Q97WL4 - SULSO - GREMLIN Contacts

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Q97WL4 - Uncharacterized protein

UniProt:	Q97WL4	Sequences: MKIILGIPDLKIPVWTFKQPLMINQLNWDRPSWENETWVDSGGYQIMVRGIKVEIEKVVEKYKILDATQYMSLDIPSIPCHKPSELNYKYFEYLYTVFDKKIVPVIHAYDPESIKKSIDFYSQYTDLVAFGGIVPPTLNKSGNKKLAVAIYYLVRKLWKGKIHVLGAGSPFMRKVYFNADSVDTSTYRVKGIHGMVIIPGKGERYVGNRKIVWGTKRASEEELEILLSFLDKTHYPFQIRFDNWIDRSLINAWVLLNSEYESNNPLIRYSKKLDTFAEDEIEEEVNELCM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	290 (258)
Sequences:	3038 (1470)
Seq/√Len:	91.5

ECOLI - TGT
BACSU - TGT
HALSA - ATGT
SULSO - Q97WL4 ATGT

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
15_W	34_E	3.469	1.00
83_P	113_S	3.216	1.00
196_V	247_R	3.161	1.00
230_L	253_W	3.041	1.00
229_F	234_H	3.018	1.00
176_Y	262_S	2.808	1.00
120_F	123_Q	2.643	1.00
264_N	270_S	2.532	1.00
115_K	119_D	2.482	1.00
13_P	245_I	2.440	1.00
56_E	97_V	2.426	1.00
92_E	117_S	2.409	1.00
29_D	51_I	2.406	1.00
92_E	120_F	2.366	1.00
231_D	234_H	2.337	1.00
146_L	149_A	2.238	1.00
95_Y	125_T	2.213	1.00
230_L	257_N	2.212	1.00
15_W	35_N	2.202	1.00
54_E	57_K	2.166	1.00
116_K	120_F	2.165	1.00
262_S	273_L	2.095	1.00
82_K	85_E	2.088	1.00
115_K	157_L	2.068	1.00
152_Y	177_F	2.063	1.00
176_Y	259_E	2.046	1.00
223_L	227_L	2.042	1.00
86_L	109_Y	2.030	1.00
106_I	158_W	1.965	1.00
67_A	70_Y	1.947	1.00
17_F	252_A	1.943	1.00
57_K	60_E	1.942	1.00
112_E	149_A	1.929	1.00
118_I	154_V	1.918	1.00
218_A	221_E	1.874	1.00
104_P	125_T	1.842	1.00
96_T	124_Y	1.809	1.00
232_K	236_P	1.793	1.00
89_K	116_K	1.788	1.00
199_P	261_E	1.760	1.00
130_F	179_A	1.748	1.00
261_E	276_F	1.731	1.00
233_T	249_L	1.730	1.00
72_S	98_F	1.717	1.00
209_R	219_S	1.705	1.00
174_K	277_A	1.656	1.00
139_N	146_L	1.599	1.00
253_W	257_N	1.593	1.00
12_I	16_T	1.589	1.00
77_S	86_L	1.580	1.00
10_L	13_P	1.573	1.00
115_K	153_L	1.559	1.00
257_N	260_Y	1.552	1.00
112_E	153_L	1.550	1.00
188_R	248_S	1.549	1.00
75_I	85_E	1.532	1.00
148_V	175_V	1.529	1.00
164_V	179_A	1.529	1.00
174_K	262_S	1.528	1.00
66_D	100_K	1.528	1.00
58_V	62_Y	1.520	1.00
103_V	181_S	1.499	1.00
95_Y	121_Y	1.497	1.00
276_F	280_E	1.448	0.99
238_Q	242_D	1.442	0.99
196_V	225_I	1.434	0.99
258_S	276_F	1.433	0.99
257_N	261_E	1.424	0.99
10_L	245_I	1.410	0.99
144_K	172_M	1.394	0.99
265_P	272_K	1.363	0.99
83_P	86_L	1.344	0.99
19_Q	256_L	1.339	0.99
208_N	217_R	1.294	0.99
173_R	259_E	1.293	0.99
164_V	167_A	1.293	0.99
118_I	157_L	1.286	0.99
190_K	193_H	1.280	0.99
72_S	91_F	1.278	0.99
119_D	123_Q	1.277	0.99
264_N	267_I	1.274	0.99
241_F	247_R	1.270	0.99
11_K	14_V	1.266	0.99
116_K	119_D	1.244	0.98
229_F	250_I	1.235	0.98
195_M	203_E	1.234	0.98
75_I	87_N	1.231	0.98
32_S	236_P	1.225	0.98
59_V	70_Y	1.222	0.98
20_P	36_E	1.220	0.98
60_E	64_I	1.216	0.98
199_P	257_N	1.215	0.98
58_V	73_L	1.213	0.98
14_V	17_F	1.198	0.98
199_P	228_S	1.194	0.98
196_V	206_V	1.193	0.98
234_H	250_I	1.193	0.98
81_H	109_Y	1.185	0.98
96_T	123_Q	1.184	0.98
72_S	95_Y	1.181	0.98
150_I	153_L	1.175	0.98
29_D	53_V	1.175	0.98
232_K	249_L	1.169	0.98
46_I	73_L	1.168	0.98
118_I	158_W	1.163	0.98
112_E	115_K	1.162	0.98
37_T	67_A	1.162	0.98
95_Y	124_Y	1.152	0.97
196_V	237_F	1.147	0.97
121_Y	128_V	1.146	0.97
260_Y	264_N	1.145	0.97
186_T	197_I	1.140	0.97
12_I	32_S	1.139	0.97
253_W	260_Y	1.137	0.97
86_L	111_P	1.128	0.97
191_G	249_L	1.123	0.97
272_K	275_T	1.111	0.97
57_K	61_K	1.105	0.97
88_Y	92_E	1.097	0.97
71_M	105_V	1.094	0.96
198_I	201_K	1.084	0.96
62_Y	67_A	1.082	0.96
119_D	157_L	1.080	0.96
53_V	58_V	1.079	0.96
233_T	237_F	1.058	0.96
12_I	15_W	1.052	0.96
173_R	262_S	1.049	0.95
59_V	73_L	1.038	0.95
87_N	90_Y	1.037	0.95
273_L	277_A	1.034	0.95
77_S	88_Y	1.028	0.95
17_F	256_L	1.026	0.95
83_P	111_P	1.021	0.95
20_P	35_N	1.018	0.95
219_S	238_Q	1.009	0.94
59_V	98_F	1.004	0.94
122_S	128_V	1.002	0.94
207_G	241_F	1.000	0.94
229_F	236_P	0.997	0.94
120_F	124_Y	0.993	0.94
89_K	93_Y	0.991	0.94
186_T	255_L	0.985	0.94
169_S	186_T	0.980	0.94
230_L	260_Y	0.971	0.93
197_I	255_L	0.969	0.93
262_S	265_P	0.960	0.93
185_S	189_V	0.959	0.93
18_K	35_N	0.959	0.93
278_E	282_E	0.957	0.93
144_K	147_A	0.942	0.92
175_V	281_I	0.938	0.92
79_P	139_N	0.934	0.92
92_E	121_Y	0.934	0.92
112_E	150_I	0.930	0.92
139_N	145_K	0.929	0.92
18_K	260_Y	0.927	0.92
199_P	226_L	0.925	0.91
101_K	126_D	0.921	0.91
79_P	110_D	0.907	0.91
106_I	118_I	0.905	0.91
77_S	87_N	0.904	0.90
71_M	165_L	0.898	0.90
199_P	254_V	0.891	0.90
106_I	121_Y	0.889	0.90
265_P	273_L	0.887	0.90
117_S	121_Y	0.885	0.90
175_V	277_A	0.879	0.89
61_K	65_L	0.879	0.89
154_V	157_L	0.873	0.89
63_K	70_Y	0.872	0.89
231_D	250_I	0.860	0.88
145_K	149_A	0.856	0.88
204_R	218_A	0.855	0.88
152_Y	155_R	0.852	0.88
190_K	195_M	0.851	0.88
59_V	72_S	0.845	0.87
21_L	37_T	0.840	0.87
63_K	99_D	0.838	0.87
81_H	86_L	0.838	0.87
91_F	94_L	0.837	0.87
19_Q	36_E	0.835	0.87
272_K	279_D	0.833	0.86
88_Y	117_S	0.831	0.86
11_K	15_W	0.830	0.86
171_F	281_I	0.829	0.86
155_R	162_I	0.828	0.86
118_I	122_S	0.820	0.86
92_E	123_Q	0.808	0.85
92_E	124_Y	0.808	0.85
96_T	120_F	0.807	0.85
110_D	135_P	0.806	0.85
117_S	120_F	0.802	0.84
12_I	245_I	0.801	0.84
80_C	109_Y	0.800	0.84
59_V	63_K	0.796	0.84
17_F	253_W	0.794	0.84
130_F	133_I	0.791	0.84
11_K	232_K	0.787	0.83
29_D	57_K	0.786	0.83
71_M	163_H	0.785	0.83
190_K	197_I	0.781	0.83
155_R	177_F	0.777	0.82
275_T	279_D	0.773	0.82
87_N	91_F	0.772	0.82
154_V	158_W	0.772	0.82
233_T	236_P	0.771	0.82
169_S	255_L	0.765	0.81
174_K	280_E	0.759	0.81
194_G	206_V	0.758	0.81
59_V	102_I	0.757	0.81
267_I	270_S	0.757	0.81
88_Y	116_K	0.755	0.81
205_Y	208_N	0.753	0.80
161_K	181_S	0.748	0.80
121_Y	125_T	0.744	0.80
262_S	276_F	0.744	0.80
121_Y	124_Y	0.744	0.80
13_P	16_T	0.742	0.79
81_H	85_E	0.741	0.79
237_F	247_R	0.737	0.79
174_K	276_F	0.735	0.79
262_S	267_I	0.728	0.78
174_K	273_L	0.724	0.78
90_Y	94_L	0.721	0.77
153_L	157_L	0.717	0.77
128_V	160_G	0.715	0.77
148_V	177_F	0.714	0.77
53_V	57_K	0.714	0.77
67_A	72_S	0.713	0.77
105_V	165_L	0.713	0.77
169_S	172_M	0.709	0.76
231_D	246_D	0.707	0.76
118_I	155_R	0.706	0.76
190_K	247_R	0.703	0.76
171_F	280_E	0.701	0.75
259_E	262_S	0.701	0.75
274_D	278_E	0.699	0.75
20_P	256_L	0.699	0.75
10_L	14_V	0.699	0.75
241_F	244_W	0.697	0.75
115_K	118_I	0.696	0.75
88_Y	91_F	0.695	0.75
152_Y	156_K	0.692	0.75
173_R	255_L	0.690	0.74
234_H	246_D	0.690	0.74
92_E	96_T	0.689	0.74
254_V	258_S	0.688	0.74
104_P	121_Y	0.686	0.74
146_L	150_I	0.682	0.73
13_P	222_E	0.681	0.73
93_Y	97_V	0.681	0.73
110_D	150_I	0.680	0.73
186_T	190_K	0.678	0.73
70_Y	100_K	0.677	0.73
249_L	253_W	0.677	0.73
155_R	158_W	0.677	0.73
130_F	154_V	0.675	0.73
110_D	146_L	0.674	0.73
265_P	271_K	0.673	0.72
29_D	61_K	0.673	0.72
233_T	253_W	0.673	0.72
245_I	249_L	0.672	0.72
196_V	241_F	0.668	0.72
189_V	192_I	0.668	0.72
33_W	37_T	0.661	0.71
77_S	110_D	0.660	0.71
14_V	20_P	0.658	0.71
187_Y	255_L	0.657	0.71
200_G	227_L	0.651	0.70
261_E	265_P	0.650	0.70
87_N	94_L	0.649	0.70
30_R	51_I	0.649	0.70
20_P	267_I	0.648	0.70
150_I	154_V	0.642	0.69
190_K	196_V	0.640	0.69
125_T	128_V	0.637	0.68
14_V	18_K	0.637	0.68
174_K	258_S	0.636	0.68
265_P	276_F	0.636	0.68
176_Y	182_V	0.635	0.68
22_M	38_W	0.634	0.68
225_I	247_R	0.633	0.68
229_F	246_D	0.633	0.68
52_K	57_K	0.632	0.68
267_I	274_D	0.629	0.67
75_I	90_Y	0.627	0.67
80_C	110_D	0.627	0.67
274_D	277_A	0.623	0.67
271_K	274_D	0.622	0.66
58_V	98_F	0.621	0.66
80_C	139_N	0.621	0.66
206_V	241_F	0.620	0.66
148_V	172_M	0.619	0.66
151_Y	155_R	0.619	0.66
237_F	241_F	0.614	0.65
201_K	204_R	0.614	0.65
195_M	205_Y	0.613	0.65
277_A	281_I	0.613	0.65
83_P	114_I	0.611	0.65
38_W	71_M	0.611	0.65
106_I	154_V	0.610	0.65
70_Y	102_I	0.610	0.65
261_E	264_N	0.609	0.65
80_C	86_L	0.606	0.64
16_T	249_L	0.605	0.64
172_M	197_I	0.601	0.64
86_L	114_I	0.596	0.63
79_P	109_Y	0.596	0.63
133_I	151_Y	0.593	0.63
11_K	233_T	0.592	0.63
200_G	228_S	0.592	0.63
267_I	271_K	0.589	0.62
72_S	125_T	0.589	0.62
204_R	223_L	0.587	0.62
70_Y	73_L	0.587	0.62
256_L	260_Y	0.587	0.62
14_V	19_Q	0.586	0.62
65_L	245_I	0.583	0.62
144_K	191_G	0.582	0.61
87_N	93_Y	0.580	0.61
197_I	247_R	0.578	0.61
260_Y	282_E	0.576	0.61
63_K	100_K	0.572	0.60
67_A	100_K	0.572	0.60
12_I	17_F	0.569	0.60
60_E	63_K	0.568	0.60
115_K	156_K	0.568	0.60
104_P	124_Y	0.567	0.59
131_G	138_L	0.566	0.59
206_V	247_R	0.564	0.59
248_S	255_L	0.562	0.59
190_K	255_L	0.561	0.59
226_L	257_N	0.555	0.58
133_I	138_L	0.554	0.58
14_V	256_L	0.554	0.58
265_P	270_S	0.552	0.57
176_Y	273_L	0.550	0.57
229_F	253_W	0.550	0.57
53_V	61_K	0.549	0.57
229_F	233_T	0.548	0.57
32_S	35_N	0.548	0.57
26_L	243_N	0.545	0.56
23_I	39_V	0.544	0.56
122_S	157_L	0.540	0.56
219_S	242_D	0.540	0.56
130_F	138_L	0.539	0.56
102_I	126_D	0.539	0.56
174_K	281_I	0.537	0.55
130_F	155_R	0.537	0.55
105_V	163_H	0.536	0.55
107_H	131_G	0.533	0.55
254_V	281_I	0.533	0.55
279_D	282_E	0.532	0.55
92_E	122_S	0.531	0.54
103_V	127_L	0.530	0.54
29_D	58_V	0.529	0.54
80_C	135_P	0.529	0.54
11_K	32_S	0.528	0.54
191_G	247_R	0.528	0.54
69_Q	103_V	0.527	0.54
47_M	135_P	0.527	0.54
12_I	236_P	0.527	0.54
234_H	253_W	0.527	0.54
61_K	64_I	0.525	0.54
144_K	171_F	0.525	0.54
170_P	201_K	0.521	0.53
90_Y	93_Y	0.519	0.53
30_R	239_I	0.517	0.53
133_I	137_T	0.517	0.53
129_A	133_I	0.515	0.52
194_G	241_F	0.514	0.52
112_E	157_L	0.513	0.52
230_L	235_Y	0.513	0.52
38_W	163_H	0.513	0.52
14_V	21_L	0.511	0.52
126_D	160_G	0.510	0.52
94_L	97_V	0.509	0.51
79_P	191_G	0.508	0.51
76_P	168_G	0.508	0.51
15_W	20_P	0.507	0.51
163_H	181_S	0.506	0.51
37_T	65_L	0.505	0.51
71_M	129_A	0.503	0.51
261_E	279_D	0.503	0.51
275_T	278_E	0.501	0.50
119_D	122_S	0.500	0.50
133_I	165_L	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ashA	3	0.9241	100	0.233	Contact Map
4q8wA	2	0.9345	100	0.234	Contact Map
1iq8A	2	0.931	100	0.287	Contact Map
1reqA	1	0.4483	92.1	0.94	Contact Map
2nx9A	2	0.931	81.6	0.95	Contact Map
1reqB	1	0.4414	75.7	0.952	Contact Map
2xijA	2	0.4483	75.3	0.952	Contact Map
1y80A	1	0.4138	72.5	0.953	Contact Map
1nvmA	2	0.9069	66	0.956	Contact Map
4xc8A	2	0.7207	64.1	0.956	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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