GREMLIN Database
Q97WK7 - Uncharacterized protein
UniProt: Q97WK7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (323)
Sequences: 11333 (9163)
Seq/√Len: 509.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_D81_E4.3031.00
195_R199_D4.2011.00
65_D137_R4.0091.00
42_S119_N3.3601.00
161_T164_N3.0801.00
123_V192_A2.7271.00
75_V113_G2.6741.00
42_S71_E2.6201.00
197_F225_G2.5491.00
81_E84_N2.5321.00
83_E87_K2.5121.00
121_I143_L2.4911.00
174_G177_S2.4641.00
150_T153_S2.4441.00
138_N232_S2.4011.00
121_I140_I2.3861.00
55_E88_K2.3291.00
164_N167_R2.1771.00
161_T165_L2.1501.00
41_V140_I2.1261.00
163_S167_R2.1021.00
40_K119_N2.0941.00
44_I75_V2.0771.00
84_N88_K2.0601.00
40_K120_D2.0461.00
200_N223_R2.0341.00
71_E119_N2.0341.00
142_P230_V2.0321.00
318_I322_P2.0291.00
160_I164_N2.0221.00
149_T152_F2.0151.00
160_I163_S1.9951.00
42_S117_A1.9791.00
215_T219_I1.9711.00
254_T258_Y1.9681.00
139_L192_A1.9561.00
143_L192_A1.9551.00
163_S166_I1.9551.00
121_I192_A1.9231.00
134_Y138_N1.9171.00
149_T154_W1.9081.00
41_V136_L1.8641.00
42_S73_I1.8511.00
106_K110_Q1.8391.00
55_E59_E1.7961.00
60_S131_Y1.7701.00
40_K118_S1.7671.00
324_A327_L1.7611.00
196_E200_N1.7561.00
267_L270_G1.7151.00
170_F173_L1.7031.00
186_L191_M1.6991.00
295_W299_N1.6881.00
74_Y86_L1.6621.00
270_G273_F1.6421.00
49_G78_K1.6411.00
59_E89_Y1.6131.00
123_V136_L1.6131.00
65_D134_Y1.5981.00
150_T157_P1.5821.00
50_I127_S1.5711.00
161_T166_I1.5621.00
91_V94_V1.5571.00
248_S251_Q1.5521.00
200_N225_G1.5471.00
71_E94_V1.5441.00
55_E85_I1.5371.00
152_F157_P1.5261.00
254_T257_A1.5251.00
330_F334_R1.5121.00
66_Y140_I1.5111.00
169_G172_T1.5051.00
247_W251_Q1.5031.00
47_I82_V1.5021.00
164_N168_A1.4971.00
117_A195_R1.4851.00
149_T153_S1.4841.00
320_A324_A1.4491.00
315_L318_I1.4451.00
135_W190_S1.4321.00
150_T154_W1.4311.00
160_I165_L1.4281.00
114_L122_I1.4131.00
151_T157_P1.3991.00
163_S168_A1.3961.00
247_W250_R1.3961.00
150_T155_P1.3951.00
169_G173_L1.3821.00
86_L95_Y1.3761.00
45_V61_L1.3741.00
91_V96_S1.3611.00
125_A131_Y1.3611.00
71_E118_S1.3481.00
153_S157_P1.3191.00
197_F220_I1.3181.00
321_I324_A1.3131.00
91_V95_Y1.3111.00
38_V67_P1.3011.00
112_S116_R1.2871.00
138_N141_S1.2791.00
60_S130_W1.2741.00
113_G117_A1.2731.00
58_I89_Y1.2641.00
321_I325_L1.2571.00
328_L331_N1.2561.00
328_L334_R1.2531.00
63_S133_R1.2451.00
131_Y135_W1.2281.00
295_W302_R1.2271.00
318_I321_I1.2171.00
145_K226_K1.2131.00
65_D133_R1.2121.00
244_L248_S1.2101.00
147_D226_K1.2081.00
295_W298_K1.2061.00
49_G79_G1.1821.00
171_W174_G1.1811.00
170_F174_G1.1701.00
169_G174_G1.1681.00
318_I323_Y1.1621.00
270_G274_A1.1621.00
291_P295_W1.1581.00
76_V83_E1.1481.00
267_L271_T1.1411.00
84_N87_K1.1371.00
267_L273_F1.1341.00
59_E63_S1.1331.00
254_T260_P1.1301.00
317_T324_A1.1261.00
56_R59_E1.1181.00
244_L247_W1.1101.00
75_V109_A1.0981.00
318_I324_A1.0931.00
39_G140_I1.0811.00
110_Q124_F1.0681.00
265_A274_A1.0571.00
17_M25_N1.0531.00
48_K103_C1.0491.00
317_T320_A1.0481.00
22_Q26_E1.0471.00
56_R130_W1.0471.00
40_K71_E1.0471.00
151_T155_P1.0441.00
151_T154_W1.0421.00
152_F156_F1.0391.00
70_Y136_L1.0311.00
85_I89_Y1.0241.00
38_V137_R1.0221.00
121_I194_R1.0171.00
266_Y270_G1.0161.00
122_I195_R1.0161.00
43_I123_V1.0151.00
264_R270_G1.0151.00
114_L198_F1.0141.00
12_V15_A1.0131.00
161_T168_A1.0101.00
162_L166_I1.0081.00
150_T158_S1.0011.00
265_A269_A1.0001.00
66_Y70_Y0.9981.00
148_T228_G0.9971.00
77_E105_G0.9951.00
152_F155_P0.9951.00
237_N240_D0.9901.00
317_T321_I0.9851.00
44_I113_G0.9841.00
319_L322_P0.9811.00
212_D215_T0.9801.00
149_T155_P0.9731.00
196_E199_D0.9691.00
122_I198_F0.9651.00
290_T294_L0.9591.00
265_A270_G0.9571.00
94_V116_R0.9541.00
85_I88_K0.9471.00
160_I166_I0.9461.00
317_T322_P0.9451.00
15_A18_L0.9441.00
159_R163_S0.9431.00
194_R225_G0.9401.00
310_A313_A0.9391.00
120_D196_E0.9381.00
174_G178_Q0.9311.00
220_I225_G0.9311.00
22_Q25_N0.9301.00
42_S195_R0.9291.00
15_A19_I0.9271.00
320_A327_L0.9251.00
100_C103_C0.9251.00
278_I281_L0.9231.00
150_T156_F0.9181.00
269_A273_F0.9171.00
323_Y326_F0.9151.00
47_I54_L0.9121.00
112_S115_L0.9111.00
81_E85_I0.9111.00
244_L251_Q0.9061.00
54_L74_Y0.9021.00
13_F16_D0.9011.00
73_I113_G0.9001.00
39_G66_Y0.9001.00
82_V86_L0.9001.00
264_R267_L0.8991.00
320_A323_Y0.8981.00
322_P326_F0.8981.00
296_I300_V0.8951.00
162_L167_R0.8901.00
274_A278_I0.8891.00
14_G22_Q0.8881.00
274_A277_L0.8811.00
238_V241_E0.8741.00
110_Q203_L0.8741.00
106_K109_A0.8731.00
16_D20_I0.8701.00
253_I258_Y0.8681.00
315_L319_L0.8651.00
71_E92_K0.8641.00
293_I297_V0.8611.00
318_I325_L0.8611.00
255_I258_Y0.8601.00
19_I22_Q0.8541.00
299_N302_R0.8531.00
294_L298_K0.8491.00
159_R164_N0.8471.00
292_Y295_W0.8451.00
162_L165_L0.8421.00
288_T295_W0.8361.00
289_F293_I0.8341.00
161_T167_R0.8331.00
160_I167_R0.8321.00
235_P239_Y0.8321.00
311_L315_L0.8321.00
155_P158_S0.8281.00
171_W175_F0.8251.00
54_L82_V0.8221.00
129_T235_P0.8171.00
24_Y27_I0.8161.00
151_T156_F0.8141.00
35_G38_V0.8121.00
86_L89_Y0.8071.00
296_I299_N0.8031.00
270_G278_I0.8001.00
323_Y327_L0.8001.00
151_T158_S0.7991.00
313_A318_I0.7981.00
243_S247_W0.7981.00
49_G80_D0.7961.00
109_A113_G0.7951.00
154_W157_P0.7951.00
16_D19_I0.7941.00
321_I327_L0.7931.00
322_P327_L0.7891.00
143_L194_R0.7851.00
149_T157_P0.7831.00
104_S108_R0.7821.00
271_T274_A0.7821.00
304_V308_K0.7821.00
268_V271_T0.7791.00
119_N195_R0.7771.00
194_R197_F0.7771.00
265_A268_V0.7741.00
149_T156_F0.7701.00
266_Y269_A0.7701.00
71_E117_A0.7661.00
73_I117_A0.7651.00
263_A270_G0.7651.00
47_I127_S0.7641.00
310_A314_S0.7641.00
134_Y137_R0.7631.00
61_L131_Y0.7591.00
310_A320_A0.7591.00
320_A325_L0.7561.00
322_P325_L0.7541.00
111_I115_L0.7531.00
123_V135_W0.7531.00
45_V57_N0.7531.00
310_A321_I0.7521.00
255_I259_S0.7521.00
277_L280_S0.7511.00
303_G306_Y0.7491.00
172_T177_S0.7491.00
83_E86_L0.7481.00
292_Y296_I0.7471.00
50_I53_R0.7461.00
43_I136_L0.7451.00
153_S156_F0.7431.00
142_P228_G0.7411.00
328_L332_W0.7401.00
190_S235_P0.7391.00
106_K188_G0.7361.00
51_D85_I0.7341.00
47_I74_Y0.7321.00
266_Y274_A0.7321.00
298_K302_R0.7321.00
264_R269_A0.7311.00
329_V333_N0.7301.00
16_D25_N0.7301.00
315_L321_I0.7291.00
14_G18_L0.7281.00
313_A316_M0.7261.00
254_T259_S0.7251.00
316_M320_A0.7181.00
313_A319_L0.7161.00
313_A317_T0.7141.00
263_A267_L0.7131.00
102_S105_G0.7091.00
288_T292_Y0.7091.00
107_I111_I0.7081.00
316_M319_L0.7071.00
217_T227_I0.7061.00
13_F17_M0.7011.00
61_L72_V0.7011.00
253_I257_A0.6981.00
57_N60_S0.6981.00
277_L281_L0.6971.00
263_A266_Y0.6961.00
298_K301_I0.6951.00
314_S318_I0.6951.00
54_L86_L0.6951.00
266_Y273_F0.6941.00
193_L220_I0.6931.00
310_A315_L0.6891.00
114_L117_A0.6891.00
304_V307_P0.6861.00
315_L320_A0.6851.00
64_Q136_L0.6821.00
331_N334_R0.6811.00
215_T218_R0.6781.00
268_V273_F0.6761.00
267_L274_A0.6761.00
40_K69_P0.6761.00
313_A320_A0.6751.00
288_T299_N0.6721.00
178_Q182_S0.6721.00
34_K37_F0.6681.00
178_Q181_Q0.6681.00
317_T327_L0.6651.00
206_L209_E0.6641.00
83_E95_Y0.6641.00
18_L26_E0.6631.00
242_N246_S0.6601.00
82_V85_I0.6601.00
266_Y271_T0.6591.00
57_N61_L0.6591.00
129_T237_N0.6581.00
22_Q29_M0.6561.00
78_K82_V0.6561.00
293_I296_I0.6561.00
270_G276_I0.6551.00
321_I326_F0.6541.00
271_T275_L0.6541.00
264_R274_A0.6531.00
316_M321_I0.6521.00
314_S321_I0.6501.00
162_L168_A0.6501.00
12_V16_D0.6491.00
178_Q183_S0.6491.00
64_Q131_Y0.6461.00
57_N62_L0.6451.00
319_L323_Y0.6431.00
235_P238_V0.6421.00
107_I212_D0.6421.00
13_F22_Q0.6411.00
69_P119_N0.6411.00
16_D23_T0.6401.00
13_F18_L0.6361.00
212_D217_T0.6351.00
237_N241_E0.6331.00
171_W177_S0.6331.00
179_S183_S0.6321.00
313_A321_I0.6311.00
48_K340_R0.6301.00
262_G265_A0.6291.00
257_A260_P0.6291.00
64_Q137_R0.6281.00
27_I31_K0.6271.00
219_I222_R0.6261.00
292_Y299_N0.6251.00
154_W158_S0.6241.00
317_T323_Y0.6241.00
111_I114_L0.6211.00
160_I168_A0.6181.00
42_S118_S0.6171.00
245_I249_S0.6151.00
49_G76_V0.6141.00
23_T26_E0.6141.00
93_I96_S0.6131.00
25_N28_K0.6131.00
159_R166_I0.6111.00
297_V301_I0.6101.00
262_G267_L0.6101.00
90_N93_I0.6091.00
15_A26_E0.6091.00
198_F203_L0.6071.00
26_E30_W0.6061.00
16_D22_Q0.6061.00
212_D218_R0.6051.00
139_L233_A0.6040.99
165_L168_A0.6030.99
129_T189_G0.6020.99
55_E89_Y0.6020.99
312_I315_L0.5980.99
262_G270_G0.5960.99
262_G266_Y0.5950.99
117_A122_I0.5950.99
269_A274_A0.5920.99
277_L284_L0.5920.99
291_P299_N0.5920.99
18_L22_Q0.5890.99
14_G17_M0.5890.99
316_M324_A0.5880.99
211_C214_C0.5880.99
43_I70_Y0.5870.99
15_A22_Q0.5860.99
92_K95_Y0.5850.99
22_Q27_I0.5850.99
153_S158_S0.5840.99
18_L21_L0.5830.99
330_F333_N0.5810.99
316_M327_L0.5810.99
139_L143_L0.5790.99
234_I240_D0.5780.99
45_V74_Y0.5770.99
294_L302_R0.5760.99
16_D26_E0.5760.99
175_F178_Q0.5750.99
317_T325_L0.5730.99
212_D220_I0.5670.99
249_S252_I0.5650.99
315_L322_P0.5620.99
43_I61_L0.5620.99
280_S283_Y0.5610.99
310_A316_M0.5590.99
21_L25_N0.5580.99
26_E29_M0.5560.99
23_T28_K0.5540.99
288_T291_P0.5530.99
19_I23_T0.5520.99
230_V233_A0.5500.99
57_N125_A0.5490.99
24_Y28_K0.5490.99
273_F278_I0.5480.99
45_V72_V0.5470.99
263_A274_A0.5460.99
263_A278_I0.5460.99
124_F191_M0.5460.99
44_I124_F0.5450.99
120_D194_R0.5450.99
179_S182_S0.5440.99
25_N31_K0.5430.99
257_A261_R0.5430.99
265_A271_T0.5410.99
132_P236_L0.5400.99
131_Y190_S0.5380.99
270_G277_L0.5370.99
38_V66_Y0.5370.99
292_Y298_K0.5340.99
171_W176_E0.5330.99
236_L240_D0.5290.99
264_R271_T0.5290.99
62_L90_N0.5280.99
96_S112_S0.5250.99
110_Q113_G0.5230.99
106_K126_D0.5230.99
278_I282_V0.5220.99
43_I64_Q0.5220.99
17_M22_Q0.5210.99
189_G247_W0.5210.99
318_I327_L0.5210.99
291_P294_L0.5200.98
303_G308_K0.5190.98
262_G268_V0.5170.98
139_L190_S0.5160.98
23_T27_I0.5160.98
173_L177_S0.5100.98
290_T293_I0.5080.98
106_K212_D0.5080.98
289_F292_Y0.5080.98
40_K70_Y0.5070.98
253_I256_L0.5040.98
125_A190_S0.5020.98
319_L324_A0.5010.98
17_M26_E0.5010.98
159_R167_R0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.9886 100 0.391 Contact Map
3bcvA 2 0.4972 100 0.538 Contact Map
2z86A 2 0.7841 100 0.539 Contact Map
3l7iA 4 0.0682 100 0.547 Contact Map
5ajoA 1 0.9773 100 0.547 Contact Map
2d7iA 1 0.9403 100 0.548 Contact Map
1xhbA 1 0.9034 100 0.55 Contact Map
1qg8A 1 0.6165 100 0.552 Contact Map
4fixA 3 0.9574 100 0.56 Contact Map
2bo4A 4 0.8182 100 0.564 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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