Q97WL9 - SULSO - GREMLIN Contacts

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Q97WL9 - Erythrocyte band 7 membrane protein homolog

UniProt:	Q97WL9	Sequences: MAISIGDIVGIVFLIIIIIIFIAMSFRVVREWERAVVLRLGRFLRVKGPGIIFLIPFVDRPLVVDLRVNTVEVPPQTILTKDNVTVSVDAVVYYKVVDPQKAVLSVFNYNVAVLNLAQTSLRDIVGQMELDELLSKREEINKRIQEILDVTTEGWGIKVTAVTIRDIRLSQDLLSAMAKQAEAERLRRAKVILSEGERQAASILADASAYYKNNPSALQLRFLETLSDISQRGGLIIVVPAGNEIYPTLGTSAALSTLSKKFQTETK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (233)
Sequences:	8446 (4826)
Seq/√Len:	316.1

ECOLI - HFLK QMCA HFLC YQIK
BACSU - YUAG
HALSA - Q9HSA8 Q9HHV6
SULSO - Q97WL9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_R	59_D	5.093	1.00
98_D	101_K	3.011	1.00
43_F	46_V	2.984	1.00
200_A	204_L	2.818	1.00
95_K	158_K	2.736	1.00
206_D	210_Y	2.703	1.00
30_R	33_E	2.502	1.00
198_R	202_S	2.253	1.00
204_L	208_S	2.244	1.00
199_Q	202_S	2.228	1.00
139_E	143_R	2.207	1.00
195_E	199_Q	2.202	1.00
29_V	35_A	2.155	1.00
45_R	59_D	2.142	1.00
33_E	63_V	2.132	1.00
101_K	105_S	2.082	1.00
219_Q	222_F	2.043	1.00
39_R	44_L	1.984	1.00
116_L	148_L	1.963	1.00
203_I	206_D	1.947	1.00
95_K	160_T	1.938	1.00
142_K	146_E	1.921	1.00
35_A	61_P	1.911	1.00
129_E	132_E	1.906	1.00
221_R	224_E	1.891	1.00
136_K	139_E	1.887	1.00
127_Q	143_R	1.867	1.00
124_I	143_R	1.849	1.00
215_P	219_Q	1.816	1.00
199_Q	203_I	1.797	1.00
81_K	129_E	1.771	1.00
201_A	204_L	1.763	1.00
92_V	117_A	1.754	1.00
202_S	206_D	1.743	1.00
197_E	201_A	1.742	1.00
38_L	104_L	1.732	1.00
195_E	198_R	1.723	1.00
209_A	213_N	1.704	1.00
146_E	150_V	1.698	1.00
143_R	146_E	1.698	1.00
34_R	66_L	1.695	1.00
210_Y	213_N	1.688	1.00
149_D	153_E	1.674	1.00
12_V	16_I	1.596	1.00
25_S	53_F	1.590	1.00
171_Q	175_S	1.585	1.00
68_V	160_T	1.565	1.00
97_V	158_K	1.536	1.00
132_E	136_K	1.529	1.00
44_L	59_D	1.520	1.00
88_V	125_V	1.514	1.00
207_A	211_Y	1.510	1.00
34_R	99_P	1.494	1.00
108_N	111_V	1.486	1.00
205_A	209_A	1.486	1.00
27_R	54_L	1.482	1.00
64_V	103_V	1.470	1.00
228_D	231_Q	1.466	1.00
179_K	182_E	1.464	1.00
224_E	227_S	1.446	1.00
36_V	103_V	1.437	1.00
20_I	24_M	1.430	1.00
224_E	228_D	1.427	1.00
27_R	47_K	1.426	1.00
236_I	239_V	1.417	1.00
113_V	152_T	1.416	1.00
193_L	197_E	1.410	1.00
189_A	193_L	1.404	1.00
145_Q	149_D	1.389	1.00
198_R	206_D	1.360	1.00
35_A	63_V	1.347	1.00
175_S	179_K	1.337	1.00
90_A	121_L	1.331	1.00
43_F	100_Q	1.323	1.00
80_T	133_L	1.317	1.00
47_K	52_I	1.304	1.00
214_N	217_A	1.295	1.00
181_A	185_R	1.282	1.00
179_K	186_L	1.271	1.00
26_F	53_F	1.265	1.00
11_I	15_I	1.263	1.00
55_I	59_D	1.262	1.00
196_G	200_A	1.238	1.00
222_F	226_L	1.233	1.00
196_G	199_Q	1.232	1.00
216_S	219_Q	1.225	1.00
186_L	189_A	1.216	1.00
216_S	220_L	1.208	1.00
125_V	133_L	1.196	1.00
196_G	205_A	1.196	1.00
214_N	218_L	1.195	1.00
182_E	186_L	1.184	1.00
217_A	221_R	1.182	1.00
38_L	62_L	1.177	1.00
77_T	87_S	1.173	1.00
102_A	109_Y	1.167	1.00
215_P	218_L	1.164	1.00
21_F	25_S	1.162	1.00
184_E	188_R	1.162	1.00
184_E	187_R	1.151	1.00
206_D	209_A	1.144	1.00
236_I	240_P	1.143	1.00
196_G	203_I	1.139	1.00
78_I	125_V	1.124	1.00
188_R	191_V	1.119	1.00
55_I	58_V	1.119	1.00
48_G	52_I	1.115	1.00
138_E	142_K	1.108	1.00
197_E	204_L	1.107	1.00
21_F	57_F	1.083	1.00
187_R	191_V	1.082	1.00
19_I	23_A	1.071	1.00
40_L	58_V	1.070	1.00
32_W	65_D	1.066	1.00
219_Q	223_L	1.063	1.00
101_K	104_L	1.062	1.00
218_L	229_I	1.060	1.00
171_Q	174_L	1.045	1.00
34_R	48_G	1.042	1.00
37_V	59_D	1.028	1.00
225_T	229_I	1.020	1.00
9_V	13_F	1.019	1.00
72_E	89_D	1.018	1.00
10_G	14_L	1.005	1.00
208_S	212_K	1.000	1.00
202_S	205_A	1.000	1.00
25_S	54_L	0.995	1.00
26_F	51_I	0.994	1.00
226_L	230_S	0.992	1.00
188_R	192_I	0.991	1.00
147_I	150_V	0.991	1.00
32_W	67_R	0.985	1.00
28_V	51_I	0.973	1.00
64_V	96_V	0.966	1.00
120_S	147_I	0.962	1.00
117_A	148_L	0.953	1.00
220_L	229_I	0.943	1.00
150_V	153_E	0.942	1.00
197_E	200_A	0.941	1.00
16_I	20_I	0.934	1.00
235_L	239_V	0.933	1.00
64_V	99_P	0.933	1.00
208_S	211_Y	0.922	1.00
18_I	22_I	0.918	1.00
69_N	110_N	0.914	1.00
215_P	220_L	0.911	1.00
34_R	46_V	0.908	1.00
24_M	27_R	0.906	1.00
24_M	54_L	0.902	1.00
128_M	143_R	0.898	1.00
186_L	190_K	0.898	1.00
198_R	203_I	0.896	1.00
218_L	222_F	0.894	1.00
190_K	193_L	0.891	1.00
172_D	175_S	0.889	1.00
13_F	17_I	0.887	1.00
128_M	140_I	0.886	1.00
72_E	165_R	0.885	1.00
194_S	201_A	0.876	1.00
194_S	203_I	0.876	1.00
54_L	59_D	0.876	1.00
71_V	94_Y	0.874	1.00
119_T	123_D	0.871	1.00
222_F	229_I	0.868	1.00
17_I	21_F	0.867	1.00
38_L	60_R	0.862	1.00
89_D	165_R	0.860	1.00
14_L	18_I	0.854	1.00
198_R	205_A	0.853	1.00
15_I	19_I	0.840	1.00
168_R	174_L	0.836	1.00
221_R	225_T	0.833	1.00
218_L	230_S	0.830	1.00
209_A	212_K	0.830	1.00
180_Q	184_E	0.825	1.00
196_G	207_A	0.824	1.00
34_R	38_L	0.819	1.00
21_F	55_I	0.811	1.00
10_G	13_F	0.809	1.00
143_R	147_I	0.808	1.00
29_V	63_V	0.806	1.00
235_L	240_P	0.803	1.00
100_Q	104_L	0.798	1.00
47_K	61_P	0.798	1.00
222_F	225_T	0.793	1.00
123_D	147_I	0.792	1.00
220_L	223_L	0.792	1.00
151_T	155_W	0.790	1.00
152_T	159_V	0.790	1.00
220_L	227_S	0.785	1.00
201_A	208_S	0.785	1.00
29_V	61_P	0.784	1.00
97_V	153_E	0.781	1.00
109_Y	157_I	0.781	1.00
65_D	69_N	0.779	1.00
139_E	142_K	0.775	1.00
37_V	47_K	0.774	1.00
71_V	114_L	0.773	1.00
191_V	195_E	0.772	1.00
149_D	158_K	0.772	1.00
124_I	127_Q	0.771	0.99
196_G	209_A	0.770	0.99
103_V	106_V	0.769	0.99
39_R	55_I	0.758	0.99
11_I	14_L	0.758	0.99
177_M	180_Q	0.757	0.99
82_D	131_D	0.754	0.99
37_V	61_P	0.749	0.99
218_L	223_L	0.734	0.99
195_E	203_I	0.733	0.99
218_L	227_S	0.731	0.99
123_D	127_Q	0.730	0.99
151_T	154_G	0.724	0.99
180_Q	185_R	0.723	0.99
186_L	193_L	0.722	0.99
27_R	35_A	0.720	0.99
94_Y	157_I	0.717	0.99
37_V	45_R	0.714	0.99
112_A	155_W	0.712	0.99
234_G	238_V	0.708	0.99
192_I	195_E	0.707	0.99
213_N	217_A	0.702	0.99
222_F	230_S	0.700	0.99
174_L	178_A	0.700	0.99
29_V	52_I	0.692	0.99
116_L	151_T	0.690	0.99
202_S	210_Y	0.689	0.99
220_L	224_E	0.683	0.99
68_V	93_Y	0.676	0.99
181_A	184_E	0.675	0.99
232_R	235_L	0.671	0.99
214_N	225_T	0.668	0.99
220_L	226_L	0.667	0.99
121_L	144_I	0.664	0.98
32_W	123_D	0.661	0.98
32_W	66_L	0.657	0.98
153_E	158_K	0.656	0.98
189_A	192_I	0.654	0.98
228_D	234_G	0.654	0.98
92_V	159_V	0.649	0.98
203_I	207_A	0.641	0.98
100_Q	105_S	0.640	0.98
200_A	203_I	0.639	0.98
9_V	12_V	0.639	0.98
27_R	52_I	0.639	0.98
84_V	170_S	0.635	0.98
237_I	240_P	0.634	0.98
70_T	93_Y	0.632	0.98
66_L	99_P	0.630	0.98
73_V	114_L	0.630	0.98
194_S	205_A	0.630	0.98
197_E	207_A	0.629	0.98
132_E	139_E	0.629	0.98
219_Q	229_I	0.628	0.98
31_E	49_P	0.628	0.98
84_V	173_L	0.622	0.98
220_L	225_T	0.618	0.98
14_L	21_F	0.618	0.98
80_T	86_V	0.618	0.98
31_E	42_R	0.618	0.98
214_N	219_Q	0.617	0.98
40_L	51_I	0.614	0.98
197_E	208_S	0.611	0.97
226_L	229_I	0.605	0.97
198_R	209_A	0.604	0.97
124_I	147_I	0.604	0.97
199_Q	206_D	0.603	0.97
122_R	126_G	0.602	0.97
230_S	234_G	0.601	0.97
33_E	65_D	0.599	0.97
92_V	173_L	0.597	0.97
54_L	61_P	0.594	0.97
219_Q	226_L	0.593	0.97
232_R	238_V	0.591	0.97
229_I	232_R	0.590	0.97
82_D	130_L	0.590	0.97
216_S	229_I	0.589	0.97
144_I	148_L	0.588	0.97
150_V	154_G	0.585	0.97
198_R	207_A	0.582	0.97
230_S	233_G	0.580	0.97
178_A	185_R	0.579	0.96
107_F	110_N	0.578	0.96
140_I	164_I	0.578	0.96
77_T	85_T	0.576	0.96
215_P	221_R	0.576	0.96
217_A	222_F	0.574	0.96
84_V	169_L	0.574	0.96
124_I	144_I	0.571	0.96
204_L	207_A	0.568	0.96
80_T	125_V	0.568	0.96
68_V	161_A	0.563	0.96
84_V	177_M	0.563	0.96
169_L	173_L	0.563	0.96
141_N	163_T	0.561	0.96
99_P	103_V	0.560	0.96
211_Y	217_A	0.559	0.96
124_I	128_M	0.558	0.96
106_V	112_A	0.556	0.96
217_A	220_L	0.556	0.96
14_L	17_I	0.556	0.96
39_R	58_V	0.553	0.95
231_Q	234_G	0.553	0.95
94_Y	113_V	0.552	0.95
232_R	236_I	0.551	0.95
20_I	23_A	0.550	0.95
231_Q	235_L	0.548	0.95
74_P	89_D	0.546	0.95
89_D	168_R	0.546	0.95
227_S	230_S	0.542	0.95
21_F	54_L	0.540	0.95
90_A	117_A	0.539	0.95
194_S	207_A	0.538	0.95
24_M	28_V	0.535	0.95
222_F	235_L	0.535	0.95
236_I	241_A	0.534	0.94
86_V	130_L	0.534	0.94
34_R	49_P	0.533	0.94
203_I	208_S	0.533	0.94
142_K	145_Q	0.531	0.94
83_N	184_E	0.529	0.94
170_S	173_L	0.529	0.94
220_L	238_V	0.526	0.94
29_V	50_G	0.525	0.94
68_V	95_K	0.524	0.94
86_V	133_L	0.523	0.94
227_S	231_Q	0.523	0.94
46_V	99_P	0.523	0.94
102_A	110_N	0.522	0.94
17_I	20_I	0.522	0.94
228_D	232_R	0.519	0.94
233_G	236_I	0.519	0.94
216_S	227_S	0.516	0.93
80_T	130_L	0.515	0.93
216_S	225_T	0.514	0.93
122_R	167_I	0.514	0.93
216_S	222_F	0.513	0.93
216_S	230_S	0.513	0.93
128_M	136_K	0.512	0.93
223_L	229_I	0.511	0.93
148_L	151_T	0.511	0.93
138_E	141_N	0.510	0.93
225_T	241_A	0.508	0.93
120_S	151_T	0.508	0.93
40_L	44_L	0.507	0.93
46_V	100_Q	0.507	0.93
238_V	241_A	0.503	0.93
119_T	126_G	0.502	0.93
195_E	201_A	0.502	0.93
202_S	207_A	0.500	0.92

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bk6A	3	0.6367	100	0.482	Contact Map
4fvgA	2	0.4082	99.9	0.55	Contact Map
1winA	1	0.5019	99.9	0.571	Contact Map
2rpbA	1	0.4232	99.8	0.64	Contact Map
2zuoA	7	0.9438	95.8	0.886	Contact Map
4efaG	1	0.3184	15.5	0.95	Contact Map
4efaE	1	0.4682	15.4	0.95	Contact Map
2marA	1	0.4644	12.7	0.952	Contact Map
3v6iA	1	0.3558	8.9	0.955	Contact Map
5a2fA	1	0	8.1	0.956	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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