CDC63 - SULSO - GREMLIN Contacts

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CDC63 - ORC1-type DNA replication protein 3

UniProt:	Q97WM8	Sequences: MHVIRETLKGGKGEVIKNPKVFIDPLSVFKEIPFREDILRDAAIAIRYFVKNEVKFSNLFLGLTGTGKTFVSKYIFNEIEEVKKEDEEYKDVKQAYVNCREVGGTPQAVLSSLAGKLTGFSVPKHGINLGEYIDKIKNGTRNIRAIIYLDEVDTLVKRRGGDIVLYQLLRSDANISVIMISNDINVRDYMEPRVLSSLGPSVIFKPYDAEQLKFILSKYAEYGLIKGTYDDEILSYIAAISAKEHGDARKAVNLLFRAAQLASGGGIIRKEHVDKAIVDYEQERLIEAVKALPFHYKLALRSLIESEDVMSAHKMYTDLCNKFKQKPLSYRRFSDIISELDMFGIVKIRIINRGRAGGVKKYALVEDKEKVLRALNETFEDSISIGDFDDVGEN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	394 (335)
Sequences:	6628 (4210)
Seq/√Len:	230.0

HALSA - CDC6A CDC65 CDC68 CDC64 CDC66 Q9HNS7 CDC67 CDC69 CDC62 CDC61
SULSO - CDC63 CDC61 CDC62

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
22_F	26_L	4.504	1.00
17_K	95_A	3.885	1.00
19_P	93_K	3.406	1.00
137_K	141_R	3.244	1.00
18_N	23_I	2.841	1.00
285_L	288_A	2.485	1.00
100_R	168_L	2.460	1.00
293_P	296_Y	2.425	1.00
297_K	300_L	2.412	1.00
212_L	238_A	2.287	1.00
267_I	270_K	2.275	1.00
213_K	235_S	2.143	1.00
293_P	297_K	2.138	1.00
318_D	322_K	2.082	1.00
296_Y	300_L	2.077	1.00
87_E	90_K	2.050	1.00
288_A	292_L	2.034	1.00
208_D	211_Q	2.008	1.00
299_A	303_L	2.007	1.00
329_S	333_F	2.007	1.00
209_A	238_A	1.994	1.00
337_I	341_D	1.986	1.00
140_T	174_N	1.950	1.00
59_L	152_V	1.946	1.00
338_S	342_M	1.933	1.00
265_G	272_H	1.933	1.00
330_Y	334_S	1.884	1.00
270_K	277_I	1.882	1.00
317_T	321_N	1.862	1.00
269_R	272_H	1.858	1.00
333_F	337_I	1.856	1.00
206_P	245_H	1.855	1.00
271_E	275_K	1.851	1.00
137_K	140_T	1.818	1.00
342_M	346_V	1.804	1.00
314_K	318_D	1.795	1.00
296_Y	299_A	1.789	1.00
335_D	339_E	1.768	1.00
313_H	317_T	1.768	1.00
316_Y	320_C	1.750	1.00
344_G	348_I	1.747	1.00
330_Y	337_I	1.732	1.00
310_M	314_K	1.725	1.00
294_F	297_K	1.717	1.00
330_Y	333_F	1.717	1.00
216_L	251_A	1.708	1.00
335_D	338_S	1.702	1.00
341_D	344_G	1.702	1.00
305_E	308_D	1.691	1.00
116_K	127_I	1.684	1.00
334_S	337_I	1.667	1.00
296_Y	303_L	1.650	1.00
300_L	303_L	1.645	1.00
220_A	255_L	1.630	1.00
274_D	278_V	1.627	1.00
300_L	304_I	1.595	1.00
297_K	304_I	1.590	1.00
276_A	280_Y	1.587	1.00
334_S	338_S	1.574	1.00
213_K	217_S	1.572	1.00
320_C	324_K	1.555	1.00
267_I	277_I	1.508	1.00
371_V	374_A	1.503	1.00
281_E	284_R	1.502	1.00
270_K	273_V	1.493	1.00
331_R	334_S	1.479	1.00
287_E	290_K	1.469	1.00
346_V	349_R	1.465	1.00
277_I	280_Y	1.453	1.00
272_H	276_A	1.450	1.00
270_K	276_A	1.447	1.00
14_E	22_F	1.435	1.00
312_A	316_Y	1.434	1.00
267_I	276_A	1.424	1.00
209_A	242_A	1.418	1.00
361_K	364_L	1.417	1.00
273_V	276_A	1.410	1.00
297_K	303_L	1.408	1.00
329_S	334_S	1.405	1.00
209_A	239_A	1.402	1.00
339_E	342_M	1.387	1.00
357_G	360_K	1.384	1.00
193_R	196_S	1.380	1.00
329_S	337_I	1.366	1.00
285_L	292_L	1.363	1.00
297_K	301_R	1.363	1.00
329_S	332_R	1.354	1.00
292_L	296_Y	1.352	1.00
268_I	278_V	1.351	1.00
220_A	234_L	1.345	1.00
364_L	367_D	1.341	1.00
293_P	303_L	1.331	1.00
296_Y	304_I	1.325	1.00
311_S	315_M	1.323	1.00
361_K	372_L	1.317	1.00
367_D	371_V	1.311	1.00
152_V	179_M	1.309	1.00
367_D	370_K	1.305	1.00
276_A	279_D	1.301	1.00
363_A	367_D	1.299	1.00
286_I	290_K	1.297	1.00
292_L	300_L	1.295	1.00
213_K	234_L	1.288	1.00
292_L	297_K	1.285	1.00
337_I	340_L	1.283	1.00
268_I	274_D	1.282	1.00
313_H	316_Y	1.269	1.00
360_K	364_L	1.268	1.00
235_S	239_A	1.265	1.00
332_R	335_D	1.261	1.00
320_C	323_F	1.254	1.00
321_N	325_Q	1.254	1.00
329_S	340_L	1.249	1.00
361_K	371_V	1.244	1.00
340_L	347_K	1.242	1.00
345_I	349_R	1.241	1.00
333_F	340_L	1.235	1.00
156_V	194_V	1.231	1.00
273_V	280_Y	1.228	1.00
345_I	352_N	1.218	1.00
275_K	279_D	1.217	1.00
334_S	341_D	1.211	1.00
336_I	339_E	1.208	1.00
60_F	204_F	1.204	1.00
269_R	273_V	1.200	1.00
82_V	90_K	1.197	1.00
371_V	375_L	1.195	1.00
268_I	276_A	1.193	1.00
365_V	370_K	1.190	1.00
284_R	288_A	1.183	1.00
285_L	289_V	1.182	1.00
356_A	359_V	1.175	1.00
291_A	297_K	1.174	1.00
319_L	323_F	1.171	1.00
290_K	293_P	1.170	1.00
309_V	313_H	1.165	1.00
268_I	272_H	1.161	1.00
214_F	217_S	1.157	1.00
268_I	273_V	1.155	1.00
355_R	358_G	1.149	1.00
343_F	346_V	1.148	1.00
349_R	353_R	1.144	1.00
293_P	300_L	1.144	1.00
99_C	102_V	1.143	1.00
22_F	25_P	1.143	1.00
267_I	280_Y	1.139	1.00
282_Q	285_L	1.134	1.00
301_R	304_I	1.129	1.00
339_E	343_F	1.127	1.00
265_G	269_R	1.126	1.00
331_R	335_D	1.124	1.00
345_I	348_I	1.105	1.00
372_L	375_L	1.105	1.00
364_L	368_K	1.104	1.00
236_Y	239_A	1.104	1.00
149_L	177_V	1.100	1.00
267_I	275_K	1.100	1.00
289_V	292_L	1.098	1.00
316_Y	323_F	1.095	1.00
287_E	291_A	1.088	1.00
352_N	356_A	1.084	1.00
326_K	330_Y	1.084	1.00
281_E	285_L	1.082	1.00
270_K	278_V	1.080	1.00
270_K	274_D	1.078	1.00
295_H	303_L	1.077	1.00
255_L	273_V	1.077	1.00
271_E	274_D	1.075	1.00
368_K	375_L	1.074	1.00
315_M	318_D	1.068	1.00
329_S	344_G	1.067	1.00
292_L	303_L	1.061	1.00
271_E	276_A	1.057	1.00
42_A	202_V	1.054	1.00
275_K	278_V	1.046	1.00
283_E	286_I	1.042	1.00
332_R	336_I	1.041	1.00
316_Y	319_L	1.037	1.00
269_R	277_I	1.037	1.00
268_I	271_E	1.034	1.00
363_A	370_K	1.032	1.00
341_D	345_I	1.030	1.00
285_L	303_L	1.030	1.00
38_I	205_K	1.027	1.00
366_E	372_L	1.027	1.00
299_A	304_I	1.025	1.00
269_R	275_K	1.024	1.00
19_P	22_F	1.022	1.00
29_F	77_N	1.019	1.00
148_Y	180_I	1.018	1.00
356_A	360_K	1.017	1.00
191_E	196_S	1.015	1.00
269_R	276_A	1.012	1.00
328_L	334_S	1.011	1.00
298_L	302_S	1.008	1.00
370_K	375_L	1.007	1.00
331_R	337_I	1.001	1.00
367_D	374_A	0.998	1.00
296_Y	301_R	0.992	1.00
289_V	297_K	0.990	1.00
289_V	293_P	0.987	1.00
35_R	38_I	0.987	1.00
295_H	299_A	0.985	1.00
155_L	166_Y	0.983	1.00
267_I	274_D	0.983	1.00
272_H	278_V	0.980	1.00
294_F	298_L	0.980	1.00
295_H	301_R	0.979	1.00
361_K	365_V	0.978	1.00
367_D	375_L	0.966	1.00
91_D	144_R	0.964	1.00
346_V	350_I	0.962	1.00
267_I	273_V	0.958	1.00
217_S	231_D	0.949	1.00
366_E	375_L	0.948	1.00
337_I	346_V	0.947	1.00
293_P	299_A	0.943	1.00
159_R	162_D	0.942	1.00
370_K	374_A	0.940	1.00
292_L	299_A	0.937	1.00
216_L	237_I	0.930	1.00
347_K	350_I	0.920	1.00
267_I	271_E	0.918	1.00
348_I	351_I	0.918	1.00
314_K	317_T	0.916	1.00
340_L	344_G	0.914	1.00
23_I	26_L	0.913	1.00
291_A	301_R	0.911	1.00
336_I	340_L	0.910	1.00
343_F	347_K	0.909	1.00
291_A	303_L	0.907	0.99
340_L	343_F	0.905	0.99
357_G	361_K	0.901	0.99
364_L	375_L	0.901	0.99
292_L	301_R	0.894	0.99
319_L	325_Q	0.890	0.99
369_E	373_R	0.890	0.99
285_L	290_K	0.885	0.99
364_L	370_K	0.883	0.99
299_A	302_S	0.883	0.99
338_S	341_D	0.876	0.99
288_A	297_K	0.874	0.99
291_A	295_H	0.873	0.99
63_L	183_D	0.873	0.99
138_N	141_R	0.873	0.99
230_D	267_I	0.872	0.99
313_H	320_C	0.870	0.99
368_K	371_V	0.868	0.99
309_V	316_Y	0.865	0.99
361_K	367_D	0.864	0.99
331_R	336_I	0.861	0.99
71_V	204_F	0.859	0.99
347_K	351_I	0.859	0.99
288_A	293_P	0.858	0.99
269_R	278_V	0.856	0.99
337_I	347_K	0.851	0.99
77_N	81_E	0.849	0.99
337_I	343_F	0.848	0.99
267_I	272_H	0.847	0.99
342_M	345_I	0.844	0.99
369_E	372_L	0.838	0.99
36_E	211_Q	0.838	0.99
361_K	374_A	0.838	0.99
14_E	17_K	0.838	0.99
333_F	339_E	0.831	0.99
285_L	296_Y	0.826	0.99
190_M	193_R	0.823	0.99
358_G	364_L	0.820	0.99
23_I	28_V	0.817	0.99
337_I	345_I	0.817	0.99
191_E	198_L	0.816	0.99
337_I	344_G	0.814	0.99
330_Y	336_I	0.814	0.99
193_R	198_L	0.813	0.99
294_F	301_R	0.812	0.99
290_K	296_Y	0.809	0.99
193_R	197_S	0.809	0.99
268_I	280_Y	0.808	0.99
331_R	338_S	0.806	0.99
102_V	135_K	0.806	0.99
331_R	340_L	0.803	0.99
79_I	94_Q	0.802	0.99
292_L	295_H	0.801	0.99
282_Q	286_I	0.800	0.99
270_K	280_Y	0.799	0.99
312_A	315_M	0.798	0.99
298_L	301_R	0.793	0.99
286_I	289_V	0.792	0.99
327_P	331_R	0.790	0.99
291_A	296_Y	0.788	0.99
320_C	325_Q	0.785	0.99
330_Y	338_S	0.784	0.99
132_Y	135_K	0.781	0.98
310_M	321_N	0.781	0.98
285_L	293_P	0.779	0.98
330_Y	340_L	0.777	0.98
293_P	298_L	0.776	0.98
364_L	371_V	0.773	0.98
334_S	342_M	0.773	0.98
294_F	300_L	0.772	0.98
330_Y	341_D	0.771	0.98
334_S	352_N	0.769	0.98
142_N	145_A	0.765	0.98
333_F	338_S	0.764	0.98
288_A	303_L	0.763	0.98
273_V	277_I	0.760	0.98
302_S	305_E	0.758	0.98
190_M	199_G	0.753	0.98
190_M	196_S	0.752	0.98
216_L	234_L	0.752	0.98
279_D	282_Q	0.748	0.98
334_S	339_E	0.746	0.98
337_I	348_I	0.745	0.98
297_K	302_S	0.744	0.98
368_K	372_L	0.743	0.98
323_F	326_K	0.742	0.98
358_G	361_K	0.741	0.98
290_K	294_F	0.741	0.98
25_P	93_K	0.738	0.98
355_R	359_V	0.738	0.98
293_P	301_R	0.737	0.98
361_K	375_L	0.734	0.98
343_F	348_I	0.731	0.98
226_K	268_I	0.731	0.98
284_R	290_K	0.729	0.98
53_E	252_V	0.727	0.98
167_Q	171_S	0.726	0.98
324_K	328_L	0.721	0.97
352_N	355_R	0.720	0.97
128_N	132_Y	0.716	0.97
351_I	354_G	0.716	0.97
313_H	323_F	0.716	0.97
350_I	354_G	0.716	0.97
341_D	350_I	0.715	0.97
313_H	321_N	0.713	0.97
295_H	302_S	0.713	0.97
332_R	337_I	0.712	0.97
330_Y	343_F	0.710	0.97
334_S	340_L	0.710	0.97
282_Q	289_V	0.709	0.97
326_K	334_S	0.708	0.97
293_P	304_I	0.708	0.97
366_E	374_A	0.707	0.97
333_F	341_D	0.705	0.97
336_I	345_I	0.704	0.97
341_D	347_K	0.703	0.97
41_D	44_I	0.702	0.97
191_E	194_V	0.700	0.97
273_V	278_V	0.695	0.97
267_I	279_D	0.692	0.97
338_S	345_I	0.687	0.97
264_G	267_I	0.687	0.97
329_S	341_D	0.687	0.97
334_S	345_I	0.685	0.97
42_A	58_N	0.685	0.97
361_K	370_K	0.684	0.97
344_G	347_K	0.684	0.97
367_D	372_L	0.683	0.97
370_K	373_R	0.681	0.96
288_A	291_A	0.681	0.96
286_I	293_P	0.675	0.96
290_K	297_K	0.674	0.96
310_M	324_K	0.674	0.96
361_K	366_E	0.674	0.96
281_E	288_A	0.674	0.96
268_I	277_I	0.673	0.96
326_K	329_S	0.672	0.96
355_R	360_K	0.671	0.96
359_V	367_D	0.671	0.96
337_I	342_M	0.666	0.96
343_F	352_N	0.665	0.96
44_I	261_L	0.665	0.96
345_I	353_R	0.659	0.96
312_A	320_C	0.655	0.96
282_Q	288_A	0.654	0.96
317_T	320_C	0.650	0.95
298_L	303_L	0.650	0.95
14_E	95_A	0.649	0.95
328_L	337_I	0.648	0.95
288_A	296_Y	0.647	0.95
29_F	32_I	0.645	0.95
93_K	144_R	0.643	0.95
359_V	362_Y	0.640	0.95
338_S	343_F	0.637	0.95
18_N	96_Y	0.636	0.95
365_V	368_K	0.636	0.95
241_S	245_H	0.634	0.95
291_A	298_L	0.633	0.95
291_A	304_I	0.630	0.95
344_G	350_I	0.627	0.94
360_K	363_A	0.627	0.94
292_L	304_I	0.625	0.94
289_V	300_L	0.624	0.94
275_K	280_Y	0.623	0.94
99_C	149_L	0.620	0.94
365_V	371_V	0.620	0.94
319_L	324_K	0.620	0.94
295_H	298_L	0.619	0.94
193_R	199_G	0.617	0.94
310_M	323_F	0.617	0.94
331_R	339_E	0.614	0.94
333_F	336_I	0.613	0.94
237_I	255_L	0.613	0.94
347_K	354_G	0.611	0.94
350_I	353_R	0.610	0.94
318_D	323_F	0.609	0.94
336_I	341_D	0.609	0.94
294_F	302_S	0.606	0.93
341_D	346_V	0.606	0.93
267_I	278_V	0.605	0.93
334_S	349_R	0.603	0.93
329_S	335_D	0.603	0.93
327_P	330_Y	0.600	0.93
285_L	297_K	0.600	0.93
194_V	198_L	0.597	0.93
286_I	295_H	0.597	0.93
272_H	280_Y	0.595	0.93
153_D	182_N	0.591	0.92
278_V	282_Q	0.588	0.92
134_D	138_N	0.588	0.92
34_F	214_F	0.586	0.92
366_E	370_K	0.584	0.92
310_M	320_C	0.583	0.92
316_Y	325_Q	0.580	0.92
342_M	353_R	0.579	0.92
177_V	262_A	0.578	0.92
285_L	300_L	0.577	0.92
332_R	348_I	0.573	0.91
336_I	343_F	0.572	0.91
236_Y	240_I	0.571	0.91
323_F	327_P	0.571	0.91
331_R	341_D	0.570	0.91
359_V	364_L	0.570	0.91
41_D	257_R	0.569	0.91
312_A	323_F	0.569	0.91
316_Y	324_K	0.567	0.91
363_A	374_A	0.567	0.91
283_E	287_E	0.565	0.91
196_S	199_G	0.562	0.90
294_F	303_L	0.561	0.90
266_G	270_K	0.559	0.90
295_H	300_L	0.557	0.90
321_N	324_K	0.556	0.90
330_Y	335_D	0.555	0.90
332_R	340_L	0.555	0.90
359_V	363_A	0.555	0.90
244_E	254_L	0.551	0.90
360_K	365_V	0.551	0.90
362_Y	366_E	0.550	0.90
360_K	369_E	0.550	0.90
360_K	367_D	0.549	0.89
20_K	96_Y	0.547	0.89
341_D	349_R	0.547	0.89
339_E	347_K	0.545	0.89
329_S	339_E	0.542	0.89
359_V	370_K	0.540	0.89
194_V	199_G	0.536	0.88
354_G	357_G	0.534	0.88
296_Y	302_S	0.534	0.88
291_A	302_S	0.533	0.88
241_S	250_K	0.531	0.88
329_S	343_F	0.529	0.88
334_S	348_I	0.529	0.88
55_K	253_N	0.529	0.88
369_E	375_L	0.528	0.88
347_K	352_N	0.528	0.88
369_E	374_A	0.527	0.87
364_L	372_L	0.526	0.87
115_G	135_K	0.526	0.87
314_K	325_Q	0.524	0.87
53_E	223_G	0.524	0.87
284_R	292_L	0.524	0.87
314_K	324_K	0.522	0.87
335_D	341_D	0.520	0.87
289_V	303_L	0.520	0.87
271_E	278_V	0.519	0.87
336_I	352_N	0.517	0.86
351_I	359_V	0.517	0.86
190_M	198_L	0.517	0.86
267_I	281_E	0.516	0.86
281_E	289_V	0.516	0.86
21_V	80_E	0.515	0.86
335_D	340_L	0.514	0.86
356_A	361_K	0.514	0.86
287_E	292_L	0.513	0.86
268_I	275_K	0.512	0.86
221_E	224_L	0.511	0.86
328_L	331_R	0.511	0.86
290_K	303_L	0.510	0.86
314_K	320_C	0.505	0.85
292_L	302_S	0.504	0.85
265_G	270_K	0.503	0.85
364_L	374_A	0.503	0.85
116_K	130_G	0.503	0.85
266_G	278_V	0.503	0.85
278_V	281_E	0.503	0.85
329_S	336_I	0.503	0.85
309_V	312_A	0.502	0.85
195_L	200_P	0.501	0.85
295_H	304_I	0.501	0.85
366_E	371_V	0.500	0.85
283_E	288_A	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2qbyA	1	0.8959	100	0.39	Contact Map
2v1uA	1	0.9365	100	0.393	Contact Map
2qbyB	1	0.9239	100	0.393	Contact Map
4xgcA	1	0.7513	100	0.403	Contact Map
1w5sA	1	0.9112	100	0.446	Contact Map
1fnnA	1	0.8858	100	0.486	Contact Map
4xgcD	1	0.9264	100	0.525	Contact Map
3te6A	1	0.665	100	0.574	Contact Map
4cr2I	1	0.6497	100	0.604	Contact Map
4cr2J	1	0.6345	100	0.609	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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