GREMLIN Database
FENR - Ferredoxin--NADP reductase
UniProt: Q97WJ5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 332 (282)
Sequences: 59845 (42383)
Seq/√Len: 2523.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
154_L235_V4.0921.00
152_R175_S3.4751.00
177_T204_W3.1731.00
209_E221_I3.0411.00
5_D109_K2.8941.00
211_K221_I2.8911.00
175_S202_Y2.8431.00
219_Q232_V2.7841.00
211_K219_Q2.5191.00
266_N270_E2.5121.00
5_D28_K2.4891.00
221_I232_V2.3881.00
152_R236_D2.3841.00
204_W231_K2.3661.00
6_I22_A2.3361.00
154_L179_I2.3251.00
224_D231_K2.3081.00
30_L81_K2.2851.00
18_G112_F2.2751.00
123_S245_K2.2551.00
7_V32_I2.2431.00
257_T264_V2.2111.00
206_E223_F2.2051.00
128_K209_E2.1911.00
4_Y30_L2.1631.00
154_L220_A2.1441.00
32_I106_Y2.1401.00
208_K223_F2.1331.00
98_I105_T2.1291.00
112_F308_A2.1161.00
152_R177_T2.1151.00
193_K197_R2.0361.00
7_V106_Y1.9661.00
208_K221_I1.9441.00
91_K273_L1.9051.00
219_Q234_D1.8861.00
100_K105_T1.8481.00
5_D30_L1.8321.00
110_T275_G1.7721.00
211_K232_V1.7531.00
181_R206_E1.6981.00
259_K262_D1.6931.00
108_T111_I1.6871.00
7_V99_V1.6851.00
118_G247_D1.6741.00
14_V279_G1.6721.00
152_R234_D1.6691.00
177_T202_Y1.6631.00
97_W101_T1.6501.00
179_I233_L1.6321.00
151_K236_D1.6231.00
7_V108_T1.6071.00
98_I101_T1.6001.00
257_T272_N1.5951.00
152_R174_K1.5871.00
132_E212_G1.5611.00
222_I233_L1.5551.00
305_I309_K1.4871.00
112_F279_G1.4801.00
28_K79_D1.4671.00
34_A84_E1.4561.00
118_G245_K1.4521.00
118_G249_G1.4481.00
97_W275_G1.4471.00
115_A282_I1.4361.00
7_V30_L1.4301.00
8_V15_G1.4261.00
98_I107_K1.4171.00
186_R189_E1.4051.00
110_T308_A1.3971.00
88_M100_K1.3841.00
11_G33_D1.3781.00
301_A305_I1.3771.00
136_R139_Y1.3691.00
277_Y307_V1.3631.00
277_Y311_Y1.3621.00
19_T31_L1.3601.00
210_V238_V1.3521.00
101_T104_A1.3331.00
110_T277_Y1.3281.00
101_T106_Y1.3251.00
8_V19_T1.3161.00
222_I225_N1.3011.00
270_E274_P1.2931.00
304_A308_A1.2801.00
259_K284_Q1.2761.00
222_I231_K1.2691.00
153_V169_L1.2661.00
126_G130_E1.2621.00
177_T235_V1.2621.00
259_K264_V1.2501.00
158_G180_H1.2301.00
72_Q76_F1.2301.00
70_I74_K1.2191.00
90_E98_I1.2141.00
6_I112_F1.2061.00
71_E74_K1.2011.00
150_G174_K1.1951.00
139_Y142_V1.1941.00
30_L106_Y1.1781.00
52_Y55_G1.1781.00
21_Y306_S1.1771.00
139_Y143_R1.1701.00
114_A279_G1.1641.00
91_K276_V1.1531.00
135_N140_Y1.1511.00
6_I27_M1.1481.00
25_R309_K1.1421.00
265_V283_V1.1401.00
61_Q64_E1.1371.00
14_V297_G1.1351.00
21_Y24_L1.1341.00
263_I278_A1.1271.00
67_Q71_E1.1191.00
170_A201_V1.1171.00
273_L276_V1.1131.00
149_E174_K1.1111.00
163_V178_L1.1111.00
89_I111_I1.1051.00
96_M101_T1.1001.00
303_I307_V1.0961.00
179_I222_I1.0721.00
136_R140_Y1.0711.00
153_V237_S1.0671.00
71_E75_M1.0601.00
213_D219_Q1.0561.00
22_A305_I1.0421.00
4_Y7_V1.0351.00
135_N141_T1.0331.00
110_T311_Y1.0261.00
135_N139_Y1.0201.00
90_E100_K1.0151.00
140_Y143_R1.0061.00
136_R142_V1.0031.00
170_A175_S1.0031.00
279_G304_A1.0011.00
96_M99_V0.9991.00
156_V238_V0.9951.00
23_G78_P0.9951.00
263_I282_I0.9951.00
42_L45_L0.9891.00
25_R306_S0.9881.00
96_M100_K0.9841.00
153_V174_K0.9831.00
195_L198_V0.9811.00
40_G45_L0.9801.00
9_I113_I0.9791.00
87_D100_K0.9781.00
36_D83_N0.9771.00
137_G140_Y0.9761.00
73_A76_F0.9711.00
217_V238_V0.9631.00
32_I81_K0.9631.00
21_Y25_R0.9611.00
32_I86_A0.9481.00
53_D56_G0.9461.00
162_A180_H0.9441.00
297_G301_A0.9441.00
173_A176_V0.9391.00
166_A178_L0.9361.00
167_L171_P0.9351.00
9_I115_A0.9311.00
213_D216_K0.9301.00
190_R193_K0.9291.00
6_I110_T0.9291.00
21_Y302_A0.9291.00
171_P199_A0.9221.00
37_E70_I0.9201.00
30_L108_T0.9191.00
269_M303_I0.9181.00
81_K106_Y0.9181.00
88_M253_K0.9071.00
202_Y231_K0.9051.00
278_A282_I0.9001.00
4_Y28_K0.9001.00
213_D234_D0.9001.00
207_L220_A0.9001.00
141_T144_R0.8991.00
270_E311_Y0.8941.00
81_K84_E0.8931.00
154_L233_L0.8931.00
283_V300_H0.8921.00
64_E68_R0.8891.00
249_G252_P0.8881.00
194_E197_R0.8861.00
269_M283_V0.8861.00
281_D297_G0.8791.00
81_K104_A0.8771.00
5_D107_K0.8761.00
22_A27_M0.8761.00
64_E67_Q0.8731.00
40_G44_S0.8711.00
18_G279_G0.8701.00
39_G42_L0.8701.00
30_L79_D0.8631.00
155_I166_A0.8561.00
5_D27_M0.8551.00
137_G141_T0.8521.00
20_F24_L0.8511.00
258_M264_V0.8501.00
168_T172_V0.8481.00
269_M304_A0.8471.00
265_V278_A0.8471.00
136_R141_T0.8441.00
277_Y308_A0.8431.00
177_T233_L0.8381.00
18_G304_A0.8381.00
27_M309_K0.8311.00
210_V220_A0.8311.00
111_I276_V0.8281.00
112_F304_A0.8281.00
39_G45_L0.8251.00
154_L238_V0.8221.00
18_G301_A0.8221.00
195_L199_A0.8191.00
156_V242_I0.8191.00
87_D102_D0.8181.00
270_E275_G0.8171.00
69_L72_Q0.8141.00
204_W233_L0.8131.00
15_G114_A0.8121.00
156_V240_I0.8121.00
268_R307_V0.8111.00
137_G142_V0.8021.00
265_V269_M0.7981.00
4_Y110_T0.7961.00
15_G19_T0.7941.00
6_I308_A0.7931.00
92_T98_I0.7891.00
278_A283_V0.7811.00
129_G132_E0.7791.00
117_I244_Y0.7741.00
22_A308_A0.7741.00
8_V18_G0.7731.00
139_Y144_R0.7731.00
19_T29_T0.7721.00
52_Y56_G0.7641.00
96_M107_K0.7631.00
212_G217_V0.7621.00
39_G44_S0.7591.00
151_K174_K0.7591.00
9_I86_A0.7581.00
66_A70_I0.7541.00
113_I282_I0.7501.00
23_G29_T0.7491.00
83_N102_D0.7441.00
73_A78_P0.7431.00
158_G185_F0.7431.00
84_E102_D0.7431.00
143_R146_K0.7431.00
179_I204_W0.7421.00
56_G60_I0.7411.00
65_L68_R0.7411.00
40_G43_V0.7331.00
304_A307_V0.7331.00
63_Y67_Q0.7321.00
275_G311_Y0.7291.00
32_I101_T0.7231.00
11_G31_L0.7171.00
167_L170_A0.7171.00
235_V238_V0.7161.00
38_L82_V0.7151.00
19_T78_P0.7151.00
41_Q45_L0.7131.00
296_V300_H0.7131.00
159_G243_G0.7111.00
5_D106_Y0.7091.00
84_E87_D0.7091.00
277_Y304_A0.7071.00
212_G216_K0.7061.00
141_T145_K0.7061.00
194_E198_V0.7051.00
190_R194_E0.7031.00
22_A29_T0.6951.00
302_A306_S0.6951.00
137_G240_I0.6941.00
279_G308_A0.6921.00
204_W222_I0.6901.00
191_S194_E0.6901.00
156_V207_L0.6901.00
152_R235_V0.6891.00
8_V114_A0.6881.00
99_V103_K0.6871.00
170_A199_A0.6871.00
110_T312_V0.6831.00
41_Q44_S0.6811.00
67_Q70_I0.6801.00
180_H183_D0.6791.00
184_Q193_K0.6751.00
125_L240_I0.6731.00
5_D108_T0.6711.00
193_K203_V0.6711.00
168_T171_P0.6711.00
271_T278_A0.6701.00
210_V217_V0.6671.00
212_G215_N0.6651.00
216_K219_Q0.6651.00
270_E307_V0.6641.00
129_G209_E0.6601.00
72_Q75_M0.6561.00
32_I108_T0.6521.00
169_L172_V0.6511.00
27_M109_K0.6511.00
17_F21_Y0.6491.00
52_Y57_L0.6461.00
72_Q77_G0.6461.00
97_W103_K0.6451.00
56_G59_G0.6451.00
299_A302_A0.6451.00
97_W273_L0.6451.00
113_I250_N0.6411.00
17_F301_A0.6381.00
90_E96_M0.6381.00
165_W239_I0.6371.00
23_G77_G0.6331.00
97_W100_K0.6331.00
165_W168_T0.6321.00
127_A130_E0.6301.00
18_G305_I0.6281.00
183_D205_H0.6271.00
130_E240_I0.6241.00
124_R240_I0.6241.00
57_L60_I0.6221.00
270_E277_Y0.6221.00
284_Q300_H0.6181.00
4_Y79_D0.6181.00
17_F298_F0.6181.00
27_M308_A0.6151.00
86_A99_V0.6151.00
92_T96_M0.6131.00
100_K103_K0.6121.00
88_M91_K0.6101.00
269_M307_V0.6091.00
264_V272_N0.6091.00
151_K237_S0.6081.00
206_E225_N0.6081.00
135_N138_V0.6051.00
39_G43_V0.6011.00
17_F20_F0.6011.00
124_R131_I0.6011.00
196_F203_V0.5991.00
84_E101_T0.5941.00
151_K175_S0.5921.00
279_G301_A0.5921.00
306_S310_K0.5901.00
139_Y237_S0.5891.00
33_D82_V0.5881.00
6_I305_I0.5871.00
170_A200_N0.5861.00
54_V57_L0.5851.00
265_V268_R0.5841.00
14_V114_A0.5831.00
4_Y109_K0.5821.00
180_H205_H0.5811.00
68_R71_E0.5811.00
8_V31_L0.5801.00
148_F151_K0.5791.00
157_G243_G0.5781.00
33_D39_G0.5761.00
258_M263_I0.5761.00
180_H185_F0.5761.00
38_L80_I0.5721.00
252_P258_M0.5691.00
191_S195_L0.5691.00
219_Q222_I0.5641.00
69_L73_A0.5641.00
91_K97_W0.5641.00
180_H203_V0.5631.00
138_V142_V0.5601.00
180_H184_Q0.5601.00
125_L130_E0.5591.00
38_L70_I0.5581.00
11_G38_L0.5581.00
295_A298_F0.5561.00
196_F199_A0.5541.00
124_R130_E0.5541.00
23_G28_K0.5531.00
113_I251_I0.5521.00
299_A303_I0.5511.00
270_E273_L0.5501.00
123_S242_I0.5461.00
300_H304_A0.5461.00
248_L258_M0.5461.00
167_L172_V0.5421.00
166_A201_V0.5411.00
166_A176_V0.5401.00
59_G62_A0.5381.00
154_L177_T0.5381.00
35_Q42_L0.5371.00
153_V239_I0.5371.00
68_R72_Q0.5351.00
155_I162_A0.5341.00
254_W258_M0.5341.00
115_A250_N0.5331.00
147_D150_G0.5321.00
197_R202_Y0.5321.00
23_G79_D0.5291.00
8_V29_T0.5291.00
165_W241_S0.5271.00
122_P125_L0.5271.00
87_D91_K0.5261.00
148_F237_S0.5251.00
137_G143_R0.5251.00
31_L80_I0.5221.00
152_R233_L0.5221.00
138_V141_T0.5201.00
178_L203_V0.5161.00
262_D292_A0.5161.00
307_V310_K0.5151.00
63_Y66_A0.5151.00
83_N87_D0.5141.00
179_I235_V0.5091.00
60_I64_E0.5081.00
108_T275_G0.5071.00
21_Y305_I0.5051.00
162_A241_S0.5051.00
97_W276_V0.5041.00
294_I297_G0.5041.00
113_I276_V0.5041.00
256_V273_L0.5031.00
260_G284_Q0.5021.00
295_A299_A0.5001.00
86_A89_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lzwA 2 0.9729 100 0.277 Contact Map
3ab1A 2 0.988 100 0.287 Contact Map
2zbwA 2 0.9789 100 0.3 Contact Map
2q0lA 2 0.9096 100 0.3 Contact Map
1vdcA 2 0.9127 100 0.309 Contact Map
4up3A 2 0.9036 100 0.309 Contact Map
2q7vA 2 0.9096 100 0.314 Contact Map
3f8dA 2 0.9096 100 0.316 Contact Map
4c5oA 5 0.8795 100 0.318 Contact Map
1trbA 2 0.9096 100 0.318 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.