Q97WI0 - SULSO - GREMLIN Contacts

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Q97WI0 - Uncharacterized protein

UniProt:	Q97WI0	Sequences: MVSLFKRNKHSLNSSTNLRLLFTSDLHASYTVFKKFINAGKIYKVNALIIGGDIAGKVLLPIIDLGNNSYNVQEKIVTSSELNSLIERFKSEGTYYAILSKGEYEEASQNKKAQDELFKKAIIETLHEWIKIAEERLKDYKIPIFINLGNDDPEYLFDVLKESEIFKVGEGEVFDLNGYEIVSYGYVNPTPWNTFREKKEEDIYSDLSKIVSKINNYSKAIYNFHAPPYNTNLDNAPLLDENLKPIIRGGEIVYTHVGSKSIRKIIEETKPLLGLHGHIHESRGFDKINNTIVINPGSEYSSGLLHAALVVLEGEFIKAHQFILG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (246)
Sequences:	130 (85)
Seq/√Len:	5.4

SULSO - Q97WI0 Q97VA9 Q97VA5 Q97WP7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
270_K	289_N	4.392	0.95
183_S	223_N	3.720	0.88
194_T	197_E	3.670	0.88
270_K	290_N	3.615	0.87
107_A	178_G	3.283	0.81
26_L	32_V	3.109	0.77
198_K	206_D	3.066	0.76
121_A	260_K	2.971	0.73
207_L	265_I	2.846	0.70
300_Y	303_G	2.769	0.68
54_I	67_N	2.763	0.67
144_I	165_I	2.696	0.65
210_I	226_A	2.521	0.60
204_Y	265_I	2.520	0.60
147_N	169_G	2.520	0.60
208_S	268_E	2.450	0.58
105_E	301_S	2.214	0.50
27_H	52_G	2.160	0.48
25_D	52_G	2.160	0.48
202_D	206_D	2.146	0.47
200_E	303_G	2.058	0.44
187_V	226_A	2.031	0.43
176_L	202_D	1.917	0.40
26_L	54_I	1.815	0.36
187_V	197_E	1.792	0.36
25_D	53_D	1.789	0.36
27_H	53_D	1.789	0.36
171_G	177_N	1.782	0.35
23_T	36_F	1.770	0.35
176_L	181_I	1.761	0.35
49_I	191_P	1.756	0.35
24_S	176_L	1.719	0.34
184_Y	233_L	1.713	0.33
43_Y	284_G	1.707	0.33
256_H	293_V	1.695	0.33
19_R	142_I	1.671	0.32
151_D	298_S	1.661	0.32
21_L	55_A	1.656	0.32
64_D	143_P	1.653	0.32
37_I	296_P	1.629	0.31
302_S	305_L	1.617	0.31
189_P	197_E	1.614	0.30
190_T	194_T	1.608	0.30
23_T	45_V	1.597	0.30
104_Y	183_S	1.594	0.30
49_I	138_K	1.578	0.29
170_E	185_G	1.560	0.29
143_P	171_G	1.549	0.29
143_P	156_L	1.547	0.29
263_R	267_E	1.532	0.28
228_P	297_G	1.522	0.28
22_F	48_L	1.462	0.26
197_E	200_E	1.457	0.26
22_F	296_P	1.446	0.26
20_L	82_L	1.419	0.25
19_R	45_V	1.405	0.25
47_A	127_H	1.397	0.25
64_D	171_G	1.397	0.25
26_L	177_N	1.381	0.24
175_D	178_G	1.369	0.24
213_K	268_E	1.365	0.24
193_N	197_E	1.353	0.24
199_K	202_D	1.351	0.23
63_I	86_I	1.333	0.23
53_D	149_G	1.314	0.23
191_P	200_E	1.300	0.22
94_T	187_V	1.284	0.22
152_D	259_S	1.282	0.22
264_K	267_E	1.257	0.21
129_W	223_N	1.256	0.21
76_I	82_L	1.250	0.21
49_I	155_Y	1.244	0.21
26_L	46_N	1.241	0.21
64_D	145_F	1.230	0.21
36_F	51_G	1.227	0.21
167_K	300_Y	1.195	0.20
201_E	214_I	1.195	0.20
105_E	261_S	1.183	0.20
178_G	215_N	1.177	0.19
166_F	290_N	1.173	0.19
70_Y	160_L	1.173	0.19
46_N	230_N	1.170	0.19
197_E	303_G	1.167	0.19
19_R	24_S	1.166	0.19
171_G	287_K	1.165	0.19
104_Y	223_N	1.159	0.19
24_S	177_N	1.157	0.19
128_E	290_N	1.151	0.19
34_K	125_T	1.150	0.19
120_K	224_F	1.140	0.19
227_P	295_N	1.136	0.19
227_P	234_D	1.136	0.19
234_D	295_N	1.136	0.19
234_D	277_G	1.136	0.19
225_H	295_N	1.136	0.19
277_G	295_N	1.136	0.19
225_H	234_D	1.136	0.19
225_H	277_G	1.136	0.19
227_P	277_G	1.136	0.19
53_D	150_N	1.128	0.18
55_A	157_F	1.127	0.18
78_T	81_E	1.115	0.18
204_Y	208_S	1.112	0.18
103_E	130_I	1.108	0.18
151_D	279_I	1.108	0.18
196_R	276_H	1.105	0.18
192_W	200_E	1.104	0.18
167_K	285_F	1.100	0.18
100_S	288_I	1.087	0.18
139_D	279_I	1.086	0.18
76_I	214_I	1.086	0.18
256_H	286_D	1.074	0.17
83_N	203_I	1.070	0.17
55_A	61_P	1.069	0.17
62_I	292_I	1.062	0.17
184_Y	207_L	1.057	0.17
202_D	205_S	1.055	0.17
171_G	283_R	1.052	0.17
236_A	298_S	1.050	0.17
184_Y	274_G	1.047	0.17
20_L	45_V	1.042	0.17
231_T	256_H	1.041	0.17
19_R	102_G	1.038	0.17
190_T	257_V	1.029	0.17
190_T	197_E	1.019	0.16
135_E	142_I	1.017	0.16
214_I	293_V	1.008	0.16
26_L	265_I	1.005	0.16
224_F	233_L	1.004	0.16
74_E	101_K	0.995	0.16
19_R	33_F	0.992	0.16
121_A	294_I	0.992	0.16
164_E	176_L	0.988	0.16
43_Y	302_S	0.986	0.16
87_E	175_D	0.985	0.16
19_R	229_Y	0.984	0.16
80_S	84_S	0.969	0.15
28_A	297_G	0.965	0.15
148_L	166_F	0.965	0.15
137_L	164_E	0.962	0.15
46_N	85_L	0.961	0.15
98_I	131_K	0.956	0.15
286_D	293_V	0.954	0.15
190_T	303_G	0.951	0.15
195_F	202_D	0.946	0.15
190_T	200_E	0.939	0.15
67_N	138_K	0.938	0.15
29_S	35_K	0.937	0.15
190_T	262_I	0.936	0.15
54_I	77_V	0.935	0.15
139_D	288_I	0.935	0.15
82_L	85_L	0.933	0.15
178_G	202_D	0.921	0.15
136_R	201_E	0.921	0.15
196_R	305_L	0.915	0.15
104_Y	270_K	0.914	0.15
101_K	161_K	0.906	0.14
23_T	33_F	0.904	0.14
90_K	176_L	0.896	0.14
48_L	292_I	0.895	0.14
51_G	137_L	0.893	0.14
98_I	231_T	0.893	0.14
150_N	278_H	0.888	0.14
61_P	200_E	0.888	0.14
173_V	264_K	0.885	0.14
191_P	303_G	0.880	0.14
80_S	205_S	0.880	0.14
151_D	188_N	0.877	0.14
55_A	148_L	0.875	0.14
87_E	269_T	0.870	0.14
92_E	121_A	0.869	0.14
151_D	236_A	0.863	0.14
64_D	156_L	0.861	0.14
147_N	191_P	0.861	0.14
75_K	98_I	0.861	0.14
74_E	178_G	0.860	0.14
50_I	148_L	0.858	0.14
264_K	286_D	0.849	0.13
20_L	34_K	0.842	0.13
274_G	299_E	0.837	0.13
93_G	294_I	0.837	0.13
128_E	199_K	0.832	0.13
37_I	46_N	0.825	0.13
34_K	120_K	0.822	0.13
141_K	212_S	0.822	0.13
63_I	289_N	0.820	0.13
203_I	284_G	0.815	0.13
234_D	280_H	0.814	0.13
227_P	280_H	0.814	0.13
280_H	295_N	0.814	0.13
277_G	280_H	0.814	0.13
225_H	280_H	0.814	0.13
45_V	107_A	0.812	0.13
49_I	292_I	0.810	0.13
236_A	276_H	0.807	0.13
71_N	117_L	0.806	0.13
35_K	190_T	0.805	0.13
97_A	182_V	0.796	0.13
45_V	182_V	0.796	0.13
203_I	261_S	0.795	0.13
262_I	303_G	0.790	0.13
266_I	288_I	0.789	0.13
66_G	74_E	0.786	0.12
87_E	260_K	0.778	0.12
85_L	160_L	0.777	0.12
145_F	176_L	0.776	0.12
196_R	203_I	0.774	0.12
98_I	153_P	0.773	0.12
22_F	37_I	0.772	0.12
65_L	145_F	0.769	0.12
186_Y	279_I	0.769	0.12
93_G	196_R	0.767	0.12
49_I	70_Y	0.765	0.12
169_G	270_K	0.759	0.12
145_F	181_I	0.759	0.12
124_E	171_G	0.759	0.12
198_K	202_D	0.757	0.12
152_D	278_H	0.753	0.12
18_L	158_D	0.751	0.12
143_P	177_N	0.748	0.12
95_Y	196_R	0.747	0.12
63_I	74_E	0.745	0.12
192_W	207_L	0.745	0.12
78_T	122_I	0.743	0.12
136_R	187_V	0.732	0.12
31_T	120_K	0.730	0.12
146_I	214_I	0.727	0.12
62_I	222_Y	0.724	0.12
89_F	177_N	0.723	0.12
166_F	175_D	0.719	0.12
24_S	126_L	0.718	0.12
33_F	51_G	0.714	0.11
276_H	281_E	0.713	0.11
78_T	177_N	0.711	0.11
54_I	175_D	0.710	0.11
116_E	264_K	0.710	0.11
126_L	177_N	0.706	0.11
99_L	102_G	0.695	0.11
261_S	290_N	0.692	0.11
221_I	273_L	0.690	0.11
270_K	291_T	0.689	0.11
77_V	193_N	0.688	0.11
82_L	193_N	0.687	0.11
123_I	268_E	0.684	0.11
69_S	87_E	0.683	0.11
209_K	261_S	0.681	0.11
149_G	277_G	0.675	0.11
149_G	295_N	0.675	0.11
149_G	227_P	0.675	0.11
149_G	225_H	0.675	0.11
149_G	234_D	0.675	0.11
68_N	159_V	0.673	0.11
44_K	186_Y	0.671	0.11
135_E	303_G	0.668	0.11
140_Y	167_K	0.666	0.11
176_L	257_V	0.666	0.11
18_L	71_N	0.662	0.11
146_I	199_K	0.660	0.11
205_S	301_S	0.658	0.11
172_E	261_S	0.647	0.11
64_D	78_T	0.646	0.11
43_Y	262_I	0.644	0.11
195_F	265_I	0.634	0.10
81_E	275_L	0.634	0.10
287_K	292_I	0.628	0.10
31_T	273_L	0.625	0.10
48_L	287_K	0.625	0.10
83_N	286_D	0.621	0.10
129_W	233_L	0.620	0.10
85_L	88_R	0.619	0.10
180_E	213_K	0.618	0.10
151_D	190_T	0.616	0.10
97_A	194_T	0.616	0.10
147_N	168_V	0.615	0.10
236_A	263_R	0.613	0.10
18_L	289_N	0.611	0.10
47_A	107_A	0.607	0.10
55_A	99_L	0.604	0.10
210_I	275_L	0.601	0.10
24_S	170_E	0.600	0.10
213_K	288_I	0.600	0.10
222_Y	289_N	0.598	0.10
84_S	87_E	0.596	0.10
129_W	296_P	0.590	0.10
200_E	300_Y	0.590	0.10
257_V	303_G	0.589	0.10
33_F	130_I	0.588	0.10
181_I	223_N	0.587	0.10
67_N	80_S	0.585	0.10
46_N	215_N	0.583	0.10
91_S	178_G	0.582	0.10
188_N	191_P	0.580	0.10
73_Q	198_K	0.579	0.10
83_N	168_V	0.575	0.10
84_S	230_N	0.575	0.10
70_Y	288_I	0.574	0.10
21_L	45_V	0.573	0.10
43_Y	275_L	0.573	0.10
120_K	264_K	0.570	0.10
48_L	291_T	0.568	0.10
47_A	154_E	0.567	0.10
102_G	202_D	0.567	0.10
29_S	103_E	0.565	0.10
192_W	196_R	0.561	0.10
184_Y	224_F	0.561	0.10
167_K	205_S	0.560	0.10
72_V	171_G	0.560	0.10
22_F	249_G	0.560	0.10
209_K	215_N	0.560	0.10
92_E	173_V	0.557	0.09
156_L	167_K	0.557	0.09
258_G	277_G	0.555	0.09
225_H	258_G	0.555	0.09
258_G	295_N	0.555	0.09
234_D	258_G	0.555	0.09
227_P	258_G	0.555	0.09
65_L	130_I	0.554	0.09
37_I	105_E	0.552	0.09
180_E	189_P	0.550	0.09
289_N	292_I	0.549	0.09
24_S	137_L	0.548	0.09
191_P	207_L	0.545	0.09
107_A	143_P	0.543	0.09
46_N	137_L	0.541	0.09
151_D	297_G	0.538	0.09
121_A	173_V	0.535	0.09
65_L	143_P	0.534	0.09
87_E	91_S	0.532	0.09
131_K	202_D	0.532	0.09
265_I	269_T	0.530	0.09
213_K	264_K	0.528	0.09
63_I	85_L	0.524	0.09
73_Q	293_V	0.524	0.09
65_L	159_V	0.524	0.09
125_T	154_E	0.522	0.09
78_T	156_L	0.522	0.09
46_N	258_G	0.521	0.09
195_F	207_L	0.521	0.09
49_I	167_K	0.521	0.09
52_G	234_D	0.519	0.09
52_G	227_P	0.519	0.09
52_G	225_H	0.519	0.09
52_G	277_G	0.519	0.09
52_G	295_N	0.519	0.09
25_D	234_D	0.519	0.09
27_H	227_P	0.519	0.09
27_H	277_G	0.519	0.09
25_D	295_N	0.519	0.09
27_H	295_N	0.519	0.09
25_D	277_G	0.519	0.09
25_D	227_P	0.519	0.09
25_D	225_H	0.519	0.09
27_H	225_H	0.519	0.09
27_H	234_D	0.519	0.09
223_N	233_L	0.518	0.09
128_E	145_F	0.513	0.09
55_A	303_G	0.513	0.09
23_T	51_G	0.513	0.09
214_I	226_A	0.511	0.09
104_Y	292_I	0.509	0.09
118_F	174_F	0.508	0.09
195_F	205_S	0.507	0.09
51_G	54_I	0.506	0.09
127_H	143_P	0.506	0.09
153_P	191_P	0.505	0.09
204_Y	294_I	0.505	0.09
35_K	43_Y	0.503	0.09
170_E	296_P	0.502	0.09
22_F	129_W	0.500	0.09

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2yvtA	1	0.7508	100	0.761	Contact Map
1uf3A	6	0.6523	100	0.772	Contact Map
4peiA	2	0.76	99.9	0.796	Contact Map
3rl5A	1	0.6615	99.9	0.814	Contact Map
3d03A	5	0.6831	99.9	0.825	Contact Map
3qfmA	2	0.6369	99.9	0.826	Contact Map
3ib7A	2	0.7231	99.9	0.827	Contact Map
4ykeA	2	0.7846	99.8	0.835	Contact Map
3rqzA	1	0.6031	99.8	0.836	Contact Map
3t1iA	2	0.7385	99.8	0.841	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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