GREMLIN Database
CDC63 - ORC1-type DNA replication protein 3
UniProt: Q97WM8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (335)
Sequences: 6628 (4210)
Seq/√Len: 230.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_F26_L4.5041.00
17_K95_A3.8851.00
19_P93_K3.4061.00
137_K141_R3.2441.00
18_N23_I2.8411.00
285_L288_A2.4851.00
100_R168_L2.4601.00
293_P296_Y2.4251.00
297_K300_L2.4121.00
212_L238_A2.2871.00
267_I270_K2.2751.00
213_K235_S2.1431.00
293_P297_K2.1381.00
318_D322_K2.0821.00
296_Y300_L2.0771.00
87_E90_K2.0501.00
288_A292_L2.0341.00
208_D211_Q2.0081.00
299_A303_L2.0071.00
329_S333_F2.0071.00
209_A238_A1.9941.00
337_I341_D1.9861.00
140_T174_N1.9501.00
59_L152_V1.9461.00
338_S342_M1.9331.00
265_G272_H1.9331.00
330_Y334_S1.8841.00
270_K277_I1.8821.00
317_T321_N1.8621.00
269_R272_H1.8581.00
333_F337_I1.8561.00
206_P245_H1.8551.00
271_E275_K1.8511.00
137_K140_T1.8181.00
342_M346_V1.8041.00
314_K318_D1.7951.00
296_Y299_A1.7891.00
335_D339_E1.7681.00
313_H317_T1.7681.00
316_Y320_C1.7501.00
344_G348_I1.7471.00
330_Y337_I1.7321.00
310_M314_K1.7251.00
294_F297_K1.7171.00
330_Y333_F1.7171.00
216_L251_A1.7081.00
335_D338_S1.7021.00
341_D344_G1.7021.00
305_E308_D1.6911.00
116_K127_I1.6841.00
334_S337_I1.6671.00
296_Y303_L1.6501.00
300_L303_L1.6451.00
220_A255_L1.6301.00
274_D278_V1.6271.00
300_L304_I1.5951.00
297_K304_I1.5901.00
276_A280_Y1.5871.00
334_S338_S1.5741.00
213_K217_S1.5721.00
320_C324_K1.5551.00
267_I277_I1.5081.00
371_V374_A1.5031.00
281_E284_R1.5021.00
270_K273_V1.4931.00
331_R334_S1.4791.00
287_E290_K1.4691.00
346_V349_R1.4651.00
277_I280_Y1.4531.00
272_H276_A1.4501.00
270_K276_A1.4471.00
14_E22_F1.4351.00
312_A316_Y1.4341.00
267_I276_A1.4241.00
209_A242_A1.4181.00
361_K364_L1.4171.00
273_V276_A1.4101.00
297_K303_L1.4081.00
329_S334_S1.4051.00
209_A239_A1.4021.00
339_E342_M1.3871.00
357_G360_K1.3841.00
193_R196_S1.3801.00
329_S337_I1.3661.00
285_L292_L1.3631.00
297_K301_R1.3631.00
329_S332_R1.3541.00
292_L296_Y1.3521.00
268_I278_V1.3511.00
220_A234_L1.3451.00
364_L367_D1.3411.00
293_P303_L1.3311.00
296_Y304_I1.3251.00
311_S315_M1.3231.00
361_K372_L1.3171.00
367_D371_V1.3111.00
152_V179_M1.3091.00
367_D370_K1.3051.00
276_A279_D1.3011.00
363_A367_D1.2991.00
286_I290_K1.2971.00
292_L300_L1.2951.00
213_K234_L1.2881.00
292_L297_K1.2851.00
337_I340_L1.2831.00
268_I274_D1.2821.00
313_H316_Y1.2691.00
360_K364_L1.2681.00
235_S239_A1.2651.00
332_R335_D1.2611.00
320_C323_F1.2541.00
321_N325_Q1.2541.00
329_S340_L1.2491.00
361_K371_V1.2441.00
340_L347_K1.2421.00
345_I349_R1.2411.00
333_F340_L1.2351.00
156_V194_V1.2311.00
273_V280_Y1.2281.00
345_I352_N1.2181.00
275_K279_D1.2171.00
334_S341_D1.2111.00
336_I339_E1.2081.00
60_F204_F1.2041.00
269_R273_V1.2001.00
82_V90_K1.1971.00
371_V375_L1.1951.00
268_I276_A1.1931.00
365_V370_K1.1901.00
284_R288_A1.1831.00
285_L289_V1.1821.00
356_A359_V1.1751.00
291_A297_K1.1741.00
319_L323_F1.1711.00
290_K293_P1.1701.00
309_V313_H1.1651.00
268_I272_H1.1611.00
214_F217_S1.1571.00
268_I273_V1.1551.00
355_R358_G1.1491.00
343_F346_V1.1481.00
349_R353_R1.1441.00
293_P300_L1.1441.00
99_C102_V1.1431.00
22_F25_P1.1431.00
267_I280_Y1.1391.00
282_Q285_L1.1341.00
301_R304_I1.1291.00
339_E343_F1.1271.00
265_G269_R1.1261.00
331_R335_D1.1241.00
345_I348_I1.1051.00
372_L375_L1.1051.00
364_L368_K1.1041.00
236_Y239_A1.1041.00
149_L177_V1.1001.00
267_I275_K1.1001.00
289_V292_L1.0981.00
316_Y323_F1.0951.00
287_E291_A1.0881.00
352_N356_A1.0841.00
326_K330_Y1.0841.00
281_E285_L1.0821.00
270_K278_V1.0801.00
270_K274_D1.0781.00
295_H303_L1.0771.00
255_L273_V1.0771.00
271_E274_D1.0751.00
368_K375_L1.0741.00
315_M318_D1.0681.00
329_S344_G1.0671.00
292_L303_L1.0611.00
271_E276_A1.0571.00
42_A202_V1.0541.00
275_K278_V1.0461.00
283_E286_I1.0421.00
332_R336_I1.0411.00
316_Y319_L1.0371.00
269_R277_I1.0371.00
268_I271_E1.0341.00
363_A370_K1.0321.00
341_D345_I1.0301.00
285_L303_L1.0301.00
38_I205_K1.0271.00
366_E372_L1.0271.00
299_A304_I1.0251.00
269_R275_K1.0241.00
19_P22_F1.0221.00
29_F77_N1.0191.00
148_Y180_I1.0181.00
356_A360_K1.0171.00
191_E196_S1.0151.00
269_R276_A1.0121.00
328_L334_S1.0111.00
298_L302_S1.0081.00
370_K375_L1.0071.00
331_R337_I1.0011.00
367_D374_A0.9981.00
296_Y301_R0.9921.00
289_V297_K0.9901.00
289_V293_P0.9871.00
35_R38_I0.9871.00
295_H299_A0.9851.00
155_L166_Y0.9831.00
267_I274_D0.9831.00
272_H278_V0.9801.00
294_F298_L0.9801.00
295_H301_R0.9791.00
361_K365_V0.9781.00
367_D375_L0.9661.00
91_D144_R0.9641.00
346_V350_I0.9621.00
267_I273_V0.9581.00
217_S231_D0.9491.00
366_E375_L0.9481.00
337_I346_V0.9471.00
293_P299_A0.9431.00
159_R162_D0.9421.00
370_K374_A0.9401.00
292_L299_A0.9371.00
216_L237_I0.9301.00
347_K350_I0.9201.00
267_I271_E0.9181.00
348_I351_I0.9181.00
314_K317_T0.9161.00
340_L344_G0.9141.00
23_I26_L0.9131.00
291_A301_R0.9111.00
336_I340_L0.9101.00
343_F347_K0.9091.00
291_A303_L0.9070.99
340_L343_F0.9050.99
357_G361_K0.9010.99
364_L375_L0.9010.99
292_L301_R0.8940.99
319_L325_Q0.8900.99
369_E373_R0.8900.99
285_L290_K0.8850.99
364_L370_K0.8830.99
299_A302_S0.8830.99
338_S341_D0.8760.99
288_A297_K0.8740.99
291_A295_H0.8730.99
63_L183_D0.8730.99
138_N141_R0.8730.99
230_D267_I0.8720.99
313_H320_C0.8700.99
368_K371_V0.8680.99
309_V316_Y0.8650.99
361_K367_D0.8640.99
331_R336_I0.8610.99
71_V204_F0.8590.99
347_K351_I0.8590.99
288_A293_P0.8580.99
269_R278_V0.8560.99
337_I347_K0.8510.99
77_N81_E0.8490.99
337_I343_F0.8480.99
267_I272_H0.8470.99
342_M345_I0.8440.99
369_E372_L0.8380.99
36_E211_Q0.8380.99
361_K374_A0.8380.99
14_E17_K0.8380.99
333_F339_E0.8310.99
285_L296_Y0.8260.99
190_M193_R0.8230.99
358_G364_L0.8200.99
23_I28_V0.8170.99
337_I345_I0.8170.99
191_E198_L0.8160.99
337_I344_G0.8140.99
330_Y336_I0.8140.99
193_R198_L0.8130.99
294_F301_R0.8120.99
290_K296_Y0.8090.99
193_R197_S0.8090.99
268_I280_Y0.8080.99
331_R338_S0.8060.99
102_V135_K0.8060.99
331_R340_L0.8030.99
79_I94_Q0.8020.99
292_L295_H0.8010.99
282_Q286_I0.8000.99
270_K280_Y0.7990.99
312_A315_M0.7980.99
298_L301_R0.7930.99
286_I289_V0.7920.99
327_P331_R0.7900.99
291_A296_Y0.7880.99
320_C325_Q0.7850.99
330_Y338_S0.7840.99
132_Y135_K0.7810.98
310_M321_N0.7810.98
285_L293_P0.7790.98
330_Y340_L0.7770.98
293_P298_L0.7760.98
364_L371_V0.7730.98
334_S342_M0.7730.98
294_F300_L0.7720.98
330_Y341_D0.7710.98
334_S352_N0.7690.98
142_N145_A0.7650.98
333_F338_S0.7640.98
288_A303_L0.7630.98
273_V277_I0.7600.98
302_S305_E0.7580.98
190_M199_G0.7530.98
190_M196_S0.7520.98
216_L234_L0.7520.98
279_D282_Q0.7480.98
334_S339_E0.7460.98
337_I348_I0.7450.98
297_K302_S0.7440.98
368_K372_L0.7430.98
323_F326_K0.7420.98
358_G361_K0.7410.98
290_K294_F0.7410.98
25_P93_K0.7380.98
355_R359_V0.7380.98
293_P301_R0.7370.98
361_K375_L0.7340.98
343_F348_I0.7310.98
226_K268_I0.7310.98
284_R290_K0.7290.98
53_E252_V0.7270.98
167_Q171_S0.7260.98
324_K328_L0.7210.97
352_N355_R0.7200.97
128_N132_Y0.7160.97
351_I354_G0.7160.97
313_H323_F0.7160.97
350_I354_G0.7160.97
341_D350_I0.7150.97
313_H321_N0.7130.97
295_H302_S0.7130.97
332_R337_I0.7120.97
330_Y343_F0.7100.97
334_S340_L0.7100.97
282_Q289_V0.7090.97
326_K334_S0.7080.97
293_P304_I0.7080.97
366_E374_A0.7070.97
333_F341_D0.7050.97
336_I345_I0.7040.97
341_D347_K0.7030.97
41_D44_I0.7020.97
191_E194_V0.7000.97
273_V278_V0.6950.97
267_I279_D0.6920.97
338_S345_I0.6870.97
264_G267_I0.6870.97
329_S341_D0.6870.97
334_S345_I0.6850.97
42_A58_N0.6850.97
361_K370_K0.6840.97
344_G347_K0.6840.97
367_D372_L0.6830.97
370_K373_R0.6810.96
288_A291_A0.6810.96
286_I293_P0.6750.96
290_K297_K0.6740.96
310_M324_K0.6740.96
361_K366_E0.6740.96
281_E288_A0.6740.96
268_I277_I0.6730.96
326_K329_S0.6720.96
355_R360_K0.6710.96
359_V367_D0.6710.96
337_I342_M0.6660.96
343_F352_N0.6650.96
44_I261_L0.6650.96
345_I353_R0.6590.96
312_A320_C0.6550.96
282_Q288_A0.6540.96
317_T320_C0.6500.95
298_L303_L0.6500.95
14_E95_A0.6490.95
328_L337_I0.6480.95
288_A296_Y0.6470.95
29_F32_I0.6450.95
93_K144_R0.6430.95
359_V362_Y0.6400.95
338_S343_F0.6370.95
18_N96_Y0.6360.95
365_V368_K0.6360.95
241_S245_H0.6340.95
291_A298_L0.6330.95
291_A304_I0.6300.95
344_G350_I0.6270.94
360_K363_A0.6270.94
292_L304_I0.6250.94
289_V300_L0.6240.94
275_K280_Y0.6230.94
99_C149_L0.6200.94
365_V371_V0.6200.94
319_L324_K0.6200.94
295_H298_L0.6190.94
193_R199_G0.6170.94
310_M323_F0.6170.94
331_R339_E0.6140.94
333_F336_I0.6130.94
237_I255_L0.6130.94
347_K354_G0.6110.94
350_I353_R0.6100.94
318_D323_F0.6090.94
336_I341_D0.6090.94
294_F302_S0.6060.93
341_D346_V0.6060.93
267_I278_V0.6050.93
334_S349_R0.6030.93
329_S335_D0.6030.93
327_P330_Y0.6000.93
285_L297_K0.6000.93
194_V198_L0.5970.93
286_I295_H0.5970.93
272_H280_Y0.5950.93
153_D182_N0.5910.92
278_V282_Q0.5880.92
134_D138_N0.5880.92
34_F214_F0.5860.92
366_E370_K0.5840.92
310_M320_C0.5830.92
316_Y325_Q0.5800.92
342_M353_R0.5790.92
177_V262_A0.5780.92
285_L300_L0.5770.92
332_R348_I0.5730.91
336_I343_F0.5720.91
236_Y240_I0.5710.91
323_F327_P0.5710.91
331_R341_D0.5700.91
359_V364_L0.5700.91
41_D257_R0.5690.91
312_A323_F0.5690.91
316_Y324_K0.5670.91
363_A374_A0.5670.91
283_E287_E0.5650.91
196_S199_G0.5620.90
294_F303_L0.5610.90
266_G270_K0.5590.90
295_H300_L0.5570.90
321_N324_K0.5560.90
330_Y335_D0.5550.90
332_R340_L0.5550.90
359_V363_A0.5550.90
244_E254_L0.5510.90
360_K365_V0.5510.90
362_Y366_E0.5500.90
360_K369_E0.5500.90
360_K367_D0.5490.89
20_K96_Y0.5470.89
341_D349_R0.5470.89
339_E347_K0.5450.89
329_S339_E0.5420.89
359_V370_K0.5400.89
194_V199_G0.5360.88
354_G357_G0.5340.88
296_Y302_S0.5340.88
291_A302_S0.5330.88
241_S250_K0.5310.88
329_S343_F0.5290.88
334_S348_I0.5290.88
55_K253_N0.5290.88
369_E375_L0.5280.88
347_K352_N0.5280.88
369_E374_A0.5270.87
364_L372_L0.5260.87
115_G135_K0.5260.87
314_K325_Q0.5240.87
53_E223_G0.5240.87
284_R292_L0.5240.87
314_K324_K0.5220.87
335_D341_D0.5200.87
289_V303_L0.5200.87
271_E278_V0.5190.87
336_I352_N0.5170.86
351_I359_V0.5170.86
190_M198_L0.5170.86
267_I281_E0.5160.86
281_E289_V0.5160.86
21_V80_E0.5150.86
335_D340_L0.5140.86
356_A361_K0.5140.86
287_E292_L0.5130.86
268_I275_K0.5120.86
221_E224_L0.5110.86
328_L331_R0.5110.86
290_K303_L0.5100.86
314_K320_C0.5050.85
292_L302_S0.5040.85
265_G270_K0.5030.85
364_L374_A0.5030.85
116_K130_G0.5030.85
266_G278_V0.5030.85
278_V281_E0.5030.85
329_S336_I0.5030.85
309_V312_A0.5020.85
195_L200_P0.5010.85
295_H304_I0.5010.85
366_E371_V0.5000.85
283_E288_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.8959 100 0.39 Contact Map
2v1uA 1 0.9365 100 0.393 Contact Map
2qbyB 1 0.9239 100 0.393 Contact Map
4xgcA 1 0.7513 100 0.403 Contact Map
1w5sA 1 0.9112 100 0.446 Contact Map
1fnnA 1 0.8858 100 0.486 Contact Map
4xgcD 1 0.9264 100 0.525 Contact Map
3te6A 1 0.665 100 0.574 Contact Map
4cr2I 1 0.6497 100 0.604 Contact Map
4cr2J 1 0.6345 100 0.609 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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