GREMLIN Database
NCPP - Probable non-canonical purine NTP phosphatase
UniProt: Q97WI6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 176 (166)
Sequences: 596 (436)
Seq/√Len: 33.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_L119_K3.6641.00
114_L127_I3.0531.00
15_S18_K2.8491.00
5_A65_A2.6091.00
133_N136_T2.5521.00
6_L30_L2.5341.00
4_I21_L2.5141.00
114_L124_A2.3340.99
125_S140_A2.3280.99
77_N116_L2.3160.99
78_V81_K2.2670.99
35_I58_N2.2540.99
53_R89_Y2.2240.99
19_E152_K2.1550.99
40_D47_Q2.1450.99
84_A105_F2.0520.98
19_E156_V2.0460.98
119_K127_I2.0450.98
86_A155_Y1.9940.98
119_K123_E1.9130.97
18_K29_D1.9100.97
49_Y99_F1.8820.97
111_I128_I1.8640.97
53_R97_E1.8240.96
17_T71_I1.8230.96
56_A70_G1.8170.96
7_G56_A1.7960.96
23_I156_V1.6980.95
152_K156_V1.6720.94
38_G58_N1.6270.93
12_V152_K1.6240.93
33_T59_A1.5920.93
88_V159_I1.5800.92
5_A59_A1.5660.92
41_K123_E1.5580.92
37_S54_N1.5130.91
20_A160_I1.4900.90
46_D87_V1.4860.90
119_K124_A1.4810.90
129_F143_L1.4730.89
3_T31_I1.4730.89
101_I104_S1.4720.89
45_C115_I1.4530.89
3_T29_D1.4190.87
158_P162_A1.4100.87
11_P122_G1.4080.87
98_N166_I1.4070.87
11_P136_T1.3980.87
24_L69_L1.3630.85
46_D104_S1.3510.85
88_V162_A1.3440.84
103_S161_L1.3390.84
125_S134_S1.3380.84
131_T138_E1.3250.84
21_L163_L1.3200.83
103_S157_Q1.3060.83
126_D131_T1.2870.82
5_A32_A1.2760.81
39_V54_N1.2530.80
83_I99_F1.2360.79
6_L17_T1.2360.79
49_Y89_Y1.2070.77
131_T143_L1.1820.76
14_I32_A1.1760.75
141_V161_L1.1590.74
34_D41_K1.1410.73
18_K22_E1.1120.71
81_K99_F1.1010.70
9_K34_D1.0950.70
86_A135_K1.0870.69
86_A158_P1.0830.69
8_S12_V1.0730.68
56_A68_G1.0720.68
15_S152_K1.0530.67
145_T164_Y1.0520.67
107_L121_L1.0460.66
98_N162_A1.0350.66
102_S154_L1.0310.65
135_K155_Y1.0310.65
7_G68_G1.0300.65
66_D93_K1.0130.64
109_S113_S1.0100.64
90_V162_A1.0090.64
12_V154_L1.0090.64
59_A70_G1.0070.63
146_N168_N1.0020.63
122_G136_T1.0010.63
117_Q132_I1.0000.63
21_L25_R0.9830.61
120_E126_D0.9820.61
9_K14_I0.9720.61
6_L12_V0.9560.59
73_G121_L0.9530.59
20_A163_L0.9420.58
44_F82_F0.9370.58
73_G142_G0.9360.58
73_G141_V0.9310.57
162_A165_P0.9300.57
107_L140_A0.9190.56
126_D135_K0.9160.56
113_S117_Q0.9150.56
50_V53_R0.9150.56
24_L167_Y0.9150.56
69_L90_V0.9010.55
46_D101_I0.9010.55
15_S19_E0.9000.55
44_F115_I0.8760.53
100_A107_L0.8750.53
82_F112_V0.8740.53
39_V51_G0.8690.52
57_L61_K0.8640.52
149_I157_Q0.8630.52
75_V82_F0.8380.49
129_F134_S0.8370.49
60_I68_G0.8180.48
100_A158_P0.8170.48
50_V57_L0.8140.47
87_V100_A0.8120.47
11_P120_E0.8110.47
11_P133_N0.8040.47
60_I65_A0.8000.46
11_P21_L0.8000.46
24_L163_L0.7980.46
21_L67_I0.7980.46
6_L32_A0.7960.46
60_I93_K0.7920.46
5_A31_I0.7870.45
84_A155_Y0.7800.45
56_A59_A0.7780.44
60_I95_G0.7740.44
52_A74_G0.7730.44
149_I161_L0.7710.44
141_V154_L0.7700.44
53_R57_L0.7690.44
87_V149_I0.7690.44
86_A102_S0.7680.44
86_A154_L0.7620.43
4_I61_K0.7600.43
8_S126_D0.7580.43
82_F87_V0.7570.43
10_N139_G0.7560.43
89_Y97_E0.7530.42
8_S32_A0.7400.41
9_K40_D0.7400.41
102_S125_S0.7390.41
114_L117_Q0.7370.41
105_F154_L0.7280.40
125_S154_L0.7120.39
4_I137_K0.7040.38
88_V155_Y0.7030.38
108_P122_G0.7030.38
122_G125_S0.7020.38
41_K119_K0.6970.38
150_D153_T0.6960.38
157_Q161_L0.6940.38
92_T95_G0.6900.37
54_N126_D0.6890.37
66_D147_N0.6870.37
7_G70_G0.6860.37
15_S113_S0.6830.37
18_K132_I0.6780.36
42_Q48_T0.6770.36
131_T134_S0.6760.36
88_V158_P0.6740.36
6_L14_I0.6730.36
73_G155_Y0.6680.36
73_G84_A0.6670.35
126_D129_F0.6660.35
42_Q140_A0.6620.35
89_Y99_F0.6620.35
85_N101_I0.6610.35
102_S155_Y0.6570.35
67_I133_N0.6570.35
126_D133_N0.6560.35
21_L69_L0.6530.34
48_T165_P0.6480.34
111_I115_I0.6400.33
35_I38_G0.6400.33
85_N155_Y0.6390.33
46_D85_N0.6390.33
71_I155_Y0.6360.33
15_S136_T0.6310.33
18_K66_D0.6300.33
40_D45_C0.6270.32
67_I148_I0.6250.32
8_S17_T0.6220.32
17_T68_G0.6210.32
107_L115_I0.6160.32
153_T160_I0.6160.32
7_G99_F0.6150.32
35_I39_V0.6150.32
37_S51_G0.6100.31
134_S143_L0.6090.31
87_V101_I0.6090.31
60_I92_T0.6060.31
105_F164_Y0.6040.31
15_S64_N0.6040.31
48_T74_G0.6040.31
146_N167_Y0.5980.30
149_I160_I0.5970.30
38_G57_L0.5930.30
98_N165_P0.5930.30
53_R124_A0.5920.30
48_T140_A0.5890.30
158_P166_I0.5880.30
7_G16_A0.5870.30
36_D40_D0.5870.30
112_V116_L0.5860.29
118_G122_G0.5860.29
159_I166_I0.5850.29
34_D58_N0.5810.29
19_E22_E0.5790.29
36_D111_I0.5790.29
100_A154_L0.5770.29
39_V47_Q0.5700.28
61_K123_E0.5680.28
28_W130_K0.5630.28
149_I154_L0.5630.28
26_L30_L0.5620.28
68_G84_A0.5600.28
49_Y53_R0.5570.27
75_V111_I0.5550.27
122_G161_L0.5490.27
111_I138_E0.5440.27
86_A129_F0.5420.27
100_A157_Q0.5370.26
124_A127_I0.5360.26
115_I156_V0.5350.26
48_T86_A0.5350.26
86_A124_A0.5330.26
31_I60_I0.5320.26
23_I33_T0.5260.25
117_Q169_T0.5250.25
111_I140_A0.5230.25
88_V102_S0.5220.25
78_V106_T0.5200.25
154_L164_Y0.5200.25
17_T23_I0.5180.25
148_I160_I0.5150.25
86_A122_G0.5140.25
20_A159_I0.5140.25
158_P165_P0.5120.25
45_C162_A0.5120.25
75_V99_F0.5080.24
84_A154_L0.5040.24
84_A102_S0.5040.24
14_I97_E0.5030.24
48_T103_S0.5020.24
103_S155_Y0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1u14A 1 0.9318 100 0.104 Contact Map
1zwyA 4 0.9659 100 0.131 Contact Map
3brcA 4 0.6761 80.5 0.93 Contact Map
3wb0A 4 0.6818 74.7 0.933 Contact Map
1k7kA 1 0.7557 61.9 0.939 Contact Map
1b78A 2 0.6818 50.1 0.943 Contact Map
2carA 2 0.733 46.7 0.944 Contact Map
4bnqA 2 0.8239 45.9 0.944 Contact Map
1vp2A 3 0.7216 45.1 0.945 Contact Map
1v7rA 1 0.6932 41.3 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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