GREMLIN Database
Q97WI8 - Transport protein, hypothetical
UniProt: Q97WI8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (267)
Sequences: 10293 (7177)
Seq/√Len: 439.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
168_V172_T3.5661.00
183_S187_R3.1371.00
213_L236_T2.9081.00
194_V199_A2.8981.00
236_T271_V2.8811.00
221_I237_Y2.8221.00
210_I214_R2.5611.00
31_A117_I2.4501.00
98_I175_L2.3611.00
99_L103_D2.2901.00
213_L256_T2.2691.00
29_L44_S2.2601.00
68_S75_L2.2391.00
216_K259_I2.1841.00
164_L169_L2.1121.00
87_S189_I2.1101.00
190_K194_V2.0881.00
78_L197_L2.0431.00
32_G41_M1.9971.00
207_F211_N1.9861.00
245_S248_K1.9851.00
212_E264_D1.9511.00
116_I120_V1.9161.00
208_Q263_Y1.8751.00
242_K247_E1.8731.00
71_F75_L1.8471.00
115_S159_G1.8421.00
98_I178_L1.8321.00
216_K256_T1.8261.00
11_S65_N1.7851.00
216_K255_K1.7811.00
77_N198_G1.7721.00
212_E259_I1.7461.00
206_K225_L1.7401.00
250_Y272_I1.7371.00
219_P241_P1.7181.00
30_I34_L1.7061.00
238_I256_T1.7051.00
103_D107_T1.6561.00
97_L174_T1.6471.00
15_L19_I1.6461.00
115_S166_N1.6201.00
11_S62_I1.6141.00
248_K251_K1.6081.00
175_L179_A1.5941.00
212_E263_Y1.5931.00
95_T99_L1.5781.00
251_K255_K1.5761.00
186_V190_K1.5561.00
179_A183_S1.5261.00
102_F106_I1.5041.00
29_L33_I1.5021.00
115_S163_I1.5021.00
246_L249_A1.4891.00
126_L130_L1.4681.00
15_L58_Y1.4671.00
163_I166_N1.4551.00
211_N215_S1.4521.00
249_A273_L1.4391.00
46_H147_H1.4371.00
55_F59_F1.4311.00
205_M208_Q1.4271.00
161_T173_V1.4201.00
202_D205_M1.4191.00
142_K191_D1.4131.00
101_M174_T1.3971.00
225_L234_V1.3961.00
20_S124_Y1.3881.00
187_R190_K1.3671.00
22_I51_F1.3651.00
208_Q212_E1.3611.00
157_V173_V1.3491.00
168_V171_D1.3311.00
28_E47_T1.3281.00
221_I274_V1.3231.00
242_K277_T1.3201.00
73_W235_Y1.3131.00
258_R262_K1.3041.00
207_F210_I1.3011.00
113_W116_I1.2931.00
96_N99_L1.2921.00
237_Y274_V1.2851.00
105_A171_D1.2791.00
255_K259_I1.2621.00
240_L246_L1.2521.00
144_D147_H1.2511.00
234_V266_I1.2371.00
119_F123_I1.2321.00
60_T82_V1.2101.00
201_I225_L1.2081.00
198_G233_A1.2071.00
68_S71_F1.2061.00
63_K78_L1.1971.00
32_G44_S1.1971.00
253_K257_K1.1891.00
16_F131_I1.1861.00
240_L252_I1.1851.00
19_I23_P1.1691.00
224_Y268_Y1.1551.00
250_Y275_P1.1551.00
35_F113_W1.1501.00
223_L236_T1.1471.00
119_F159_G1.1441.00
127_T130_L1.1401.00
94_S182_L1.1351.00
91_V185_V1.1351.00
253_K272_I1.1301.00
38_Y101_M1.1231.00
76_Y231_F1.1181.00
246_L273_L1.1151.00
35_F114_Y1.1141.00
133_R145_M1.0981.00
71_F194_V1.0921.00
24_I28_E1.0911.00
206_K210_I1.0901.00
105_A168_V1.0901.00
127_T131_I1.0891.00
215_S259_I1.0891.00
25_F44_S1.0861.00
56_I82_V1.0731.00
25_F48_L1.0721.00
80_S195_S1.0711.00
203_S207_F1.0691.00
115_S162_L1.0661.00
109_S112_P1.0661.00
130_L134_R1.0641.00
250_Y253_K1.0571.00
216_K252_I1.0531.00
234_V269_V1.0471.00
259_I263_Y1.0451.00
247_E251_K1.0451.00
100_S103_D1.0451.00
209_L260_I1.0441.00
18_S51_F1.0421.00
257_K272_I1.0411.00
87_S188_E1.0391.00
63_K66_T1.0371.00
123_I127_T1.0371.00
253_K273_L1.0341.00
249_A253_K1.0321.00
25_F29_L1.0311.00
212_E216_K1.0261.00
70_R75_L1.0211.00
62_I65_N1.0091.00
122_S159_G1.0031.00
116_I119_F0.9991.00
91_V186_V0.9941.00
17_S128_L0.9941.00
125_S132_E0.9931.00
98_I102_F0.9931.00
20_S128_L0.9921.00
125_S128_L0.9901.00
12_I16_F0.9901.00
254_R258_R0.9851.00
208_Q211_N0.9821.00
118_L159_G0.9821.00
243_D247_E0.9821.00
221_I239_G0.9801.00
108_L111_S0.9761.00
24_I124_Y0.9731.00
130_L133_R0.9721.00
260_I266_I0.9711.00
145_M149_L0.9691.00
209_L225_L0.9661.00
163_I167_T0.9651.00
114_Y162_L0.9581.00
129_F133_R0.9581.00
91_V182_L0.9551.00
198_G226_K0.9511.00
57_F143_N0.9501.00
263_Y266_I0.9501.00
128_L131_I0.9481.00
198_G228_C0.9441.00
43_D155_E0.9421.00
131_I135_Y0.9411.00
29_L41_M0.9381.00
26_L30_I0.9381.00
88_I92_Y0.9311.00
156_V160_V0.9281.00
101_M175_L0.9261.00
217_N248_K0.9251.00
220_I223_L0.9211.00
59_F63_K0.9211.00
43_D46_H0.9191.00
18_S58_Y0.9191.00
211_N214_R0.9161.00
72_P200_S0.9151.00
91_V95_T0.9121.00
128_L132_E0.9121.00
102_F175_L0.9021.00
79_E138_I0.9021.00
38_Y104_N0.8971.00
18_S55_F0.8941.00
228_C233_A0.8931.00
195_S227_K0.8921.00
254_R257_K0.8911.00
33_I41_M0.8901.00
81_L197_L0.8801.00
212_E215_S0.8791.00
57_F140_I0.8781.00
70_R199_A0.8771.00
239_G276_L0.8661.00
222_N268_Y0.8641.00
201_I232_Y0.8621.00
105_A175_L0.8601.00
100_S104_N0.8591.00
38_Y174_T0.8541.00
261_K267_A0.8531.00
250_Y274_V0.8521.00
205_M232_Y0.8521.00
46_H50_D0.8511.00
240_L273_L0.8511.00
214_R220_I0.8461.00
172_T176_L0.8441.00
147_H151_D0.8431.00
217_N252_I0.8361.00
27_S120_V0.8261.00
240_L249_A0.8251.00
200_S206_K0.8241.00
219_P239_G0.8231.00
209_L234_V0.8221.00
222_N237_Y0.8191.00
22_I26_L0.8171.00
253_K271_V0.8131.00
259_I262_K0.8091.00
13_I134_R0.7911.00
201_I206_K0.7891.00
21_L47_T0.7871.00
128_L148_S0.7861.00
126_L149_L0.7781.00
38_Y100_S0.7781.00
118_L121_S0.7771.00
73_W226_K0.7711.00
124_Y128_L0.7691.00
260_I269_V0.7681.00
77_N226_K0.7671.00
84_L189_I0.7641.00
103_D106_I0.7611.00
96_N100_S0.7571.00
201_I205_M0.7571.00
121_S125_S0.7571.00
92_Y96_N0.7571.00
173_V177_I0.7551.00
169_L173_V0.7521.00
129_F145_M0.7511.00
213_L220_I0.7501.00
39_V173_V0.7481.00
272_I275_P0.7481.00
249_A252_I0.7421.00
29_L48_L0.7401.00
217_N241_P0.7391.00
227_K232_Y0.7381.00
115_S119_F0.7371.00
161_T169_L0.7361.00
13_I135_Y0.7311.00
61_L140_I0.7281.00
256_T271_V0.7281.00
59_F62_I0.7271.00
220_I236_T0.7261.00
49_I93_L0.7261.00
128_L135_Y0.7221.00
84_L88_I0.7221.00
146_I149_L0.7161.00
104_N109_S0.7161.00
92_Y99_L0.7141.00
103_D109_S0.7141.00
25_F51_F0.7131.00
266_I269_V0.7131.00
258_R261_K0.7101.00
28_E44_S0.7101.00
81_L85_T0.7061.00
11_S58_Y0.7041.00
142_K146_I0.7011.00
120_V124_Y0.7001.00
158_S161_T0.6981.00
64_I79_E0.6961.00
180_F184_D0.6911.00
210_I220_I0.6901.00
25_F47_T0.6871.00
46_H90_I0.6811.00
32_G35_F0.6791.00
84_L192_S0.6771.00
114_Y121_S0.6761.00
249_A275_P0.6751.00
252_I256_T0.6731.00
33_I44_S0.6711.00
94_S185_V0.6701.00
15_L18_S0.6681.00
27_S117_I0.6671.00
143_N188_E0.6661.00
242_K276_L0.6651.00
257_K261_K0.6651.00
150_L184_D0.6641.00
101_M178_L0.6621.00
83_V140_I0.6591.00
176_L180_F0.6581.00
21_L50_D0.6571.00
129_F132_E0.6561.00
121_S132_E0.6551.00
81_L193_I0.6531.00
118_L125_S0.6480.99
67_R75_L0.6470.99
37_S170_M0.6470.99
255_K258_R0.6460.99
129_F149_L0.6460.99
256_T259_I0.6450.99
257_K269_V0.6430.99
224_Y235_Y0.6420.99
48_L52_L0.6400.99
30_I33_I0.6390.99
17_S148_S0.6380.99
213_L238_I0.6380.99
139_Q195_S0.6340.99
260_I271_V0.6320.99
218_I238_I0.6310.99
251_K254_R0.6270.99
219_P276_L0.6240.99
31_A113_W0.6230.99
142_K145_M0.6220.99
54_S144_D0.6220.99
17_S144_D0.6200.99
147_H150_L0.6200.99
139_Q191_D0.6190.99
125_S129_F0.6170.99
62_I66_T0.6140.99
70_R194_V0.6130.99
250_Y254_R0.6120.99
53_M57_F0.6110.99
17_S54_S0.6060.99
122_S156_V0.6050.99
114_Y118_L0.6050.99
11_S15_L0.6030.99
19_I22_I0.6010.99
72_P224_Y0.5990.99
132_E144_D0.5970.99
235_Y268_Y0.5970.99
83_V188_E0.5970.99
53_M89_F0.5970.99
238_I273_L0.5960.99
114_Y125_S0.5940.99
58_Y62_I0.5940.99
162_L166_N0.5900.99
28_E43_D0.5890.99
227_K230_S0.5890.99
223_L234_V0.5860.99
10_V61_L0.5860.99
93_L96_N0.5840.99
126_L152_G0.5840.99
217_N255_K0.5810.99
204_P225_L0.5800.99
84_L196_I0.5790.99
13_I131_I0.5790.99
183_S186_V0.5750.99
132_E135_Y0.5730.99
154_T158_S0.5700.99
114_Y161_T0.5690.99
129_F148_S0.5670.99
153_V156_V0.5660.99
253_K256_T0.5580.98
17_S132_E0.5580.98
87_S192_S0.5560.98
137_E142_K0.5520.98
101_M171_D0.5520.98
122_S126_L0.5510.98
149_L153_V0.5500.98
122_S125_S0.5490.98
36_K109_S0.5460.98
66_T75_L0.5450.98
78_L82_V0.5430.98
194_V202_D0.5420.98
238_I271_V0.5410.98
82_V140_I0.5410.98
38_Y41_M0.5410.98
137_E265_N0.5400.98
71_F199_A0.5370.98
52_L55_F0.5360.98
53_M147_H0.5350.98
21_L51_F0.5330.98
73_W224_Y0.5300.98
120_V127_T0.5300.98
248_K255_K0.5290.98
14_F57_F0.5290.98
171_D174_T0.5260.98
84_L193_I0.5240.98
191_D194_V0.5230.98
83_V192_S0.5230.98
264_D267_A0.5230.98
18_S54_S0.5200.98
200_S227_K0.5200.98
29_L45_Y0.5190.98
95_T182_L0.5190.98
16_F19_I0.5150.97
180_F183_S0.5120.97
178_L185_V0.5120.97
116_I123_I0.5100.97
107_T110_I0.5090.97
173_V176_L0.5070.97
213_L216_K0.5000.97
40_L162_L0.5000.97
193_I197_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.9626 100 0.177 Contact Map
3h90A 3 0.9218 100 0.211 Contact Map
3bypA 2 0.2653 99.4 0.776 Contact Map
2zztA 2 0.2653 99.3 0.782 Contact Map
3w61A 2 0.2619 99.1 0.797 Contact Map
1ib8A 1 0.3469 56.6 0.94 Contact Map
1uwdA 1 0.3435 51.5 0.941 Contact Map
3cq1A 2 0.3299 51.4 0.941 Contact Map
2ko1A 2 0.2993 51.1 0.942 Contact Map
1zpvA 3 0.2993 47.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0098 seconds.