GREMLIN Database
Q97WL4 - Uncharacterized protein
UniProt: Q97WL4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (258)
Sequences: 3038 (1470)
Seq/√Len: 91.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_W34_E3.4691.00
83_P113_S3.2161.00
196_V247_R3.1611.00
230_L253_W3.0411.00
229_F234_H3.0181.00
176_Y262_S2.8081.00
120_F123_Q2.6431.00
264_N270_S2.5321.00
115_K119_D2.4821.00
13_P245_I2.4401.00
56_E97_V2.4261.00
92_E117_S2.4091.00
29_D51_I2.4061.00
92_E120_F2.3661.00
231_D234_H2.3371.00
146_L149_A2.2381.00
95_Y125_T2.2131.00
230_L257_N2.2121.00
15_W35_N2.2021.00
54_E57_K2.1661.00
116_K120_F2.1651.00
262_S273_L2.0951.00
82_K85_E2.0881.00
115_K157_L2.0681.00
152_Y177_F2.0631.00
176_Y259_E2.0461.00
223_L227_L2.0421.00
86_L109_Y2.0301.00
106_I158_W1.9651.00
67_A70_Y1.9471.00
17_F252_A1.9431.00
57_K60_E1.9421.00
112_E149_A1.9291.00
118_I154_V1.9181.00
218_A221_E1.8741.00
104_P125_T1.8421.00
96_T124_Y1.8091.00
232_K236_P1.7931.00
89_K116_K1.7881.00
199_P261_E1.7601.00
130_F179_A1.7481.00
261_E276_F1.7311.00
233_T249_L1.7301.00
72_S98_F1.7171.00
209_R219_S1.7051.00
174_K277_A1.6561.00
139_N146_L1.5991.00
253_W257_N1.5931.00
12_I16_T1.5891.00
77_S86_L1.5801.00
10_L13_P1.5731.00
115_K153_L1.5591.00
257_N260_Y1.5521.00
112_E153_L1.5501.00
188_R248_S1.5491.00
75_I85_E1.5321.00
148_V175_V1.5291.00
164_V179_A1.5291.00
174_K262_S1.5281.00
66_D100_K1.5281.00
58_V62_Y1.5201.00
103_V181_S1.4991.00
95_Y121_Y1.4971.00
276_F280_E1.4480.99
238_Q242_D1.4420.99
196_V225_I1.4340.99
258_S276_F1.4330.99
257_N261_E1.4240.99
10_L245_I1.4100.99
144_K172_M1.3940.99
265_P272_K1.3630.99
83_P86_L1.3440.99
19_Q256_L1.3390.99
208_N217_R1.2940.99
173_R259_E1.2930.99
164_V167_A1.2930.99
118_I157_L1.2860.99
190_K193_H1.2800.99
72_S91_F1.2780.99
119_D123_Q1.2770.99
264_N267_I1.2740.99
241_F247_R1.2700.99
11_K14_V1.2660.99
116_K119_D1.2440.98
229_F250_I1.2350.98
195_M203_E1.2340.98
75_I87_N1.2310.98
32_S236_P1.2250.98
59_V70_Y1.2220.98
20_P36_E1.2200.98
60_E64_I1.2160.98
199_P257_N1.2150.98
58_V73_L1.2130.98
14_V17_F1.1980.98
199_P228_S1.1940.98
196_V206_V1.1930.98
234_H250_I1.1930.98
81_H109_Y1.1850.98
96_T123_Q1.1840.98
72_S95_Y1.1810.98
150_I153_L1.1750.98
29_D53_V1.1750.98
232_K249_L1.1690.98
46_I73_L1.1680.98
118_I158_W1.1630.98
112_E115_K1.1620.98
37_T67_A1.1620.98
95_Y124_Y1.1520.97
196_V237_F1.1470.97
121_Y128_V1.1460.97
260_Y264_N1.1450.97
186_T197_I1.1400.97
12_I32_S1.1390.97
253_W260_Y1.1370.97
86_L111_P1.1280.97
191_G249_L1.1230.97
272_K275_T1.1110.97
57_K61_K1.1050.97
88_Y92_E1.0970.97
71_M105_V1.0940.96
198_I201_K1.0840.96
62_Y67_A1.0820.96
119_D157_L1.0800.96
53_V58_V1.0790.96
233_T237_F1.0580.96
12_I15_W1.0520.96
173_R262_S1.0490.95
59_V73_L1.0380.95
87_N90_Y1.0370.95
273_L277_A1.0340.95
77_S88_Y1.0280.95
17_F256_L1.0260.95
83_P111_P1.0210.95
20_P35_N1.0180.95
219_S238_Q1.0090.94
59_V98_F1.0040.94
122_S128_V1.0020.94
207_G241_F1.0000.94
229_F236_P0.9970.94
120_F124_Y0.9930.94
89_K93_Y0.9910.94
186_T255_L0.9850.94
169_S186_T0.9800.94
230_L260_Y0.9710.93
197_I255_L0.9690.93
262_S265_P0.9600.93
185_S189_V0.9590.93
18_K35_N0.9590.93
278_E282_E0.9570.93
144_K147_A0.9420.92
175_V281_I0.9380.92
79_P139_N0.9340.92
92_E121_Y0.9340.92
112_E150_I0.9300.92
139_N145_K0.9290.92
18_K260_Y0.9270.92
199_P226_L0.9250.91
101_K126_D0.9210.91
79_P110_D0.9070.91
106_I118_I0.9050.91
77_S87_N0.9040.90
71_M165_L0.8980.90
199_P254_V0.8910.90
106_I121_Y0.8890.90
265_P273_L0.8870.90
117_S121_Y0.8850.90
175_V277_A0.8790.89
61_K65_L0.8790.89
154_V157_L0.8730.89
63_K70_Y0.8720.89
231_D250_I0.8600.88
145_K149_A0.8560.88
204_R218_A0.8550.88
152_Y155_R0.8520.88
190_K195_M0.8510.88
59_V72_S0.8450.87
21_L37_T0.8400.87
63_K99_D0.8380.87
81_H86_L0.8380.87
91_F94_L0.8370.87
19_Q36_E0.8350.87
272_K279_D0.8330.86
88_Y117_S0.8310.86
11_K15_W0.8300.86
171_F281_I0.8290.86
155_R162_I0.8280.86
118_I122_S0.8200.86
92_E123_Q0.8080.85
92_E124_Y0.8080.85
96_T120_F0.8070.85
110_D135_P0.8060.85
117_S120_F0.8020.84
12_I245_I0.8010.84
80_C109_Y0.8000.84
59_V63_K0.7960.84
17_F253_W0.7940.84
130_F133_I0.7910.84
11_K232_K0.7870.83
29_D57_K0.7860.83
71_M163_H0.7850.83
190_K197_I0.7810.83
155_R177_F0.7770.82
275_T279_D0.7730.82
87_N91_F0.7720.82
154_V158_W0.7720.82
233_T236_P0.7710.82
169_S255_L0.7650.81
174_K280_E0.7590.81
194_G206_V0.7580.81
59_V102_I0.7570.81
267_I270_S0.7570.81
88_Y116_K0.7550.81
205_Y208_N0.7530.80
161_K181_S0.7480.80
121_Y125_T0.7440.80
262_S276_F0.7440.80
121_Y124_Y0.7440.80
13_P16_T0.7420.79
81_H85_E0.7410.79
237_F247_R0.7370.79
174_K276_F0.7350.79
262_S267_I0.7280.78
174_K273_L0.7240.78
90_Y94_L0.7210.77
153_L157_L0.7170.77
128_V160_G0.7150.77
148_V177_F0.7140.77
53_V57_K0.7140.77
67_A72_S0.7130.77
105_V165_L0.7130.77
169_S172_M0.7090.76
231_D246_D0.7070.76
118_I155_R0.7060.76
190_K247_R0.7030.76
171_F280_E0.7010.75
259_E262_S0.7010.75
274_D278_E0.6990.75
20_P256_L0.6990.75
10_L14_V0.6990.75
241_F244_W0.6970.75
115_K118_I0.6960.75
88_Y91_F0.6950.75
152_Y156_K0.6920.75
173_R255_L0.6900.74
234_H246_D0.6900.74
92_E96_T0.6890.74
254_V258_S0.6880.74
104_P121_Y0.6860.74
146_L150_I0.6820.73
13_P222_E0.6810.73
93_Y97_V0.6810.73
110_D150_I0.6800.73
186_T190_K0.6780.73
70_Y100_K0.6770.73
249_L253_W0.6770.73
155_R158_W0.6770.73
130_F154_V0.6750.73
110_D146_L0.6740.73
265_P271_K0.6730.72
29_D61_K0.6730.72
233_T253_W0.6730.72
245_I249_L0.6720.72
196_V241_F0.6680.72
189_V192_I0.6680.72
33_W37_T0.6610.71
77_S110_D0.6600.71
14_V20_P0.6580.71
187_Y255_L0.6570.71
200_G227_L0.6510.70
261_E265_P0.6500.70
87_N94_L0.6490.70
30_R51_I0.6490.70
20_P267_I0.6480.70
150_I154_V0.6420.69
190_K196_V0.6400.69
125_T128_V0.6370.68
14_V18_K0.6370.68
174_K258_S0.6360.68
265_P276_F0.6360.68
176_Y182_V0.6350.68
22_M38_W0.6340.68
225_I247_R0.6330.68
229_F246_D0.6330.68
52_K57_K0.6320.68
267_I274_D0.6290.67
75_I90_Y0.6270.67
80_C110_D0.6270.67
274_D277_A0.6230.67
271_K274_D0.6220.66
58_V98_F0.6210.66
80_C139_N0.6210.66
206_V241_F0.6200.66
148_V172_M0.6190.66
151_Y155_R0.6190.66
237_F241_F0.6140.65
201_K204_R0.6140.65
195_M205_Y0.6130.65
277_A281_I0.6130.65
83_P114_I0.6110.65
38_W71_M0.6110.65
106_I154_V0.6100.65
70_Y102_I0.6100.65
261_E264_N0.6090.65
80_C86_L0.6060.64
16_T249_L0.6050.64
172_M197_I0.6010.64
86_L114_I0.5960.63
79_P109_Y0.5960.63
133_I151_Y0.5930.63
11_K233_T0.5920.63
200_G228_S0.5920.63
267_I271_K0.5890.62
72_S125_T0.5890.62
204_R223_L0.5870.62
70_Y73_L0.5870.62
256_L260_Y0.5870.62
14_V19_Q0.5860.62
65_L245_I0.5830.62
144_K191_G0.5820.61
87_N93_Y0.5800.61
197_I247_R0.5780.61
260_Y282_E0.5760.61
63_K100_K0.5720.60
67_A100_K0.5720.60
12_I17_F0.5690.60
60_E63_K0.5680.60
115_K156_K0.5680.60
104_P124_Y0.5670.59
131_G138_L0.5660.59
206_V247_R0.5640.59
248_S255_L0.5620.59
190_K255_L0.5610.59
226_L257_N0.5550.58
133_I138_L0.5540.58
14_V256_L0.5540.58
265_P270_S0.5520.57
176_Y273_L0.5500.57
229_F253_W0.5500.57
53_V61_K0.5490.57
229_F233_T0.5480.57
32_S35_N0.5480.57
26_L243_N0.5450.56
23_I39_V0.5440.56
122_S157_L0.5400.56
219_S242_D0.5400.56
130_F138_L0.5390.56
102_I126_D0.5390.56
174_K281_I0.5370.55
130_F155_R0.5370.55
105_V163_H0.5360.55
107_H131_G0.5330.55
254_V281_I0.5330.55
279_D282_E0.5320.55
92_E122_S0.5310.54
103_V127_L0.5300.54
29_D58_V0.5290.54
80_C135_P0.5290.54
11_K32_S0.5280.54
191_G247_R0.5280.54
69_Q103_V0.5270.54
47_M135_P0.5270.54
12_I236_P0.5270.54
234_H253_W0.5270.54
61_K64_I0.5250.54
144_K171_F0.5250.54
170_P201_K0.5210.53
90_Y93_Y0.5190.53
30_R239_I0.5170.53
133_I137_T0.5170.53
129_A133_I0.5150.52
194_G241_F0.5140.52
112_E157_L0.5130.52
230_L235_Y0.5130.52
38_W163_H0.5130.52
14_V21_L0.5110.52
126_D160_G0.5100.52
94_L97_V0.5090.51
79_P191_G0.5080.51
76_P168_G0.5080.51
15_W20_P0.5070.51
163_H181_S0.5060.51
37_T65_L0.5050.51
71_M129_A0.5030.51
261_E279_D0.5030.51
275_T278_E0.5010.50
119_D122_S0.5000.50
133_I165_L0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ashA 3 0.9241 100 0.233 Contact Map
4q8wA 2 0.9345 100 0.234 Contact Map
1iq8A 2 0.931 100 0.287 Contact Map
1reqA 1 0.4483 92.1 0.94 Contact Map
2nx9A 2 0.931 81.6 0.95 Contact Map
1reqB 1 0.4414 75.7 0.952 Contact Map
2xijA 2 0.4483 75.3 0.952 Contact Map
1y80A 1 0.4138 72.5 0.953 Contact Map
1nvmA 2 0.9069 66 0.956 Contact Map
4xc8A 2 0.7207 64.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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