GREMLIN Database
Q97WK5 - Uncharacterized protein
UniProt: Q97WK5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (301)
Sequences: 7068 (5531)
Seq/√Len: 318.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_E120_K5.9141.00
13_L83_I4.0481.00
35_I70_N3.4571.00
39_K70_N3.3921.00
111_N117_G3.0791.00
12_N81_N3.0341.00
87_L128_Y3.0291.00
33_Y261_N2.9611.00
30_G33_Y2.9071.00
127_K159_G2.8611.00
242_R259_N2.8011.00
91_R132_L2.7611.00
246_C288_C2.6931.00
228_C246_C2.6661.00
119_Y155_L2.6601.00
104_D114_R2.5791.00
242_R256_E2.5301.00
31_I66_A2.4981.00
106_R109_I2.3881.00
36_N40_K2.3771.00
39_K74_K2.3191.00
148_I151_D2.2691.00
82_G101_L2.1711.00
238_T242_R2.1331.00
35_I66_A2.1171.00
106_R148_I2.1001.00
259_N262_L2.0911.00
34_D67_V2.0871.00
10_K28_P2.0311.00
87_L131_D1.9891.00
154_H158_L1.9811.00
109_I148_I1.9651.00
128_Y131_D1.9521.00
3_W41_L1.8991.00
70_N73_A1.8981.00
107_E111_N1.8601.00
86_R89_P1.8041.00
138_A156_I1.7781.00
127_K131_D1.7651.00
101_L126_A1.7641.00
70_N74_K1.7561.00
12_N84_A1.7481.00
31_I35_I1.7141.00
87_L132_L1.7001.00
29_Y33_Y1.6861.00
71_V76_Y1.6811.00
112_K145_D1.6741.00
121_A124_R1.6651.00
150_T191_R1.6511.00
69_D73_A1.6501.00
52_F76_Y1.6401.00
122_V125_S1.6351.00
110_T118_I1.6171.00
151_D154_H1.6071.00
184_S188_G1.6051.00
65_M92_Y1.5831.00
89_P93_W1.5641.00
155_L159_G1.5491.00
28_P60_N1.5481.00
58_L78_I1.5431.00
94_R132_L1.5231.00
79_Q100_L1.5051.00
187_N191_R1.4961.00
35_I39_K1.4841.00
101_L125_S1.4791.00
50_I71_V1.4711.00
90_E128_Y1.4711.00
33_Y36_N1.4661.00
140_M152_V1.4651.00
72_R97_N1.4521.00
124_R127_K1.4481.00
17_Y104_D1.4241.00
113_H143_T1.4241.00
154_H195_Y1.4141.00
107_E119_Y1.4071.00
127_K130_K1.4001.00
238_T244_L1.3901.00
190_K194_D1.3831.00
105_G109_I1.3761.00
60_N67_V1.3751.00
90_E132_L1.3541.00
124_R128_Y1.3531.00
16_D112_K1.3461.00
99_A129_L1.3421.00
66_A69_D1.3421.00
111_N114_R1.3211.00
128_Y132_L1.3181.00
195_Y198_S1.3111.00
29_Y34_D1.3071.00
12_N56_E1.2811.00
90_E94_R1.2751.00
7_T52_F1.2751.00
228_C288_C1.2721.00
58_L84_A1.2641.00
69_D92_Y1.2521.00
138_A161_F1.2491.00
140_M164_V1.2401.00
38_V71_V1.2221.00
88_L92_Y1.2181.00
123_L159_G1.2121.00
9_G239_P1.2081.00
52_F71_V1.1971.00
95_K98_V1.1961.00
185_Y188_G1.1961.00
85_V90_E1.1941.00
144_Q184_S1.1921.00
29_Y37_S1.1811.00
120_K124_R1.1781.00
102_S141_T1.1641.00
88_L91_R1.1641.00
62_K66_A1.1561.00
19_G53_Y1.1551.00
103_I138_A1.1531.00
123_L155_L1.1521.00
106_R151_D1.1521.00
195_Y199_E1.1461.00
153_M157_D1.1461.00
154_H157_D1.1391.00
38_V74_K1.1301.00
5_L34_D1.1251.00
110_T122_V1.1251.00
130_K160_L1.1191.00
110_T114_R1.1131.00
111_N118_I1.1101.00
187_N190_K1.1071.00
203_G206_V1.1061.00
36_N39_K1.1051.00
272_P298_G1.0931.00
65_M95_K1.0851.00
13_L118_I1.0771.00
105_G119_Y1.0751.00
156_I161_F1.0711.00
186_L190_K1.0681.00
123_L127_K1.0661.00
129_L134_V1.0601.00
94_R133_G1.0551.00
16_D113_H1.0551.00
87_L91_R1.0541.00
125_S128_Y1.0471.00
36_N261_N1.0451.00
66_A70_N1.0361.00
119_Y123_L1.0351.00
60_N63_F1.0351.00
12_N83_I1.0291.00
72_R76_Y1.0241.00
235_V264_Y1.0221.00
284_C288_C1.0211.00
184_S187_N1.0061.00
249_A290_Y1.0041.00
58_L89_P0.9941.00
289_L292_Q0.9871.00
157_D199_E0.9831.00
101_L129_L0.9781.00
150_T195_Y0.9761.00
100_L139_R0.9741.00
41_L50_I0.9711.00
94_R134_V0.9711.00
89_P92_Y0.9701.00
78_I93_W0.9681.00
72_R95_K0.9651.00
126_A136_T0.9631.00
273_D276_K0.9571.00
53_Y79_Q0.9551.00
275_C278_C0.9551.00
8_T28_P0.9521.00
106_R155_L0.9511.00
43_E74_K0.9471.00
274_D302_F0.9421.00
61_Y65_M0.9371.00
189_I192_L0.9351.00
49_T75_R0.9311.00
105_G114_R0.9301.00
121_A125_S0.9271.00
49_T77_G0.9261.00
85_V129_L0.9261.00
92_Y96_I0.9261.00
65_M88_L0.9231.00
27_V240_D0.9141.00
58_L125_S0.9101.00
68_L92_Y0.9031.00
17_Y113_H0.9021.00
31_I62_K0.8991.00
79_Q247_P0.8941.00
78_I99_A0.8931.00
56_E80_T0.8891.00
244_L256_E0.8891.00
5_L37_S0.8851.00
150_T154_H0.8841.00
99_A134_V0.8831.00
85_V125_S0.8821.00
178_F181_W0.8761.00
167_Q170_V0.8721.00
37_S237_V0.8721.00
191_R195_Y0.8701.00
152_V156_I0.8701.00
183_F187_N0.8681.00
179_K182_S0.8641.00
126_A138_A0.8641.00
185_Y189_I0.8641.00
7_T60_N0.8591.00
90_E125_S0.8581.00
8_T60_N0.8551.00
56_E81_N0.8551.00
81_N84_A0.8491.00
130_K136_T0.8481.00
110_T117_G0.8481.00
169_D173_S0.8451.00
185_Y196_F0.8441.00
110_T119_Y0.8431.00
69_D95_K0.8411.00
72_R96_I0.8401.00
79_Q139_R0.8401.00
243_I264_Y0.8361.00
11_C15_C0.8321.00
11_C18_C0.8221.00
107_E117_G0.8211.00
37_S40_K0.8161.00
17_Y114_R0.8151.00
284_C306_D0.8131.00
20_G53_Y0.8121.00
6_M236_T0.8111.00
40_K44_K0.8081.00
275_C284_C0.8051.00
191_R194_D0.8041.00
15_C18_C0.8031.00
253_K256_E0.8011.00
87_L90_E0.8001.00
38_V50_I0.7961.00
86_R92_Y0.7931.00
91_R94_R0.7921.00
273_D277_R0.7921.00
12_N59_L0.7911.00
111_N119_Y0.7811.00
32_K36_N0.7771.00
53_Y247_P0.7771.00
129_L136_T0.7711.00
37_S41_L0.7701.00
68_L96_I0.7701.00
3_W235_V0.7660.99
138_A164_V0.7650.99
208_I211_I0.7650.99
6_M53_Y0.7620.99
103_I119_Y0.7600.99
65_M89_P0.7600.99
130_K162_D0.7590.99
205_V208_I0.7580.99
211_I214_V0.7560.99
192_L196_F0.7560.99
35_I73_A0.7540.99
103_I123_L0.7520.99
155_L158_L0.7510.99
52_F68_L0.7510.99
126_A161_F0.7510.99
210_P213_G0.7490.99
105_G110_T0.7480.99
258_G263_G0.7450.99
143_T146_T0.7430.99
302_F306_D0.7410.99
83_I125_S0.7400.99
259_N263_G0.7390.99
108_E112_K0.7370.99
135_E162_D0.7370.99
56_E82_G0.7310.99
274_D303_K0.7290.99
4_L234_S0.7280.99
245_S249_A0.7250.99
67_V71_V0.7220.99
104_D110_T0.7180.99
50_I76_Y0.7180.99
100_L137_I0.7170.99
34_D37_S0.7150.99
68_L76_Y0.7140.99
33_Y37_S0.7110.99
202_K206_V0.7100.99
296_Y301_G0.7100.99
80_T101_L0.7090.99
226_S230_A0.7060.99
90_E93_W0.7060.99
7_T63_F0.7060.99
31_I70_N0.7060.99
237_V243_I0.7060.99
34_D38_V0.7020.99
6_M239_P0.7000.99
194_D197_L0.6990.99
204_R209_I0.6980.99
263_G267_L0.6970.99
188_G191_R0.6930.99
51_I79_Q0.6920.99
225_G228_C0.6920.99
203_G207_K0.6880.99
41_L47_D0.6860.99
6_M20_G0.6830.99
56_E59_L0.6820.99
169_D175_E0.6820.99
10_K26_V0.6810.99
62_K65_M0.6810.99
236_T247_P0.6810.99
7_T67_V0.6770.99
35_I74_K0.6770.99
32_K35_I0.6770.99
92_Y95_K0.6760.99
51_I77_G0.6760.99
75_R97_N0.6760.99
140_M156_I0.6720.99
58_L63_F0.6720.99
130_K161_F0.6680.99
26_V29_Y0.6670.99
281_K285_G0.6630.99
53_Y100_L0.6630.99
52_F67_V0.6590.98
63_F68_L0.6580.98
47_D75_R0.6560.98
14_K21_S0.6550.98
204_R208_I0.6540.98
3_W237_V0.6540.98
222_G225_G0.6530.98
101_L122_V0.6490.98
120_K123_L0.6490.98
102_S114_R0.6470.98
272_P302_F0.6450.98
193_T196_F0.6440.98
59_L84_A0.6440.98
17_Y141_T0.6440.98
34_D60_N0.6430.98
156_I159_G0.6410.98
226_S229_G0.6370.98
118_I122_V0.6340.98
126_A159_G0.6320.98
26_V30_G0.6290.98
275_C306_D0.6270.98
287_R303_K0.6250.98
148_I152_V0.6240.98
86_R125_S0.6240.98
71_V74_K0.6230.98
61_Y89_P0.6220.98
153_M164_V0.6200.98
105_G148_I0.6160.98
224_K227_P0.6150.98
142_V149_F0.6110.98
38_V52_F0.6070.97
209_I213_G0.6070.97
241_G259_N0.6060.97
61_Y64_V0.6050.97
85_V89_P0.6030.97
243_I263_G0.6020.97
213_G217_A0.6010.97
83_I121_A0.6000.97
39_K43_E0.5980.97
79_Q248_I0.5970.97
235_V265_R0.5960.97
86_R90_E0.5950.97
167_Q173_S0.5950.97
139_R247_P0.5950.97
256_E259_N0.5940.97
61_Y92_Y0.5940.97
22_F174_E0.5940.97
82_G125_S0.5900.97
114_R118_I0.5900.97
68_L71_V0.5880.97
17_Y20_G0.5840.97
149_F191_R0.5840.97
31_I60_N0.5820.97
20_G236_T0.5820.97
242_R258_G0.5810.97
4_L247_P0.5800.97
278_C306_D0.5800.97
299_E302_F0.5790.97
58_L83_I0.5780.97
209_I212_L0.5780.97
31_I34_D0.5770.96
188_G192_L0.5760.96
86_R93_W0.5710.96
255_A293_K0.5680.96
103_I122_V0.5660.96
306_D309_N0.5660.96
104_D141_T0.5650.96
53_Y139_R0.5630.96
184_S196_F0.5620.96
185_Y192_L0.5600.96
139_R167_Q0.5600.96
140_M166_W0.5600.96
147_D188_G0.5580.96
20_G247_P0.5570.96
185_Y193_T0.5560.96
93_W98_V0.5540.96
17_Y53_Y0.5540.96
149_F153_M0.5530.96
202_K208_I0.5520.95
65_M91_R0.5510.95
33_Y40_K0.5510.95
37_S260_V0.5500.95
111_N116_K0.5500.95
125_S129_L0.5490.95
78_I96_I0.5470.95
186_L196_F0.5460.95
31_I67_V0.5450.95
141_T169_D0.5440.95
188_G196_F0.5440.95
234_S247_P0.5430.95
4_L51_I0.5410.95
156_I164_V0.5400.95
230_A246_C0.5380.95
189_I193_T0.5380.95
296_Y302_F0.5360.95
130_K159_G0.5360.95
34_D52_F0.5320.95
292_Q304_A0.5310.94
189_I196_F0.5310.94
183_F186_L0.5300.94
210_P214_V0.5300.94
298_G301_G0.5290.94
207_K210_P0.5280.94
196_F199_E0.5270.94
147_D150_T0.5270.94
89_P94_R0.5270.94
60_N66_A0.5250.94
293_K296_Y0.5240.94
177_D180_S0.5230.94
17_Y143_T0.5230.94
6_M139_R0.5220.94
109_I112_K0.5200.94
164_V168_L0.5200.94
194_D198_S0.5200.94
7_T34_D0.5200.94
153_M199_E0.5190.94
149_F166_W0.5180.94
303_K309_N0.5170.94
223_Y226_S0.5160.94
4_L53_Y0.5140.93
249_A255_A0.5140.93
222_G226_S0.5130.93
304_A307_E0.5110.93
203_G208_I0.5110.93
142_V166_W0.5110.93
245_S248_I0.5100.93
175_E178_F0.5090.93
115_G118_I0.5080.93
35_I40_K0.5080.93
207_K212_L0.5080.93
6_M9_G0.5070.93
305_V308_V0.5070.93
206_V211_I0.5070.93
278_C284_C0.5070.93
54_G57_P0.5070.93
221_E224_K0.5060.93
292_Q298_G0.5060.93
222_G227_P0.5050.93
243_I258_G0.5040.93
255_A258_G0.5040.93
136_T161_F0.5030.93
147_D184_S0.5010.93
5_L17_Y0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4k36A 1 0.9629 100 0.318 Contact Map
1tv8A 2 0.78 100 0.534 Contact Map
4m7tA 1 0.6086 100 0.55 Contact Map
4rtbA 2 0.8886 100 0.58 Contact Map
4wcxA 1 0.9457 100 0.611 Contact Map
3c8fA 1 0.58 99.9 0.618 Contact Map
2z2uA 1 0.5629 99.9 0.646 Contact Map
2yx0A 1 0.6486 99.9 0.647 Contact Map
3rfaA 1 0.6514 99.9 0.664 Contact Map
2a5hA 4 0.7886 99.9 0.667 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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