GREMLIN Database
Y2213 - UPF0284 protein SSO2213
UniProt: Q97WK3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (320)
Sequences: 313 (233)
Seq/√Len: 13.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_D273_S5.9211.00
167_A206_R5.1881.00
222_S244_V4.2371.00
127_V208_A3.6900.99
32_P41_P3.5000.99
22_V218_V3.4330.99
287_L315_T3.3970.98
19_Y310_G3.1570.98
196_L210_V3.0210.97
23_I153_S2.9880.97
118_R191_V2.9350.96
166_L189_R2.8820.96
261_K265_E2.7680.95
135_I223_L2.6190.93
329_V333_D2.5750.92
163_A195_A2.4040.89
39_A50_A2.3980.89
328_L332_I2.3720.88
150_I313_G2.3570.88
238_T275_A2.3500.88
264_V272_L2.3110.87
164_T206_R2.2940.87
262_W287_L2.2030.84
232_A313_G2.1870.84
79_L311_A2.1670.83
258_G316_I2.0540.80
172_A175_K2.0530.80
95_N108_D2.0450.79
162_M172_A2.0300.79
262_W301_E1.9930.78
39_A199_L1.9740.77
237_M240_A1.9640.76
222_S255_I1.9610.76
245_N278_V1.9530.76
108_D111_G1.9470.76
276_K313_G1.9350.75
215_L240_A1.9270.75
28_V117_I1.9240.75
214_V218_V1.9000.74
24_G214_V1.8820.73
114_G183_N1.8490.72
114_G213_P1.8330.71
35_T156_A1.8250.71
84_L89_S1.8160.70
202_D205_Q1.8160.70
80_T322_G1.7910.69
148_I220_G1.7260.66
21_L52_A1.7230.66
80_T314_S1.7230.66
177_S183_N1.6840.64
156_A217_G1.6710.64
192_V196_L1.6420.62
16_D326_S1.6270.62
230_L258_G1.6000.60
96_A109_L1.5980.60
23_I98_S1.5940.60
55_V163_A1.5920.60
134_G221_I1.5760.59
69_S75_T1.5560.58
92_I137_L1.5370.57
238_T271_M1.5240.56
48_P118_R1.4910.55
271_M275_A1.4790.54
154_I214_V1.4780.54
167_A264_V1.4590.53
155_P184_P1.4430.52
55_V309_V1.4360.52
266_D306_K1.4280.51
20_I139_E1.4230.51
75_T154_I1.4190.51
28_V210_V1.4120.51
238_T274_L1.4110.51
313_G322_G1.3940.50
331_K334_E1.3790.49
73_I262_W1.3690.48
95_N102_P1.3610.48
28_V179_A1.3460.47
96_A217_G1.3240.46
50_A63_I1.3170.46
42_E314_S1.3130.45
194_E276_K1.2920.44
221_I224_G1.2890.44
273_S277_Q1.2880.44
177_S269_A1.2870.44
148_I225_F1.2870.44
134_G320_I1.2840.44
189_R193_E1.2830.44
141_L172_A1.2730.43
109_L257_I1.2690.43
139_E227_G1.2610.43
163_A222_S1.2520.42
241_A255_I1.2490.42
96_A134_G1.2490.42
297_I322_G1.2470.42
73_I299_T1.2450.42
26_T37_A1.2440.42
179_A243_I1.2410.42
177_S271_M1.2330.41
79_L315_T1.2320.41
40_T44_T1.2210.41
203_P287_L1.2140.40
36_I179_A1.2090.40
168_L242_A1.2080.40
44_T69_S1.2050.40
121_A208_A1.1940.39
131_I220_G1.1920.39
178_S266_D1.1810.39
263_I271_M1.1630.38
58_G274_L1.1520.37
181_P264_V1.1390.37
261_K301_E1.1380.37
92_I107_I1.1370.37
75_T114_G1.1360.36
293_I337_S1.1350.36
43_L314_S1.1350.36
163_A192_V1.1280.36
141_L242_A1.1230.36
203_P246_E1.1220.36
232_A320_I1.1130.35
24_G178_S1.1090.35
131_I204_L1.1090.35
112_E115_K1.0990.35
105_P296_G1.0990.35
235_T332_I1.0960.35
23_I311_A1.0960.35
83_S264_V1.0900.34
159_T333_D1.0850.34
110_Q113_P1.0820.34
39_A43_L1.0720.33
81_R85_S1.0700.33
164_T211_S1.0680.33
199_L280_V1.0660.33
163_A167_A1.0640.33
34_L195_A1.0610.33
75_T315_T1.0510.32
137_L184_P1.0490.32
17_F21_L1.0430.32
213_P239_A1.0420.32
132_E222_S1.0370.32
27_D115_K1.0330.32
230_L271_M1.0330.32
150_I225_F1.0320.32
56_I123_S1.0290.31
113_P255_I1.0240.31
190_K200_P1.0220.31
114_G257_I1.0190.31
154_I263_I1.0190.31
23_I104_I1.0190.31
112_E123_S1.0150.31
142_S314_S1.0090.31
73_I116_D0.9990.30
44_T48_P0.9910.30
190_K194_E0.9870.30
21_L90_L0.9870.30
57_L61_K0.9860.30
193_E282_V0.9850.30
201_T205_Q0.9850.30
142_S317_M0.9840.29
110_Q335_L0.9810.29
43_L130_I0.9810.29
261_K288_D0.9780.29
142_S281_K0.9770.29
177_S235_T0.9720.29
239_A311_A0.9720.29
62_S100_I0.9660.29
262_W288_D0.9650.29
62_S103_K0.9650.29
71_T78_L0.9640.29
280_V284_A0.9630.29
112_E150_I0.9620.29
48_P69_S0.9550.28
27_D273_S0.9540.28
96_A148_I0.9520.28
144_E198_N0.9510.28
34_L148_I0.9500.28
45_H80_T0.9490.28
226_R274_L0.9470.28
78_L170_Y0.9430.28
94_V202_D0.9420.28
258_G283_L0.9400.28
29_S36_I0.9380.28
28_V195_A0.9370.27
43_L304_Y0.9340.27
27_D30_L0.9340.27
181_P218_V0.9330.27
222_S332_I0.9320.27
292_S333_D0.9300.27
68_V71_T0.9260.27
109_L130_I0.9250.27
257_I339_L0.9240.27
244_V255_I0.9180.27
20_I24_G0.9170.27
38_G51_D0.9120.26
48_P116_D0.9120.26
207_L275_A0.9110.26
132_E322_G0.9090.26
230_L279_G0.9080.26
276_K337_S0.9060.26
187_L271_M0.9050.26
171_D200_P0.9040.26
48_P215_L0.9020.26
155_P177_S0.9010.26
121_A226_R0.9000.26
71_T122_L0.8980.26
18_A92_I0.8940.26
154_I289_L0.8920.26
163_A263_I0.8920.26
95_N111_G0.8900.26
128_N324_S0.8900.26
86_F132_E0.8890.26
140_E255_I0.8850.25
81_R178_S0.8810.25
162_M166_L0.8770.25
162_M192_V0.8700.25
270_D277_Q0.8700.25
206_R211_S0.8660.25
272_L282_V0.8620.24
82_A288_D0.8620.24
50_A195_A0.8620.24
28_V225_F0.8550.24
270_D315_T0.8510.24
150_I194_E0.8490.24
27_D45_H0.8460.24
85_S331_K0.8410.24
214_V263_I0.8370.23
177_S184_P0.8370.23
146_E278_V0.8350.23
42_E45_H0.8310.23
117_I163_A0.8300.23
110_Q324_S0.8280.23
96_A141_L0.8280.23
32_P261_K0.8270.23
121_A328_L0.8230.23
132_E135_I0.8200.23
164_T199_L0.8150.23
165_L263_I0.8150.23
138_G151_G0.8130.23
146_E286_M0.8120.23
24_G94_V0.8110.23
297_I333_D0.8110.23
92_I216_L0.8090.22
21_L39_A0.8070.22
228_K284_A0.8060.22
73_I336_Y0.8050.22
28_V192_V0.8020.22
275_A335_L0.8010.22
94_V107_I0.7960.22
75_T184_P0.7950.22
114_G154_I0.7950.22
129_I133_N0.7910.22
43_L332_I0.7880.22
94_V137_L0.7850.22
204_L267_K0.7810.21
94_V295_E0.7800.21
93_V104_I0.7790.21
278_V313_G0.7780.21
171_D330_R0.7740.21
17_F34_L0.7730.21
16_D70_P0.7730.21
122_L270_D0.7730.21
267_K330_R0.7710.21
164_T318_A0.7690.21
94_V177_S0.7680.21
287_L301_E0.7680.21
29_S44_T0.7670.21
325_N329_V0.7580.21
55_V93_V0.7580.21
79_L332_I0.7550.21
314_S335_L0.7520.20
163_A262_W0.7490.20
130_I206_R0.7470.20
42_E242_A0.7470.20
95_N100_I0.7440.20
293_I333_D0.7420.20
53_E312_G0.7410.20
139_E324_S0.7410.20
130_I154_I0.7400.20
87_T202_D0.7400.20
268_S275_A0.7400.20
295_E299_T0.7350.20
45_H89_S0.7310.20
207_L243_I0.7310.20
108_D218_V0.7250.20
195_A210_V0.7230.19
149_M279_G0.7230.19
261_K290_S0.7210.19
100_I218_V0.7190.19
27_D99_R0.7190.19
23_I246_E0.7180.19
238_T257_I0.7150.19
197_R280_V0.7130.19
204_L247_F0.7100.19
230_L255_I0.7090.19
264_V284_A0.7070.19
293_I331_K0.7070.19
78_L150_I0.7060.19
59_K63_I0.7060.19
27_D110_Q0.7040.19
29_S98_S0.7030.19
248_D252_L0.7020.19
58_G81_R0.7010.19
232_A263_I0.6980.19
194_E327_T0.6960.19
104_I144_E0.6960.19
21_L25_T0.6940.19
59_K336_Y0.6930.19
114_G118_R0.6910.18
93_V313_G0.6890.18
116_D183_N0.6880.18
28_V131_I0.6880.18
43_L69_S0.6800.18
283_L316_I0.6800.18
48_P53_E0.6790.18
131_I243_I0.6790.18
31_I140_E0.6780.18
77_A137_L0.6760.18
57_L63_I0.6750.18
85_S148_I0.6730.18
39_A270_D0.6720.18
25_T116_D0.6680.18
223_L247_F0.6660.18
35_T71_T0.6630.18
17_F63_I0.6560.17
171_D197_R0.6550.17
115_K199_L0.6550.17
44_T116_D0.6510.17
215_L257_I0.6510.17
146_E324_S0.6510.17
117_I192_V0.6490.17
119_K304_Y0.6490.17
38_G47_T0.6490.17
47_T51_D0.6490.17
95_N203_P0.6490.17
130_I209_K0.6480.17
279_G324_S0.6440.17
178_S336_Y0.6420.17
77_A155_P0.6410.17
162_M176_V0.6410.17
69_S155_P0.6410.17
147_L191_V0.6390.17
19_Y269_A0.6390.17
182_D293_I0.6370.17
70_P248_D0.6350.17
19_Y263_I0.6340.17
117_I195_A0.6330.17
150_I291_I0.6290.17
23_I35_T0.6270.17
166_L218_V0.6270.17
218_V240_A0.6270.17
181_P258_G0.6270.17
198_N248_D0.6270.17
253_K288_D0.6240.16
24_G285_S0.6240.16
60_C86_F0.6230.16
236_Q306_K0.6220.16
102_P237_M0.6210.16
164_T216_L0.6200.16
50_A160_T0.6200.16
47_T53_E0.6190.16
222_S239_A0.6180.16
17_F35_T0.6170.16
193_E207_L0.6160.16
197_R227_G0.6150.16
58_G154_I0.6150.16
40_T305_V0.6140.16
70_P155_P0.6120.16
39_A181_P0.6110.16
28_V163_A0.6100.16
285_S323_V0.6090.16
132_E326_S0.6090.16
119_K319_F0.6080.16
21_L241_A0.6060.16
296_G336_Y0.6050.16
17_F331_K0.6050.16
191_V336_Y0.6030.16
69_S73_I0.6030.16
81_R159_T0.6030.16
83_S109_L0.6020.16
166_L192_V0.6000.16
49_A315_T0.5990.16
48_P75_T0.5990.16
143_N247_F0.5980.16
107_I256_I0.5960.16
184_P224_G0.5950.16
132_E191_V0.5940.16
214_V311_A0.5930.16
121_A134_G0.5900.15
102_P214_V0.5890.15
195_A262_W0.5880.15
17_F332_I0.5880.15
69_S296_G0.5860.15
167_A315_T0.5860.15
281_K299_T0.5860.15
70_P314_S0.5850.15
180_S187_L0.5840.15
109_L217_G0.5830.15
181_P235_T0.5830.15
149_M281_K0.5830.15
32_P318_A0.5830.15
104_I214_V0.5830.15
57_L270_D0.5800.15
81_R113_P0.5780.15
57_L150_I0.5780.15
102_P160_T0.5760.15
87_T314_S0.5750.15
37_A51_D0.5740.15
243_I271_M0.5740.15
170_Y279_G0.5730.15
176_V213_P0.5730.15
18_A146_E0.5720.15
79_L331_K0.5720.15
106_Y149_M0.5720.15
49_A336_Y0.5710.15
263_I333_D0.5710.15
257_I280_V0.5700.15
197_R201_T0.5640.15
211_S216_L0.5630.15
203_P285_S0.5600.15
114_G269_A0.5590.15
221_I244_V0.5580.15
194_E324_S0.5580.15
69_S154_I0.5570.15
73_I301_E0.5560.15
194_E197_R0.5550.15
266_D332_I0.5550.15
50_A306_K0.5540.15
24_G332_I0.5520.14
176_V219_A0.5520.14
294_H333_D0.5500.14
22_V140_E0.5500.14
69_S215_L0.5480.14
122_L134_G0.5480.14
34_L243_I0.5470.14
20_I133_N0.5460.14
30_L225_F0.5460.14
162_M240_A0.5450.14
125_E334_E0.5450.14
155_P228_K0.5420.14
56_I105_P0.5410.14
104_I320_I0.5410.14
154_I274_L0.5400.14
26_T271_M0.5400.14
50_A62_S0.5360.14
146_E195_A0.5360.14
133_N203_P0.5360.14
122_L199_L0.5360.14
136_K190_K0.5350.14
79_L287_L0.5350.14
116_D130_I0.5340.14
134_G153_S0.5330.14
59_K64_N0.5300.14
126_K129_I0.5300.14
113_P267_K0.5280.14
250_S267_K0.5260.14
273_S315_T0.5250.14
132_E186_E0.5240.14
328_L338_E0.5230.14
22_V221_I0.5220.14
44_T118_R0.5210.14
279_G330_R0.5210.14
104_I246_E0.5200.14
95_N271_M0.5190.14
34_L126_K0.5180.14
18_A148_I0.5170.14
52_A55_V0.5150.14
128_N204_L0.5150.14
92_I115_K0.5140.14
54_Y335_L0.5120.13
50_A229_I0.5110.13
149_M309_V0.5110.13
23_I40_T0.5100.13
194_E268_S0.5080.13
120_Q136_K0.5080.13
262_W289_L0.5070.13
255_I298_R0.5060.13
186_E197_R0.5060.13
71_T116_D0.5050.13
17_F147_L0.5020.13
85_S338_E0.5010.13
100_I313_G0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u4gA 2 0.9193 100 0.335 Contact Map
3l0zA 2 0.9568 100 0.373 Contact Map
4hdrA 1 0.8012 100 0.757 Contact Map
1wx1A 2 0.8242 100 0.761 Contact Map
4kqiA 2 0.8156 100 0.761 Contact Map
4hdrB 1 0.8127 100 0.772 Contact Map
2r62A 1 0.6282 24.7 0.976 Contact Map
2e0nA 2 0.6052 15.7 0.979 Contact Map
2an7A 2 0.1354 14.8 0.979 Contact Map
3eieA 1 0.6398 14.7 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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