GREMLIN Database
NADK - NAD kinase
UniProt: Q97WJ8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (230)
Sequences: 4344 (3007)
Seq/√Len: 198.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_L223_R4.0871.00
93_E230_K4.0301.00
129_D188_S3.7261.00
165_N186_P3.3021.00
152_G170_I3.2051.00
83_R88_D3.1651.00
27_L82_L2.9091.00
98_E223_R2.7881.00
192_R219_E2.7631.00
48_L231_I2.6941.00
127_S132_R2.6281.00
103_D218_Q2.6221.00
160_L168_E2.5871.00
189_L221_T2.4471.00
93_E228_K2.3641.00
169_I184_I2.3601.00
100_V221_T2.3571.00
76_K79_D2.3331.00
125_G194_E2.1831.00
94_Y146_Q2.1781.00
127_S192_R2.1611.00
82_L86_K2.1141.00
19_K78_E2.0821.00
39_V55_G2.0101.00
91_E230_K1.9571.00
21_K25_N1.9211.00
131_E238_D1.9201.00
126_I169_I1.9161.00
23_I78_E1.9121.00
92_E233_R1.9021.00
125_G192_R1.8891.00
128_F190_I1.8781.00
48_L60_A1.8531.00
155_A170_I1.8471.00
112_I204_V1.8001.00
23_I82_L1.7851.00
107_L225_S1.7731.00
100_V223_R1.7501.00
96_L229_A1.7131.00
99_M112_I1.6941.00
158_S168_E1.6211.00
42_V63_A1.6181.00
122_I202_A1.6051.00
23_I27_L1.5671.00
111_E141_L1.5451.00
128_F188_S1.5321.00
125_G134_S1.5261.00
53_K209_E1.5251.00
149_S159_L1.5131.00
22_N26_K1.5041.00
96_L225_S1.4551.00
130_T189_L1.4391.00
155_A173_N1.4311.00
112_I222_V1.4251.00
20_I81_L1.4141.00
158_S183_V1.4091.00
62_K67_G1.3471.00
97_L167_I1.3391.00
160_L166_A1.3251.00
177_Y180_R1.3241.00
98_E225_S1.3221.00
126_I140_V1.3211.00
72_V80_A1.3211.00
102_N219_E1.3201.00
108_G206_V1.3031.00
24_S31_V1.3031.00
48_L70_M1.3001.00
160_L183_V1.2951.00
66_R175_I1.2891.00
138_D151_W1.2611.00
38_Y84_L1.2581.00
71_D233_R1.2521.00
20_I77_I1.2321.00
131_E241_G1.2241.00
165_N228_K1.2151.00
161_Y240_I1.2021.00
112_I206_V1.2001.00
102_N221_T1.2001.00
52_V58_V1.1901.00
143_S168_E1.1891.00
25_N30_E1.1871.00
98_E226_Q1.1851.00
38_Y232_L1.1771.00
61_I72_V1.1591.00
161_Y185_P1.1561.00
96_L228_K1.1551.00
239_L243_V1.1411.00
23_I81_L1.1391.00
99_M206_V1.1391.00
142_V167_I1.1381.00
141_L155_A1.1331.00
142_V169_I1.1141.00
184_I190_I1.1091.00
102_N105_V1.1001.00
215_K218_Q1.0991.00
27_L85_K1.0951.00
18_E22_N1.0921.00
79_D83_R1.0901.00
201_T215_K1.0821.00
124_V137_G1.0761.00
28_G31_V1.0741.00
84_L89_Y1.0721.00
59_I84_L1.0561.00
184_I188_S1.0551.00
241_G245_H1.0541.00
107_L227_H1.0531.00
79_D82_L1.0521.00
40_I81_L1.0511.00
68_L240_I1.0271.00
88_D235_F1.0031.00
142_V222_V0.9951.00
98_E107_L0.9931.00
95_M224_V0.9931.00
90_N236_K0.9911.00
52_V109_F0.9871.00
102_N218_Q0.9811.00
153_M175_I0.9750.99
161_Y188_S0.9750.99
41_A51_A0.9710.99
140_V169_I0.9660.99
118_R203_R0.9650.99
127_S130_T0.9640.99
125_G132_R0.9620.99
167_I190_I0.9600.99
29_F85_K0.9590.99
186_P224_V0.9580.99
153_M177_Y0.9560.99
163_D185_P0.9510.99
194_E219_E0.9480.99
83_R234_F0.9470.99
95_M165_N0.9460.99
201_T213_L0.9380.99
62_K246_A0.9370.99
61_I77_I0.9360.99
117_D201_T0.9210.99
52_V229_A0.9210.99
80_A234_F0.9170.99
17_V21_K0.9150.99
59_I72_V0.9130.99
113_G141_L0.9080.99
25_N28_G0.9020.99
32_V36_F0.9020.99
129_D189_L0.9010.99
106_E206_V0.8960.99
16_T19_K0.8960.99
42_V61_I0.8960.99
111_E115_L0.8890.99
168_E183_V0.8890.99
165_N224_V0.8840.99
39_V58_V0.8730.99
95_M145_P0.8710.99
124_V193_L0.8710.99
153_M158_S0.8630.99
95_M186_P0.8540.99
139_G172_V0.8520.99
59_I232_L0.8480.99
103_D215_K0.8460.99
165_N187_K0.8430.98
23_I26_K0.8400.98
32_V35_D0.8340.98
95_M166_A0.8340.98
124_V140_V0.8340.98
128_F184_I0.8300.98
185_P188_S0.8270.98
20_I42_V0.8270.98
133_V240_I0.8260.98
109_F229_A0.8260.98
161_Y239_L0.8060.98
238_D241_G0.8060.98
126_I135_V0.7990.98
170_I181_S0.7960.98
193_L196_K0.7930.98
142_V190_I0.7890.98
18_E25_N0.7860.98
224_V228_K0.7840.98
109_F146_Q0.7680.97
240_I243_V0.7640.97
116_Y120_E0.7640.97
24_S29_F0.7630.97
18_E21_K0.7630.97
138_D173_N0.7610.97
56_K225_S0.7580.97
123_K136_E0.7570.97
19_K23_I0.7560.97
123_K134_S0.7510.97
71_D237_L0.7500.97
20_I24_S0.7450.97
38_Y59_I0.7420.97
92_E163_D0.7420.97
128_F133_V0.7420.97
101_H214_I0.7400.97
24_S28_G0.7400.97
22_N25_N0.7350.96
146_Q162_K0.7320.96
90_N233_R0.7310.96
96_L109_F0.7310.96
55_G58_V0.7300.96
78_E82_L0.7300.96
48_L58_V0.7280.96
113_G208_G0.7270.96
58_V229_A0.7270.96
65_R136_E0.7260.96
238_D242_E0.7260.96
203_R213_L0.7230.96
94_Y162_K0.7230.96
178_Y247_Y0.7220.96
79_D236_K0.7190.96
135_V159_L0.7150.96
46_G64_G0.7070.96
163_D187_K0.7070.96
45_D110_N0.7060.96
95_M167_I0.7050.96
24_S40_I0.7030.95
40_I59_I0.6990.95
129_D187_K0.6960.95
237_L242_E0.6930.95
97_L108_G0.6910.95
71_D150_G0.6880.95
20_I23_I0.6790.94
153_M247_Y0.6730.94
17_V31_V0.6730.94
50_R209_E0.6690.94
21_K33_D0.6640.94
121_A136_E0.6580.94
133_V184_I0.6580.94
49_L152_G0.6570.93
57_P230_K0.6500.93
153_M180_R0.6500.93
94_Y97_L0.6480.93
244_L247_Y0.6470.93
79_D85_K0.6460.93
99_M220_I0.6420.93
39_V59_I0.6410.93
27_L78_E0.6390.93
120_E210_V0.6380.92
138_D170_I0.6380.92
111_E154_S0.6380.92
56_K96_L0.6380.92
71_D234_F0.6370.92
232_L242_E0.6330.92
115_L203_R0.6310.92
56_K227_H0.6300.92
178_Y181_S0.6300.92
203_R211_V0.6290.92
214_I220_I0.6240.92
73_P76_K0.6230.92
176_F179_L0.6220.92
89_Y232_L0.6210.91
162_K239_L0.6200.91
96_L107_L0.6200.91
36_F154_S0.6190.91
74_V78_E0.6180.91
44_G64_G0.6120.91
59_I80_A0.6120.91
46_G110_N0.6080.91
69_L146_Q0.6050.90
26_K29_F0.6050.90
99_M204_V0.6050.90
94_Y239_L0.6050.90
67_G70_M0.6010.90
195_D202_A0.6010.90
44_G110_N0.6000.90
89_Y234_F0.5970.90
239_L242_E0.5970.90
44_G47_T0.5930.89
84_L87_G0.5920.89
44_G67_G0.5920.89
113_G205_V0.5910.89
175_I180_R0.5910.89
124_V202_A0.5880.89
26_K104_K0.5870.89
17_V22_N0.5840.89
71_D242_E0.5830.89
68_L180_R0.5820.89
101_H105_V0.5810.89
84_L234_F0.5760.88
101_H218_Q0.5750.88
60_A67_G0.5750.88
89_Y93_E0.5730.88
82_L184_I0.5720.88
50_R53_K0.5710.88
135_V171_F0.5700.88
166_A183_V0.5680.87
18_E27_L0.5670.87
40_I180_R0.5670.87
143_S171_F0.5640.87
41_A48_L0.5630.87
20_I40_I0.5620.87
76_K80_A0.5600.87
204_V214_I0.5560.86
19_K22_N0.5560.86
105_V219_E0.5560.86
114_I202_A0.5550.86
71_D92_E0.5540.86
154_S157_N0.5520.86
155_A172_V0.5510.86
167_I188_S0.5500.86
44_G62_K0.5490.86
53_K56_K0.5460.85
25_N29_F0.5460.85
61_I80_A0.5460.85
152_G168_E0.5410.85
92_E101_H0.5400.85
56_K107_L0.5400.85
174_P180_R0.5390.85
177_Y181_S0.5390.85
41_A152_G0.5360.84
165_N235_F0.5340.84
187_K224_V0.5340.84
68_L149_S0.5340.84
36_F55_G0.5330.84
63_A111_E0.5320.84
105_V218_Q0.5310.84
113_G137_G0.5290.83
120_E209_E0.5270.83
237_L241_G0.5270.83
47_T208_G0.5260.83
25_N32_V0.5260.83
25_N100_V0.5250.83
90_N235_F0.5220.83
28_G32_V0.5210.83
213_L216_T0.5210.83
36_F39_V0.5200.82
130_T200_Q0.5190.82
49_L109_F0.5190.82
74_V140_V0.5190.82
116_Y173_N0.5170.82
114_I124_V0.5170.82
113_G142_V0.5160.82
111_E209_E0.5150.82
119_P205_V0.5130.82
163_D210_V0.5120.81
176_F222_V0.5110.81
153_M159_L0.5090.81
52_V96_L0.5080.81
151_W172_V0.5080.81
16_T42_V0.5080.81
101_H220_I0.5070.81
21_K165_N0.5060.81
27_L81_L0.5050.81
225_S228_K0.5030.80
101_H204_V0.5020.80
237_L245_H0.5020.80
176_F208_G0.5010.80
19_K26_K0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pfnA 4 0.996 100 0.135 Contact Map
3afoA 4 0.996 100 0.198 Contact Map
2an1A 4 0.9679 100 0.32 Contact Map
1yt5A 4 0.9679 100 0.323 Contact Map
1u0tA 4 0.996 100 0.325 Contact Map
2i2cA 3 0.9839 100 0.326 Contact Map
1z0sA 4 0.9357 100 0.349 Contact Map
2qv7A 2 0.9197 100 0.625 Contact Map
3s40A 3 0.8795 99.9 0.658 Contact Map
4werA 2 0.8755 99.9 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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