GREMLIN Database
Q97WL6 - Uncharacterized protein
UniProt: Q97WL6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 537 (464)
Sequences: 1695 (1344)
Seq/√Len: 62.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_V82_M7.2421.00
319_A322_I6.1551.00
156_M441_I4.3241.00
157_G458_I4.0251.00
319_A326_K3.9921.00
169_N514_I3.7271.00
462_F497_V3.6071.00
170_M443_V3.5751.00
316_I319_A3.3741.00
158_V170_M3.2721.00
312_T318_S3.2431.00
430_A440_L3.1411.00
197_N435_K3.0791.00
134_E515_P2.9801.00
272_L276_E2.9401.00
410_I426_L2.8851.00
169_N464_H2.7751.00
134_E144_P2.7711.00
197_N432_Q2.7521.00
322_I326_K2.6821.00
23_G82_M2.6581.00
169_N462_F2.6461.00
380_T401_F2.6391.00
313_A319_A2.6051.00
37_L108_V2.5851.00
20_E81_D2.5701.00
198_G358_D2.5691.00
37_L48_V2.5321.00
499_V512_V2.5171.00
174_I193_V2.4841.00
292_T296_E2.4551.00
282_T288_I2.4371.00
462_F499_V2.2781.00
163_G434_R2.2351.00
464_H497_V2.2331.00
261_N264_Q2.2161.00
404_E443_V2.2001.00
427_V451_D2.1741.00
400_G441_I2.1641.00
431_T449_F2.1571.00
493_D496_Y2.1561.00
172_Y176_L2.1431.00
407_Q447_P2.1241.00
218_I222_I2.1201.00
315_G319_A2.1151.00
155_H162_T2.0781.00
178_S354_L2.0491.00
447_P457_M1.9651.00
260_Y264_Q1.9611.00
289_G292_T1.9501.00
312_T315_G1.9361.00
264_Q272_L1.9181.00
138_L145_L1.9001.00
38_L45_L1.8921.00
316_I327_V1.8851.00
168_Y495_G1.8801.00
446_R470_D1.8691.00
383_I438_A1.8471.00
315_G326_K1.8431.00
176_L515_P1.8411.00
152_I156_M1.8341.00
271_V274_N1.8231.00
37_L82_M1.8211.00
408_N432_Q1.8121.00
175_K521_G1.8091.00
312_T316_I1.7961.00
192_I357_I1.7951.00
109_R119_E1.7891.00
257_E260_Y1.7831.00
197_N443_V1.7821.00
446_R457_M1.7801.00
319_A324_K1.7490.99
293_L296_E1.7320.99
263_L266_N1.7270.99
316_I326_K1.7120.99
315_G318_S1.6970.99
449_F453_Y1.6970.99
446_R501_G1.6910.99
518_P522_S1.6890.99
312_T319_A1.6880.99
14_Q22_Q1.6850.99
432_Q435_K1.6810.99
456_S470_D1.6710.99
155_H433_G1.6560.99
264_Q267_F1.6530.99
8_I11_I1.6330.99
194_I379_I1.6240.99
322_I329_S1.6090.99
237_D240_I1.6010.99
402_V441_I1.5930.99
496_Y513_R1.5870.99
199_D435_K1.5860.99
16_S21_M1.5670.99
319_A329_S1.5490.99
137_A144_P1.5440.99
404_E428_T1.5300.99
309_T315_G1.5290.99
315_G322_I1.5150.98
197_N464_H1.4890.98
161_E444_S1.4790.98
116_S119_E1.4660.98
157_G404_E1.4580.98
436_F457_M1.4540.98
326_K329_S1.4380.98
404_E449_F1.4350.98
171_R523_Y1.4230.98
195_D435_K1.4220.98
263_L267_F1.4210.98
319_A327_V1.4190.98
131_G148_D1.4080.97
165_G195_D1.4000.97
176_L179_N1.3720.97
407_Q432_Q1.3700.97
315_G323_F1.3680.97
457_M470_D1.3640.97
322_I325_N1.3570.97
67_A70_I1.3490.97
326_K330_R1.3420.97
463_F489_L1.3420.97
344_T348_I1.3370.97
311_G315_G1.3340.96
443_V464_H1.3160.96
291_E295_N1.3160.96
427_V453_Y1.3090.96
501_G509_P1.3050.96
309_T313_A1.3030.96
37_L266_N1.3000.96
384_F433_G1.2840.96
427_V444_S1.2820.96
23_G108_V1.2810.96
269_E276_E1.2800.96
319_A323_F1.2780.96
157_G455_L1.2770.95
318_S322_I1.2760.95
270_Q274_N1.2680.95
345_L348_I1.2660.95
315_G320_L1.2580.95
430_A454_V1.2580.95
68_K72_K1.2520.95
324_K328_I1.2450.95
445_Q457_M1.2440.95
483_E487_K1.2440.95
383_I399_L1.2420.95
432_Q456_S1.2370.95
314_R317_A1.2340.95
257_E261_N1.2300.94
116_S122_S1.2290.94
269_E272_L1.2200.94
39_V48_V1.2170.94
518_P521_G1.2060.94
98_H436_F1.2040.94
332_Q335_N1.2030.94
380_T429_L1.1940.94
155_H434_R1.1890.93
167_S444_S1.1880.93
380_T426_L1.1880.93
155_H459_N1.1870.93
309_T312_T1.1860.93
159_F458_I1.1770.93
8_I107_F1.1760.93
469_E472_R1.1720.93
118_K121_L1.1630.93
317_A321_E1.1630.93
199_D457_M1.1630.93
308_I318_S1.1600.93
301_A305_D1.1600.93
314_R319_A1.1540.92
432_Q436_F1.1450.92
407_Q457_M1.1450.92
252_S257_E1.1420.92
276_E279_E1.1400.92
8_I26_R1.1390.92
198_G360_S1.1380.92
276_E281_N1.1330.92
38_L109_R1.1300.92
320_L330_R1.1240.91
291_E298_L1.1190.91
447_P470_D1.1150.91
316_I324_K1.1120.91
40_D109_R1.1120.91
314_R329_S1.1030.91
155_H465_R1.1010.90
311_G317_A1.1010.90
148_D151_A1.1000.90
150_N444_S1.1000.90
219_K222_I1.0940.90
196_A443_V1.0930.90
270_Q275_H1.0850.90
13_L24_L1.0820.90
435_K445_Q1.0820.90
296_E299_T1.0810.90
164_S465_R1.0810.90
313_A321_E1.0750.89
167_S199_D1.0740.89
194_I376_V1.0690.89
264_Q270_Q1.0600.89
195_D406_A1.0540.88
117_E142_E1.0520.88
12_V33_V1.0450.88
200_Y404_E1.0440.88
407_Q431_T1.0430.88
409_Y458_I1.0380.88
446_R456_S1.0290.87
200_Y406_A1.0250.87
309_T316_I1.0240.87
325_N328_I1.0210.87
200_Y435_K1.0190.87
275_H279_E1.0180.87
519_R522_S1.0160.87
456_S501_G1.0110.86
160_G443_V1.0080.86
117_E121_L0.9980.86
270_Q279_E0.9970.85
420_N451_D0.9950.85
147_L499_V0.9940.85
274_N278_K0.9920.85
157_G428_T0.9900.85
157_G444_S0.9890.85
274_N296_E0.9860.85
275_H278_K0.9800.84
195_D444_S0.9780.84
279_E282_T0.9770.84
155_H437_G0.9740.84
422_T470_D0.9730.84
309_T317_A0.9690.84
470_D501_G0.9670.84
313_A316_I0.9620.83
478_S496_Y0.9550.83
452_K469_E0.9550.83
269_E273_A0.9550.83
373_Q422_T0.9540.83
294_R301_A0.9520.83
446_R453_Y0.9490.83
319_A325_N0.9480.82
92_L347_V0.9470.82
271_V279_E0.9470.82
80_L85_I0.9470.82
268_L272_L0.9420.82
169_N467_Y0.9400.82
311_G318_S0.9370.82
313_A317_A0.9340.81
404_E423_K0.9310.81
254_K258_A0.9270.81
316_I322_I0.9260.81
258_A261_N0.9250.81
293_L327_V0.9180.80
335_N340_L0.9170.80
429_L433_G0.9170.80
431_T444_S0.9150.80
433_G495_G0.9150.80
433_G446_R0.9140.80
34_G439_S0.9120.80
309_T318_S0.9110.80
270_Q276_E0.9080.80
197_N451_D0.9080.80
242_T381_R0.9070.80
47_L115_K0.9070.80
97_D160_G0.9060.79
311_G322_I0.9050.79
37_L205_S0.9030.79
197_N404_E0.9000.79
312_T322_I0.8960.79
313_A326_K0.8950.79
121_L293_L0.8950.79
162_T459_N0.8910.78
312_T328_I0.8900.78
310_T314_R0.8880.78
196_A460_T0.8880.78
316_I320_L0.8860.78
34_G441_I0.8850.78
501_G508_S0.8830.78
431_T436_F0.8830.78
170_M196_A0.8790.77
40_D43_E0.8790.77
315_G324_K0.8790.77
102_P410_I0.8780.77
199_D426_L0.8770.77
316_I325_N0.8760.77
342_E345_L0.8750.77
429_L456_S0.8730.77
155_H163_G0.8690.77
318_S323_F0.8690.77
408_N431_T0.8680.76
250_I253_L0.8670.76
446_R467_Y0.8660.76
291_E347_V0.8640.76
161_E449_F0.8600.76
403_I426_L0.8600.76
218_I223_L0.8580.76
191_M400_G0.8560.75
164_S464_H0.8540.75
271_V275_H0.8530.75
277_S280_Y0.8500.75
429_L440_L0.8470.75
267_F270_Q0.8450.75
25_I41_D0.8440.74
377_S381_R0.8430.74
408_N428_T0.8410.74
435_K456_S0.8410.74
344_T347_V0.8380.74
406_A447_P0.8360.74
174_I409_Y0.8350.74
432_Q501_G0.8350.74
313_A318_S0.8330.73
272_L278_K0.8290.73
11_I107_F0.8280.73
313_A329_S0.8280.73
315_G321_E0.8270.73
257_E265_L0.8240.73
160_G404_E0.8230.73
260_Y272_L0.8220.72
384_F428_T0.8210.72
159_F463_F0.8150.72
199_D431_T0.8140.72
69_S74_P0.8140.72
34_G138_L0.8120.72
158_V401_F0.8100.71
277_S281_N0.8070.71
160_G479_G0.8050.71
168_Y175_K0.8040.71
317_A327_V0.8040.71
218_I221_Y0.8030.71
116_S121_L0.8000.70
406_A442_L0.7980.70
400_G439_S0.7980.70
197_N501_G0.7980.70
412_S452_K0.7970.70
84_T87_K0.7960.70
98_H102_P0.7940.70
165_G406_A0.7940.70
240_I479_G0.7930.70
358_D441_I0.7910.70
137_A142_E0.7880.69
136_G499_V0.7860.69
311_G325_N0.7860.69
256_G259_S0.7850.69
404_E491_S0.7810.69
128_N132_L0.7790.68
263_L271_V0.7790.68
253_L261_N0.7780.68
9_I114_I0.7770.68
167_S435_K0.7770.68
58_E63_K0.7760.68
278_K281_N0.7750.68
83_N88_A0.7710.68
448_A467_Y0.7710.68
260_Y269_E0.7700.67
50_V202_D0.7700.67
192_I383_I0.7690.67
197_N436_F0.7690.67
77_Y80_L0.7690.67
461_F467_Y0.7690.67
92_L95_K0.7680.67
133_I177_L0.7670.67
169_N172_Y0.7660.67
162_T439_S0.7660.67
357_I375_I0.7660.67
154_M404_E0.7650.67
139_A496_Y0.7630.67
72_K76_I0.7630.67
29_E454_V0.7620.67
519_R523_Y0.7620.67
343_N346_E0.7620.67
103_K106_S0.7610.67
39_V106_S0.7600.66
384_F467_Y0.7590.66
228_E233_K0.7590.66
319_A330_R0.7570.66
432_Q445_Q0.7570.66
270_Q321_E0.7570.66
428_T432_Q0.7550.66
274_N277_S0.7540.66
429_L446_R0.7490.65
317_A322_I0.7480.65
58_E62_E0.7480.65
159_F435_K0.7470.65
70_I73_E0.7470.65
407_Q446_R0.7460.65
312_T326_K0.7440.65
157_G359_F0.7430.65
457_M490_T0.7410.65
314_R321_E0.7410.65
167_S482_P0.7410.65
198_G465_R0.7400.64
9_I31_I0.7400.64
470_D509_P0.7380.64
264_Q268_L0.7360.64
162_T432_Q0.7360.64
261_N267_F0.7320.64
291_E294_R0.7310.63
343_N347_V0.7300.63
197_N446_R0.7300.63
159_F444_S0.7290.63
159_F167_S0.7270.63
313_A320_L0.7260.63
20_E24_L0.7250.63
429_L492_L0.7230.63
198_G433_G0.7230.63
50_V109_R0.7220.62
141_S393_N0.7180.62
147_L266_N0.7170.62
157_G195_D0.7160.62
385_N389_R0.7150.62
197_N470_D0.7110.61
322_I328_I0.7110.61
68_K73_E0.7110.61
223_L229_Q0.7100.61
411_P450_I0.7090.61
21_M24_L0.7050.61
115_K120_L0.7030.60
192_I399_L0.7020.60
195_D200_Y0.7010.60
266_N269_E0.7000.60
297_I318_S0.6990.60
94_K237_D0.6990.60
86_I461_F0.6990.60
435_K457_M0.6980.60
320_L324_K0.6980.60
453_Y457_M0.6970.60
87_K160_G0.6960.60
274_N281_N0.6960.60
252_S261_N0.6950.60
162_T407_Q0.6940.59
384_F388_T0.6940.59
50_V222_I0.6910.59
260_Y263_L0.6890.59
180_I413_I0.6880.59
69_S73_E0.6860.59
194_I403_I0.6830.58
197_N407_Q0.6830.58
264_Q271_V0.6830.58
162_T436_F0.6810.58
430_A433_G0.6810.58
308_I326_K0.6780.58
311_G319_A0.6780.58
318_S321_E0.6780.58
442_L450_I0.6780.58
314_R323_F0.6770.58
299_T306_I0.6760.57
329_S333_L0.6760.57
453_Y467_Y0.6750.57
160_G523_Y0.6740.57
437_G492_L0.6730.57
245_E248_E0.6720.57
85_I121_L0.6720.57
257_E264_Q0.6720.57
276_E280_Y0.6710.57
160_G449_F0.6700.57
346_E395_N0.6690.57
360_S448_A0.6670.56
167_S504_S0.6670.56
161_E479_G0.6670.56
194_I476_S0.6660.56
257_E426_L0.6650.56
318_S329_S0.6640.56
172_Y515_P0.6640.56
170_M489_L0.6640.56
69_S72_K0.6640.56
384_F448_A0.6630.56
433_G444_S0.6620.56
272_L280_Y0.6610.56
459_N464_H0.6600.56
165_G407_Q0.6580.55
97_D199_D0.6570.55
159_F462_F0.6550.55
162_T466_I0.6550.55
501_G505_I0.6550.55
265_L269_E0.6540.55
377_S464_H0.6530.55
155_H454_V0.6530.55
373_Q420_N0.6530.55
191_M402_V0.6520.55
18_A173_L0.6510.55
251_M257_E0.6500.55
158_V429_L0.6500.55
431_T460_T0.6490.54
320_L327_V0.6480.54
443_V510_A0.6480.54
36_L47_L0.6470.54
321_E324_K0.6460.54
472_R476_S0.6450.54
446_R465_R0.6440.54
310_T324_K0.6430.54
485_L498_I0.6430.54
442_L470_D0.6410.53
22_Q25_I0.6390.53
235_T404_E0.6380.53
201_I220_R0.6380.53
116_S311_G0.6360.53
294_R297_I0.6340.53
467_Y501_G0.6330.53
404_E441_I0.6330.53
190_P386_Y0.6320.52
157_G406_A0.6320.52
11_I14_Q0.6320.52
316_I323_F0.6310.52
167_S200_Y0.6310.52
161_E442_L0.6300.52
198_G375_I0.6300.52
377_S444_S0.6300.52
174_I191_M0.6300.52
309_T472_R0.6250.52
152_I509_P0.6240.52
430_A447_P0.6230.51
173_L441_I0.6210.51
160_G166_K0.6210.51
160_G405_E0.6210.51
157_G501_G0.6180.51
331_L335_N0.6160.51
168_Y372_K0.6160.51
120_L167_S0.6140.50
342_E348_I0.6130.50
164_S169_N0.6130.50
147_L173_L0.6130.50
102_P199_D0.6130.50
498_I511_L0.6130.50
170_M461_F0.6120.50
199_D470_D0.6100.50
377_S409_Y0.6090.50
23_G262_T0.6090.50
40_D45_L0.6090.50
437_G470_D0.6090.50
165_G444_S0.6090.50
200_Y407_Q0.6070.50
262_T272_L0.6050.49
318_S325_N0.6050.49
71_L75_S0.6050.49
404_E485_L0.6050.49
36_L407_Q0.6030.49
23_G27_A0.6030.49
149_L380_T0.6030.49
325_N332_Q0.6010.49
274_N299_T0.6010.49
344_T349_W0.6000.49
12_V174_I0.6000.49
104_P199_D0.6000.49
466_I474_V0.6000.49
274_N351_N0.5990.49
196_A408_N0.5980.49
432_Q447_P0.5980.49
274_N462_F0.5980.49
236_I505_I0.5980.49
274_N282_T0.5960.48
446_R449_F0.5960.48
270_Q273_A0.5960.48
190_P355_A0.5960.48
444_S457_M0.5950.48
166_K405_E0.5930.48
130_K357_I0.5930.48
261_N370_L0.5930.48
34_G44_K0.5920.48
11_I24_L0.5910.48
189_L400_G0.5900.48
442_L457_M0.5890.48
432_Q465_R0.5880.47
296_E301_A0.5870.47
373_Q426_L0.5870.47
430_A448_A0.5870.47
191_M354_L0.5860.47
138_L495_G0.5850.47
310_T323_F0.5830.47
297_I307_G0.5810.47
498_I512_V0.5800.47
317_A326_K0.5800.47
289_G296_E0.5800.47
406_A501_G0.5790.46
251_M326_K0.5790.46
267_F383_I0.5790.46
318_S328_I0.5780.46
457_M501_G0.5780.46
431_T453_Y0.5760.46
165_G435_K0.5760.46
16_S22_Q0.5760.46
170_M420_N0.5750.46
350_R379_I0.5750.46
431_T461_F0.5750.46
267_F272_L0.5740.46
39_V129_K0.5740.46
145_L510_A0.5740.46
309_T320_L0.5740.46
98_H523_Y0.5740.46
154_M431_T0.5740.46
121_L236_I0.5720.46
435_K466_I0.5700.45
373_Q451_D0.5690.45
349_W404_E0.5680.45
156_M462_F0.5670.45
432_Q457_M0.5670.45
36_L447_P0.5660.45
235_T336_S0.5650.45
277_S288_I0.5650.45
176_L180_I0.5640.45
161_E464_H0.5630.45
84_T98_H0.5610.44
427_V431_T0.5600.44
71_L76_I0.5600.44
444_S448_A0.5580.44
267_F271_V0.5580.44
63_K72_K0.5570.44
274_N279_E0.5560.44
423_K451_D0.5560.44
170_M374_L0.5560.44
179_N349_W0.5550.44
256_G261_N0.5550.44
48_V84_T0.5540.44
407_Q444_S0.5520.43
51_E83_N0.5520.43
231_D235_T0.5510.43
45_L119_E0.5510.43
20_E74_P0.5500.43
168_Y172_Y0.5500.43
388_T432_Q0.5500.43
118_K295_N0.5490.43
50_V77_Y0.5490.43
83_N498_I0.5480.43
372_K408_N0.5470.43
161_E453_Y0.5470.43
123_F452_K0.5460.43
269_E288_I0.5460.43
101_T468_H0.5460.43
167_S171_R0.5450.43
221_Y454_V0.5440.42
67_A73_E0.5440.42
451_D460_T0.5430.42
314_R328_I0.5430.42
243_P331_L0.5420.42
453_Y456_S0.5420.42
37_L188_A0.5420.42
17_E192_I0.5410.42
391_K444_S0.5410.42
379_I383_I0.5390.42
280_Y288_I0.5390.42
306_I309_T0.5380.42
161_E465_R0.5360.42
109_R116_S0.5360.42
86_I167_S0.5350.41
311_G314_R0.5350.41
308_I312_T0.5340.41
433_G465_R0.5340.41
127_K518_P0.5340.41
431_T495_G0.5340.41
410_I492_L0.5330.41
321_E329_S0.5330.41
345_L386_Y0.5330.41
307_G520_L0.5300.41
108_V349_W0.5300.41
78_E85_I0.5300.41
289_G301_A0.5270.41
292_T307_G0.5270.41
38_L119_E0.5270.41
164_S407_Q0.5260.40
203_L404_E0.5260.40
387_L449_F0.5250.40
270_Q280_Y0.5250.40
46_S102_P0.5240.40
235_T338_A0.5230.40
190_P399_L0.5230.40
311_G327_V0.5230.40
377_S422_T0.5220.40
435_K455_L0.5220.40
188_A380_T0.5200.40
253_L259_S0.5200.40
346_E386_Y0.5190.40
403_I454_V0.5180.40
369_V408_N0.5170.39
221_Y355_A0.5160.39
310_T319_A0.5150.39
383_I401_F0.5140.39
135_Y514_I0.5130.39
197_N448_A0.5130.39
268_L321_E0.5130.39
155_H375_I0.5130.39
432_Q446_R0.5130.39
162_T433_G0.5130.39
177_L400_G0.5120.39
455_L497_V0.5110.39
453_Y501_G0.5110.39
200_Y401_F0.5100.39
308_I315_G0.5090.39
47_L53_Y0.5090.39
118_K282_T0.5090.39
81_D92_L0.5080.38
129_K132_L0.5080.38
29_E32_S0.5080.38
297_I448_A0.5070.38
10_G109_R0.5060.38
436_F446_R0.5040.38
20_E28_D0.5040.38
123_F508_S0.5020.38
237_D382_L0.5020.38
162_T455_L0.5020.38
336_S345_L0.5020.38
156_M460_T0.5020.38
244_R249_F0.5010.38
194_I487_K0.5010.38
197_N457_M0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d2iA 3 0.8492 100 0.363 Contact Map
4ag6A 2 0.6406 100 0.539 Contact Map
1e9rA 3 0.7188 100 0.653 Contact Map
2iusA 1 0.6853 99.7 0.817 Contact Map
2iutA 2 0.7039 99.4 0.851 Contact Map
4lyaA 1 0.4972 99.1 0.874 Contact Map
4nh0A 1 0.5251 99 0.878 Contact Map
4kfuA 1 0.3836 98.1 0.907 Contact Map
2r2aA 1 0.3296 98.1 0.909 Contact Map
2c9oA 3 0.622 97.2 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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