GREMLIN Database
Q97WI1 - Phosphoglycerate mutase, putative
UniProt: Q97WI1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (184)
Sequences: 14305 (10214)
Seq/√Len: 753.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
88_R138_S2.9751.00
64_P90_R2.9241.00
42_I70_Q2.8091.00
11_I183_I2.7571.00
69_Y85_V2.7461.00
96_E121_G2.7101.00
11_I146_I2.4751.00
133_K162_Y2.4491.00
132_M155_P2.3691.00
19_Q40_E2.3311.00
88_R134_S2.2651.00
59_K84_I2.1861.00
88_R135_F2.1621.00
151_S155_P2.0171.00
11_I185_R1.9861.00
89_L135_F1.9841.00
46_K74_I1.9371.00
15_I48_A1.9131.00
36_P70_Q1.9061.00
19_Q38_T1.8761.00
42_I74_I1.8171.00
70_Q73_L1.7881.00
31_D90_R1.7771.00
57_V148_T1.7691.00
21_T38_T1.7681.00
36_P66_L1.7621.00
60_I76_G1.7091.00
86_D138_S1.6671.00
15_I75_I1.6321.00
58_E145_R1.5781.00
124_S127_D1.5711.00
60_I72_A1.5701.00
64_P87_Q1.5611.00
69_Y73_L1.5441.00
13_I57_V1.5401.00
15_I148_T1.5321.00
31_D93_F1.5281.00
151_S156_I1.5191.00
62_T85_V1.5111.00
118_E127_D1.5071.00
50_K78_V1.5061.00
58_E146_I1.4981.00
43_N46_K1.4911.00
156_I176_I1.4851.00
43_N47_E1.4691.00
21_T25_S1.4691.00
123_E131_R1.4671.00
13_I146_I1.4531.00
86_D135_F1.4421.00
13_I183_I1.4411.00
75_I150_V1.4311.00
101_S104_P1.4131.00
39_E42_I1.4031.00
40_E44_Q1.3771.00
19_Q24_V1.3581.00
133_K137_E1.3461.00
42_I46_K1.3411.00
40_E43_N1.3211.00
113_F116_Q1.3181.00
108_W112_V1.3161.00
45_A71_T1.3051.00
100_T104_P1.2721.00
22_S35_Y1.2651.00
61_Y135_F1.2581.00
186_C193_C1.2471.00
132_M159_I1.2411.00
127_D130_K1.2021.00
22_S29_S1.1981.00
126_E130_K1.1981.00
22_S27_I1.1881.00
73_L77_E1.1871.00
66_L70_Q1.1661.00
59_K145_R1.1651.00
63_S152_H1.1281.00
63_S68_A1.1211.00
50_K53_T1.1141.00
10_T143_D1.1081.00
93_F98_N1.0981.00
129_T133_K1.0971.00
62_T83_P1.0941.00
135_F139_V1.0901.00
23_N178_N1.0891.00
128_I155_P1.0871.00
47_E50_K1.0671.00
46_K77_E1.0661.00
32_T98_N1.0491.00
72_A150_V1.0471.00
14_F156_I1.0421.00
76_G83_P1.0401.00
38_T41_G1.0341.00
62_T69_Y1.0271.00
61_Y86_D1.0191.00
170_S173_G1.0131.00
89_L149_A1.0051.00
65_V90_R0.9971.00
19_Q44_Q0.9971.00
116_Q126_E0.9921.00
14_F159_I0.9851.00
138_S142_K0.9831.00
72_A83_P0.9811.00
59_K147_I0.9761.00
68_A152_H0.9751.00
57_V146_I0.9711.00
64_P85_V0.9681.00
73_L83_P0.9641.00
87_Q90_R0.9601.00
96_E120_K0.9571.00
136_L159_I0.9541.00
49_G74_I0.9511.00
107_H111_K0.9461.00
34_T66_L0.9451.00
128_I158_A0.9361.00
130_K134_S0.9301.00
20_S178_N0.9261.00
29_S35_Y0.9251.00
135_F149_A0.9141.00
160_I164_L0.9121.00
74_I77_E0.9111.00
13_I55_L0.9111.00
187_D192_S0.9051.00
53_T78_V0.8961.00
27_I101_S0.8951.00
167_D170_S0.8901.00
137_E141_N0.8901.00
46_K78_V0.8841.00
177_P180_S0.8781.00
139_V149_A0.8781.00
13_I181_F0.8781.00
110_L114_K0.8771.00
39_E43_N0.8751.00
176_I182_T0.8741.00
185_R194_R0.8741.00
20_S29_S0.8691.00
60_I81_T0.8671.00
164_L174_I0.8661.00
91_E153_S0.8641.00
62_T68_A0.8621.00
59_K142_K0.8561.00
61_Y84_I0.8531.00
176_I180_S0.8481.00
129_T162_Y0.8431.00
48_A179_A0.8391.00
128_I132_M0.8351.00
188_N191_D0.8351.00
111_K114_K0.8341.00
31_D64_P0.8291.00
55_L146_I0.8221.00
35_Y38_T0.8201.00
129_T158_A0.8201.00
160_I182_T0.8161.00
21_T36_P0.8121.00
66_L69_Y0.8051.00
164_L184_L0.7961.00
18_G37_L0.7901.00
188_N192_S0.7891.00
107_H110_L0.7791.00
156_I182_T0.7581.00
84_I142_K0.7561.00
32_T35_Y0.7551.00
20_S38_T0.7531.00
74_I78_V0.7511.00
49_G78_V0.7491.00
46_K50_K0.7471.00
105_N108_W0.7451.00
44_Q178_N0.7441.00
61_Y139_V0.7411.00
24_V40_E0.7391.00
23_N29_S0.7371.00
61_Y143_D0.7351.00
15_I181_F0.7331.00
166_M170_S0.7311.00
105_N109_K0.7301.00
22_S32_T0.7291.00
30_H98_N0.7281.00
109_K113_F0.7281.00
14_F184_L0.7281.00
139_V147_I0.7221.00
160_I184_L0.7211.00
92_R128_I0.7121.00
10_T186_C0.7101.00
51_E181_F0.7071.00
61_Y147_I0.7061.00
45_A49_G0.6981.00
163_L184_L0.6971.00
10_T144_N0.6941.00
18_G71_T0.6921.00
45_A179_A0.6901.00
70_Q74_I0.6871.00
21_T24_V0.6851.00
140_I186_C0.6851.00
94_L98_N0.6831.00
62_T72_A0.6791.00
31_D65_V0.6781.00
10_T145_R0.6721.00
161_T166_M0.6701.00
137_E140_I0.6671.00
12_I136_L0.6671.00
32_T93_F0.6571.00
60_I79_L0.6531.00
20_S23_N0.6531.00
32_T99_N0.6381.00
48_A181_F0.6351.00
46_K49_G0.6351.00
109_K112_V0.6321.00
56_K146_I0.6291.00
108_W111_K0.6291.00
57_V79_L0.6281.00
161_T171_G0.6251.00
125_W158_A0.6241.00
115_K119_I0.6241.00
187_D191_D0.6231.00
15_I150_V0.6171.00
115_K118_E0.6161.00
14_F149_A0.6151.00
36_P42_I0.6141.00
60_I148_T0.6111.00
37_L45_A0.6101.00
133_K159_I0.6091.00
161_T168_D0.6031.00
76_G79_L0.6021.00
65_V68_A0.6011.00
41_G44_Q0.5981.00
10_T140_I0.5981.00
91_E154_D0.5961.00
130_K133_K0.5961.00
89_L139_V0.5961.00
110_L113_F0.5961.00
134_S138_S0.5941.00
41_G45_A0.5921.00
137_E162_Y0.5911.00
37_L41_G0.5911.00
55_L79_L0.5861.00
49_G53_T0.5821.00
51_E54_K0.5811.00
106_D109_K0.5811.00
76_G81_T0.5801.00
18_G41_G0.5801.00
128_I154_D0.5791.00
9_M187_D0.5771.00
135_F138_S0.5771.00
56_K79_L0.5711.00
45_A74_I0.5701.00
21_T35_Y0.5661.00
171_G174_I0.5641.00
64_P86_D0.5641.00
97_L119_I0.5611.00
17_H91_E0.5601.00
132_M162_Y0.5591.00
20_S35_Y0.5561.00
18_G44_Q0.5471.00
24_V38_T0.5391.00
138_S141_N0.5391.00
61_Y142_K0.5381.00
58_E148_T0.5371.00
30_H65_V0.5361.00
28_L102_F0.5291.00
57_V60_I0.5281.00
156_I160_I0.5261.00
184_L195_I0.5251.00
92_R125_W0.5251.00
107_H114_K0.5241.00
60_I83_P0.5231.00
26_K101_S0.5211.00
95_G122_I0.5181.00
166_M174_I0.5181.00
26_K102_F0.5131.00
69_Y83_P0.5081.00
159_I163_L0.5081.00
26_K103_D0.5071.00
71_T179_A0.5061.00
157_R161_T0.5051.00
16_R67_R0.5041.00
22_S99_N0.5031.00
18_G179_A0.5021.00
29_S178_N0.5011.00
108_W114_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gp3A 1 0.8843 100 0.183 Contact Map
1h2eA 1 0.9213 100 0.2 Contact Map
4pzaA 2 0.9028 100 0.201 Contact Map
3kkkA 3 0.8843 100 0.206 Contact Map
1e58A 2 0.963 100 0.206 Contact Map
4ij5A 2 0.9444 100 0.208 Contact Map
2hhjA 2 0.963 100 0.208 Contact Map
3d8hA 2 0.9028 100 0.209 Contact Map
4embA 2 0.9537 100 0.22 Contact Map
4odiA 3 0.9537 100 0.221 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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