GREMLIN Database
Q97WJ3 - Uncharacterized protein
UniProt: Q97WJ3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (134)
Sequences: 184 (131)
Seq/√Len: 11.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_G108_M3.7090.99
95_I105_S3.4120.98
31_L35_G3.3360.97
93_K103_E3.1180.96
23_L69_I2.7320.92
93_K105_S2.6560.90
30_Y41_I2.6000.89
76_D113_K2.2880.82
5_D45_K2.2580.81
118_I122_I2.2100.80
114_A117_D2.1370.77
9_I28_D2.0640.75
47_A50_L1.9850.72
78_V112_D1.9400.70
71_V122_I1.9250.69
27_K46_G1.8890.68
32_T35_G1.8740.67
95_I103_E1.8600.66
47_A107_V1.8540.66
90_N104_G1.7810.63
69_I132_G1.7720.62
70_R73_E1.7690.62
83_S109_I1.7280.60
87_T102_I1.6570.57
10_K42_L1.6340.56
96_F118_I1.6120.55
7_V43_A1.5730.53
19_H82_G1.5660.53
90_N93_K1.5560.52
28_D92_N1.5440.52
25_I104_G1.5320.51
55_K88_F1.5240.51
90_N103_E1.4780.48
93_K101_F1.4590.47
70_R75_L1.4270.46
5_D80_G1.4250.46
67_G136_I1.4190.46
46_G90_N1.4160.45
94_I136_I1.4110.45
87_T104_G1.3940.44
129_E132_G1.3410.42
9_I40_G1.3400.42
67_G80_G1.3290.41
7_V44_N1.3210.41
92_N103_E1.2950.40
39_I118_I1.2740.39
13_H100_T1.2530.38
72_K132_G1.2510.38
25_I89_E1.1880.35
27_K113_K1.1410.33
79_H112_D1.1290.32
44_N54_L1.1170.32
67_G134_I1.1160.32
56_K100_T1.0920.31
67_G113_K1.0810.30
76_D119_N1.0700.30
82_G86_F1.0680.30
96_F107_V1.0670.30
21_T93_K1.0480.29
7_V53_D1.0470.29
27_K94_I1.0450.29
122_I135_I1.0420.29
28_D96_F1.0350.28
28_D65_I1.0050.27
113_K117_D1.0030.27
28_D58_A0.9860.26
14_N80_G0.9850.26
39_I78_V0.9840.26
71_V118_I0.9830.26
40_G69_I0.9820.26
23_L41_I0.9760.26
41_I64_F0.9620.26
66_Y95_I0.9590.25
102_I109_I0.9520.25
71_V91_Q0.9470.25
19_H86_F0.9440.25
69_I118_I0.9320.24
45_K51_S0.9320.24
15_V29_D0.9280.24
113_K118_I0.9270.24
65_I80_G0.9250.24
27_K49_D0.8970.23
124_D130_I0.8780.23
68_V75_L0.8770.23
71_V74_F0.8740.22
96_F108_M0.8740.22
129_E133_E0.8620.22
119_N135_I0.8520.22
111_S115_A0.8490.22
59_R78_V0.8460.21
61_D112_D0.8440.21
58_A65_I0.8390.21
71_V78_V0.8380.21
30_Y101_F0.8340.21
65_I88_F0.8340.21
5_D54_L0.8250.21
72_K102_I0.8170.21
23_L96_F0.8150.20
70_R123_I0.8080.20
5_D105_S0.8070.20
57_I114_A0.8040.20
57_I111_S0.7850.20
15_V53_D0.7830.19
21_T54_L0.7810.19
79_H134_I0.7790.19
49_D87_T0.7780.19
87_T136_I0.7770.19
23_L88_F0.7670.19
19_H41_I0.7650.19
36_D117_D0.7630.19
17_A111_S0.7570.19
18_F89_E0.7510.19
73_E91_Q0.7460.18
107_V132_G0.7450.18
122_I134_I0.7340.18
5_D51_S0.7320.18
26_T109_I0.7270.18
46_G67_G0.7270.18
112_D116_R0.7170.18
36_D114_A0.7170.18
67_G108_M0.7080.17
59_R87_T0.7030.17
88_F104_G0.6960.17
25_I47_A0.6940.17
39_I42_L0.6900.17
9_I133_E0.6850.17
25_I60_N0.6770.16
28_D42_L0.6710.16
108_M119_N0.6650.16
34_R127_K0.6640.16
52_E56_K0.6620.16
21_T91_Q0.6590.16
34_R110_N0.6580.16
54_L65_I0.6470.16
107_V128_T0.6460.16
7_V86_F0.6430.16
78_V135_I0.6420.16
52_E118_I0.6350.15
52_E107_V0.6310.15
82_G88_F0.6300.15
67_G96_F0.6300.15
80_G96_F0.6300.15
31_L126_L0.6210.15
23_L90_N0.6190.15
34_R59_R0.6190.15
20_K113_K0.6130.15
19_H55_K0.6110.15
40_G117_D0.6090.15
44_N51_S0.6060.15
48_R63_S0.6040.15
61_D64_F0.6010.15
83_S89_E0.5960.14
17_A123_I0.5920.14
76_D102_I0.5920.14
80_G129_E0.5850.14
20_K50_L0.5840.14
128_T132_G0.5810.14
28_D118_I0.5800.14
76_D122_I0.5800.14
28_D116_R0.5780.14
41_I82_G0.5760.14
29_D41_I0.5720.14
41_I75_L0.5680.14
73_E78_V0.5670.14
58_A88_F0.5640.14
4_I62_K0.5600.14
88_F102_I0.5530.13
46_G134_I0.5510.13
6_K133_E0.5460.13
50_L130_I0.5460.13
20_K48_R0.5440.13
33_S115_A0.5430.13
46_G50_L0.5410.13
68_V94_I0.5380.13
10_K72_K0.5370.13
44_N125_L0.5370.13
56_K96_F0.5370.13
30_Y90_N0.5370.13
30_Y35_G0.5360.13
57_I101_F0.5360.13
130_I135_I0.5340.13
88_F91_Q0.5340.13
19_H88_F0.5340.13
68_V71_V0.5320.13
49_D100_T0.5300.13
61_D84_S0.5290.13
129_E136_I0.5280.13
58_A109_I0.5270.13
47_A111_S0.5270.13
124_D127_K0.5240.13
80_G114_A0.5210.13
8_K44_N0.5190.13
25_I40_G0.5170.13
48_R90_N0.5160.13
43_A63_S0.5160.13
15_V115_A0.5130.13
10_K90_N0.5120.12
60_N127_K0.5120.12
72_K84_S0.5110.12
16_R101_F0.5070.12
80_G112_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cbnA 1 0.8882 100 0.207 Contact Map
3pl5A 1 0.323 36.8 0.951 Contact Map
3fysA 1 0.3354 20.3 0.957 Contact Map
2pt5A 2 0.7578 14.6 0.96 Contact Map
2rodB 1 0.1677 14.4 0.96 Contact Map
3f3fC 2 0.205 10.7 0.962 Contact Map
1mgpA 1 0.3416 10.4 0.962 Contact Map
1xgwA 1 0.4099 8.7 0.963 Contact Map
3nyiA 1 0.3478 7.1 0.965 Contact Map
3j3bC 1 0.9193 6.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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