87
332_I349_G0.6180.87
82_K113_A0.6170.87
358_L370_I0.6150.86
205_M208_K0.6150.86
199_T296_P0.6150.86
97_G350_I0.6140.86
147_I293_I0.6120.86
74_K104_G0.6110.86
159_I193_L0.6090.86
160_E163_Y0.6090.86
27_I61_I0.6090.86
369_L373_A0.6090.86
67_L83_E0.6060.86
119_D153_D0.6050.85
351_I370_I0.6050.85
361_M364_D0.6010.85
119_D197_F0.5970.85
382_K408_I0.5960.85
110_I113_A0.5950.85
345_A385_Q0.5940.84
40_T44_M0.5930.84
220_I234_F0.5920.84
130_I352_K0.5880.84
208_K259_N0.5880.84
27_I63_W0.5880.84
50_A369_L0.5880.84
216_K262_G0.5870.84
329_F360_F0.5860.84
164_D182_E0.5850.84
146_I292_I0.5840.83
327_G360_F0.5820.83
27_I357_M0.5810.83
144_D215_R0.5800.83
322_I360_F0.5800.83
68_A80_F0.5770.83
70_D104_G0.5770.83
186_D197_F0.5770.83
88_I91_Y0.5760.83
162_P228_K0.5760.83
278_N289_E0.5750.83
156_Y330_E0.5740.82
184_E196_R0.5740.82
101_T109_S0.5720.82
242_A269_V0.5720.82
100_E107_W0.5710.82
99_L335_T0.5710.82
236_E258_K0.5700.82
119_D323_G0.5690.82
164_D187_T0.5690.82
121_Y202_I0.5680.82
184_E197_F0.5670.82
198_K201_R0.5650.81
351_I402_T0.5640.81
80_F113_A0.5630.81
159_I191_I0.5630.81
146_I215_R0.5620.81
203_A237_W0.5620.81
84_S110_I0.5610.81
322_I327_G0.5560.80
223_K277_D0.5560.80
65_E71_K0.5560.80
358_L367_A0.5550.80
211_I242_A0.5550.80
61_I363_W0.5540.80
30_V66_V0.5520.80
88_I114_I0.5520.80
365_K369_L0.5510.80
313_N316_M0.5500.80
183_V186_D0.5480.79
163_Y236_E0.5480.79
78_N105_K0.5460.79
40_T95_L0.5450.79
61_I366_A0.5440.79
143_I288_D0.5400.78
208_K241_V0.5390.78
68_A84_S0.5390.78
230_T296_P0.5370.78
190_G227_M0.5370.78
227_M230_T0.5360.78
28_L64_V0.5330.78
118_L328_M0.5320.77
278_N290_Y0.5300.77
96_K114_I0.5300.77
323_G327_G0.5290.77
80_F84_S0.5290.77
43_A46_V0.5270.77
187_T196_R0.5270.77
41_H44_M0.5270.77
296_P299_N0.5260.77
210_A218_V0.5260.77
369_L406_I0.5250.76
181_V184_E0.5250.76
153_D195_S0.5250.76
385_Q389_R0.5240.76
164_D185_D0.5230.76
242_A260_Y0.5220.76
279_M303_I0.5210.76
37_H71_K0.5190.76
239_Y258_K0.5180.76
189_I193_L0.5180.76
88_I118_L0.5170.75
301_D305_D0.5160.75
31_E44_M0.5130.75
205_M322_I0.5130.75
382_K395_A0.5130.75
79_R83_E0.5120.75
326_G360_F0.5120.75
398_T402_T0.5100.74
109_S113_A0.5100.74
334_G337_P0.5090.74
163_Y196_R0.5090.74
69_G72_A0.5070.74
102_P332_I0.5050.74
125_R301_D0.5040.74
34_G345_A0.5020.73
50_A351_I0.5010.73
50_A61_I0.5010.73
355_E367_A0.5000.73
31_E37_H0.5000.73
47_I50_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e0cA 2 0.9637 100 0.076 Contact Map
1tyoA 2 0.9976 100 0.081 Contact Map
2d4vA 2 0.9758 100 0.086 Contact Map
2iv0A 2 0.9903 100 0.087 Contact Map
3dmsA 2 0.9685 100 0.093 Contact Map
1hqsA 2 0.9661 100 0.104 Contact Map
2d1cA 2 0.862 100 0.142 Contact Map
3flkA 3 0.8329 100 0.144 Contact Map
1x0lA 4 0.8015 100 0.15 Contact Map
3ty4A 2 0.8184 100 0.153 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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