GREMLIN Database
Q97WM3 - Uncharacterized protein
UniProt: Q97WM3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (219)
Sequences: 28740 (25187)
Seq/√Len: 1702.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
216_L219_E3.4321.00
250_R253_E3.3811.00
148_K151_D3.3631.00
182_N185_E3.3471.00
117_N120_K3.1291.00
63_K66_E2.9971.00
29_N32_Y2.8541.00
204_Y223_M2.6091.00
170_Y189_D2.3641.00
140_G156_L2.2311.00
242_A258_I2.2071.00
238_Y257_D2.1771.00
174_A190_L2.1611.00
208_G224_Y2.1321.00
136_Y155_D2.1061.00
207_L223_M2.0431.00
191_E207_L2.0231.00
211_K223_M1.9231.00
51_Y70_N1.8791.00
109_G125_I1.8751.00
177_Q189_D1.8701.00
245_L257_D1.8511.00
211_K219_E1.8461.00
55_G71_F1.8151.00
173_R189_D1.8001.00
139_R155_D1.7701.00
187_E191_E1.7691.00
157_S173_R1.7571.00
143_E155_D1.7231.00
105_R124_E1.6961.00
221_V225_S1.6951.00
21_A37_L1.6851.00
156_L172_Y1.6581.00
38_D54_K1.6331.00
143_E151_D1.6001.00
153_I157_S1.5991.00
225_S241_R1.5731.00
126_K139_R1.5641.00
241_R245_L1.5461.00
177_Q185_E1.5411.00
122_L126_K1.5311.00
224_Y240_R1.5271.00
34_L38_D1.5171.00
58_L70_N1.5151.00
112_Y124_E1.5111.00
190_L206_S1.4951.00
241_R257_D1.4931.00
112_Y120_K1.4901.00
139_R143_E1.4681.00
187_E211_K1.4641.00
211_K216_L1.4551.00
24_Q36_L1.4451.00
112_Y117_N1.4091.00
245_L253_E1.3881.00
54_K58_L1.3741.00
221_V245_L1.3531.00
58_L66_E1.3521.00
20_E24_Q1.3521.00
54_K70_N1.3491.00
177_Q182_N1.3451.00
153_I177_Q1.3441.00
24_Q32_Y1.3361.00
245_L250_R1.3321.00
187_E214_R1.3201.00
207_L211_K1.3121.00
221_V248_L1.3061.00
231_N234_Y1.3021.00
173_R177_Q1.2991.00
20_E36_L1.2981.00
34_L58_L1.2961.00
159_A169_L1.2781.00
227_S237_A1.2721.00
108_R124_E1.2591.00
193_A203_V1.2581.00
140_G152_A1.2561.00
143_E148_K1.2341.00
37_L53_L1.2291.00
106_K135_V1.2231.00
108_R112_Y1.2171.00
40_L50_A1.2161.00
58_L63_K1.2151.00
23_T27_N1.2131.00
226_K230_I1.1911.00
24_Q29_N1.1851.00
136_Y158_L1.1751.00
209_E240_R1.1701.00
239_V243_K1.1651.00
68_Y72_Q1.1641.00
205_F237_A1.1561.00
204_Y226_K1.1331.00
205_F240_R1.1261.00
25_Y57_I1.1021.00
120_K123_D1.0921.00
105_R127_V1.0881.00
122_L143_E1.0721.00
105_R128_V1.0691.00
51_Y73_K1.0691.00
170_Y192_I1.0541.00
137_K172_Y1.0511.00
111_I115_L1.0461.00
151_D154_I1.0451.00
137_K169_L1.0451.00
219_E222_D1.0431.00
51_Y74_A1.0391.00
125_I138_I1.0381.00
158_L162_K1.0311.00
228_I238_Y1.0281.00
171_F206_S1.0191.00
155_D158_L1.0161.00
22_Y26_K1.0161.00
178_R210_L1.0121.00
171_F203_V1.0081.00
208_G227_S1.0011.00
170_Y193_A0.9991.00
185_E188_N0.9901.00
192_I196_L0.9881.00
197_N200_Y0.9861.00
136_Y159_A0.9811.00
113_L142_S0.9781.00
153_I180_L0.9751.00
55_G67_A0.9711.00
226_K229_N0.9681.00
25_Y53_L0.9681.00
253_E256_A0.9581.00
175_L206_S0.9521.00
109_G121_A0.9471.00
70_N73_K0.9471.00
153_I173_R0.9421.00
205_F209_E0.9411.00
208_G220_A0.9321.00
212_E240_R0.9311.00
140_G159_A0.9301.00
246_M258_I0.9241.00
204_Y227_S0.9181.00
149_Y176_A0.9161.00
110_L138_I0.9141.00
187_E207_L0.9091.00
246_M251_E0.9081.00
178_R206_S0.9081.00
206_S209_E0.9021.00
174_A186_A0.8971.00
175_L179_E0.8951.00
32_Y35_K0.8901.00
66_E69_E0.8881.00
73_K77_K0.8881.00
36_L39_E0.8851.00
122_L146_L0.8801.00
34_L61_L0.8791.00
209_E213_S0.8751.00
52_S56_K0.8751.00
221_V241_R0.8751.00
109_G128_V0.8681.00
171_F175_L0.8651.00
141_I172_Y0.8601.00
56_K60_E0.8581.00
122_L139_R0.8571.00
194_I204_Y0.8561.00
55_G74_A0.8561.00
174_A193_A0.8391.00
220_A244_S0.8371.00
200_Y203_V0.8311.00
221_V244_S0.8301.00
160_I170_Y0.8271.00
184_K214_R0.8261.00
53_L56_K0.8191.00
21_A40_L0.8171.00
217_L248_L0.8171.00
242_A254_A0.8171.00
124_E127_V0.8151.00
217_L244_S0.8091.00
20_E23_T0.7981.00
172_Y175_L0.7971.00
22_Y53_L0.7951.00
64_L68_Y0.7911.00
187_E210_L0.7911.00
212_E247_K0.7911.00
136_Y162_K0.7901.00
110_L114_K0.7891.00
141_I145_K0.7871.00
189_D192_I0.7861.00
106_K110_L0.7861.00
201_A227_S0.7851.00
153_I176_A0.7811.00
193_A196_L0.7801.00
59_F67_A0.7771.00
48_K52_S0.7771.00
118_Y142_S0.7711.00
142_S146_L0.7711.00
218_E248_L0.7631.00
107_L110_L0.7631.00
30_L57_I0.7591.00
113_L121_A0.7581.00
34_L54_K0.7561.00
34_L57_I0.7551.00
192_I195_N0.7551.00
159_A162_K0.7551.00
204_Y230_I0.7491.00
228_I237_A0.7491.00
44_N47_L0.7471.00
158_L161_E0.7461.00
183_Y214_R0.7461.00
113_L118_Y0.7451.00
150_N180_L0.7411.00
234_Y237_A0.7401.00
128_V135_V0.7351.00
166_D169_L0.7311.00
59_F64_L0.7301.00
39_E43_Q0.7301.00
149_Y153_I0.7291.00
240_R243_K0.7291.00
106_K138_I0.7281.00
102_K128_V0.7241.00
183_Y210_L0.7231.00
52_S55_G0.7211.00
160_I173_R0.7161.00
41_I51_Y0.7121.00
223_M226_K0.7121.00
21_A33_A0.7101.00
144_L172_Y0.7091.00
154_I158_L0.7081.00
167_A193_A0.7061.00
33_A57_I0.7021.00
176_A180_L0.7011.00
212_E220_A0.7001.00
210_L214_R0.6981.00
246_M254_A0.6961.00
244_S248_L0.6941.00
217_L247_K0.6931.00
19_K23_T0.6931.00
159_A163_Y0.6861.00
144_L152_A0.6861.00
170_Y196_L0.6851.00
194_I203_V0.6821.00
212_E217_L0.6821.00
201_A205_F0.6811.00
243_K247_K0.6811.00
144_L149_Y0.6801.00
57_I61_L0.6801.00
138_I141_I0.6721.00
239_V242_A0.6721.00
25_Y30_L0.6701.00
40_L43_Q0.6691.00
48_K74_A0.6661.00
191_E195_N0.6581.00
183_Y187_E0.6531.00
212_E224_Y0.6521.00
225_S229_N0.6491.00
41_I54_K0.6481.00
222_D226_K0.6441.00
163_Y166_D0.6411.00
212_E244_S0.6411.00
123_D127_V0.6401.00
137_K141_I0.6381.00
141_I144_L0.6371.00
209_E212_E0.6361.00
155_D159_A0.6331.00
227_S230_I0.6331.00
149_Y180_L0.6321.00
184_K187_E0.6321.00
201_A231_N0.6311.00
202_E206_S0.6291.00
221_V250_R0.6281.00
224_Y237_A0.6271.00
69_E73_K0.6231.00
185_E189_D0.6221.00
144_L176_A0.6171.00
143_E146_L0.6121.00
219_E223_M0.6021.00
251_E255_Y0.6011.00
178_R186_A0.6011.00
24_Q27_N0.5981.00
242_A246_M0.5981.00
25_Y33_A0.5941.00
35_K39_E0.5931.00
72_Q75_E0.5921.00
178_R190_L0.5871.00
153_I182_N0.5801.00
113_L138_I0.5791.00
188_N192_I0.5761.00
103_D107_L0.5751.00
242_A257_D0.5721.00
119_E146_L0.5691.00
224_Y244_S0.5661.00
144_L179_E0.5651.00
175_L178_R0.5641.00
66_E70_N0.5631.00
178_R183_Y0.5621.00
160_I169_L0.5611.00
222_D225_S0.5611.00
36_L40_L0.5611.00
151_D155_D0.5591.00
39_E42_T0.5581.00
101_S104_S0.5581.00
51_Y77_K0.5531.00
235_R239_V0.5521.00
73_K76_D0.5511.00
31_N61_L0.5501.00
122_L151_D0.5501.00
243_K246_M0.5491.00
41_I50_A0.5491.00
236_N240_R0.5481.00
122_L148_K0.5471.00
157_S160_I0.5461.00
163_Y169_L0.5441.00
134_L138_I0.5421.00
35_K38_D0.5421.00
253_E257_D0.5411.00
102_K106_K0.5371.00
183_Y213_S0.5361.00
37_L54_K0.5341.00
52_S74_A0.5311.00
40_L44_N0.5311.00
21_A25_Y0.5291.00
235_R242_A0.5241.00
168_E172_Y0.5201.00
184_K188_N0.5181.00
137_K166_D0.5181.00
206_S210_L0.5171.00
201_A234_Y0.5141.00
218_E221_V0.5131.00
209_E224_Y0.5121.00
103_D106_K0.5111.00
47_L50_A0.5081.00
23_T26_K0.5061.00
167_A200_Y0.5041.00
144_L156_L0.5031.00
154_I157_S0.5031.00
55_G59_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w3bA 2 1 100 0.168 Contact Map
4ui9J 2 1 100 0.189 Contact Map
2xpiA 2 0.9963 100 0.2 Contact Map
3dssA 1 0.9251 100 0.206 Contact Map
4rg9A 2 0.764 100 0.211 Contact Map
4ui9C 2 1 100 0.214 Contact Map
2y4tA 1 1 100 0.215 Contact Map
4l9pA 1 0.9064 100 0.217 Contact Map
4eqfA 1 0.8839 100 0.226 Contact Map
4ui9F 2 0.9213 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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