GREMLIN Database
Q97WH8 - BPS2 protein homolog (Bps2)
UniProt: Q97WH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 587 (476)
Sequences: 9152 (8531)
Seq/√Len: 391.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R81_R3.0601.00
272_L276_E2.4691.00
4_R16_S2.2221.00
51_A54_L2.1571.00
311_I315_E1.9961.00
6_F14_E1.9791.00
4_R14_E1.9761.00
439_L443_E1.9721.00
293_C297_G1.9721.00
271_E274_V1.9461.00
75_R79_R1.9101.00
206_E210_K1.8831.00
297_G301_D1.8541.00
438_E441_E1.8411.00
265_R269_E1.8201.00
337_K341_D1.8151.00
252_E255_N1.7981.00
158_Y162_R1.7891.00
4_R65_E1.7871.00
436_L440_K1.7751.00
375_I379_E1.7731.00
369_G372_K1.7311.00
376_D379_E1.7291.00
220_N224_A1.7241.00
234_N238_K1.7221.00
176_D179_E1.7201.00
75_R78_K1.7181.00
221_L224_A1.6941.00
79_R82_N1.6891.00
273_K276_E1.6851.00
199_T203_K1.6831.00
307_E311_I1.6821.00
431_I434_S1.6761.00
318_D322_L1.6701.00
361_K365_I1.6661.00
304_I308_R1.6621.00
319_K322_L1.6551.00
70_N73_Y1.6471.00
264_D267_E1.6411.00
407_S411_R1.6401.00
78_K82_N1.6351.00
479_L483_E1.6341.00
50_K54_L1.6341.00
411_R414_E1.6321.00
260_L264_D1.6131.00
226_K229_E1.6051.00
278_V281_E1.5941.00
151_R155_Q1.5851.00
267_E271_E1.5831.00
213_V217_E1.5631.00
231_E234_N1.5621.00
325_S329_D1.5621.00
356_K360_K1.5571.00
398_A402_N1.5561.00
182_R186_S1.5551.00
229_E233_Q1.5541.00
346_E349_T1.5501.00
293_C296_C1.5491.00
382_R386_E1.5481.00
78_K81_R1.5461.00
296_C299_K1.5401.00
302_P306_K1.5381.00
253_E257_K1.5371.00
227_K231_E1.5341.00
443_E447_E1.5341.00
274_V278_V1.5261.00
76_R79_R1.5241.00
303_S306_K1.5231.00
332_G336_R1.5151.00
453_V457_Q1.5131.00
187_N191_K1.5101.00
300_V304_I1.5051.00
77_I81_R1.5041.00
316_L320_T1.5041.00
333_L337_K1.5021.00
174_E177_K1.5001.00
334_Q338_E1.4951.00
208_L212_K1.4871.00
190_A193_T1.4871.00
228_I231_E1.4831.00
314_R318_D1.4791.00
327_R331_I1.4781.00
414_E418_K1.4741.00
450_Q454_D1.4741.00
257_K260_L1.4731.00
76_R81_R1.4721.00
381_Q384_E1.4701.00
224_A227_K1.4681.00
313_S317_R1.4591.00
417_K421_E1.4541.00
306_K310_E1.4531.00
354_I358_K1.4481.00
335_K339_E1.4441.00
266_S269_E1.4411.00
6_F63_Y1.4361.00
250_E253_E1.4361.00
210_K213_V1.4351.00
333_L336_R1.4321.00
412_I416_R1.4321.00
211_I215_K1.4271.00
217_E220_N1.4251.00
418_K421_E1.4151.00
280_E283_N1.4141.00
353_E356_K1.4121.00
232_I236_E1.4061.00
390_S393_E1.4031.00
225_L229_E1.4021.00
75_R82_N1.3971.00
9_G36_S1.3931.00
413_E416_R1.3901.00
209_N213_V1.3851.00
383_R386_E1.3851.00
291_D294_N1.3811.00
294_N297_G1.3801.00
309_A313_S1.3731.00
252_E256_E1.3731.00
475_A479_L1.3681.00
472_N476_N1.3551.00
77_I80_I1.3551.00
330_I334_Q1.3531.00
294_N298_S1.3461.00
446_I450_Q1.3451.00
246_Q250_E1.3401.00
370_S374_Q1.3321.00
441_E445_H1.3311.00
310_E313_S1.3311.00
277_R281_E1.3301.00
290_L294_N1.3281.00
371_V374_Q1.3281.00
408_I412_I1.3281.00
212_K216_D1.3261.00
256_E260_L1.3231.00
459_E463_R1.3221.00
351_E355_A1.3201.00
126_T129_K1.3201.00
352_N356_K1.3171.00
365_I369_G1.3131.00
357_L361_K1.3121.00
288_H292_T1.3091.00
262_T266_S1.3081.00
321_S325_S1.3061.00
322_L325_S1.3021.00
270_I273_K1.3021.00
230_E234_N1.2961.00
226_K230_E1.2961.00
261_K265_R1.2961.00
179_E183_E1.2941.00
437_E441_E1.2941.00
315_E319_K1.2931.00
268_L272_L1.2931.00
360_K363_E1.2901.00
266_S270_I1.2881.00
289_H293_C1.2841.00
76_R82_N1.2831.00
255_N259_K1.2821.00
329_D332_G1.2821.00
203_K206_E1.2801.00
415_L419_R1.2721.00
413_E417_K1.2721.00
368_I372_K1.2701.00
105_P108_R1.2671.00
75_R80_I1.2661.00
298_S301_D1.2651.00
247_L251_M1.2651.00
386_E390_S1.2651.00
317_R320_T1.2651.00
216_D220_N1.2631.00
292_T296_C1.2621.00
373_F376_D1.2541.00
358_K362_E1.2521.00
254_I258_L1.2511.00
267_E270_I1.2451.00
44_L66_A1.2411.00
215_K219_A1.2401.00
308_R311_I1.2391.00
100_L104_S1.2391.00
218_L222_E1.2371.00
189_V193_T1.2371.00
303_S307_E1.2361.00
359_A363_E1.2341.00
367_R370_S1.2341.00
233_Q236_E1.2331.00
212_K215_K1.2311.00
373_F377_D1.2311.00
440_K443_E1.2281.00
236_E240_S1.2251.00
336_R339_E1.2241.00
432_P436_L1.2231.00
338_E341_D1.2221.00
374_Q377_D1.2211.00
9_G25_S1.2121.00
324_D327_R1.2111.00
235_K239_V1.2081.00
289_H292_T1.2081.00
447_E450_Q1.2041.00
323_L327_R1.2021.00
263_N267_E1.1991.00
384_E388_R1.1981.00
321_S324_D1.1971.00
271_E275_L1.1951.00
105_P109_L1.1901.00
90_L93_D1.1891.00
186_S190_A1.1891.00
445_H448_Q1.1871.00
349_T353_E1.1861.00
328_N332_G1.1851.00
222_E226_K1.1831.00
416_R420_E1.1831.00
363_E367_R1.1821.00
150_A154_L1.1811.00
319_K323_L1.1781.00
320_T324_D1.1771.00
270_I274_V1.1771.00
310_E314_R1.1751.00
312_I315_E1.1751.00
357_L360_K1.1711.00
434_S438_E1.1681.00
315_E318_D1.1681.00
471_F475_A1.1651.00
8_I43_S1.1631.00
364_L368_I1.1621.00
385_T389_F1.1611.00
466_K470_E1.1591.00
219_A222_E1.1571.00
476_N479_L1.1561.00
326_L329_D1.1551.00
340_I343_R1.1541.00
442_K445_H1.1531.00
399_I402_N1.1521.00
305_W309_A1.1511.00
377_D381_Q1.1491.00
397_G400_A1.1491.00
183_E186_S1.1481.00
163_E166_A1.1471.00
269_E273_K1.1471.00
457_Q461_I1.1441.00
258_L262_T1.1441.00
274_V277_R1.1441.00
372_K376_D1.1431.00
361_K364_L1.1431.00
86_E90_L1.1411.00
347_L351_E1.1381.00
335_K338_E1.1331.00
200_R203_K1.1321.00
148_I151_R1.1321.00
410_K414_E1.1311.00
438_E442_K1.1291.00
275_L279_L1.1281.00
411_R415_L1.1251.00
314_R317_R1.1251.00
170_A174_E1.1241.00
298_S302_P1.1231.00
84_L90_L1.1231.00
301_D305_W1.1071.00
248_E252_E1.1061.00
77_I82_N1.1061.00
405_S409_L1.1021.00
214_K217_E1.1011.00
219_A223_F1.1001.00
307_E310_E1.0991.00
235_K238_K1.0951.00
296_C300_V1.0921.00
9_G39_R1.0911.00
87_E90_L1.0901.00
451_K455_E1.0891.00
50_K53_D1.0881.00
406_A409_L1.0871.00
364_L367_R1.0871.00
324_D328_N1.0871.00
43_S64_V1.0861.00
376_D380_R1.0851.00
172_D176_D1.0851.00
400_A404_D1.0811.00
69_D73_Y1.0811.00
280_E284_E1.0781.00
406_A410_K1.0721.00
408_I411_R1.0721.00
475_A483_E1.0641.00
148_I152_D1.0641.00
350_L354_I1.0631.00
106_E109_L1.0621.00
301_D304_I1.0611.00
209_N212_K1.0601.00
458_V462_R1.0571.00
383_R387_E1.0541.00
99_L102_Y1.0531.00
421_E425_E1.0501.00
306_K309_A1.0501.00
308_R312_I1.0481.00
269_E272_L1.0481.00
149_N153_E1.0431.00
281_E284_E1.0421.00
264_D268_L1.0411.00
475_A478_L1.0371.00
449_L453_V1.0351.00
360_K364_L1.0351.00
21_K24_T1.0341.00
374_Q378_L1.0311.00
115_S123_F1.0291.00
201_Q205_N1.0271.00
456_L460_Y1.0231.00
322_L326_L1.0231.00
207_I211_I1.0211.00
211_I214_K1.0201.00
237_S241_P1.0171.00
145_T149_N1.0141.00
401_T405_S1.0131.00
188_I191_K1.0131.00
229_E236_E1.0091.00
355_A358_K1.0071.00
380_R384_E1.0041.00
160_N163_E1.0031.00
86_E92_M1.0011.00
249_K252_E1.0001.00
273_K277_R0.9981.00
420_E423_E0.9981.00
9_G43_S0.9971.00
356_K359_A0.9941.00
5_V40_S0.9911.00
388_R392_S0.9901.00
203_K207_I0.9881.00
208_L211_I0.9851.00
214_K218_L0.9851.00
479_L482_F0.9821.00
275_L278_V0.9801.00
387_E390_S0.9771.00
188_I192_T0.9771.00
407_S410_K0.9751.00
164_I168_I0.9751.00
281_E285_S0.9721.00
339_E342_L0.9701.00
474_I477_Q0.9691.00
366_N369_G0.9671.00
415_L418_K0.9661.00
259_K262_T0.9631.00
19_L24_T0.9611.00
448_Q452_K0.9591.00
331_I334_Q0.9541.00
216_D219_A0.9541.00
10_G36_S0.9541.00
238_K241_P0.9531.00
171_I175_I0.9521.00
362_E366_N0.9501.00
402_N405_S0.9491.00
387_E391_K0.9471.00
433_S437_E0.9461.00
378_L381_Q0.9441.00
390_S394_S0.9441.00
55_L58_F0.9431.00
332_G335_K0.9431.00
399_I403_D0.9431.00
105_P110_V0.9421.00
400_A403_D0.9411.00
251_M255_N0.9411.00
318_D321_S0.9401.00
371_V375_I0.9391.00
129_K132_E0.9381.00
325_S328_N0.9371.00
409_L413_E0.9371.00
144_L148_I0.9351.00
466_K469_E0.9351.00
167_K170_A0.9341.00
468_R479_L0.9341.00
86_E91_I0.9331.00
259_K263_N0.9311.00
279_L283_N0.9301.00
440_K444_E0.9301.00
403_D407_S0.9281.00
205_N209_N0.9261.00
277_R280_E0.9251.00
431_I435_I0.9251.00
237_S240_S0.9241.00
446_I449_L0.9211.00
210_K214_K0.9211.00
435_I438_E0.9181.00
349_T352_N0.9171.00
338_E342_L0.9151.00
87_E91_I0.9141.00
445_H449_L0.9141.00
444_E447_E0.9131.00
295_V299_K0.9131.00
217_E221_L0.9111.00
105_P111_T0.9061.00
119_N122_W0.9051.00
163_E167_K0.9041.00
152_D155_Q0.9021.00
384_E387_E0.9001.00
442_K446_I0.8991.00
401_T404_D0.8981.00
417_K420_E0.8981.00
433_S436_L0.8981.00
459_E462_R0.8971.00
326_L330_I0.8951.00
115_S118_G0.8921.00
131_N135_A0.8901.00
116_G119_N0.8871.00
98_L101_T0.8871.00
350_L353_E0.8861.00
5_V37_L0.8861.00
366_N370_S0.8851.00
362_E365_I0.8851.00
9_G46_T0.8851.00
159_N162_R0.8831.00
169_R172_D0.8831.00
9_G42_I0.8821.00
257_K261_K0.8821.00
341_D345_K0.8811.00
185_S188_I0.8801.00
263_N266_S0.8801.00
355_A359_A0.8791.00
190_A194_Y0.8791.00
380_R383_R0.8791.00
153_E157_K0.8781.00
354_I357_L0.8761.00
83_G90_L0.8741.00
478_L482_F0.8731.00
385_T388_R0.8711.00
348_Q351_E0.8701.00
175_I179_E0.8691.00
353_E357_L0.8661.00
83_G86_E0.8651.00
452_K459_E0.8621.00
204_I208_L0.8621.00
339_E343_R0.8571.00
439_L442_K0.8561.00
40_S44_L0.8551.00
480_K484_F0.8541.00
472_N475_A0.8541.00
113_I116_G0.8541.00
207_I210_K0.8531.00
388_R391_K0.8521.00
363_E366_N0.8511.00
230_E233_Q0.8511.00
143_L147_E0.8501.00
202_N206_E0.8501.00
7_N27_E0.8501.00
86_E93_D0.8491.00
11_I15_Y0.8491.00
317_R321_S0.8441.00
327_R330_I0.8401.00
370_S373_F0.8391.00
346_E350_L0.8361.00
460_Y464_L0.8361.00
8_I30_N0.8351.00
165_Q169_R0.8311.00
473_R477_Q0.8301.00
96_R99_L0.8271.00
276_E280_E0.8261.00
329_D333_L0.8251.00
145_T148_I0.8251.00
245_T249_K0.8251.00
84_L91_I0.8161.00
425_E428_L0.8131.00
430_G433_S0.8101.00
437_E440_K0.8091.00
250_E254_I0.8081.00
448_Q451_K0.8071.00
282_V285_S0.8061.00
140_L143_L0.8041.00
412_I415_L0.8031.00
220_N223_F0.8031.00
447_E451_K0.8031.00
422_Y426_L0.8021.00
224_A228_I0.7981.00
199_T202_N0.7971.00
28_A32_Y0.7961.00
419_R422_Y0.7951.00
3_V19_L0.7931.00
480_K483_E0.7921.00
109_L112_Q0.7911.00
200_R208_L0.7881.00
260_L263_N0.7871.00
222_E225_L0.7871.00
225_L228_I0.7861.00
245_T248_E0.7861.00
262_T265_R0.7851.00
348_Q352_N0.7851.00
358_K361_K0.7821.00
471_F478_L0.7811.00
247_L250_E0.7781.00
474_I482_F0.7781.00
185_S189_V0.7771.00
443_E446_I0.7741.00
477_Q480_K0.7721.00
134_K139_E0.7721.00
402_N406_A0.7661.00
342_L345_K0.7651.00
136_K139_E0.7601.00
305_W308_R0.7601.00
84_L93_D0.7601.00
233_Q237_S0.7591.00
391_K394_S0.7581.00
436_L439_L0.7561.00
404_D407_S0.7551.00
454_D458_V0.7531.00
253_E256_E0.7521.00
218_L221_L0.7511.00
130_I133_I0.7501.00
84_L87_E0.7471.00
205_N208_L0.7471.00
41_L66_A0.7431.00
181_E184_S0.7431.00
56_N59_A0.7401.00
261_K264_D0.7391.00
378_L382_R0.7371.00
424_Y427_Q0.7361.00
99_L104_S0.7351.00
168_I172_D0.7341.00
229_E232_I0.7291.00
312_I316_L0.7271.00
159_N163_E0.7251.00
227_K230_E0.7251.00
106_E110_V0.7241.00
428_L431_I0.7241.00
444_E448_Q0.7231.00
328_N331_I0.7191.00
467_A474_I0.7191.00
258_L261_K0.7181.00
469_E483_E0.7161.00
31_A43_S0.7151.00
204_I211_I0.7131.00
223_F227_K0.7121.00
340_I344_L0.7111.00
87_E93_D0.7091.00
481_R484_F0.7091.00
323_L330_I0.7081.00
146_A149_N0.7081.00
454_D457_Q0.7061.00
85_G90_L0.7051.00
474_I478_L0.7031.00
108_R111_T0.7021.00
10_G38_V0.7021.00
381_Q385_T0.7011.00
156_K160_N0.7011.00
255_N258_L0.7011.00
223_F226_K0.7001.00
434_S437_E0.6951.00
432_P439_L0.6941.00
92_M95_D0.6910.99
347_L354_I0.6900.99
435_I439_L0.6900.99
452_K455_E0.6900.99
98_L104_S0.6880.99
475_A482_F0.6870.99
89_N92_M0.6870.99
244_K248_E0.6870.99
379_E383_R0.6830.99
120_V124_I0.6810.99
192_T195_T0.6810.99
109_L114_L0.6800.99
470_E478_L0.6790.99
228_I232_I0.6790.99
278_V282_V0.6790.99
453_V456_L0.6780.99
108_R113_I0.6780.99
152_D156_K0.6770.99
389_F392_S0.6740.99
200_R204_I0.6730.99
365_I368_I0.6720.99
76_R80_I0.6710.99
389_F393_E0.6690.99
56_N61_S0.6670.99
106_E111_T0.6660.99
427_Q430_G0.6660.99
461_I464_L0.6620.99
231_E235_K0.6620.99
336_R340_I0.6620.99
467_A479_L0.6610.99
458_V461_I0.6600.99
297_G300_V0.6580.99
375_I378_L0.6580.99
10_G27_E0.6560.99
331_I335_K0.6560.99
221_L225_L0.6520.99
202_N205_N0.6520.99
121_E125_S0.6500.99
249_K253_E0.6490.99
290_L293_C0.6480.99
300_V303_S0.6470.99
27_E46_T0.6450.99
55_L59_A0.6420.99
116_G120_V0.6420.99
469_E473_R0.6420.99
93_D96_R0.6420.99
372_K375_I0.6410.99
161_I165_Q0.6400.99
44_L64_V0.6390.99
291_D295_V0.6380.99
397_G401_T0.6360.99
239_V243_I0.6350.99
469_E472_N0.6350.99
39_R124_I0.6350.99
439_L446_I0.6330.99
62_G66_A0.6310.99
215_K218_L0.6310.99
470_E474_I0.6310.99
162_R165_Q0.6300.99
10_G31_A0.6300.99
24_T43_S0.6280.99
87_E92_M0.6270.99
465_T478_L0.6270.99
369_G373_F0.6260.99
83_G88_K0.6250.99
177_K181_E0.6250.99
255_N262_T0.6240.99
472_N479_L0.6230.99
246_Q249_K0.6200.99
23_V43_S0.6180.99
183_E187_N0.6160.99
271_E278_V0.6160.99
299_K303_S0.6150.99
84_L92_M0.6150.99
471_F474_I0.6130.99
143_L146_A0.6100.99
419_R423_E0.6100.99
367_R371_V0.6090.99
42_I46_T0.6070.99
96_R102_Y0.6060.99
20_E24_T0.6050.99
308_R315_E0.6040.99
478_L483_E0.6040.99
149_N152_D0.6040.99
184_S187_N0.6020.99
471_F482_F0.6020.99
11_I37_L0.6010.99
105_P112_Q0.5990.99
302_P305_W0.5980.99
236_E239_V0.5970.99
181_E185_S0.5900.98
27_E31_A0.5900.98
147_E151_R0.5880.98
262_T269_E0.5880.98
468_R472_N0.5870.98
455_E458_V0.5870.98
468_R474_I0.5860.98
418_K422_Y0.5850.98
153_E156_K0.5830.98
97_A101_T0.5820.98
36_S46_T0.5780.98
5_V11_I0.5750.98
42_I49_I0.5690.98
46_T49_I0.5680.98
358_K365_I0.5680.98
68_L73_Y0.5650.98
449_L452_K0.5640.98
429_L432_P0.5640.98
456_L463_R0.5630.98
268_L271_E0.5630.98
459_E464_L0.5630.98
25_S39_R0.5600.98
256_E259_K0.5590.98
179_E182_R0.5590.98
29_P39_R0.5590.98
460_Y467_A0.5530.98
478_L481_R0.5500.97
56_N60_D0.5500.97
330_I333_L0.5490.97
160_N164_I0.5490.97
162_R166_A0.5470.97
352_N355_A0.5470.97
187_N190_A0.5460.97
86_E89_N0.5450.97
476_N483_E0.5430.97
150_A153_E0.5410.97
35_T43_S0.5390.97
128_S132_E0.5370.97
463_R467_A0.5350.97
41_L45_L0.5340.97
425_E429_L0.5340.97
391_K397_G0.5340.97
467_A482_F0.5330.97
288_H291_D0.5330.97
475_A481_R0.5320.97
174_E178_L0.5320.97
112_Q116_G0.5320.97
63_Y66_A0.5300.97
468_R478_L0.5280.97
139_E142_K0.5270.97
357_L364_L0.5260.97
385_T392_S0.5240.97
178_L182_R0.5220.97
24_T42_I0.5220.97
42_I114_L0.5220.97
471_F483_E0.5190.96
169_R173_E0.5170.96
83_G87_E0.5160.96
323_L326_L0.5150.96
441_E448_Q0.5150.96
178_L181_E0.5150.96
17_L37_L0.5130.96
9_G48_S0.5130.96
211_I218_L0.5120.96
377_D380_R0.5080.96
63_Y76_R0.5080.96
471_F479_L0.5080.96
32_Y35_T0.5080.96
107_N110_V0.5070.96
108_R112_Q0.5070.96
476_N482_F0.5060.96
113_I124_I0.5060.96
31_A46_T0.5060.96
10_G24_T0.5060.96
164_I167_K0.5050.96
191_K194_Y0.5040.96
248_E251_M0.5040.96
10_G39_R0.5030.96
295_V298_S0.5030.96
27_E39_R0.5030.96
423_E427_Q0.5020.96
8_I39_R0.5020.96
467_A471_F0.5010.96
474_I483_E0.5010.96
101_T104_S0.5010.96
138_E141_Q0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ux3A 1 0.6763 100 0.517 Contact Map
3auyA 2 0.569 100 0.551 Contact Map
4ad8A 1 0.6576 100 0.557 Contact Map
3zgxA 2 0.5451 100 0.564 Contact Map
1w1wA 2 0.506 100 0.609 Contact Map
3qf7A 2 0.5486 100 0.629 Contact Map
3qktA 2 0.5145 100 0.636 Contact Map
4abyA 1 0.5315 100 0.643 Contact Map
4i99A 2 0.4719 100 0.662 Contact Map
3qksA 1 0.2981 99.9 0.712 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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