GREMLIN Database
Q97WH6 - Purine nucleosidase, putative (IunH-2)
UniProt: Q97WH6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 307 (300)
Sequences: 3905 (2815)
Seq/√Len: 162.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
99_E107_R3.9311.00
103_D133_K3.6271.00
172_K176_D3.2681.00
132_L173_I2.9581.00
3_K26_Q2.8701.00
252_L290_K2.8521.00
164_F271_M2.7021.00
64_S129_L2.5411.00
29_G104_A2.5171.00
256_L286_E2.4571.00
172_K260_D2.4401.00
110_K134_D2.4331.00
191_I290_K2.3611.00
32_I43_V2.3581.00
247_D295_K2.3361.00
110_K140_R2.2191.00
107_R111_E2.2021.00
131_Y138_V2.1491.00
6_V121_I2.1091.00
18_I30_V2.1041.00
3_K28_L2.0961.00
110_K136_S2.0841.00
119_L242_V2.0771.00
21_A242_V2.0741.00
254_S288_V2.0371.00
31_T101_A2.0081.00
10_T46_A1.9831.00
164_F171_A1.9811.00
159_I270_A1.9441.00
115_E142_K1.9431.00
106_L134_D1.9421.00
262_E267_S1.9211.00
47_L60_V1.9121.00
120_A127_I1.9001.00
61_Y104_A1.8981.00
292_D295_K1.8661.00
61_Y97_E1.8391.00
143_K182_T1.8321.00
189_A237_P1.8321.00
120_A146_I1.7851.00
28_L116_L1.7651.00
109_S116_L1.7401.00
70_G268_R1.7111.00
19_L53_I1.6871.00
130_A134_D1.6821.00
236_H239_S1.6671.00
4_V119_L1.6441.00
39_Y62_L1.6391.00
44_K48_F1.6301.00
5_I31_T1.6201.00
104_A108_L1.6081.00
244_I251_I1.6031.00
106_L130_A1.5961.00
146_I183_I1.5951.00
7_D126_N1.5841.00
120_A124_L1.5811.00
117_E145_W1.5711.00
47_L95_R1.5671.00
106_L137_V1.5471.00
130_A137_V1.5381.00
298_N302_N1.5301.00
100_H103_D1.5241.00
212_N216_N1.5221.00
124_L174_V1.5211.00
8_S121_I1.5201.00
134_D137_V1.5131.00
109_S140_R1.5101.00
250_I295_K1.5061.00
184_V288_V1.4841.00
127_I144_I1.4771.00
204_S215_I1.4721.00
146_I175_L1.4661.00
169_E268_R1.4431.00
146_I164_F1.4431.00
100_H133_K1.4181.00
294_G298_N1.3841.00
108_L111_E1.3811.00
39_Y43_V1.3781.00
109_S130_A1.3691.00
182_T286_E1.3621.00
164_F175_L1.3601.00
70_G169_E1.3461.00
40_N62_L1.3411.00
105_I130_A1.3251.00
202_Y298_N1.3211.00
262_E265_S1.3181.00
243_S296_F1.3161.00
51_E94_K1.3101.00
117_E143_K1.3091.00
43_V62_L1.2961.00
108_L116_L1.2951.00
3_K112_H1.2831.00
22_S303_S1.2801.00
118_I141_V1.2801.00
20_L299_L1.2801.00
124_L146_I1.2761.00
50_L58_V1.2741.00
82_N88_N1.2721.00
243_S299_L1.2631.00
202_Y301_F1.2611.00
143_K180_D1.2541.00
254_S286_E1.2471.00
182_T254_S1.2471.00
44_K91_E1.2471.00
8_S46_A1.2411.00
112_H115_E1.2391.00
119_L245_A1.2331.00
262_E266_K1.2221.00
24_F303_S1.2161.00
103_D107_R1.2141.00
172_K263_L1.2111.00
113_E140_R1.2051.00
207_N212_N1.2031.00
175_L183_I1.2001.00
6_V27_L1.1951.00
68_I128_A1.1881.00
267_S270_A1.1611.00
240_L291_A1.1551.00
148_G164_F1.1491.00
255_S289_L1.1461.00
66_R132_L1.1431.00
5_I29_G1.1391.00
199_D297_K1.1341.00
52_Y213_F1.1291.00
267_S272_L1.1221.00
22_S246_H1.1211.00
6_V21_A1.1201.00
201_E205_K1.1151.00
109_S137_V1.1101.00
240_L251_I1.1081.00
157_T160_A1.0971.00
182_T244_I1.0911.00
257_K287_I1.0911.00
194_S233_G1.0911.00
259_V285_A1.0881.00
38_N41_Q1.0871.00
102_I133_K1.0851.00
109_S141_V1.0841.00
37_V41_Q1.0820.99
102_I130_A1.0790.99
257_K273_I1.0780.99
27_L121_I1.0750.99
51_E93_N1.0610.99
69_L169_E1.0600.99
51_E92_P1.0570.99
32_I46_A1.0570.99
105_I137_V1.0520.99
139_K142_K1.0470.99
145_W245_A1.0390.99
50_L55_K1.0370.99
28_L108_L1.0300.99
151_F185_P1.0250.99
106_L110_K1.0150.99
6_V18_I1.0110.99
145_W244_I1.0090.99
119_L241_T1.0060.99
105_I109_S1.0020.99
204_S219_K1.0020.99
144_I179_F1.0000.99
43_V96_P1.0000.99
78_V224_Y0.9960.99
30_V50_L0.9880.99
3_K115_E0.9850.99
20_L303_S0.9720.99
94_K97_E0.9720.99
16_I300_L0.9670.99
80_G83_G0.9670.99
82_N85_S0.9640.99
141_V179_F0.9640.99
247_D299_L0.9630.99
136_S139_K0.9610.99
193_G291_A0.9560.99
12_T221_L0.9530.99
241_T245_A0.9510.99
109_S112_H0.9490.99
249_S295_K0.9460.99
258_Y281_N0.9460.99
34_A166_V0.9440.99
15_T49_T0.9410.99
243_S250_I0.9370.99
40_N65_Q0.9360.99
144_I181_I0.9340.99
50_L60_V0.9340.99
81_S86_N0.9320.98
120_A144_I0.9300.98
244_I254_S0.9190.98
4_V25_F0.9190.98
118_I127_I0.9170.98
105_I127_I0.9150.98
5_I105_I0.9140.98
196_N199_D0.9120.98
197_E201_E0.9070.98
199_D301_F0.9060.98
124_L171_A0.9040.98
168_P268_R0.9010.98
61_Y99_E0.8980.98
37_V42_E0.8960.98
160_A165_W0.8930.98
123_P166_V0.8900.98
147_M189_A0.8900.98
129_L132_L0.8890.98
131_Y177_A0.8880.98
64_S125_T0.8860.98
29_G108_L0.8850.98
180_D286_E0.8820.98
55_K58_V0.8820.98
62_L96_P0.8820.98
184_V244_I0.8810.98
21_A119_L0.8790.98
176_D260_D0.8780.98
77_E156_T0.8770.98
5_I104_A0.8770.98
175_L181_I0.8730.98
223_E227_K0.8710.98
5_I116_L0.8710.98
146_I181_I0.8700.98
31_T105_I0.8700.98
44_K92_P0.8690.98
106_L133_K0.8690.98
51_E56_Q0.8650.98
298_N301_F0.8620.97
258_Y284_N0.8610.97
79_H83_G0.8610.97
162_F166_V0.8570.97
10_T42_E0.8560.97
117_E142_K0.8530.97
151_F183_I0.8460.97
28_L112_H0.8450.97
242_V245_A0.8410.97
80_G85_S0.8290.97
73_R165_W0.8280.97
115_E140_R0.8260.97
39_Y42_E0.8250.97
32_I42_E0.8230.97
31_T126_N0.8220.97
183_I287_I0.8210.97
113_E116_L0.8200.97
256_L284_N0.8190.97
252_L292_D0.8180.97
247_D250_I0.8180.97
68_I129_L0.8160.96
161_E186_W0.8140.96
11_A15_T0.8100.96
295_K299_L0.8090.96
82_N86_N0.8050.96
169_E263_L0.8030.96
64_S100_H0.8020.96
193_G296_F0.8010.96
21_A25_F0.7910.96
150_A153_K0.7870.96
69_L173_I0.7820.96
102_I129_L0.7810.96
261_V271_M0.7800.95
186_W237_P0.7710.95
251_I288_V0.7690.95
145_W241_T0.7680.95
251_I254_S0.7680.95
241_T244_I0.7660.95
147_M238_D0.7650.95
157_T165_W0.7640.95
25_F246_H0.7620.95
112_H116_L0.7590.95
20_L243_S0.7560.95
114_G142_K0.7550.95
53_I210_L0.7530.95
109_S138_V0.7500.94
36_N45_N0.7490.94
18_I21_A0.7480.94
155_N186_W0.7460.94
74_T166_V0.7440.94
19_L49_T0.7400.94
207_N211_S0.7400.94
258_Y283_P0.7370.94
16_I214_F0.7340.94
259_V271_M0.7320.94
175_L271_M0.7300.94
68_I173_I0.7300.94
30_V46_A0.7290.94
293_G297_K0.7270.93
19_L214_F0.7260.93
68_I132_L0.7260.93
184_V241_T0.7240.93
12_T85_S0.7180.93
143_K244_I0.7160.93
143_K286_E0.7110.93
82_N87_W0.7100.93
169_E264_C0.7030.92
131_Y141_V0.6990.92
124_L164_F0.6980.92
112_H140_R0.6950.92
33_V122_S0.6940.92
206_L211_S0.6940.92
36_N79_H0.6930.92
109_S113_E0.6920.92
143_K248_N0.6920.92
43_V47_L0.6910.92
109_S134_D0.6910.92
208_T211_S0.6900.92
194_S235_I0.6880.91
32_I126_N0.6870.91
118_I144_I0.6850.91
7_D31_T0.6830.91
17_A242_V0.6810.91
299_L303_S0.6810.91
185_P188_V0.6770.91
173_I176_D0.6770.91
27_L30_V0.6750.91
31_T104_A0.6740.91
41_Q44_K0.6730.91
49_T213_F0.6720.90
154_G160_A0.6720.90
213_F217_V0.6710.90
226_T232_S0.6680.90
114_G140_R0.6670.90
200_W204_S0.6640.90
151_F289_L0.6610.90
183_I271_M0.6590.90
68_I170_A0.6590.90
156_T165_W0.6580.90
299_L302_N0.6550.89
240_L296_F0.6550.89
131_Y179_F0.6540.89
244_I288_V0.6520.89
47_L96_P0.6490.89
47_L94_K0.6440.89
5_I108_L0.6430.88
198_R201_E0.6420.88
150_A187_E0.6400.88
138_V141_V0.6390.88
13_D238_D0.6390.88
14_D238_D0.6360.88
99_E103_D0.6350.88
137_V140_R0.6340.88
199_D293_G0.6340.88
138_V179_F0.6320.88
184_V254_S0.6300.87
62_L65_Q0.6290.87
265_S268_R0.6260.87
72_W166_V0.6230.87
103_D106_L0.6230.87
79_H85_S0.6220.87
200_W219_K0.6220.87
280_K283_P0.6210.87
204_S212_N0.6190.87
188_V291_A0.6180.86
11_A237_P0.6180.86
111_E114_G0.6120.86
250_I299_L0.6110.86
102_I106_L0.6100.86
56_Q94_K0.6090.86
209_K212_N0.6040.85
48_F92_P0.6040.85
152_S187_E0.6030.85
38_N74_T0.5990.85
155_N160_A0.5990.85
117_E245_A0.5980.85
259_V287_I0.5970.85
3_K114_G0.5970.85
204_S216_N0.5960.84
124_L127_I0.5960.84
104_A107_R0.5960.84
151_F273_I0.5950.84
145_W184_V0.5940.84
87_W216_N0.5940.84
199_D202_Y0.5940.84
224_Y228_N0.5940.84
29_G61_Y0.5930.84
106_L136_S0.5920.84
215_I219_K0.5880.84
127_I141_V0.5880.84
138_V178_G0.5860.83
134_D140_R0.5840.83
75_V78_V0.5840.83
4_V21_A0.5840.83
48_F52_Y0.5830.83
121_I146_I0.5820.83
108_L112_H0.5820.83
170_A174_V0.5800.83
45_N80_G0.5780.83
171_A174_V0.5780.83
25_F245_A0.5760.82
195_L234_S0.5750.82
254_S289_L0.5740.82
158_P279_H0.5730.82
101_A126_N0.5730.82
16_I218_N0.5720.82
172_K266_K0.5680.81
39_Y65_Q0.5680.81
257_K289_L0.5680.81
110_K137_V0.5670.81
130_A133_K0.5670.81
147_M237_P0.5650.81
197_E222_K0.5650.81
33_V126_N0.5640.81
150_A154_G0.5600.81
15_T45_N0.5570.80
20_L242_V0.5550.80
148_G171_A0.5550.80
131_Y137_V0.5530.80
100_H129_L0.5520.80
69_L132_L0.5500.79
155_N161_E0.5480.79
69_L172_K0.5480.79
45_N83_G0.5470.79
121_I241_T0.5460.79
131_Y173_I0.5420.78
190_E237_P0.5370.78
203_I211_S0.5360.78
139_K143_K0.5350.78
68_I125_T0.5350.78
183_I285_A0.5350.78
262_E272_L0.5340.77
66_R71_N0.5330.77
34_A162_F0.5330.77
186_W189_A0.5310.77
137_V141_V0.5290.77
218_N234_S0.5290.77
145_W182_T0.5280.77
171_A261_V0.5270.76
186_W190_E0.5270.76
225_T234_S0.5270.76
151_F187_E0.5260.76
255_S275_W0.5250.76
10_T49_T0.5250.76
195_L218_N0.5250.76
113_E142_K0.5190.75
12_T79_H0.5180.75
75_V79_H0.5180.75
106_L109_S0.5170.75
262_E274_D0.5160.75
256_L282_K0.5150.75
32_I62_L0.5150.75
216_N219_K0.5140.75
14_D17_A0.5130.75
27_L58_V0.5130.75
17_A121_I0.5120.74
83_G86_N0.5100.74
202_Y205_K0.5080.74
221_L237_P0.5080.74
258_Y279_H0.5080.74
25_F119_L0.5080.74
27_L55_K0.5070.74
13_D17_A0.5070.74
219_K223_E0.5070.74
93_N139_K0.5050.73
98_K139_K0.5040.73
128_A173_I0.5040.73
10_T122_S0.5030.73
4_V245_A0.5020.73
214_F304_L0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t8iA 3 0.9935 100 0.047 Contact Map
4wr2A 4 0.9609 100 0.049 Contact Map
2masA 3 0.9935 100 0.052 Contact Map
3t8jA 3 0.9935 100 0.058 Contact Map
4kpoA 2 0.9935 100 0.063 Contact Map
4kpnA 2 0.9935 100 0.064 Contact Map
1q8fA 4 0.9902 100 0.067 Contact Map
3fz0A 3 0.9739 100 0.098 Contact Map
2c40A 2 0.9251 100 0.129 Contact Map
4i71A 2 0.9544 100 0.144 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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