GREMLIN Database
Q97WL0 - Transcriptional activator (TenA-1)
UniProt: Q97WL0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 213 (201)
Sequences: 1991 (1516)
Seq/√Len: 106.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_K206_L4.2591.00
203_D207_R3.6251.00
13_G188_L3.5011.00
61_A129_F3.2091.00
156_K160_S3.1411.00
117_H194_S3.0661.00
125_D183_I3.0451.00
141_S168_K2.7281.00
7_V179_D2.6511.00
19_N23_K2.5871.00
29_K32_D2.5621.00
31_R147_V2.4921.00
128_K186_D2.3811.00
25_E29_K2.3811.00
94_K157_T2.3021.00
193_N196_R2.3011.00
125_D128_K2.2741.00
60_I64_K2.1301.00
9_N184_T2.0791.00
165_T169_K2.0701.00
124_L128_K2.0641.00
23_K28_L2.0491.00
98_S101_V1.9951.00
172_E176_Y1.9951.00
130_L178_L1.9911.00
9_N188_L1.9741.00
200_G203_D1.9531.00
28_L32_D1.8961.00
21_Y139_G1.8561.00
112_Y116_R1.8361.00
53_D115_T1.8031.00
108_N204_A1.7141.00
69_K180_E1.7021.00
37_L41_R1.6811.00
135_P194_S1.6761.00
45_I105_T1.6561.00
148_I163_A1.6331.00
157_T160_S1.6001.00
99_R103_V1.5861.00
36_P39_I1.5531.00
141_S171_I1.5501.00
49_K107_Y1.5501.00
14_V192_I1.4871.00
42_Y108_N1.4841.00
113_A197_F1.4841.00
198_E201_F1.4781.00
15_G19_N1.4491.00
128_K190_I1.4401.00
50_Y54_M1.4371.00
60_I122_A1.4281.00
134_T138_F1.4281.00
78_F82_D1.4251.00
138_F175_L1.3821.00
144_G163_A1.3591.00
187_L190_I1.3160.99
145_D168_K1.3130.99
121_Y190_I1.3030.99
144_G147_V1.2910.99
137_M174_I1.2780.99
167_Y171_I1.2600.99
14_V188_L1.2310.99
8_E175_L1.2250.99
65_G126_W1.2240.99
144_G158_W1.2200.99
116_R120_Y1.2070.99
13_G192_I1.2030.99
176_Y180_E1.1990.99
137_M171_I1.1940.99
67_I70_V1.1870.99
50_Y118_L1.1740.99
146_Y150_S1.1730.99
16_E192_I1.1470.98
87_T161_F1.1450.98
111_N204_A1.1450.98
10_L188_L1.1440.98
120_Y123_N1.1410.98
6_N10_L1.1270.98
127_N187_L1.1120.98
76_L137_M1.1100.98
8_E179_D1.1060.98
29_K39_I1.1010.98
134_T178_L1.1010.98
136_C162_Y1.0990.98
66_P69_K1.0950.98
139_G195_V1.0850.98
188_L192_I1.0800.98
35_L155_Y1.0580.97
6_N182_S1.0560.97
54_M133_W1.0470.97
88_H162_Y1.0430.97
153_E160_S1.0400.97
131_V187_L1.0390.97
127_N183_I1.0360.97
57_A118_L1.0290.97
193_N197_F1.0250.97
122_A129_F1.0170.97
185_E188_L1.0130.97
12_N15_G1.0010.96
126_W181_V0.9980.96
70_V81_R0.9930.96
137_M170_R0.9930.96
139_G143_V0.9920.96
177_A180_E0.9900.96
58_L137_M0.9880.96
17_L195_V0.9840.96
11_I15_G0.9730.96
40_F155_Y0.9710.96
90_K157_T0.9710.96
28_L150_S0.9650.95
37_L152_N0.9620.95
71_T82_D0.9530.95
90_K94_K0.9520.95
83_K86_E0.9510.95
43_Y140_Y0.9460.95
8_E12_N0.9330.94
75_N78_F0.9160.94
196_R200_G0.9050.94
25_E206_L0.9040.94
74_L78_F0.9040.94
43_Y158_W0.9010.93
112_Y117_H0.8930.93
75_N79_S0.8880.93
16_E19_N0.8880.93
49_K106_G0.8860.93
141_S145_D0.8840.93
41_R45_I0.8820.93
6_N184_T0.8760.92
139_G202_W0.8740.92
92_Y97_I0.8690.92
11_I14_V0.8640.92
39_I42_Y0.8530.91
76_L173_A0.8510.91
20_K199_I0.8440.91
41_R101_V0.8440.91
117_H121_Y0.8380.91
7_V138_F0.8310.90
11_I142_I0.8290.90
58_L133_W0.8250.90
114_Y118_L0.8180.90
68_D78_F0.8100.89
61_A65_G0.8060.89
137_M167_Y0.8020.89
88_H136_C0.7990.88
115_T119_Y0.7950.88
40_F136_C0.7910.88
85_L89_G0.7860.88
25_E28_L0.7820.87
14_V191_F0.7820.87
53_D107_Y0.7740.87
143_V194_S0.7730.87
27_I139_G0.7730.87
50_Y136_C0.7670.86
18_W142_I0.7620.86
79_S83_K0.7590.86
172_E175_L0.7580.86
184_T188_L0.7570.86
88_H158_W0.7560.86
72_K173_A0.7510.85
43_Y92_Y0.7460.85
175_L179_D0.7440.85
146_Y149_D0.7440.85
153_E156_K0.7430.85
38_D169_K0.7390.84
165_T168_K0.7300.84
143_V162_Y0.7300.84
111_N202_W0.7270.83
147_V159_A0.7250.83
86_E90_K0.7250.83
42_Y204_A0.7240.83
119_Y124_L0.7230.83
86_E89_G0.7220.83
121_Y132_A0.7220.83
67_I77_V0.7220.83
7_V175_L0.7200.83
17_L199_I0.7180.83
54_M87_T0.7170.82
19_N22_V0.7170.82
54_M57_A0.7140.82
47_D201_F0.7110.82
12_N172_E0.7100.82
67_I78_F0.7100.82
186_D190_I0.7080.82
88_H144_G0.7080.82
24_H203_D0.7080.82
90_K93_S0.7040.81
18_W139_G0.7000.81
183_I186_D0.6980.81
135_P191_F0.6960.81
56_R63_S0.6950.80
13_G184_T0.6910.80
60_I63_S0.6900.80
51_V54_M0.6900.80
22_V142_I0.6900.80
123_N129_F0.6840.79
197_F200_G0.6840.79
183_I187_L0.6830.79
107_Y115_T0.6810.79
91_L157_T0.6790.79
98_S105_T0.6750.79
166_E169_K0.6710.78
51_V162_Y0.6690.78
30_M159_A0.6690.78
19_N146_Y0.6670.78
29_K34_S0.6660.78
54_M194_S0.6660.78
39_I206_L0.6650.77
47_D84_G0.6610.77
58_L110_I0.6600.77
203_D206_L0.6590.77
50_Y137_M0.6480.76
17_L192_I0.6480.76
117_H190_I0.6430.75
22_V25_E0.6380.75
60_I123_N0.6380.75
77_V80_S0.6360.74
70_V80_S0.6350.74
89_G102_I0.6310.74
27_I31_R0.6300.74
144_G162_Y0.6290.73
22_V146_Y0.6250.73
78_F81_R0.6250.73
83_K166_E0.6230.73
140_Y198_E0.6210.73
199_I203_D0.6200.72
20_K23_K0.6190.72
84_G88_H0.6170.72
16_E20_K0.6150.72
46_Q111_N0.6140.72
43_Y144_G0.6080.71
161_F167_Y0.6070.71
51_V88_H0.6070.71
108_N111_N0.6070.71
49_K53_D0.6070.71
11_I138_F0.6020.70
49_K105_T0.6020.70
59_L62_S0.6000.70
91_L161_F0.5990.70
132_A136_C0.5990.70
76_L79_S0.5970.70
131_V178_L0.5970.70
57_A129_F0.5960.69
115_T118_L0.5910.69
53_D119_Y0.5900.69
17_L196_R0.5870.68
67_I71_T0.5850.68
135_P162_Y0.5850.68
69_K173_A0.5850.68
56_R60_I0.5830.68
64_K124_L0.5820.68
134_T175_L0.5810.68
158_W162_Y0.5750.67
54_M170_R0.5720.66
43_Y191_F0.5700.66
114_Y202_W0.5670.66
89_G101_V0.5630.65
9_N13_G0.5580.64
127_N197_F0.5580.64
131_V190_I0.5560.64
113_A116_R0.5560.64
144_G161_F0.5550.64
84_G144_G0.5530.64
27_I30_M0.5500.63
114_Y136_C0.5500.63
141_S172_E0.5470.63
57_A194_S0.5430.62
37_L154_V0.5360.61
14_V17_L0.5350.61
87_T162_Y0.5330.61
159_A171_I0.5320.61
6_N179_D0.5310.61
77_V81_R0.5310.61
30_M35_L0.5300.60
110_I204_A0.5290.60
18_W22_V0.5280.60
22_V27_I0.5270.60
118_L121_Y0.5260.60
48_G89_G0.5220.59
118_L139_G0.5210.59
72_K76_L0.5200.59
177_A181_V0.5200.59
27_I202_W0.5180.59
173_A177_A0.5170.59
69_K72_K0.5170.59
139_G196_R0.5160.58
138_F191_F0.5150.58
73_I77_V0.5140.58
49_K111_N0.5100.58
38_D185_E0.5090.57
149_D168_K0.5090.57
140_Y201_F0.5090.57
145_D148_I0.5080.57
106_G189_N0.5070.57
7_V11_I0.5060.57
59_L65_G0.5040.57
64_K129_F0.5030.57
14_V195_V0.5030.57
55_L62_S0.5020.56
118_L135_P0.5020.56
192_I196_R0.5010.56
128_K183_I0.5010.56
189_N192_I0.5000.56
199_I202_W0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qzcA 4 0.9812 100 0.133 Contact Map
3no6A 4 0.9953 100 0.167 Contact Map
2qcxA 4 0.9953 100 0.176 Contact Map
1uddA 4 0.9765 100 0.178 Contact Map
3rm5A 2 0.9812 100 0.185 Contact Map
2f2gA 1 0.9437 100 0.196 Contact Map
3mvuA 4 0.9765 100 0.203 Contact Map
1rtwA 4 0.939 100 0.204 Contact Map
4fn6A 4 0.9812 100 0.204 Contact Map
2gm8A 4 0.9812 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0075 seconds.