GREMLIN Database
Q97WI7 - Uncharacterized protein
UniProt: Q97WI7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (260)
Sequences: 577 (371)
Seq/√Len: 23.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_G53_V4.6511.00
87_M91_A4.5891.00
113_T269_F3.8361.00
130_I145_G3.5191.00
86_G91_A3.4011.00
130_I138_I3.1621.00
42_Q46_E3.1471.00
88_P91_A3.1161.00
58_P66_I3.0561.00
215_Y219_H3.0461.00
74_S263_R2.9240.99
54_D196_E2.7970.99
8_A22_M2.7830.99
17_P256_N2.7720.99
106_I145_G2.6060.99
109_G112_T2.5660.99
104_R126_G2.5110.98
128_L145_G2.4660.98
69_D196_E2.4040.98
51_K69_D2.3850.98
87_M92_I2.3680.98
56_S192_V2.2380.97
19_I223_I2.1950.96
60_V190_M2.1290.95
115_F149_V2.1050.95
47_A53_V2.0470.94
81_V86_G2.0260.94
214_K218_K2.0110.94
58_P77_V2.0080.94
138_I145_G1.9760.93
17_P41_V1.9740.93
214_K257_V1.9700.93
81_V87_M1.9030.92
5_R54_D1.8990.92
198_G202_A1.8940.92
88_P92_I1.8570.91
159_A162_K1.8130.90
47_A52_E1.7740.89
72_I190_M1.7260.87
104_R146_D1.6900.86
19_I25_K1.6350.84
115_F127_R1.5880.82
268_F271_K1.5680.81
107_V110_P1.5270.80
8_A226_K1.5130.79
29_E204_R1.5060.79
110_P129_I1.4960.78
29_E208_T1.4920.78
193_I202_A1.4680.77
86_G92_I1.4300.75
75_N206_K1.4110.74
13_G57_V1.3990.73
79_T156_M1.3820.72
115_F119_R1.3770.72
268_F272_I1.3770.72
78_A247_T1.3760.72
57_V78_A1.3660.71
74_S206_K1.3530.71
106_I139_K1.3430.70
219_H222_E1.3340.70
48_V56_S1.3330.70
139_K142_G1.3190.69
11_D57_V1.3130.68
55_V205_F1.2930.67
29_E207_E1.2800.66
223_I227_D1.2740.66
11_D15_L1.2700.66
107_V115_F1.2700.66
17_P213_K1.2640.65
132_R213_K1.2550.65
25_K222_E1.2390.64
58_P192_V1.2370.64
82_D255_Y1.2260.63
71_Y195_K1.2250.63
8_A13_G1.2150.62
162_K240_D1.2130.62
213_K217_E1.2130.62
13_G78_A1.2110.62
140_A163_M1.2080.62
250_A253_Q1.1870.60
55_V68_D1.1820.60
57_V155_K1.1770.60
132_R135_L1.1600.59
245_R249_W1.1470.58
5_R215_Y1.1440.57
33_L208_T1.1420.57
61_A64_P1.1340.57
8_A11_D1.1230.56
41_V112_T1.1210.56
66_I192_V1.1210.56
89_I105_L1.1210.56
211_K214_K1.1160.56
131_V134_V1.1130.55
145_G266_L1.1110.55
10_A72_I1.1060.55
79_T155_K1.1050.55
16_Y217_E1.1040.55
224_I248_I1.0850.53
74_S259_V1.0800.53
13_G17_P1.0760.53
104_R128_L1.0750.53
94_E166_S1.0740.53
81_V88_P1.0730.53
42_Q64_P1.0630.52
47_A50_K1.0590.52
11_D78_A1.0590.52
60_V77_V1.0570.51
17_P209_Y1.0540.51
220_L245_R1.0540.51
57_V156_M1.0510.51
57_V247_T1.0480.51
19_I222_E1.0450.51
273_T279_L1.0450.51
56_S109_G1.0430.50
24_G142_G1.0360.50
191_V247_T1.0330.50
227_D247_T1.0330.50
166_S267_E1.0310.50
44_I112_T1.0270.49
78_A191_V1.0260.49
61_A65_Y1.0250.49
128_L143_K1.0210.49
13_G155_K1.0060.48
261_E264_R1.0060.48
7_G150_A1.0020.48
87_M95_M1.0020.48
15_L227_D1.0000.47
11_D17_P0.9930.47
132_R146_D0.9870.47
7_G47_A0.9850.46
78_A155_K0.9840.46
81_V84_I0.9830.46
267_E271_K0.9810.46
155_K247_T0.9780.46
134_V137_E0.9780.46
20_P26_V0.9770.46
39_P43_D0.9760.46
44_I109_G0.9750.46
56_S112_T0.9750.46
57_V191_V0.9710.45
275_E281_R0.9710.45
82_D261_E0.9530.44
78_A243_I0.9490.44
4_I54_D0.9440.44
156_M175_D0.9440.44
21_L33_L0.9440.44
11_D155_K0.9430.44
6_V55_V0.9420.43
155_K191_V0.9390.43
142_G267_E0.9370.43
139_K145_G0.9370.43
256_N277_G0.9350.43
107_V129_I0.9350.43
56_S129_I0.9290.43
262_I265_G0.9170.42
181_S272_I0.9160.42
57_V243_I0.9150.42
75_N256_N0.9050.41
15_L155_K0.8820.39
91_A95_M0.8810.39
104_R210_E0.8800.39
61_A111_N0.8770.39
13_G247_T0.8740.39
60_V64_P0.8740.39
68_D277_G0.8730.39
155_K250_A0.8700.39
13_G156_M0.8630.38
15_L78_A0.8620.38
92_I105_L0.8620.38
5_R34_E0.8610.38
224_I245_R0.8540.38
15_L247_T0.8520.37
41_V109_G0.8510.37
31_F207_E0.8490.37
23_E213_K0.8480.37
7_G41_V0.8480.37
72_I257_V0.8460.37
215_Y222_E0.8450.37
155_K175_D0.8320.36
11_D156_M0.8280.36
20_P23_E0.8280.36
91_A166_S0.8230.36
113_T123_G0.8200.35
208_T211_K0.8180.35
183_N267_E0.8160.35
11_D247_T0.8160.35
118_Y149_V0.8150.35
277_G282_V0.8130.35
54_D192_V0.8120.35
248_I255_Y0.8110.35
58_P219_H0.8100.35
156_M243_I0.8090.35
191_V248_I0.8070.35
201_L204_R0.8010.34
132_R250_A0.8000.34
13_G191_V0.7950.34
54_D132_R0.7900.34
43_D47_A0.7890.33
217_E257_V0.7860.33
78_A156_M0.7860.33
63_Y118_Y0.7810.33
218_K273_T0.7790.33
38_I226_K0.7710.32
79_T259_V0.7700.32
106_I147_V0.7700.32
224_I227_D0.7690.32
132_R138_I0.7670.32
89_I107_V0.7670.32
204_R208_T0.7670.32
33_L132_R0.7630.32
11_D191_V0.7580.32
90_L150_A0.7570.31
115_F129_I0.7560.31
50_K69_D0.7560.31
91_A94_E0.7510.31
84_I250_A0.7500.31
100_I147_V0.7470.31
8_A57_V0.7440.31
17_P78_A0.7440.31
15_L57_V0.7430.31
15_L191_V0.7410.31
13_G243_I0.7380.30
46_E50_K0.7370.30
89_I100_I0.7360.30
64_P273_T0.7350.30
137_E163_M0.7340.30
17_P57_V0.7340.30
121_L168_V0.7340.30
65_Y111_N0.7330.30
60_V79_T0.7320.30
87_M93_K0.7310.30
61_A223_I0.7300.30
155_K243_I0.7260.30
22_M226_K0.7250.30
84_I88_P0.7220.29
76_A169_R0.7210.29
21_L208_T0.7190.29
169_R252_I0.7170.29
278_I281_R0.7170.29
29_E213_K0.7150.29
264_R268_F0.7150.29
19_I226_K0.7120.29
137_E141_L0.7120.29
117_L259_V0.7110.29
41_V227_D0.7060.29
135_L213_K0.7040.28
7_G21_L0.7040.28
65_Y280_P0.7030.28
8_A78_A0.7030.28
4_I55_V0.7010.28
42_Q56_S0.6990.28
156_M234_A0.6980.28
132_R142_G0.6980.28
135_L150_A0.6950.28
63_Y186_M0.6920.28
19_I23_E0.6920.28
32_N246_K0.6920.28
60_V250_A0.6910.28
271_K275_E0.6890.28
108_H169_R0.6890.28
104_R275_E0.6870.27
247_T250_A0.6850.27
171_G248_I0.6820.27
89_I254_E0.6790.27
248_I262_I0.6780.27
71_Y202_A0.6740.27
76_A108_H0.6720.27
113_T117_L0.6720.27
94_E242_E0.6700.27
156_M191_V0.6690.26
44_I154_I0.6670.26
43_D150_A0.6650.26
26_V208_T0.6640.26
58_P64_P0.6620.26
78_A227_D0.6610.26
136_D154_I0.6600.26
27_K194_S0.6600.26
83_G271_K0.6590.26
39_P150_A0.6590.26
9_L171_G0.6580.26
132_R253_Q0.6580.26
88_P93_K0.6530.26
186_M250_A0.6510.26
242_E245_R0.6470.25
6_V221_D0.6450.25
164_G241_E0.6450.25
49_L111_N0.6430.25
74_S77_V0.6430.25
135_L139_K0.6340.25
154_I251_D0.6330.25
11_D243_I0.6330.25
111_N118_Y0.6330.25
42_Q111_N0.6310.24
73_L206_K0.6310.24
8_A41_V0.6270.24
41_V78_A0.6270.24
255_Y261_E0.6250.24
60_V192_V0.6240.24
99_E102_R0.6220.24
7_G123_G0.6210.24
105_L274_E0.6210.24
52_E134_V0.6180.24
67_Q158_Y0.6160.24
94_E162_K0.6150.24
118_Y168_V0.6140.24
105_L210_E0.6130.24
201_L254_E0.6130.24
67_Q270_F0.6100.23
88_P150_A0.6070.23
55_V192_V0.6060.23
88_P156_M0.6050.23
121_L190_M0.6040.23
108_H252_I0.6040.23
242_E261_E0.6020.23
47_A54_D0.6020.23
232_R244_V0.6010.23
200_D204_R0.6000.23
191_V227_D0.6000.23
60_V259_V0.5990.23
64_P129_I0.5950.23
33_L149_V0.5920.23
217_E254_E0.5910.22
63_Y270_F0.5890.22
227_D248_I0.5880.22
198_G267_E0.5860.22
128_L142_G0.5860.22
94_E99_E0.5850.22
114_A153_E0.5820.22
63_Y193_I0.5810.22
204_R246_K0.5760.22
58_P63_Y0.5750.22
50_K242_E0.5720.22
128_L138_I0.5670.21
78_A250_A0.5660.21
190_M259_V0.5660.21
66_I70_Y0.5590.21
105_L118_Y0.5560.21
156_M247_T0.5530.21
242_E246_K0.5520.21
116_T269_F0.5510.21
199_K203_L0.5510.21
74_S129_I0.5490.20
128_L133_R0.5490.20
241_E245_R0.5490.20
83_G202_A0.5460.20
33_L205_F0.5460.20
39_P47_A0.5430.20
243_I247_T0.5410.20
210_E214_K0.5380.20
91_A105_L0.5380.20
62_M273_T0.5370.20
247_T252_I0.5320.20
205_F209_Y0.5320.20
227_D256_N0.5270.20
53_V61_A0.5260.19
90_L104_R0.5260.19
191_V250_A0.5250.19
95_M99_E0.5250.19
142_G258_P0.5220.19
9_L14_D0.5210.19
46_E167_V0.5210.19
94_E197_V0.5210.19
232_R260_D0.5170.19
41_V248_I0.5170.19
86_G95_M0.5150.19
135_L142_G0.5150.19
149_V241_E0.5140.19
51_K264_R0.5130.19
193_I197_V0.5130.19
107_V244_V0.5120.19
165_I216_A0.5110.19
200_D275_E0.5100.19
134_V143_K0.5100.19
66_I275_E0.5100.19
57_V250_A0.5080.19
155_K234_A0.5080.19
239_L244_V0.5070.19
101_K124_K0.5070.19
64_P270_F0.5070.19
98_D260_D0.5070.19
220_L249_W0.5060.19
9_L12_S0.5040.19
101_K125_Y0.5030.18
25_K215_Y0.5030.18
84_I87_M0.5030.18
8_A36_E0.5030.18
43_D253_Q0.5020.18
32_N37_V0.5010.18
79_T247_T0.5000.18
209_Y214_K0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i6eA 3 0.8681 100 0.686 Contact Map
2czlA 1 0.9306 100 0.702 Contact Map
1zbmA 1 0.9028 100 0.72 Contact Map
2nxoA 2 0.8993 100 0.772 Contact Map
3hn0A 2 0.9028 99.9 0.81 Contact Map
4eswA 2 0.934 99.9 0.811 Contact Map
3ix1A 2 0.9444 99.9 0.82 Contact Map
3qslA 1 0.9549 99.8 0.832 Contact Map
2x7qA 1 0.8993 99.8 0.836 Contact Map
4nmyA 1 0.9201 99.8 0.837 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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