Q97WJ4 - SULSO - GREMLIN Contacts

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Q97WJ4 - Uncharacterized protein

UniProt:	Q97WJ4	Sequences: MWSLMHPYLPATVRKWTNLNLSNHSFSLNTMKTKRLSEFFPGVRSYYIVGEIAIITPKRVNVDYNLVAEKIMQAHPKIKAVYLKKKVKGELRTNELEFLSGERISSTIYKENGVLFYVDINKVYVNPSLSGDRLKNLELVEEGSTVLDAFTGYGAIALNIAHKKRVYVVAGDINIDGLYMLKKSLSLNKIKGMIDIVQYDAHHLPFRDKVFKLSFGDNPTLIIDFKEELCRVSENVVFYILCESEDKANSSLGRTSWIKINDYSKNLFIFKGLVRC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	276 (224)
Sequences:	973 (678)
Seq/√Len:	45.3

HALSA - Q9HMM2 Q9HQK5
SULSO - Q97WJ4 Q97W08

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
117_Y	183_K	3.987	1.00
176_D	179_Y	3.955	1.00
202_H	227_E	3.127	1.00
105_S	121_N	2.892	1.00
148_D	217_D	2.725	1.00
98_F	105_S	2.660	1.00
47_Y	127_P	2.609	1.00
79_K	102_E	2.595	1.00
65_N	97_E	2.588	1.00
157_A	170_A	2.574	1.00
178_L	182_K	2.564	1.00
147_L	211_F	2.535	1.00
150_F	225_F	2.518	1.00
185_L	194_I	2.478	1.00
185_L	196_I	2.451	1.00
53_A	78_I	2.449	1.00
134_L	138_E	2.403	1.00
107_T	118_V	2.384	1.00
167_Y	195_D	2.369	1.00
213_L	237_V	2.355	1.00
83_L	97_E	2.348	1.00
178_L	196_I	2.263	1.00
149_A	201_A	2.238	1.00
122_K	176_D	2.093	1.00
110_K	115_L	2.052	0.99
108_I	115_L	2.016	0.99
82_Y	96_L	2.013	0.99
116_F	159_N	1.993	0.99
118_V	180_M	1.947	0.99
117_Y	187_L	1.926	0.99
91_L	173_I	1.918	0.99
106_S	180_M	1.899	0.99
144_S	213_L	1.871	0.99
252_L	255_T	1.868	0.99
115_L	187_L	1.863	0.99
108_I	117_Y	1.858	0.99
160_I	215_F	1.835	0.99
124_Y	129_L	1.730	0.98
129_L	217_D	1.725	0.98
124_Y	217_D	1.647	0.97
251_S	255_T	1.623	0.97
53_A	75_H	1.617	0.97
250_S	254_R	1.600	0.97
154_G	181_L	1.597	0.97
140_V	160_I	1.593	0.97
144_S	212_K	1.572	0.96
253_G	257_W	1.567	0.96
72_M	100_S	1.566	0.96
140_V	146_V	1.561	0.96
114_V	158_L	1.481	0.95
129_L	172_D	1.463	0.95
169_V	197_V	1.455	0.95
90_E	173_I	1.442	0.94
145_T	211_F	1.436	0.94
254_R	258_I	1.419	0.94
124_Y	128_S	1.404	0.93
119_D	122_K	1.392	0.93
68_A	81_V	1.383	0.93
172_D	217_D	1.374	0.93
114_V	162_H	1.370	0.93
128_S	155_A	1.367	0.92
148_D	181_L	1.354	0.92
56_T	84_K	1.343	0.92
155_A	217_D	1.343	0.92
197_V	204_L	1.333	0.92
118_V	123_V	1.328	0.91
149_A	229_L	1.324	0.91
218_N	222_I	1.315	0.91
80_A	101_G	1.296	0.90
53_A	71_I	1.285	0.90
47_Y	128_S	1.283	0.90
161_A	216_G	1.278	0.90
136_N	140_V	1.275	0.90
88_K	95_E	1.272	0.89
186_S	191_K	1.265	0.89
68_A	99_L	1.265	0.89
68_A	100_S	1.249	0.89
129_L	219_P	1.242	0.88
151_T	181_L	1.238	0.88
140_V	215_F	1.237	0.88
146_V	215_F	1.237	0.88
124_Y	155_A	1.226	0.88
183_K	186_S	1.225	0.88
124_Y	219_P	1.215	0.87
52_I	107_T	1.184	0.86
136_N	215_F	1.181	0.86
170_A	181_L	1.153	0.84
148_D	172_D	1.149	0.84
216_G	222_I	1.144	0.84
128_S	217_D	1.140	0.84
175_I	198_Q	1.108	0.82
129_L	155_A	1.093	0.81
217_D	241_L	1.084	0.80
84_K	241_L	1.077	0.80
105_S	119_D	1.069	0.79
190_I	194_I	1.052	0.78
128_S	219_P	1.047	0.78
255_T	258_I	1.046	0.78
116_F	158_L	1.045	0.78
48_I	76_P	1.037	0.77
99_L	189_K	1.036	0.77
69_E	73_Q	1.017	0.76
109_Y	125_V	1.012	0.75
176_D	180_M	1.010	0.75
79_K	104_I	1.009	0.75
214_S	233_S	1.008	0.75
183_K	187_L	1.006	0.75
147_L	171_G	0.989	0.74
54_I	120_I	0.980	0.73
75_H	78_I	0.968	0.72
135_K	237_V	0.967	0.72
156_I	226_K	0.960	0.72
112_N	134_L	0.949	0.71
216_G	225_F	0.948	0.71
89_G	93_T	0.944	0.70
223_I	240_I	0.938	0.70
172_D	218_N	0.938	0.70
87_V	129_L	0.938	0.70
48_I	78_I	0.935	0.70
151_T	172_D	0.931	0.69
172_D	178_L	0.929	0.69
132_D	135_K	0.927	0.69
149_A	205_P	0.927	0.69
155_A	219_P	0.926	0.69
42_G	46_Y	0.922	0.68
71_I	75_H	0.919	0.68
159_N	181_L	0.914	0.68
150_F	238_F	0.912	0.68
55_I	99_L	0.911	0.67
89_G	111_E	0.910	0.67
242_C	246_D	0.908	0.67
161_A	194_I	0.907	0.67
83_L	99_L	0.907	0.67
80_A	104_I	0.905	0.67
179_Y	183_K	0.899	0.66
177_G	239_Y	0.899	0.66
251_S	254_R	0.896	0.66
158_L	184_S	0.895	0.66
82_Y	120_I	0.888	0.65
71_I	78_I	0.887	0.65
71_I	235_N	0.886	0.65
182_K	186_S	0.875	0.64
142_E	191_K	0.873	0.64
156_I	177_G	0.865	0.63
133_R	156_I	0.863	0.63
220_T	241_L	0.860	0.63
202_H	224_D	0.860	0.63
126_N	133_R	0.859	0.63
82_Y	172_D	0.854	0.62
109_Y	130_S	0.845	0.62
146_V	168_V	0.844	0.62
57_P	67_V	0.840	0.61
133_R	220_T	0.836	0.61
62_V	65_N	0.835	0.61
201_A	204_L	0.828	0.60
149_A	153_Y	0.822	0.59
148_D	154_G	0.821	0.59
219_P	222_I	0.820	0.59
60_V	65_N	0.813	0.59
106_S	117_Y	0.812	0.59
142_E	165_R	0.812	0.59
178_L	198_Q	0.809	0.58
161_A	190_I	0.806	0.58
219_P	241_L	0.806	0.58
37_S	64_Y	0.806	0.58
251_S	256_S	0.806	0.58
84_K	126_N	0.805	0.58
81_V	100_S	0.799	0.57
124_Y	148_D	0.797	0.57
242_C	247_K	0.797	0.57
172_D	201_A	0.784	0.56
129_L	241_L	0.780	0.55
60_V	63_D	0.777	0.55
210_V	214_S	0.776	0.55
244_S	256_S	0.776	0.55
124_Y	239_Y	0.766	0.54
141_E	192_G	0.766	0.54
252_L	257_W	0.766	0.54
155_A	239_Y	0.764	0.54
130_S	134_L	0.762	0.54
87_V	148_D	0.762	0.54
250_S	255_T	0.761	0.54
137_L	213_L	0.759	0.53
85_K	95_E	0.755	0.53
146_V	185_L	0.754	0.53
49_V	52_I	0.753	0.53
129_L	239_Y	0.752	0.53
147_L	214_S	0.749	0.52
82_Y	105_S	0.747	0.52
155_A	241_L	0.746	0.52
133_R	172_D	0.743	0.52
129_L	148_D	0.742	0.52
67_V	97_E	0.740	0.52
59_R	81_V	0.731	0.51
133_R	177_G	0.727	0.50
45_S	124_Y	0.723	0.50
254_R	257_W	0.718	0.49
146_V	160_I	0.715	0.49
57_P	64_Y	0.713	0.49
124_Y	130_S	0.712	0.49
79_K	107_T	0.711	0.49
128_S	239_Y	0.708	0.48
118_V	177_G	0.707	0.48
211_F	240_I	0.703	0.48
128_S	218_N	0.701	0.48
77_K	136_N	0.696	0.47
158_L	190_I	0.691	0.47
138_E	209_K	0.691	0.47
88_K	258_I	0.690	0.47
94_N	155_A	0.688	0.47
94_N	217_D	0.688	0.47
156_I	159_N	0.685	0.46
141_E	144_S	0.683	0.46
60_V	64_Y	0.682	0.46
108_I	189_K	0.677	0.45
136_N	160_I	0.674	0.45
111_E	130_S	0.672	0.45
160_I	168_V	0.671	0.45
63_D	142_E	0.669	0.45
94_N	128_S	0.668	0.45
180_M	183_K	0.655	0.43
147_L	237_V	0.650	0.43
205_P	228_E	0.648	0.43
46_Y	71_I	0.642	0.42
116_F	124_Y	0.639	0.42
68_A	72_M	0.636	0.42
89_G	95_E	0.635	0.41
249_N	255_T	0.632	0.41
124_Y	172_D	0.630	0.41
73_Q	145_T	0.627	0.41
217_D	239_Y	0.627	0.41
202_H	225_F	0.625	0.40
166_V	238_F	0.624	0.40
166_V	193_M	0.621	0.40
149_A	236_V	0.620	0.40
106_S	119_D	0.612	0.39
109_Y	220_T	0.611	0.39
246_D	250_S	0.610	0.39
148_D	220_T	0.608	0.39
243_E	248_A	0.608	0.39
227_E	236_V	0.607	0.39
34_K	40_F	0.606	0.39
49_V	127_P	0.606	0.39
217_D	222_I	0.605	0.39
36_L	62_V	0.604	0.39
87_V	93_T	0.604	0.39
47_Y	169_V	0.602	0.38
47_Y	180_M	0.601	0.38
54_I	125_V	0.600	0.38
147_L	169_V	0.600	0.38
133_R	155_A	0.599	0.38
51_E	104_I	0.596	0.38
94_N	127_P	0.596	0.38
171_G	204_L	0.596	0.38
98_F	173_I	0.594	0.38
112_N	222_I	0.594	0.38
140_V	164_K	0.593	0.38
98_F	110_K	0.592	0.37
187_L	252_L	0.591	0.37
55_I	112_N	0.590	0.37
171_G	199_Y	0.589	0.37
111_E	119_D	0.588	0.37
73_Q	81_V	0.587	0.37
82_Y	184_S	0.587	0.37
149_A	216_G	0.586	0.37
199_Y	204_L	0.583	0.37
49_V	118_V	0.581	0.36
143_G	166_V	0.581	0.36
34_K	149_A	0.581	0.36
167_Y	251_S	0.579	0.36
193_M	214_S	0.573	0.36
120_I	173_I	0.572	0.36
82_Y	135_K	0.571	0.36
61_N	67_V	0.571	0.36
214_S	229_L	0.567	0.35
218_N	241_L	0.566	0.35
120_I	171_G	0.564	0.35
253_G	256_S	0.563	0.35
219_P	239_Y	0.562	0.35
157_A	186_S	0.561	0.35
129_L	133_R	0.560	0.35
145_T	169_V	0.560	0.35
145_T	179_Y	0.559	0.34
157_A	172_D	0.552	0.34
221_L	224_D	0.551	0.34
146_V	166_V	0.549	0.34
113_G	189_K	0.546	0.33
108_I	137_L	0.546	0.33
47_Y	213_L	0.545	0.33
72_M	78_I	0.545	0.33
231_R	236_V	0.544	0.33
40_F	62_V	0.544	0.33
117_Y	191_K	0.542	0.33
156_I	221_L	0.542	0.33
66_L	143_G	0.539	0.33
227_E	231_R	0.539	0.33
184_S	200_D	0.536	0.32
141_E	206_F	0.535	0.32
157_A	171_G	0.535	0.32
45_S	169_V	0.534	0.32
145_T	236_V	0.534	0.32
80_A	105_S	0.532	0.32
94_N	159_N	0.531	0.32
107_T	181_L	0.530	0.32
49_V	211_F	0.529	0.32
111_E	133_R	0.528	0.32
89_G	107_T	0.527	0.32
181_L	217_D	0.527	0.32
155_A	201_A	0.525	0.32
148_D	218_N	0.524	0.31
216_G	226_K	0.523	0.31
49_V	120_I	0.523	0.31
217_D	220_T	0.519	0.31
244_S	247_K	0.516	0.31
139_L	182_K	0.516	0.31
178_L	181_L	0.515	0.31
94_N	156_I	0.513	0.31
132_D	156_I	0.513	0.31
52_I	104_I	0.512	0.30
106_S	150_F	0.511	0.30
116_F	173_I	0.509	0.30
41_P	110_K	0.508	0.30
155_A	159_N	0.508	0.30
156_I	220_T	0.508	0.30
110_K	158_L	0.506	0.30
94_N	129_L	0.505	0.30
178_L	185_L	0.504	0.30
179_Y	210_V	0.503	0.30
202_H	228_E	0.503	0.30
137_L	164_K	0.503	0.30
65_N	68_A	0.503	0.30
37_S	182_K	0.503	0.30
99_L	202_H	0.503	0.30
216_G	238_F	0.501	0.30
92_R	174_N	0.501	0.30
93_T	239_Y	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3k6rA	1	0.8587	100	0.599	Contact Map
2yx1A	2	0.9094	100	0.615	Contact Map
3a27A	1	0.7101	100	0.633	Contact Map
2b78A	1	0.9565	99.9	0.726	Contact Map
2as0A	2	0.9819	99.9	0.732	Contact Map
3vseA	1	0.9674	99.9	0.738	Contact Map
1wxxA	2	0.9601	99.9	0.744	Contact Map
4dmgA	2	0.9674	99.9	0.748	Contact Map
3c0kA	2	0.9783	99.9	0.751	Contact Map
3v97A	1	0.8768	99.9	0.755	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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