GREMLIN Database
Q97WI4 - Thioredoxin (TrxA-2)
UniProt: Q97WI4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 135 (105)
Sequences: 7622 (5023)
Seq/√Len: 490.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_T94_A2.8151.00
72_E123_R2.4131.00
42_D96_R2.3811.00
36_L83_G2.2491.00
76_D127_E2.1401.00
106_M116_Q2.1081.00
122_P125_E2.0671.00
38_S92_D1.9621.00
127_E131_K1.9161.00
38_S93_I1.8861.00
69_V123_R1.8591.00
97_Y108_F1.7791.00
60_C63_C1.7421.00
76_D123_R1.7351.00
86_N89_E1.7321.00
54_D84_K1.6801.00
113_L116_Q1.6781.00
69_V72_E1.6371.00
52_V70_I1.6201.00
51_V81_A1.6181.00
70_I82_F1.5881.00
77_Y127_E1.5781.00
120_A125_E1.5691.00
34_K44_F1.5211.00
37_N40_N1.5161.00
40_N44_F1.5071.00
87_T102_L1.4971.00
77_Y131_K1.4871.00
50_I107_F1.4861.00
44_F81_A1.4781.00
38_S90_S1.4611.00
32_P75_N1.4361.00
85_L93_I1.3921.00
66_L105_I1.3761.00
36_L44_F1.3751.00
49_K81_A1.3711.00
32_P78_P1.3711.00
58_E86_N1.3661.00
42_D46_T1.3521.00
125_E128_V1.3481.00
107_F133_L1.2991.00
54_D67_A1.2591.00
73_L82_F1.2391.00
51_V83_G1.2361.00
106_M113_L1.2301.00
44_F51_V1.2211.00
53_V108_F1.1821.00
123_R127_E1.1611.00
52_V105_I1.1581.00
67_A71_E1.1511.00
73_L127_E1.1481.00
115_D129_R1.1311.00
73_L123_R1.1221.00
66_L69_V1.1201.00
34_K81_A1.0981.00
37_N90_S1.0731.00
85_L94_A1.0681.00
67_A84_K1.0491.00
121_V125_E1.0471.00
91_Q95_M1.0031.00
124_E128_V0.9991.00
71_E84_K0.9971.00
129_R133_L0.9851.00
66_L126_I0.9821.00
107_F129_R0.9771.00
55_F97_Y0.9551.00
55_F99_I0.9521.00
45_I51_V0.9411.00
117_I121_V0.9271.00
41_F45_I0.9191.00
117_I129_R0.9131.00
57_A88_E0.8961.00
58_E88_E0.8941.00
56_W86_N0.8931.00
35_H84_K0.8851.00
41_F55_F0.8681.00
74_A82_F0.8681.00
55_F106_M0.8661.00
48_N110_N0.8511.00
107_F130_L0.8511.00
52_V82_F0.8371.00
73_L126_I0.8221.00
69_V122_P0.8201.00
50_I79_Q0.8181.00
92_D96_R0.7891.00
80_V130_L0.7741.00
56_W84_K0.7731.00
105_I126_I0.7701.00
52_V107_F0.7661.00
75_N78_P0.7461.00
128_V131_K0.7421.00
54_D62_P0.7221.00
121_V129_R0.7161.00
61_A64_L0.7131.00
109_K114_V0.7061.00
66_L70_I0.7061.00
90_S93_I0.6951.00
41_F97_Y0.6901.00
36_L40_N0.6891.00
73_L77_Y0.6881.00
62_P101_S0.6881.00
34_K51_V0.6831.00
33_V74_A0.6781.00
33_V70_I0.6771.00
91_Q94_A0.6621.00
70_I105_I0.6591.00
55_F87_T0.6581.00
50_I109_K0.6531.00
100_M116_Q0.6451.00
115_D133_L0.6391.00
79_Q131_K0.6371.00
52_V126_I0.6371.00
70_I130_L0.6251.00
69_V73_L0.6211.00
129_R132_S0.6170.99
52_V130_L0.6130.99
59_W64_L0.6080.99
43_E46_T0.6060.99
35_H89_E0.6060.99
77_Y80_V0.6040.99
65_I69_V0.6020.99
40_N83_G0.5970.99
49_K79_Q0.5870.99
34_K83_G0.5860.99
57_A68_P0.5810.99
41_F93_I0.5800.99
31_E71_E0.5730.99
115_D132_S0.5720.99
36_L53_V0.5710.99
56_W102_L0.5710.99
53_V83_G0.5700.99
59_W88_E0.5680.99
44_F48_N0.5660.99
57_A60_C0.5610.99
57_A63_C0.5540.99
77_Y82_F0.5500.99
76_D124_E0.5470.99
119_G125_E0.5460.99
55_F85_L0.5450.99
58_E89_E0.5440.99
41_F53_V0.5430.99
59_W102_L0.5370.99
93_I97_Y0.5330.99
54_D66_L0.5320.99
61_A65_I0.5310.99
99_I104_T0.5300.98
61_A101_S0.5190.98
36_L51_V0.5180.98
70_I126_I0.5170.98
87_T99_I0.5140.98
29_V32_P0.5130.98
34_K40_N0.5090.98
62_P119_G0.5070.98
88_E91_Q0.5070.98
63_C68_P0.5060.98
92_D95_M0.5060.98
72_E75_N0.5000.98
85_L90_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r2jA 2 0.7556 99.9 0.239 Contact Map
3f8uA 2 0.7778 99.9 0.241 Contact Map
2b5eA 1 0.8519 99.8 0.252 Contact Map
3apoA 1 0.8296 99.8 0.265 Contact Map
4ekzA 1 0.9333 99.8 0.28 Contact Map
3us3A 2 0.8593 99.8 0.283 Contact Map
1sjiA 2 0.8444 99.8 0.289 Contact Map
3ed3A 1 0.8296 99.8 0.309 Contact Map
3idvA 1 0.8296 99.8 0.313 Contact Map
3t58A 1 0.8296 99.8 0.326 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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