GREMLIN Database
Q97WI0 - Uncharacterized protein
UniProt: Q97WI0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (246)
Sequences: 130 (85)
Seq/√Len: 5.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_K289_N4.3920.95
183_S223_N3.7200.88
194_T197_E3.6700.88
270_K290_N3.6150.87
107_A178_G3.2830.81
26_L32_V3.1090.77
198_K206_D3.0660.76
121_A260_K2.9710.73
207_L265_I2.8460.70
300_Y303_G2.7690.68
54_I67_N2.7630.67
144_I165_I2.6960.65
210_I226_A2.5210.60
204_Y265_I2.5200.60
147_N169_G2.5200.60
208_S268_E2.4500.58
105_E301_S2.2140.50
27_H52_G2.1600.48
25_D52_G2.1600.48
202_D206_D2.1460.47
200_E303_G2.0580.44
187_V226_A2.0310.43
176_L202_D1.9170.40
26_L54_I1.8150.36
187_V197_E1.7920.36
25_D53_D1.7890.36
27_H53_D1.7890.36
171_G177_N1.7820.35
23_T36_F1.7700.35
176_L181_I1.7610.35
49_I191_P1.7560.35
24_S176_L1.7190.34
184_Y233_L1.7130.33
43_Y284_G1.7070.33
256_H293_V1.6950.33
19_R142_I1.6710.32
151_D298_S1.6610.32
21_L55_A1.6560.32
64_D143_P1.6530.32
37_I296_P1.6290.31
302_S305_L1.6170.31
189_P197_E1.6140.30
190_T194_T1.6080.30
23_T45_V1.5970.30
104_Y183_S1.5940.30
49_I138_K1.5780.29
170_E185_G1.5600.29
143_P171_G1.5490.29
143_P156_L1.5470.29
263_R267_E1.5320.28
228_P297_G1.5220.28
22_F48_L1.4620.26
197_E200_E1.4570.26
22_F296_P1.4460.26
20_L82_L1.4190.25
19_R45_V1.4050.25
47_A127_H1.3970.25
64_D171_G1.3970.25
26_L177_N1.3810.24
175_D178_G1.3690.24
213_K268_E1.3650.24
193_N197_E1.3530.24
199_K202_D1.3510.23
63_I86_I1.3330.23
53_D149_G1.3140.23
191_P200_E1.3000.22
94_T187_V1.2840.22
152_D259_S1.2820.22
264_K267_E1.2570.21
129_W223_N1.2560.21
76_I82_L1.2500.21
49_I155_Y1.2440.21
26_L46_N1.2410.21
64_D145_F1.2300.21
36_F51_G1.2270.21
167_K300_Y1.1950.20
201_E214_I1.1950.20
105_E261_S1.1830.20
178_G215_N1.1770.19
166_F290_N1.1730.19
70_Y160_L1.1730.19
46_N230_N1.1700.19
197_E303_G1.1670.19
19_R24_S1.1660.19
171_G287_K1.1650.19
104_Y223_N1.1590.19
24_S177_N1.1570.19
128_E290_N1.1510.19
34_K125_T1.1500.19
120_K224_F1.1400.19
227_P295_N1.1360.19
227_P234_D1.1360.19
234_D295_N1.1360.19
234_D277_G1.1360.19
225_H295_N1.1360.19
277_G295_N1.1360.19
225_H234_D1.1360.19
225_H277_G1.1360.19
227_P277_G1.1360.19
53_D150_N1.1280.18
55_A157_F1.1270.18
78_T81_E1.1150.18
204_Y208_S1.1120.18
103_E130_I1.1080.18
151_D279_I1.1080.18
196_R276_H1.1050.18
192_W200_E1.1040.18
167_K285_F1.1000.18
100_S288_I1.0870.18
139_D279_I1.0860.18
76_I214_I1.0860.18
256_H286_D1.0740.17
83_N203_I1.0700.17
55_A61_P1.0690.17
62_I292_I1.0620.17
184_Y207_L1.0570.17
202_D205_S1.0550.17
171_G283_R1.0520.17
236_A298_S1.0500.17
184_Y274_G1.0470.17
20_L45_V1.0420.17
231_T256_H1.0410.17
19_R102_G1.0380.17
190_T257_V1.0290.17
190_T197_E1.0190.16
135_E142_I1.0170.16
214_I293_V1.0080.16
26_L265_I1.0050.16
224_F233_L1.0040.16
74_E101_K0.9950.16
19_R33_F0.9920.16
121_A294_I0.9920.16
164_E176_L0.9880.16
43_Y302_S0.9860.16
87_E175_D0.9850.16
19_R229_Y0.9840.16
80_S84_S0.9690.15
28_A297_G0.9650.15
148_L166_F0.9650.15
137_L164_E0.9620.15
46_N85_L0.9610.15
98_I131_K0.9560.15
286_D293_V0.9540.15
190_T303_G0.9510.15
195_F202_D0.9460.15
190_T200_E0.9390.15
67_N138_K0.9380.15
29_S35_K0.9370.15
190_T262_I0.9360.15
54_I77_V0.9350.15
139_D288_I0.9350.15
82_L85_L0.9330.15
178_G202_D0.9210.15
136_R201_E0.9210.15
196_R305_L0.9150.15
104_Y270_K0.9140.15
101_K161_K0.9060.14
23_T33_F0.9040.14
90_K176_L0.8960.14
48_L292_I0.8950.14
51_G137_L0.8930.14
98_I231_T0.8930.14
150_N278_H0.8880.14
61_P200_E0.8880.14
173_V264_K0.8850.14
191_P303_G0.8800.14
80_S205_S0.8800.14
151_D188_N0.8770.14
55_A148_L0.8750.14
87_E269_T0.8700.14
92_E121_A0.8690.14
151_D236_A0.8630.14
64_D156_L0.8610.14
147_N191_P0.8610.14
75_K98_I0.8610.14
74_E178_G0.8600.14
50_I148_L0.8580.14
264_K286_D0.8490.13
20_L34_K0.8420.13
274_G299_E0.8370.13
93_G294_I0.8370.13
128_E199_K0.8320.13
37_I46_N0.8250.13
34_K120_K0.8220.13
141_K212_S0.8220.13
63_I289_N0.8200.13
203_I284_G0.8150.13
234_D280_H0.8140.13
227_P280_H0.8140.13
280_H295_N0.8140.13
277_G280_H0.8140.13
225_H280_H0.8140.13
45_V107_A0.8120.13
49_I292_I0.8100.13
236_A276_H0.8070.13
71_N117_L0.8060.13
35_K190_T0.8050.13
97_A182_V0.7960.13
45_V182_V0.7960.13
203_I261_S0.7950.13
262_I303_G0.7900.13
266_I288_I0.7890.13
66_G74_E0.7860.12
87_E260_K0.7780.12
85_L160_L0.7770.12
145_F176_L0.7760.12
196_R203_I0.7740.12
98_I153_P0.7730.12
22_F37_I0.7720.12
65_L145_F0.7690.12
186_Y279_I0.7690.12
93_G196_R0.7670.12
49_I70_Y0.7650.12
169_G270_K0.7590.12
145_F181_I0.7590.12
124_E171_G0.7590.12
198_K202_D0.7570.12
152_D278_H0.7530.12
18_L158_D0.7510.12
143_P177_N0.7480.12
95_Y196_R0.7470.12
63_I74_E0.7450.12
192_W207_L0.7450.12
78_T122_I0.7430.12
136_R187_V0.7320.12
31_T120_K0.7300.12
146_I214_I0.7270.12
62_I222_Y0.7240.12
89_F177_N0.7230.12
166_F175_D0.7190.12
24_S126_L0.7180.12
33_F51_G0.7140.11
276_H281_E0.7130.11
78_T177_N0.7110.11
54_I175_D0.7100.11
116_E264_K0.7100.11
126_L177_N0.7060.11
99_L102_G0.6950.11
261_S290_N0.6920.11
221_I273_L0.6900.11
270_K291_T0.6890.11
77_V193_N0.6880.11
82_L193_N0.6870.11
123_I268_E0.6840.11
69_S87_E0.6830.11
209_K261_S0.6810.11
149_G277_G0.6750.11
149_G295_N0.6750.11
149_G227_P0.6750.11
149_G225_H0.6750.11
149_G234_D0.6750.11
68_N159_V0.6730.11
44_K186_Y0.6710.11
135_E303_G0.6680.11
140_Y167_K0.6660.11
176_L257_V0.6660.11
18_L71_N0.6620.11
146_I199_K0.6600.11
205_S301_S0.6580.11
172_E261_S0.6470.11
64_D78_T0.6460.11
43_Y262_I0.6440.11
195_F265_I0.6340.10
81_E275_L0.6340.10
287_K292_I0.6280.10
31_T273_L0.6250.10
48_L287_K0.6250.10
83_N286_D0.6210.10
129_W233_L0.6200.10
85_L88_R0.6190.10
180_E213_K0.6180.10
151_D190_T0.6160.10
97_A194_T0.6160.10
147_N168_V0.6150.10
236_A263_R0.6130.10
18_L289_N0.6110.10
47_A107_A0.6070.10
55_A99_L0.6040.10
210_I275_L0.6010.10
24_S170_E0.6000.10
213_K288_I0.6000.10
222_Y289_N0.5980.10
84_S87_E0.5960.10
129_W296_P0.5900.10
200_E300_Y0.5900.10
257_V303_G0.5890.10
33_F130_I0.5880.10
181_I223_N0.5870.10
67_N80_S0.5850.10
46_N215_N0.5830.10
91_S178_G0.5820.10
188_N191_P0.5800.10
73_Q198_K0.5790.10
83_N168_V0.5750.10
84_S230_N0.5750.10
70_Y288_I0.5740.10
21_L45_V0.5730.10
43_Y275_L0.5730.10
120_K264_K0.5700.10
48_L291_T0.5680.10
47_A154_E0.5670.10
102_G202_D0.5670.10
29_S103_E0.5650.10
192_W196_R0.5610.10
184_Y224_F0.5610.10
167_K205_S0.5600.10
72_V171_G0.5600.10
22_F249_G0.5600.10
209_K215_N0.5600.10
92_E173_V0.5570.09
156_L167_K0.5570.09
258_G277_G0.5550.09
225_H258_G0.5550.09
258_G295_N0.5550.09
234_D258_G0.5550.09
227_P258_G0.5550.09
65_L130_I0.5540.09
37_I105_E0.5520.09
180_E189_P0.5500.09
289_N292_I0.5490.09
24_S137_L0.5480.09
191_P207_L0.5450.09
107_A143_P0.5430.09
46_N137_L0.5410.09
151_D297_G0.5380.09
121_A173_V0.5350.09
65_L143_P0.5340.09
87_E91_S0.5320.09
131_K202_D0.5320.09
265_I269_T0.5300.09
213_K264_K0.5280.09
63_I85_L0.5240.09
73_Q293_V0.5240.09
65_L159_V0.5240.09
125_T154_E0.5220.09
78_T156_L0.5220.09
46_N258_G0.5210.09
195_F207_L0.5210.09
49_I167_K0.5210.09
52_G234_D0.5190.09
52_G227_P0.5190.09
52_G225_H0.5190.09
52_G277_G0.5190.09
52_G295_N0.5190.09
25_D234_D0.5190.09
27_H227_P0.5190.09
27_H277_G0.5190.09
25_D295_N0.5190.09
27_H295_N0.5190.09
25_D277_G0.5190.09
25_D227_P0.5190.09
25_D225_H0.5190.09
27_H225_H0.5190.09
27_H234_D0.5190.09
223_N233_L0.5180.09
128_E145_F0.5130.09
55_A303_G0.5130.09
23_T51_G0.5130.09
214_I226_A0.5110.09
104_Y292_I0.5090.09
118_F174_F0.5080.09
195_F205_S0.5070.09
51_G54_I0.5060.09
127_H143_P0.5060.09
153_P191_P0.5050.09
204_Y294_I0.5050.09
35_K43_Y0.5030.09
170_E296_P0.5020.09
22_F129_W0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yvtA 1 0.7508 100 0.761 Contact Map
1uf3A 6 0.6523 100 0.772 Contact Map
4peiA 2 0.76 99.9 0.796 Contact Map
3rl5A 1 0.6615 99.9 0.814 Contact Map
3d03A 5 0.6831 99.9 0.825 Contact Map
3qfmA 2 0.6369 99.9 0.826 Contact Map
3ib7A 2 0.7231 99.9 0.827 Contact Map
4ykeA 2 0.7846 99.8 0.835 Contact Map
3rqzA 1 0.6031 99.8 0.836 Contact Map
3t1iA 2 0.7385 99.8 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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