GREMLIN Database
Q97WM7 - Uncharacterized protein
UniProt: Q97WM7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (227)
Sequences: 127 (95)
Seq/√Len: 6.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_I187_A4.0350.95
196_Y200_A3.1800.84
48_I89_L3.0500.81
60_L168_A2.9460.78
49_G84_I2.7810.74
222_Y233_L2.7250.72
122_L168_A2.6600.70
32_I93_L2.5710.68
132_L160_L2.5590.67
45_G92_A2.5450.67
38_F92_A2.4800.65
225_F228_Y2.4330.63
60_L118_A2.3620.61
44_V48_I2.3040.59
73_V171_L2.2630.57
48_I173_I2.2600.57
160_L187_A2.0560.50
80_V185_F2.0260.49
41_I92_A1.9920.47
49_G85_I1.9730.47
39_V183_Y1.9270.45
162_A193_V1.9030.44
97_Q121_L1.8740.43
44_V55_S1.8380.42
42_L92_A1.8300.42
35_I69_V1.8290.42
96_L207_V1.7790.40
121_L136_M1.7560.39
32_I136_M1.7230.38
223_G228_Y1.7130.38
159_G200_A1.6790.36
197_A200_A1.6470.35
142_A168_A1.5760.33
149_I183_Y1.5700.33
72_S187_A1.5690.33
97_Q129_V1.5560.32
108_I137_Q1.5510.32
107_Q160_L1.5380.32
73_V89_L1.5280.32
98_L121_L1.5250.31
64_F177_I1.5240.31
169_A209_F1.5170.31
119_I173_I1.5090.31
81_K200_A1.5070.31
183_Y186_Y1.4970.31
162_A185_F1.4760.30
22_S59_F1.4690.30
45_G207_V1.4600.29
36_I52_V1.4500.29
36_I152_I1.4260.28
119_I239_I1.3990.28
81_K207_V1.3930.27
111_Y205_V1.3760.27
72_S133_V1.3670.27
32_I192_A1.3620.27
152_I173_I1.3560.26
119_I152_I1.3460.26
118_A168_A1.3440.26
121_L159_G1.3360.26
160_L175_S1.3350.26
164_I176_V1.3220.25
115_L179_Y1.3210.25
13_A16_S1.3210.25
117_G209_F1.3190.25
17_I52_V1.3130.25
60_L80_V1.3070.25
167_V222_Y1.3060.25
40_I127_T1.2720.24
66_E198_A1.2640.24
118_A174_F1.2560.24
77_A84_I1.2480.23
224_R231_V1.2460.23
174_F213_N1.2310.23
112_L190_L1.2310.23
140_I197_A1.2280.23
53_A184_V1.2250.23
37_L85_I1.2170.23
31_A35_I1.2140.23
72_S83_L1.2090.22
48_I76_I1.2070.22
68_H118_A1.1990.22
45_G73_V1.1980.22
23_G90_S1.1950.22
56_I116_A1.1820.22
87_I191_G1.1810.22
48_I126_L1.1770.22
118_A171_L1.1750.22
157_R171_L1.1690.21
55_S128_L1.1550.21
157_R233_L1.1540.21
213_N221_N1.1510.21
105_I116_A1.1470.21
202_I240_V1.1380.21
92_A210_A1.1370.21
35_I43_L1.1310.21
37_L204_K1.1310.21
69_V215_D1.1300.21
16_S117_G1.1260.20
29_I119_I1.1210.20
48_I119_I1.1210.20
51_I69_V1.1150.20
59_F131_I1.0950.20
183_Y204_K1.0890.20
112_L115_L1.0880.20
216_L237_A1.0870.20
37_L206_L1.0870.20
76_I142_A1.0850.19
31_A177_I1.0820.19
84_I189_I1.0720.19
99_G112_L1.0660.19
32_I79_T1.0620.19
115_L149_I1.0560.19
51_I168_A1.0540.19
27_S226_I1.0480.19
31_A162_A1.0450.19
92_A207_V1.0430.19
77_A193_V1.0310.18
88_A202_I1.0260.18
141_G145_Q1.0230.18
233_L242_P1.0200.18
111_Y150_T1.0110.18
43_L47_I1.0070.18
20_A109_A1.0040.18
230_I235_A1.0000.18
36_I57_R0.9990.18
92_A96_L0.9950.18
47_I79_T0.9950.18
35_I101_A0.9870.17
60_L235_A0.9860.17
45_G160_L0.9860.17
47_I75_I0.9840.17
222_Y232_L0.9780.17
42_L196_Y0.9720.17
13_A77_A0.9690.17
67_E85_I0.9690.17
78_G127_T0.9630.17
85_I111_Y0.9580.17
35_I228_Y0.9520.17
17_I222_Y0.9470.17
147_D192_A0.9440.16
61_G94_S0.9440.16
133_V157_R0.9430.16
53_A78_G0.9430.16
178_P200_A0.9360.16
163_A170_A0.9240.16
92_A203_D0.9220.16
65_R183_Y0.9210.16
43_L103_G0.9170.16
112_L232_L0.9150.16
41_I155_V0.9150.16
132_L168_A0.9100.16
62_R138_R0.9100.16
68_H153_F0.8970.16
56_I87_I0.8940.15
74_D101_A0.8930.15
29_I162_A0.8850.15
122_L237_A0.8850.15
45_G88_A0.8800.15
176_V205_V0.8790.15
22_S89_L0.8740.15
122_L188_V0.8700.15
114_K222_Y0.8670.15
145_Q209_F0.8670.15
90_S94_S0.8640.15
85_I150_T0.8580.15
146_D190_L0.8550.15
102_S236_I0.8540.15
88_A96_L0.8500.15
56_I236_I0.8480.15
114_K175_S0.8480.15
115_L161_Y0.8460.15
115_L182_P0.8440.15
64_F188_V0.8430.15
148_L172_A0.8370.14
44_V101_A0.8330.14
166_T237_A0.8320.14
179_Y188_V0.8300.14
46_Y175_S0.8270.14
132_L135_Y0.8180.14
43_L215_D0.8160.14
86_L89_L0.8130.14
39_V194_I0.8120.14
102_S202_I0.8070.14
221_N224_R0.8070.14
101_A111_Y0.8060.14
130_N159_G0.8060.14
203_D206_L0.7980.14
74_D103_G0.7970.14
24_I55_S0.7970.14
76_I126_L0.7950.14
73_V157_R0.7920.14
112_L117_G0.7910.14
226_I241_E0.7900.14
106_Q145_Q0.7900.14
119_I233_L0.7860.14
35_I120_V0.7840.14
145_Q208_P0.7800.13
66_E202_I0.7790.13
121_L186_Y0.7790.13
121_L200_A0.7750.13
201_L209_F0.7710.13
124_I188_V0.7710.13
75_I97_Q0.7640.13
46_Y238_I0.7590.13
79_T136_M0.7590.13
99_G162_A0.7580.13
190_L215_D0.7580.13
38_F168_A0.7550.13
117_G185_F0.7500.13
171_L192_A0.7450.13
221_N231_V0.7430.13
168_A237_A0.7370.13
77_A112_L0.7340.13
227_L232_L0.7320.13
70_R76_I0.7300.13
67_E152_I0.7290.13
161_Y228_Y0.7280.13
202_I218_Y0.7250.13
175_S193_V0.7220.12
30_D43_L0.7220.12
93_L174_F0.7170.12
21_L182_P0.7130.12
146_D228_Y0.7120.12
43_L56_I0.7070.12
92_A152_I0.7040.12
127_T238_I0.7020.12
159_G187_A0.6990.12
17_I56_I0.6920.12
73_V205_V0.6850.12
98_L159_G0.6820.12
231_V236_I0.6820.12
222_Y231_V0.6760.12
205_V209_F0.6740.12
177_I197_A0.6730.12
194_I219_V0.6710.12
166_T172_A0.6690.12
93_L102_S0.6650.12
163_A208_P0.6640.12
42_L128_L0.6590.12
41_I86_L0.6560.11
97_Q206_L0.6510.11
153_F194_I0.6510.11
66_E129_V0.6510.11
166_T178_P0.6480.11
188_V194_I0.6450.11
58_T152_I0.6440.11
73_V211_N0.6440.11
91_I205_V0.6390.11
68_H139_Q0.6380.11
50_N132_L0.6380.11
85_I119_I0.6330.11
64_F81_K0.6310.11
77_A199_Y0.6300.11
75_I152_I0.6290.11
88_A92_A0.6280.11
149_I194_I0.6270.11
129_V197_A0.6270.11
94_S153_F0.6250.11
38_F45_G0.6230.11
133_V161_Y0.6220.11
65_R93_L0.6190.11
132_L202_I0.6180.11
52_V155_V0.6160.11
31_A43_L0.6120.11
40_I225_F0.6120.11
105_I110_N0.6120.11
201_L231_V0.6100.11
116_A134_D0.6090.11
87_I132_L0.6080.11
128_L154_N0.6060.11
68_H213_N0.6060.11
103_G147_D0.6050.11
32_I135_Y0.6050.11
87_I194_I0.6030.11
22_S123_T0.5980.11
46_Y172_A0.5970.11
52_V89_L0.5930.11
31_A208_P0.5930.11
105_I160_L0.5920.11
40_I202_I0.5910.11
65_R173_I0.5880.11
116_A211_N0.5880.11
34_S49_G0.5860.10
105_I132_L0.5850.10
44_V184_V0.5820.10
193_V218_Y0.5810.10
48_I203_D0.5790.10
85_I112_L0.5770.10
47_I59_F0.5770.10
76_I203_D0.5750.10
90_S233_L0.5750.10
122_L186_Y0.5740.10
126_L170_A0.5730.10
59_F123_T0.5730.10
50_N224_R0.5730.10
25_A41_I0.5700.10
25_A89_L0.5690.10
167_V205_V0.5650.10
119_I168_A0.5630.10
124_I214_P0.5610.10
40_I116_A0.5600.10
50_N102_S0.5560.10
128_L168_A0.5550.10
194_I199_Y0.5540.10
94_S99_G0.5540.10
120_V162_A0.5520.10
85_I155_V0.5520.10
134_D173_I0.5510.10
73_V110_N0.5510.10
44_V51_I0.5500.10
92_A240_V0.5490.10
19_Q122_L0.5450.10
191_G217_A0.5440.10
46_Y65_R0.5430.10
145_Q199_Y0.5420.10
45_G117_G0.5410.10
29_I63_I0.5410.10
105_I145_Q0.5410.10
72_S99_G0.5370.10
43_L146_D0.5360.10
39_V45_G0.5350.10
174_F212_S0.5300.10
98_L197_A0.5270.10
112_L211_N0.5240.10
49_G145_Q0.5230.10
111_Y230_I0.5230.10
115_L184_V0.5220.10
201_L205_V0.5210.10
37_L40_I0.5190.10
171_L180_V0.5190.10
13_A86_L0.5130.10
115_L168_A0.5130.10
30_D203_D0.5110.10
55_S150_T0.5090.09
50_N80_V0.5080.09
42_L96_L0.5070.09
28_I122_L0.5030.09
111_Y177_I0.5020.09
133_V174_F0.5020.09
81_K239_I0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ajiA 3 0.6085 99.1 0.839 Contact Map
4hw9A 3 0.5765 99.1 0.845 Contact Map
3udcA 3 0.5907 98.8 0.859 Contact Map
4czbA 2 0.8399 17 0.964 Contact Map
3e8tA 1 0.2206 14.1 0.965 Contact Map
4cz8A 2 0.8256 6.6 0.97 Contact Map
4xk8J 1 0.1352 6 0.97 Contact Map
2rqfA 1 0.2384 4.3 0.972 Contact Map
4gh4D 3 0.1246 3.9 0.973 Contact Map
4bwzA 2 0.8078 3.7 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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