GREMLIN Database
Q97WJ4 - Uncharacterized protein
UniProt: Q97WJ4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (224)
Sequences: 973 (678)
Seq/√Len: 45.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_Y183_K3.9871.00
176_D179_Y3.9551.00
202_H227_E3.1271.00
105_S121_N2.8921.00
148_D217_D2.7251.00
98_F105_S2.6601.00
47_Y127_P2.6091.00
79_K102_E2.5951.00
65_N97_E2.5881.00
157_A170_A2.5741.00
178_L182_K2.5641.00
147_L211_F2.5351.00
150_F225_F2.5181.00
185_L194_I2.4781.00
185_L196_I2.4511.00
53_A78_I2.4491.00
134_L138_E2.4031.00
107_T118_V2.3841.00
167_Y195_D2.3691.00
213_L237_V2.3551.00
83_L97_E2.3481.00
178_L196_I2.2631.00
149_A201_A2.2381.00
122_K176_D2.0931.00
110_K115_L2.0520.99
108_I115_L2.0160.99
82_Y96_L2.0130.99
116_F159_N1.9930.99
118_V180_M1.9470.99
117_Y187_L1.9260.99
91_L173_I1.9180.99
106_S180_M1.8990.99
144_S213_L1.8710.99
252_L255_T1.8680.99
115_L187_L1.8630.99
108_I117_Y1.8580.99
160_I215_F1.8350.99
124_Y129_L1.7300.98
129_L217_D1.7250.98
124_Y217_D1.6470.97
251_S255_T1.6230.97
53_A75_H1.6170.97
250_S254_R1.6000.97
154_G181_L1.5970.97
140_V160_I1.5930.97
144_S212_K1.5720.96
253_G257_W1.5670.96
72_M100_S1.5660.96
140_V146_V1.5610.96
114_V158_L1.4810.95
129_L172_D1.4630.95
169_V197_V1.4550.95
90_E173_I1.4420.94
145_T211_F1.4360.94
254_R258_I1.4190.94
124_Y128_S1.4040.93
119_D122_K1.3920.93
68_A81_V1.3830.93
172_D217_D1.3740.93
114_V162_H1.3700.93
128_S155_A1.3670.92
148_D181_L1.3540.92
56_T84_K1.3430.92
155_A217_D1.3430.92
197_V204_L1.3330.92
118_V123_V1.3280.91
149_A229_L1.3240.91
218_N222_I1.3150.91
80_A101_G1.2960.90
53_A71_I1.2850.90
47_Y128_S1.2830.90
161_A216_G1.2780.90
136_N140_V1.2750.90
88_K95_E1.2720.89
186_S191_K1.2650.89
68_A99_L1.2650.89
68_A100_S1.2490.89
129_L219_P1.2420.88
151_T181_L1.2380.88
140_V215_F1.2370.88
146_V215_F1.2370.88
124_Y155_A1.2260.88
183_K186_S1.2250.88
124_Y219_P1.2150.87
52_I107_T1.1840.86
136_N215_F1.1810.86
170_A181_L1.1530.84
148_D172_D1.1490.84
216_G222_I1.1440.84
128_S217_D1.1400.84
175_I198_Q1.1080.82
129_L155_A1.0930.81
217_D241_L1.0840.80
84_K241_L1.0770.80
105_S119_D1.0690.79
190_I194_I1.0520.78
128_S219_P1.0470.78
255_T258_I1.0460.78
116_F158_L1.0450.78
48_I76_P1.0370.77
99_L189_K1.0360.77
69_E73_Q1.0170.76
109_Y125_V1.0120.75
176_D180_M1.0100.75
79_K104_I1.0090.75
214_S233_S1.0080.75
183_K187_L1.0060.75
147_L171_G0.9890.74
54_I120_I0.9800.73
75_H78_I0.9680.72
135_K237_V0.9670.72
156_I226_K0.9600.72
112_N134_L0.9490.71
216_G225_F0.9480.71
89_G93_T0.9440.70
223_I240_I0.9380.70
172_D218_N0.9380.70
87_V129_L0.9380.70
48_I78_I0.9350.70
151_T172_D0.9310.69
172_D178_L0.9290.69
132_D135_K0.9270.69
149_A205_P0.9270.69
155_A219_P0.9260.69
42_G46_Y0.9220.68
71_I75_H0.9190.68
159_N181_L0.9140.68
150_F238_F0.9120.68
55_I99_L0.9110.67
89_G111_E0.9100.67
242_C246_D0.9080.67
161_A194_I0.9070.67
83_L99_L0.9070.67
80_A104_I0.9050.67
179_Y183_K0.8990.66
177_G239_Y0.8990.66
251_S254_R0.8960.66
158_L184_S0.8950.66
82_Y120_I0.8880.65
71_I78_I0.8870.65
71_I235_N0.8860.65
182_K186_S0.8750.64
142_E191_K0.8730.64
156_I177_G0.8650.63
133_R156_I0.8630.63
220_T241_L0.8600.63
202_H224_D0.8600.63
126_N133_R0.8590.63
82_Y172_D0.8540.62
109_Y130_S0.8450.62
146_V168_V0.8440.62
57_P67_V0.8400.61
133_R220_T0.8360.61
62_V65_N0.8350.61
201_A204_L0.8280.60
149_A153_Y0.8220.59
148_D154_G0.8210.59
219_P222_I0.8200.59
60_V65_N0.8130.59
106_S117_Y0.8120.59
142_E165_R0.8120.59
178_L198_Q0.8090.58
161_A190_I0.8060.58
219_P241_L0.8060.58
37_S64_Y0.8060.58
251_S256_S0.8060.58
84_K126_N0.8050.58
81_V100_S0.7990.57
124_Y148_D0.7970.57
242_C247_K0.7970.57
172_D201_A0.7840.56
129_L241_L0.7800.55
60_V63_D0.7770.55
210_V214_S0.7760.55
244_S256_S0.7760.55
124_Y239_Y0.7660.54
141_E192_G0.7660.54
252_L257_W0.7660.54
155_A239_Y0.7640.54
130_S134_L0.7620.54
87_V148_D0.7620.54
250_S255_T0.7610.54
137_L213_L0.7590.53
85_K95_E0.7550.53
146_V185_L0.7540.53
49_V52_I0.7530.53
129_L239_Y0.7520.53
147_L214_S0.7490.52
82_Y105_S0.7470.52
155_A241_L0.7460.52
133_R172_D0.7430.52
129_L148_D0.7420.52
67_V97_E0.7400.52
59_R81_V0.7310.51
133_R177_G0.7270.50
45_S124_Y0.7230.50
254_R257_W0.7180.49
146_V160_I0.7150.49
57_P64_Y0.7130.49
124_Y130_S0.7120.49
79_K107_T0.7110.49
128_S239_Y0.7080.48
118_V177_G0.7070.48
211_F240_I0.7030.48
128_S218_N0.7010.48
77_K136_N0.6960.47
158_L190_I0.6910.47
138_E209_K0.6910.47
88_K258_I0.6900.47
94_N155_A0.6880.47
94_N217_D0.6880.47
156_I159_N0.6850.46
141_E144_S0.6830.46
60_V64_Y0.6820.46
108_I189_K0.6770.45
136_N160_I0.6740.45
111_E130_S0.6720.45
160_I168_V0.6710.45
63_D142_E0.6690.45
94_N128_S0.6680.45
180_M183_K0.6550.43
147_L237_V0.6500.43
205_P228_E0.6480.43
46_Y71_I0.6420.42
116_F124_Y0.6390.42
68_A72_M0.6360.42
89_G95_E0.6350.41
249_N255_T0.6320.41
124_Y172_D0.6300.41
73_Q145_T0.6270.41
217_D239_Y0.6270.41
202_H225_F0.6250.40
166_V238_F0.6240.40
166_V193_M0.6210.40
149_A236_V0.6200.40
106_S119_D0.6120.39
109_Y220_T0.6110.39
246_D250_S0.6100.39
148_D220_T0.6080.39
243_E248_A0.6080.39
227_E236_V0.6070.39
34_K40_F0.6060.39
49_V127_P0.6060.39
217_D222_I0.6050.39
36_L62_V0.6040.39
87_V93_T0.6040.39
47_Y169_V0.6020.38
47_Y180_M0.6010.38
54_I125_V0.6000.38
147_L169_V0.6000.38
133_R155_A0.5990.38
51_E104_I0.5960.38
94_N127_P0.5960.38
171_G204_L0.5960.38
98_F173_I0.5940.38
112_N222_I0.5940.38
140_V164_K0.5930.38
98_F110_K0.5920.37
187_L252_L0.5910.37
55_I112_N0.5900.37
171_G199_Y0.5890.37
111_E119_D0.5880.37
73_Q81_V0.5870.37
82_Y184_S0.5870.37
149_A216_G0.5860.37
199_Y204_L0.5830.37
49_V118_V0.5810.36
143_G166_V0.5810.36
34_K149_A0.5810.36
167_Y251_S0.5790.36
193_M214_S0.5730.36
120_I173_I0.5720.36
82_Y135_K0.5710.36
61_N67_V0.5710.36
214_S229_L0.5670.35
218_N241_L0.5660.35
120_I171_G0.5640.35
253_G256_S0.5630.35
219_P239_Y0.5620.35
157_A186_S0.5610.35
129_L133_R0.5600.35
145_T169_V0.5600.35
145_T179_Y0.5590.34
157_A172_D0.5520.34
221_L224_D0.5510.34
146_V166_V0.5490.34
113_G189_K0.5460.33
108_I137_L0.5460.33
47_Y213_L0.5450.33
72_M78_I0.5450.33
231_R236_V0.5440.33
40_F62_V0.5440.33
117_Y191_K0.5420.33
156_I221_L0.5420.33
66_L143_G0.5390.33
227_E231_R0.5390.33
184_S200_D0.5360.32
141_E206_F0.5350.32
157_A171_G0.5350.32
45_S169_V0.5340.32
145_T236_V0.5340.32
80_A105_S0.5320.32
94_N159_N0.5310.32
107_T181_L0.5300.32
49_V211_F0.5290.32
111_E133_R0.5280.32
89_G107_T0.5270.32
181_L217_D0.5270.32
155_A201_A0.5250.32
148_D218_N0.5240.31
216_G226_K0.5230.31
49_V120_I0.5230.31
217_D220_T0.5190.31
244_S247_K0.5160.31
139_L182_K0.5160.31
178_L181_L0.5150.31
94_N156_I0.5130.31
132_D156_I0.5130.31
52_I104_I0.5120.30
106_S150_F0.5110.30
116_F173_I0.5090.30
41_P110_K0.5080.30
155_A159_N0.5080.30
156_I220_T0.5080.30
110_K158_L0.5060.30
94_N129_L0.5050.30
178_L185_L0.5040.30
179_Y210_V0.5030.30
202_H228_E0.5030.30
137_L164_K0.5030.30
65_N68_A0.5030.30
37_S182_K0.5030.30
99_L202_H0.5030.30
216_G238_F0.5010.30
92_R174_N0.5010.30
93_T239_Y0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k6rA 1 0.8587 100 0.599 Contact Map
2yx1A 2 0.9094 100 0.615 Contact Map
3a27A 1 0.7101 100 0.633 Contact Map
2b78A 1 0.9565 99.9 0.726 Contact Map
2as0A 2 0.9819 99.9 0.732 Contact Map
3vseA 1 0.9674 99.9 0.738 Contact Map
1wxxA 2 0.9601 99.9 0.744 Contact Map
4dmgA 2 0.9674 99.9 0.748 Contact Map
3c0kA 2 0.9783 99.9 0.751 Contact Map
3v97A 1 0.8768 99.9 0.755 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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