Q97WI7 - SULSO - GREMLIN Contacts

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Q97WI7 - Uncharacterized protein

UniProt:	Q97WI7	Sequences: MVTIRVGALADSGDLYPFIPLMEGKVKPEGFNLEFEVIPTVQDINEAVLKKEVDVSVPSVAMYPYIQDDYYILSNAVATAVDGITGMPILAIKEMSEDEIKRSRLIVHGPNTTAFTLYRLLIGKYGRLIIVRRVLDEIKALGKEGDVLVAVHEIKMMYALRKMGISVVRIGSMWDMWKTISNNTPMPMGMVVISKEVGKDLALRFKETYEKSKKYAEKHLDEIIPKDVQIMREAQKADLDEEIVRKTIWADIQEYNVPVDEIRRGLEFFFKITEEKGILPRVKNIDLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	288 (260)
Sequences:	577 (371)
Seq/√Len:	23.0

SULSO - Q97WI7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
7_G	53_V	4.651	1.00
87_M	91_A	4.589	1.00
113_T	269_F	3.836	1.00
130_I	145_G	3.519	1.00
86_G	91_A	3.401	1.00
130_I	138_I	3.162	1.00
42_Q	46_E	3.147	1.00
88_P	91_A	3.116	1.00
58_P	66_I	3.056	1.00
215_Y	219_H	3.046	1.00
74_S	263_R	2.924	0.99
54_D	196_E	2.797	0.99
8_A	22_M	2.783	0.99
17_P	256_N	2.772	0.99
106_I	145_G	2.606	0.99
109_G	112_T	2.566	0.99
104_R	126_G	2.511	0.98
128_L	145_G	2.466	0.98
69_D	196_E	2.404	0.98
51_K	69_D	2.385	0.98
87_M	92_I	2.368	0.98
56_S	192_V	2.238	0.97
19_I	223_I	2.195	0.96
60_V	190_M	2.129	0.95
115_F	149_V	2.105	0.95
47_A	53_V	2.047	0.94
81_V	86_G	2.026	0.94
214_K	218_K	2.011	0.94
58_P	77_V	2.008	0.94
138_I	145_G	1.976	0.93
17_P	41_V	1.974	0.93
214_K	257_V	1.970	0.93
81_V	87_M	1.903	0.92
5_R	54_D	1.899	0.92
198_G	202_A	1.894	0.92
88_P	92_I	1.857	0.91
159_A	162_K	1.813	0.90
47_A	52_E	1.774	0.89
72_I	190_M	1.726	0.87
104_R	146_D	1.690	0.86
19_I	25_K	1.635	0.84
115_F	127_R	1.588	0.82
268_F	271_K	1.568	0.81
107_V	110_P	1.527	0.80
8_A	226_K	1.513	0.79
29_E	204_R	1.506	0.79
110_P	129_I	1.496	0.78
29_E	208_T	1.492	0.78
193_I	202_A	1.468	0.77
86_G	92_I	1.430	0.75
75_N	206_K	1.411	0.74
13_G	57_V	1.399	0.73
79_T	156_M	1.382	0.72
115_F	119_R	1.377	0.72
268_F	272_I	1.377	0.72
78_A	247_T	1.376	0.72
57_V	78_A	1.366	0.71
74_S	206_K	1.353	0.71
106_I	139_K	1.343	0.70
219_H	222_E	1.334	0.70
48_V	56_S	1.333	0.70
139_K	142_G	1.319	0.69
11_D	57_V	1.313	0.68
55_V	205_F	1.293	0.67
29_E	207_E	1.280	0.66
223_I	227_D	1.274	0.66
11_D	15_L	1.270	0.66
107_V	115_F	1.270	0.66
17_P	213_K	1.264	0.65
132_R	213_K	1.255	0.65
25_K	222_E	1.239	0.64
58_P	192_V	1.237	0.64
82_D	255_Y	1.226	0.63
71_Y	195_K	1.225	0.63
8_A	13_G	1.215	0.62
162_K	240_D	1.213	0.62
213_K	217_E	1.213	0.62
13_G	78_A	1.211	0.62
140_A	163_M	1.208	0.62
250_A	253_Q	1.187	0.60
55_V	68_D	1.182	0.60
57_V	155_K	1.177	0.60
132_R	135_L	1.160	0.59
245_R	249_W	1.147	0.58
5_R	215_Y	1.144	0.57
33_L	208_T	1.142	0.57
61_A	64_P	1.134	0.57
8_A	11_D	1.123	0.56
41_V	112_T	1.121	0.56
66_I	192_V	1.121	0.56
89_I	105_L	1.121	0.56
211_K	214_K	1.116	0.56
131_V	134_V	1.113	0.55
145_G	266_L	1.111	0.55
10_A	72_I	1.106	0.55
79_T	155_K	1.105	0.55
16_Y	217_E	1.104	0.55
224_I	248_I	1.085	0.53
74_S	259_V	1.080	0.53
13_G	17_P	1.076	0.53
104_R	128_L	1.075	0.53
94_E	166_S	1.074	0.53
81_V	88_P	1.073	0.53
42_Q	64_P	1.063	0.52
47_A	50_K	1.059	0.52
11_D	78_A	1.059	0.52
60_V	77_V	1.057	0.51
17_P	209_Y	1.054	0.51
220_L	245_R	1.054	0.51
57_V	156_M	1.051	0.51
57_V	247_T	1.048	0.51
19_I	222_E	1.045	0.51
273_T	279_L	1.045	0.51
56_S	109_G	1.043	0.50
24_G	142_G	1.036	0.50
191_V	247_T	1.033	0.50
227_D	247_T	1.033	0.50
166_S	267_E	1.031	0.50
44_I	112_T	1.027	0.49
78_A	191_V	1.026	0.49
61_A	65_Y	1.025	0.49
128_L	143_K	1.021	0.49
13_G	155_K	1.006	0.48
261_E	264_R	1.006	0.48
7_G	150_A	1.002	0.48
87_M	95_M	1.002	0.48
15_L	227_D	1.000	0.47
11_D	17_P	0.993	0.47
132_R	146_D	0.987	0.47
7_G	47_A	0.985	0.46
78_A	155_K	0.984	0.46
81_V	84_I	0.983	0.46
267_E	271_K	0.981	0.46
155_K	247_T	0.978	0.46
134_V	137_E	0.978	0.46
20_P	26_V	0.977	0.46
39_P	43_D	0.976	0.46
44_I	109_G	0.975	0.46
56_S	112_T	0.975	0.46
57_V	191_V	0.971	0.45
275_E	281_R	0.971	0.45
82_D	261_E	0.953	0.44
78_A	243_I	0.949	0.44
4_I	54_D	0.944	0.44
156_M	175_D	0.944	0.44
21_L	33_L	0.944	0.44
11_D	155_K	0.943	0.44
6_V	55_V	0.942	0.43
155_K	191_V	0.939	0.43
142_G	267_E	0.937	0.43
139_K	145_G	0.937	0.43
256_N	277_G	0.935	0.43
107_V	129_I	0.935	0.43
56_S	129_I	0.929	0.43
262_I	265_G	0.917	0.42
181_S	272_I	0.916	0.42
57_V	243_I	0.915	0.42
75_N	256_N	0.905	0.41
15_L	155_K	0.882	0.39
91_A	95_M	0.881	0.39
104_R	210_E	0.880	0.39
61_A	111_N	0.877	0.39
13_G	247_T	0.874	0.39
60_V	64_P	0.874	0.39
68_D	277_G	0.873	0.39
155_K	250_A	0.870	0.39
13_G	156_M	0.863	0.38
15_L	78_A	0.862	0.38
92_I	105_L	0.862	0.38
5_R	34_E	0.861	0.38
224_I	245_R	0.854	0.38
15_L	247_T	0.852	0.37
41_V	109_G	0.851	0.37
31_F	207_E	0.849	0.37
23_E	213_K	0.848	0.37
7_G	41_V	0.848	0.37
72_I	257_V	0.846	0.37
215_Y	222_E	0.845	0.37
155_K	175_D	0.832	0.36
11_D	156_M	0.828	0.36
20_P	23_E	0.828	0.36
91_A	166_S	0.823	0.36
113_T	123_G	0.820	0.35
208_T	211_K	0.818	0.35
183_N	267_E	0.816	0.35
11_D	247_T	0.816	0.35
118_Y	149_V	0.815	0.35
277_G	282_V	0.813	0.35
54_D	192_V	0.812	0.35
248_I	255_Y	0.811	0.35
58_P	219_H	0.810	0.35
156_M	243_I	0.809	0.35
191_V	248_I	0.807	0.35
201_L	204_R	0.801	0.34
132_R	250_A	0.800	0.34
13_G	191_V	0.795	0.34
54_D	132_R	0.790	0.34
43_D	47_A	0.789	0.33
217_E	257_V	0.786	0.33
78_A	156_M	0.786	0.33
63_Y	118_Y	0.781	0.33
218_K	273_T	0.779	0.33
38_I	226_K	0.771	0.32
79_T	259_V	0.770	0.32
106_I	147_V	0.770	0.32
224_I	227_D	0.769	0.32
132_R	138_I	0.767	0.32
89_I	107_V	0.767	0.32
204_R	208_T	0.767	0.32
33_L	132_R	0.763	0.32
11_D	191_V	0.758	0.32
90_L	150_A	0.757	0.31
115_F	129_I	0.756	0.31
50_K	69_D	0.756	0.31
91_A	94_E	0.751	0.31
84_I	250_A	0.750	0.31
100_I	147_V	0.747	0.31
8_A	57_V	0.744	0.31
17_P	78_A	0.744	0.31
15_L	57_V	0.743	0.31
15_L	191_V	0.741	0.31
13_G	243_I	0.738	0.30
46_E	50_K	0.737	0.30
89_I	100_I	0.736	0.30
64_P	273_T	0.735	0.30
137_E	163_M	0.734	0.30
17_P	57_V	0.734	0.30
121_L	168_V	0.734	0.30
65_Y	111_N	0.733	0.30
60_V	79_T	0.732	0.30
87_M	93_K	0.731	0.30
61_A	223_I	0.730	0.30
155_K	243_I	0.726	0.30
22_M	226_K	0.725	0.30
84_I	88_P	0.722	0.29
76_A	169_R	0.721	0.29
21_L	208_T	0.719	0.29
169_R	252_I	0.717	0.29
278_I	281_R	0.717	0.29
29_E	213_K	0.715	0.29
264_R	268_F	0.715	0.29
19_I	226_K	0.712	0.29
137_E	141_L	0.712	0.29
117_L	259_V	0.711	0.29
41_V	227_D	0.706	0.29
135_L	213_K	0.704	0.28
7_G	21_L	0.704	0.28
65_Y	280_P	0.703	0.28
8_A	78_A	0.703	0.28
4_I	55_V	0.701	0.28
42_Q	56_S	0.699	0.28
156_M	234_A	0.698	0.28
132_R	142_G	0.698	0.28
135_L	150_A	0.695	0.28
63_Y	186_M	0.692	0.28
19_I	23_E	0.692	0.28
32_N	246_K	0.692	0.28
60_V	250_A	0.691	0.28
271_K	275_E	0.689	0.28
108_H	169_R	0.689	0.28
104_R	275_E	0.687	0.27
247_T	250_A	0.685	0.27
171_G	248_I	0.682	0.27
89_I	254_E	0.679	0.27
248_I	262_I	0.678	0.27
71_Y	202_A	0.674	0.27
76_A	108_H	0.672	0.27
113_T	117_L	0.672	0.27
94_E	242_E	0.670	0.27
156_M	191_V	0.669	0.26
44_I	154_I	0.667	0.26
43_D	150_A	0.665	0.26
26_V	208_T	0.664	0.26
58_P	64_P	0.662	0.26
78_A	227_D	0.661	0.26
136_D	154_I	0.660	0.26
27_K	194_S	0.660	0.26
83_G	271_K	0.659	0.26
39_P	150_A	0.659	0.26
9_L	171_G	0.658	0.26
132_R	253_Q	0.658	0.26
88_P	93_K	0.653	0.26
186_M	250_A	0.651	0.26
242_E	245_R	0.647	0.25
6_V	221_D	0.645	0.25
164_G	241_E	0.645	0.25
49_L	111_N	0.643	0.25
74_S	77_V	0.643	0.25
135_L	139_K	0.634	0.25
154_I	251_D	0.633	0.25
11_D	243_I	0.633	0.25
111_N	118_Y	0.633	0.25
42_Q	111_N	0.631	0.24
73_L	206_K	0.631	0.24
8_A	41_V	0.627	0.24
41_V	78_A	0.627	0.24
255_Y	261_E	0.625	0.24
60_V	192_V	0.624	0.24
99_E	102_R	0.622	0.24
7_G	123_G	0.621	0.24
105_L	274_E	0.621	0.24
52_E	134_V	0.618	0.24
67_Q	158_Y	0.616	0.24
94_E	162_K	0.615	0.24
118_Y	168_V	0.614	0.24
105_L	210_E	0.613	0.24
201_L	254_E	0.613	0.24
67_Q	270_F	0.610	0.23
88_P	150_A	0.607	0.23
55_V	192_V	0.606	0.23
88_P	156_M	0.605	0.23
121_L	190_M	0.604	0.23
108_H	252_I	0.604	0.23
242_E	261_E	0.602	0.23
47_A	54_D	0.602	0.23
232_R	244_V	0.601	0.23
200_D	204_R	0.600	0.23
191_V	227_D	0.600	0.23
60_V	259_V	0.599	0.23
64_P	129_I	0.595	0.23
33_L	149_V	0.592	0.23
217_E	254_E	0.591	0.22
63_Y	270_F	0.589	0.22
227_D	248_I	0.588	0.22
198_G	267_E	0.586	0.22
128_L	142_G	0.586	0.22
94_E	99_E	0.585	0.22
114_A	153_E	0.582	0.22
63_Y	193_I	0.581	0.22
204_R	246_K	0.576	0.22
58_P	63_Y	0.575	0.22
50_K	242_E	0.572	0.22
128_L	138_I	0.567	0.21
78_A	250_A	0.566	0.21
190_M	259_V	0.566	0.21
66_I	70_Y	0.559	0.21
105_L	118_Y	0.556	0.21
156_M	247_T	0.553	0.21
242_E	246_K	0.552	0.21
116_T	269_F	0.551	0.21
199_K	203_L	0.551	0.21
74_S	129_I	0.549	0.20
128_L	133_R	0.549	0.20
241_E	245_R	0.549	0.20
83_G	202_A	0.546	0.20
33_L	205_F	0.546	0.20
39_P	47_A	0.543	0.20
243_I	247_T	0.541	0.20
210_E	214_K	0.538	0.20
91_A	105_L	0.538	0.20
62_M	273_T	0.537	0.20
247_T	252_I	0.532	0.20
205_F	209_Y	0.532	0.20
227_D	256_N	0.527	0.20
53_V	61_A	0.526	0.19
90_L	104_R	0.526	0.19
191_V	250_A	0.525	0.19
95_M	99_E	0.525	0.19
142_G	258_P	0.522	0.19
9_L	14_D	0.521	0.19
46_E	167_V	0.521	0.19
94_E	197_V	0.521	0.19
232_R	260_D	0.517	0.19
41_V	248_I	0.517	0.19
86_G	95_M	0.515	0.19
135_L	142_G	0.515	0.19
149_V	241_E	0.514	0.19
51_K	264_R	0.513	0.19
193_I	197_V	0.513	0.19
107_V	244_V	0.512	0.19
165_I	216_A	0.511	0.19
200_D	275_E	0.510	0.19
134_V	143_K	0.510	0.19
66_I	275_E	0.510	0.19
57_V	250_A	0.508	0.19
155_K	234_A	0.508	0.19
239_L	244_V	0.507	0.19
101_K	124_K	0.507	0.19
64_P	270_F	0.507	0.19
98_D	260_D	0.507	0.19
220_L	249_W	0.506	0.19
9_L	12_S	0.504	0.19
101_K	125_Y	0.503	0.18
25_K	215_Y	0.503	0.18
84_I	87_M	0.503	0.18
8_A	36_E	0.503	0.18
43_D	253_Q	0.502	0.18
32_N	37_V	0.501	0.18
79_T	247_T	0.500	0.18
209_Y	214_K	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2i6eA	3	0.8681	100	0.686	Contact Map
2czlA	1	0.9306	100	0.702	Contact Map
1zbmA	1	0.9028	100	0.72	Contact Map
2nxoA	2	0.8993	100	0.772	Contact Map
3hn0A	2	0.9028	99.9	0.81	Contact Map
4eswA	2	0.934	99.9	0.811	Contact Map
3ix1A	2	0.9444	99.9	0.82	Contact Map
3qslA	1	0.9549	99.8	0.832	Contact Map
2x7qA	1	0.8993	99.8	0.836	Contact Map
4nmyA	1	0.9201	99.8	0.837	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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