GREMLIN Database
Q97WL9 - Erythrocyte band 7 membrane protein homolog
UniProt: Q97WL9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (233)
Sequences: 8446 (4826)
Seq/√Len: 316.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_R59_D5.0931.00
98_D101_K3.0111.00
43_F46_V2.9841.00
200_A204_L2.8181.00
95_K158_K2.7361.00
206_D210_Y2.7031.00
30_R33_E2.5021.00
198_R202_S2.2531.00
204_L208_S2.2441.00
199_Q202_S2.2281.00
139_E143_R2.2071.00
195_E199_Q2.2021.00
29_V35_A2.1551.00
45_R59_D2.1421.00
33_E63_V2.1321.00
101_K105_S2.0821.00
219_Q222_F2.0431.00
39_R44_L1.9841.00
116_L148_L1.9631.00
203_I206_D1.9471.00
95_K160_T1.9381.00
142_K146_E1.9211.00
35_A61_P1.9111.00
129_E132_E1.9061.00
221_R224_E1.8911.00
136_K139_E1.8871.00
127_Q143_R1.8671.00
124_I143_R1.8491.00
215_P219_Q1.8161.00
199_Q203_I1.7971.00
81_K129_E1.7711.00
201_A204_L1.7631.00
92_V117_A1.7541.00
202_S206_D1.7431.00
197_E201_A1.7421.00
38_L104_L1.7321.00
195_E198_R1.7231.00
209_A213_N1.7041.00
146_E150_V1.6981.00
143_R146_E1.6981.00
34_R66_L1.6951.00
210_Y213_N1.6881.00
149_D153_E1.6741.00
12_V16_I1.5961.00
25_S53_F1.5901.00
171_Q175_S1.5851.00
68_V160_T1.5651.00
97_V158_K1.5361.00
132_E136_K1.5291.00
44_L59_D1.5201.00
88_V125_V1.5141.00
207_A211_Y1.5101.00
34_R99_P1.4941.00
108_N111_V1.4861.00
205_A209_A1.4861.00
27_R54_L1.4821.00
64_V103_V1.4701.00
228_D231_Q1.4661.00
179_K182_E1.4641.00
224_E227_S1.4461.00
36_V103_V1.4371.00
20_I24_M1.4301.00
224_E228_D1.4271.00
27_R47_K1.4261.00
236_I239_V1.4171.00
113_V152_T1.4161.00
193_L197_E1.4101.00
189_A193_L1.4041.00
145_Q149_D1.3891.00
198_R206_D1.3601.00
35_A63_V1.3471.00
175_S179_K1.3371.00
90_A121_L1.3311.00
43_F100_Q1.3231.00
80_T133_L1.3171.00
47_K52_I1.3041.00
214_N217_A1.2951.00
181_A185_R1.2821.00
179_K186_L1.2711.00
26_F53_F1.2651.00
11_I15_I1.2631.00
55_I59_D1.2621.00
196_G200_A1.2381.00
222_F226_L1.2331.00
196_G199_Q1.2321.00
216_S219_Q1.2251.00
186_L189_A1.2161.00
216_S220_L1.2081.00
125_V133_L1.1961.00
196_G205_A1.1961.00
214_N218_L1.1951.00
182_E186_L1.1841.00
217_A221_R1.1821.00
38_L62_L1.1771.00
77_T87_S1.1731.00
102_A109_Y1.1671.00
215_P218_L1.1641.00
21_F25_S1.1621.00
184_E188_R1.1621.00
184_E187_R1.1511.00
206_D209_A1.1441.00
236_I240_P1.1431.00
196_G203_I1.1391.00
78_I125_V1.1241.00
188_R191_V1.1191.00
55_I58_V1.1191.00
48_G52_I1.1151.00
138_E142_K1.1081.00
197_E204_L1.1071.00
21_F57_F1.0831.00
187_R191_V1.0821.00
19_I23_A1.0711.00
40_L58_V1.0701.00
32_W65_D1.0661.00
219_Q223_L1.0631.00
101_K104_L1.0621.00
218_L229_I1.0601.00
171_Q174_L1.0451.00
34_R48_G1.0421.00
37_V59_D1.0281.00
225_T229_I1.0201.00
9_V13_F1.0191.00
72_E89_D1.0181.00
10_G14_L1.0051.00
208_S212_K1.0001.00
202_S205_A1.0001.00
25_S54_L0.9951.00
26_F51_I0.9941.00
226_L230_S0.9921.00
188_R192_I0.9911.00
147_I150_V0.9911.00
32_W67_R0.9851.00
28_V51_I0.9731.00
64_V96_V0.9661.00
120_S147_I0.9621.00
117_A148_L0.9531.00
220_L229_I0.9431.00
150_V153_E0.9421.00
197_E200_A0.9411.00
16_I20_I0.9341.00
235_L239_V0.9331.00
64_V99_P0.9331.00
208_S211_Y0.9221.00
18_I22_I0.9181.00
69_N110_N0.9141.00
215_P220_L0.9111.00
34_R46_V0.9081.00
24_M27_R0.9061.00
24_M54_L0.9021.00
128_M143_R0.8981.00
186_L190_K0.8981.00
198_R203_I0.8961.00
218_L222_F0.8941.00
190_K193_L0.8911.00
172_D175_S0.8891.00
13_F17_I0.8871.00
128_M140_I0.8861.00
72_E165_R0.8851.00
194_S201_A0.8761.00
194_S203_I0.8761.00
54_L59_D0.8761.00
71_V94_Y0.8741.00
119_T123_D0.8711.00
222_F229_I0.8681.00
17_I21_F0.8671.00
38_L60_R0.8621.00
89_D165_R0.8601.00
14_L18_I0.8541.00
198_R205_A0.8531.00
15_I19_I0.8401.00
168_R174_L0.8361.00
221_R225_T0.8331.00
218_L230_S0.8301.00
209_A212_K0.8301.00
180_Q184_E0.8251.00
196_G207_A0.8241.00
34_R38_L0.8191.00
21_F55_I0.8111.00
10_G13_F0.8091.00
143_R147_I0.8081.00
29_V63_V0.8061.00
235_L240_P0.8031.00
100_Q104_L0.7981.00
47_K61_P0.7981.00
222_F225_T0.7931.00
123_D147_I0.7921.00
220_L223_L0.7921.00
151_T155_W0.7901.00
152_T159_V0.7901.00
220_L227_S0.7851.00
201_A208_S0.7851.00
29_V61_P0.7841.00
97_V153_E0.7811.00
109_Y157_I0.7811.00
65_D69_N0.7791.00
139_E142_K0.7751.00
37_V47_K0.7741.00
71_V114_L0.7731.00
191_V195_E0.7721.00
149_D158_K0.7721.00
124_I127_Q0.7710.99
196_G209_A0.7700.99
103_V106_V0.7690.99
39_R55_I0.7580.99
11_I14_L0.7580.99
177_M180_Q0.7570.99
82_D131_D0.7540.99
37_V61_P0.7490.99
218_L223_L0.7340.99
195_E203_I0.7330.99
218_L227_S0.7310.99
123_D127_Q0.7300.99
151_T154_G0.7240.99
180_Q185_R0.7230.99
186_L193_L0.7220.99
27_R35_A0.7200.99
94_Y157_I0.7170.99
37_V45_R0.7140.99
112_A155_W0.7120.99
234_G238_V0.7080.99
192_I195_E0.7070.99
213_N217_A0.7020.99
222_F230_S0.7000.99
174_L178_A0.7000.99
29_V52_I0.6920.99
116_L151_T0.6900.99
202_S210_Y0.6890.99
220_L224_E0.6830.99
68_V93_Y0.6760.99
181_A184_E0.6750.99
232_R235_L0.6710.99
214_N225_T0.6680.99
220_L226_L0.6670.99
121_L144_I0.6640.98
32_W123_D0.6610.98
32_W66_L0.6570.98
153_E158_K0.6560.98
189_A192_I0.6540.98
228_D234_G0.6540.98
92_V159_V0.6490.98
203_I207_A0.6410.98
100_Q105_S0.6400.98
200_A203_I0.6390.98
9_V12_V0.6390.98
27_R52_I0.6390.98
84_V170_S0.6350.98
237_I240_P0.6340.98
70_T93_Y0.6320.98
66_L99_P0.6300.98
73_V114_L0.6300.98
194_S205_A0.6300.98
197_E207_A0.6290.98
132_E139_E0.6290.98
219_Q229_I0.6280.98
31_E49_P0.6280.98
84_V173_L0.6220.98
220_L225_T0.6180.98
14_L21_F0.6180.98
80_T86_V0.6180.98
31_E42_R0.6180.98
214_N219_Q0.6170.98
40_L51_I0.6140.98
197_E208_S0.6110.97
226_L229_I0.6050.97
198_R209_A0.6040.97
124_I147_I0.6040.97
199_Q206_D0.6030.97
122_R126_G0.6020.97
230_S234_G0.6010.97
33_E65_D0.5990.97
92_V173_L0.5970.97
54_L61_P0.5940.97
219_Q226_L0.5930.97
232_R238_V0.5910.97
229_I232_R0.5900.97
82_D130_L0.5900.97
216_S229_I0.5890.97
144_I148_L0.5880.97
150_V154_G0.5850.97
198_R207_A0.5820.97
230_S233_G0.5800.97
178_A185_R0.5790.96
107_F110_N0.5780.96
140_I164_I0.5780.96
77_T85_T0.5760.96
215_P221_R0.5760.96
217_A222_F0.5740.96
84_V169_L0.5740.96
124_I144_I0.5710.96
204_L207_A0.5680.96
80_T125_V0.5680.96
68_V161_A0.5630.96
84_V177_M0.5630.96
169_L173_L0.5630.96
141_N163_T0.5610.96
99_P103_V0.5600.96
211_Y217_A0.5590.96
124_I128_M0.5580.96
106_V112_A0.5560.96
217_A220_L0.5560.96
14_L17_I0.5560.96
39_R58_V0.5530.95
231_Q234_G0.5530.95
94_Y113_V0.5520.95
232_R236_I0.5510.95
20_I23_A0.5500.95
231_Q235_L0.5480.95
74_P89_D0.5460.95
89_D168_R0.5460.95
227_S230_S0.5420.95
21_F54_L0.5400.95
90_A117_A0.5390.95
194_S207_A0.5380.95
24_M28_V0.5350.95
222_F235_L0.5350.95
236_I241_A0.5340.94
86_V130_L0.5340.94
34_R49_P0.5330.94
203_I208_S0.5330.94
142_K145_Q0.5310.94
83_N184_E0.5290.94
170_S173_L0.5290.94
220_L238_V0.5260.94
29_V50_G0.5250.94
68_V95_K0.5240.94
86_V133_L0.5230.94
227_S231_Q0.5230.94
46_V99_P0.5230.94
102_A110_N0.5220.94
17_I20_I0.5220.94
228_D232_R0.5190.94
233_G236_I0.5190.94
216_S227_S0.5160.93
80_T130_L0.5150.93
216_S225_T0.5140.93
122_R167_I0.5140.93
216_S222_F0.5130.93
216_S230_S0.5130.93
128_M136_K0.5120.93
223_L229_I0.5110.93
148_L151_T0.5110.93
138_E141_N0.5100.93
225_T241_A0.5080.93
120_S151_T0.5080.93
40_L44_L0.5070.93
46_V100_Q0.5070.93
238_V241_A0.5030.93
119_T126_G0.5020.93
195_E201_A0.5020.93
202_S207_A0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bk6A 3 0.6367 100 0.482 Contact Map
4fvgA 2 0.4082 99.9 0.55 Contact Map
1winA 1 0.5019 99.9 0.571 Contact Map
2rpbA 1 0.4232 99.8 0.64 Contact Map
2zuoA 7 0.9438 95.8 0.886 Contact Map
4efaG 1 0.3184 15.5 0.95 Contact Map
4efaE 1 0.4682 15.4 0.95 Contact Map
2marA 1 0.4644 12.7 0.952 Contact Map
3v6iA 1 0.3558 8.9 0.955 Contact Map
5a2fA 1 0 8.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.