Q97WH6 - SULSO - GREMLIN Contacts

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Q97WH6 - Purine nucleosidase, putative (IunH-2)

UniProt:	Q97WH6	Sequences: MRKVIVDSDTATDDTIAILLASRFFQLLGVTIVAGNVNYNQEVKNALFTLEYIGKQDVPVYLGSQRPILGNWRTVEEVHGSNGMSNWNYPEPNKRPEKEHAIDAILRLSKEHEGELEILAISPLTNIALAYLKDPSVVKRVKKIWIMGGAFSKGNTTPIAEFNFWVDPEAAKIVLDAGFDITIVPWEVAEISGSLNERDWEYISKLNTKLSNFFINVNKTLKEYTTKNQGISGSIHPDSLTVSIAHDNSIILDSSLKYVDVELCSKSRGAMLIDWYSLHKNKPNAEIVLKADGGKFKNLLFNSLSQL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	307 (300)
Sequences:	3905 (2815)
Seq/√Len:	162.5

ECOLI - RIHB RIHC RIHA
SULSO - Q97WH6 Q97ZS5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
99_E	107_R	3.931	1.00
103_D	133_K	3.627	1.00
172_K	176_D	3.268	1.00
132_L	173_I	2.958	1.00
3_K	26_Q	2.870	1.00
252_L	290_K	2.852	1.00
164_F	271_M	2.702	1.00
64_S	129_L	2.541	1.00
29_G	104_A	2.517	1.00
256_L	286_E	2.457	1.00
172_K	260_D	2.440	1.00
110_K	134_D	2.433	1.00
191_I	290_K	2.361	1.00
32_I	43_V	2.358	1.00
247_D	295_K	2.336	1.00
110_K	140_R	2.219	1.00
107_R	111_E	2.202	1.00
131_Y	138_V	2.149	1.00
6_V	121_I	2.109	1.00
18_I	30_V	2.104	1.00
3_K	28_L	2.096	1.00
110_K	136_S	2.084	1.00
119_L	242_V	2.077	1.00
21_A	242_V	2.074	1.00
254_S	288_V	2.037	1.00
31_T	101_A	2.008	1.00
10_T	46_A	1.983	1.00
164_F	171_A	1.981	1.00
159_I	270_A	1.944	1.00
115_E	142_K	1.943	1.00
106_L	134_D	1.942	1.00
262_E	267_S	1.921	1.00
47_L	60_V	1.912	1.00
120_A	127_I	1.900	1.00
61_Y	104_A	1.898	1.00
292_D	295_K	1.866	1.00
61_Y	97_E	1.839	1.00
143_K	182_T	1.832	1.00
189_A	237_P	1.832	1.00
120_A	146_I	1.785	1.00
28_L	116_L	1.765	1.00
109_S	116_L	1.740	1.00
70_G	268_R	1.711	1.00
19_L	53_I	1.687	1.00
130_A	134_D	1.682	1.00
236_H	239_S	1.667	1.00
4_V	119_L	1.644	1.00
39_Y	62_L	1.639	1.00
44_K	48_F	1.630	1.00
5_I	31_T	1.620	1.00
104_A	108_L	1.608	1.00
244_I	251_I	1.603	1.00
106_L	130_A	1.596	1.00
146_I	183_I	1.595	1.00
7_D	126_N	1.584	1.00
120_A	124_L	1.581	1.00
117_E	145_W	1.571	1.00
47_L	95_R	1.567	1.00
106_L	137_V	1.547	1.00
130_A	137_V	1.538	1.00
298_N	302_N	1.530	1.00
100_H	103_D	1.524	1.00
212_N	216_N	1.522	1.00
124_L	174_V	1.521	1.00
8_S	121_I	1.520	1.00
134_D	137_V	1.513	1.00
109_S	140_R	1.510	1.00
250_I	295_K	1.506	1.00
184_V	288_V	1.484	1.00
127_I	144_I	1.477	1.00
204_S	215_I	1.472	1.00
146_I	175_L	1.466	1.00
169_E	268_R	1.443	1.00
146_I	164_F	1.443	1.00
100_H	133_K	1.418	1.00
294_G	298_N	1.384	1.00
108_L	111_E	1.381	1.00
39_Y	43_V	1.378	1.00
109_S	130_A	1.369	1.00
182_T	286_E	1.362	1.00
164_F	175_L	1.360	1.00
70_G	169_E	1.346	1.00
40_N	62_L	1.341	1.00
105_I	130_A	1.325	1.00
202_Y	298_N	1.321	1.00
262_E	265_S	1.318	1.00
243_S	296_F	1.316	1.00
51_E	94_K	1.310	1.00
117_E	143_K	1.309	1.00
43_V	62_L	1.296	1.00
108_L	116_L	1.295	1.00
3_K	112_H	1.283	1.00
22_S	303_S	1.280	1.00
118_I	141_V	1.280	1.00
20_L	299_L	1.280	1.00
124_L	146_I	1.276	1.00
50_L	58_V	1.274	1.00
82_N	88_N	1.272	1.00
243_S	299_L	1.263	1.00
202_Y	301_F	1.261	1.00
143_K	180_D	1.254	1.00
254_S	286_E	1.247	1.00
182_T	254_S	1.247	1.00
44_K	91_E	1.247	1.00
8_S	46_A	1.241	1.00
112_H	115_E	1.239	1.00
119_L	245_A	1.233	1.00
262_E	266_K	1.222	1.00
24_F	303_S	1.216	1.00
103_D	107_R	1.214	1.00
172_K	263_L	1.211	1.00
113_E	140_R	1.205	1.00
207_N	212_N	1.203	1.00
175_L	183_I	1.200	1.00
6_V	27_L	1.195	1.00
68_I	128_A	1.188	1.00
267_S	270_A	1.161	1.00
240_L	291_A	1.155	1.00
148_G	164_F	1.149	1.00
255_S	289_L	1.146	1.00
66_R	132_L	1.143	1.00
5_I	29_G	1.139	1.00
199_D	297_K	1.134	1.00
52_Y	213_F	1.129	1.00
267_S	272_L	1.122	1.00
22_S	246_H	1.121	1.00
6_V	21_A	1.120	1.00
201_E	205_K	1.115	1.00
109_S	137_V	1.110	1.00
240_L	251_I	1.108	1.00
157_T	160_A	1.097	1.00
182_T	244_I	1.091	1.00
257_K	287_I	1.091	1.00
194_S	233_G	1.091	1.00
259_V	285_A	1.088	1.00
38_N	41_Q	1.087	1.00
102_I	133_K	1.085	1.00
109_S	141_V	1.084	1.00
37_V	41_Q	1.082	0.99
102_I	130_A	1.079	0.99
257_K	273_I	1.078	0.99
27_L	121_I	1.075	0.99
51_E	93_N	1.061	0.99
69_L	169_E	1.060	0.99
51_E	92_P	1.057	0.99
32_I	46_A	1.057	0.99
105_I	137_V	1.052	0.99
139_K	142_K	1.047	0.99
145_W	245_A	1.039	0.99
50_L	55_K	1.037	0.99
28_L	108_L	1.030	0.99
151_F	185_P	1.025	0.99
106_L	110_K	1.015	0.99
6_V	18_I	1.011	0.99
145_W	244_I	1.009	0.99
119_L	241_T	1.006	0.99
105_I	109_S	1.002	0.99
204_S	219_K	1.002	0.99
144_I	179_F	1.000	0.99
43_V	96_P	1.000	0.99
78_V	224_Y	0.996	0.99
30_V	50_L	0.988	0.99
3_K	115_E	0.985	0.99
20_L	303_S	0.972	0.99
94_K	97_E	0.972	0.99
16_I	300_L	0.967	0.99
80_G	83_G	0.967	0.99
82_N	85_S	0.964	0.99
141_V	179_F	0.964	0.99
247_D	299_L	0.963	0.99
136_S	139_K	0.961	0.99
193_G	291_A	0.956	0.99
12_T	221_L	0.953	0.99
241_T	245_A	0.951	0.99
109_S	112_H	0.949	0.99
249_S	295_K	0.946	0.99
258_Y	281_N	0.946	0.99
34_A	166_V	0.944	0.99
15_T	49_T	0.941	0.99
243_S	250_I	0.937	0.99
40_N	65_Q	0.936	0.99
144_I	181_I	0.934	0.99
50_L	60_V	0.934	0.99
81_S	86_N	0.932	0.98
120_A	144_I	0.930	0.98
244_I	254_S	0.919	0.98
4_V	25_F	0.919	0.98
118_I	127_I	0.917	0.98
105_I	127_I	0.915	0.98
5_I	105_I	0.914	0.98
196_N	199_D	0.912	0.98
197_E	201_E	0.907	0.98
199_D	301_F	0.906	0.98
124_L	171_A	0.904	0.98
168_P	268_R	0.901	0.98
61_Y	99_E	0.898	0.98
37_V	42_E	0.896	0.98
160_A	165_W	0.893	0.98
123_P	166_V	0.890	0.98
147_M	189_A	0.890	0.98
129_L	132_L	0.889	0.98
131_Y	177_A	0.888	0.98
64_S	125_T	0.886	0.98
29_G	108_L	0.885	0.98
180_D	286_E	0.882	0.98
55_K	58_V	0.882	0.98
62_L	96_P	0.882	0.98
184_V	244_I	0.881	0.98
21_A	119_L	0.879	0.98
176_D	260_D	0.878	0.98
77_E	156_T	0.877	0.98
5_I	104_A	0.877	0.98
175_L	181_I	0.873	0.98
223_E	227_K	0.871	0.98
5_I	116_L	0.871	0.98
146_I	181_I	0.870	0.98
31_T	105_I	0.870	0.98
44_K	92_P	0.869	0.98
106_L	133_K	0.869	0.98
51_E	56_Q	0.865	0.98
298_N	301_F	0.862	0.97
258_Y	284_N	0.861	0.97
79_H	83_G	0.861	0.97
162_F	166_V	0.857	0.97
10_T	42_E	0.856	0.97
117_E	142_K	0.853	0.97
151_F	183_I	0.846	0.97
28_L	112_H	0.845	0.97
242_V	245_A	0.841	0.97
80_G	85_S	0.829	0.97
73_R	165_W	0.828	0.97
115_E	140_R	0.826	0.97
39_Y	42_E	0.825	0.97
32_I	42_E	0.823	0.97
31_T	126_N	0.822	0.97
183_I	287_I	0.821	0.97
113_E	116_L	0.820	0.97
256_L	284_N	0.819	0.97
252_L	292_D	0.818	0.97
247_D	250_I	0.818	0.97
68_I	129_L	0.816	0.96
161_E	186_W	0.814	0.96
11_A	15_T	0.810	0.96
295_K	299_L	0.809	0.96
82_N	86_N	0.805	0.96
169_E	263_L	0.803	0.96
64_S	100_H	0.802	0.96
193_G	296_F	0.801	0.96
21_A	25_F	0.791	0.96
150_A	153_K	0.787	0.96
69_L	173_I	0.782	0.96
102_I	129_L	0.781	0.96
261_V	271_M	0.780	0.95
186_W	237_P	0.771	0.95
251_I	288_V	0.769	0.95
145_W	241_T	0.768	0.95
251_I	254_S	0.768	0.95
241_T	244_I	0.766	0.95
147_M	238_D	0.765	0.95
157_T	165_W	0.764	0.95
25_F	246_H	0.762	0.95
112_H	116_L	0.759	0.95
20_L	243_S	0.756	0.95
114_G	142_K	0.755	0.95
53_I	210_L	0.753	0.95
109_S	138_V	0.750	0.94
36_N	45_N	0.749	0.94
18_I	21_A	0.748	0.94
155_N	186_W	0.746	0.94
74_T	166_V	0.744	0.94
19_L	49_T	0.740	0.94
207_N	211_S	0.740	0.94
258_Y	283_P	0.737	0.94
16_I	214_F	0.734	0.94
259_V	271_M	0.732	0.94
175_L	271_M	0.730	0.94
68_I	173_I	0.730	0.94
30_V	46_A	0.729	0.94
293_G	297_K	0.727	0.93
19_L	214_F	0.726	0.93
68_I	132_L	0.726	0.93
184_V	241_T	0.724	0.93
12_T	85_S	0.718	0.93
143_K	244_I	0.716	0.93
143_K	286_E	0.711	0.93
82_N	87_W	0.710	0.93
169_E	264_C	0.703	0.92
131_Y	141_V	0.699	0.92
124_L	164_F	0.698	0.92
112_H	140_R	0.695	0.92
33_V	122_S	0.694	0.92
206_L	211_S	0.694	0.92
36_N	79_H	0.693	0.92
109_S	113_E	0.692	0.92
143_K	248_N	0.692	0.92
43_V	47_L	0.691	0.92
109_S	134_D	0.691	0.92
208_T	211_S	0.690	0.92
194_S	235_I	0.688	0.91
32_I	126_N	0.687	0.91
118_I	144_I	0.685	0.91
7_D	31_T	0.683	0.91
17_A	242_V	0.681	0.91
299_L	303_S	0.681	0.91
185_P	188_V	0.677	0.91
173_I	176_D	0.677	0.91
27_L	30_V	0.675	0.91
31_T	104_A	0.674	0.91
41_Q	44_K	0.673	0.91
49_T	213_F	0.672	0.90
154_G	160_A	0.672	0.90
213_F	217_V	0.671	0.90
226_T	232_S	0.668	0.90
114_G	140_R	0.667	0.90
200_W	204_S	0.664	0.90
151_F	289_L	0.661	0.90
183_I	271_M	0.659	0.90
68_I	170_A	0.659	0.90
156_T	165_W	0.658	0.90
299_L	302_N	0.655	0.89
240_L	296_F	0.655	0.89
131_Y	179_F	0.654	0.89
244_I	288_V	0.652	0.89
47_L	96_P	0.649	0.89
47_L	94_K	0.644	0.89
5_I	108_L	0.643	0.88
198_R	201_E	0.642	0.88
150_A	187_E	0.640	0.88
138_V	141_V	0.639	0.88
13_D	238_D	0.639	0.88
14_D	238_D	0.636	0.88
99_E	103_D	0.635	0.88
137_V	140_R	0.634	0.88
199_D	293_G	0.634	0.88
138_V	179_F	0.632	0.88
184_V	254_S	0.630	0.87
62_L	65_Q	0.629	0.87
265_S	268_R	0.626	0.87
72_W	166_V	0.623	0.87
103_D	106_L	0.623	0.87
79_H	85_S	0.622	0.87
200_W	219_K	0.622	0.87
280_K	283_P	0.621	0.87
204_S	212_N	0.619	0.87
188_V	291_A	0.618	0.86
11_A	237_P	0.618	0.86
111_E	114_G	0.612	0.86
250_I	299_L	0.611	0.86
102_I	106_L	0.610	0.86
56_Q	94_K	0.609	0.86
209_K	212_N	0.604	0.85
48_F	92_P	0.604	0.85
152_S	187_E	0.603	0.85
38_N	74_T	0.599	0.85
155_N	160_A	0.599	0.85
117_E	245_A	0.598	0.85
259_V	287_I	0.597	0.85
3_K	114_G	0.597	0.85
204_S	216_N	0.596	0.84
124_L	127_I	0.596	0.84
104_A	107_R	0.596	0.84
151_F	273_I	0.595	0.84
145_W	184_V	0.594	0.84
87_W	216_N	0.594	0.84
199_D	202_Y	0.594	0.84
224_Y	228_N	0.594	0.84
29_G	61_Y	0.593	0.84
106_L	136_S	0.592	0.84
215_I	219_K	0.588	0.84
127_I	141_V	0.588	0.84
138_V	178_G	0.586	0.83
134_D	140_R	0.584	0.83
75_V	78_V	0.584	0.83
4_V	21_A	0.584	0.83
48_F	52_Y	0.583	0.83
121_I	146_I	0.582	0.83
108_L	112_H	0.582	0.83
170_A	174_V	0.580	0.83
45_N	80_G	0.578	0.83
171_A	174_V	0.578	0.83
25_F	245_A	0.576	0.82
195_L	234_S	0.575	0.82
254_S	289_L	0.574	0.82
158_P	279_H	0.573	0.82
101_A	126_N	0.573	0.82
16_I	218_N	0.572	0.82
172_K	266_K	0.568	0.81
39_Y	65_Q	0.568	0.81
257_K	289_L	0.568	0.81
110_K	137_V	0.567	0.81
130_A	133_K	0.567	0.81
147_M	237_P	0.565	0.81
197_E	222_K	0.565	0.81
33_V	126_N	0.564	0.81
150_A	154_G	0.560	0.81
15_T	45_N	0.557	0.80
20_L	242_V	0.555	0.80
148_G	171_A	0.555	0.80
131_Y	137_V	0.553	0.80
100_H	129_L	0.552	0.80
69_L	132_L	0.550	0.79
155_N	161_E	0.548	0.79
69_L	172_K	0.548	0.79
45_N	83_G	0.547	0.79
121_I	241_T	0.546	0.79
131_Y	173_I	0.542	0.78
190_E	237_P	0.537	0.78
203_I	211_S	0.536	0.78
139_K	143_K	0.535	0.78
68_I	125_T	0.535	0.78
183_I	285_A	0.535	0.78
262_E	272_L	0.534	0.77
66_R	71_N	0.533	0.77
34_A	162_F	0.533	0.77
186_W	189_A	0.531	0.77
137_V	141_V	0.529	0.77
218_N	234_S	0.529	0.77
145_W	182_T	0.528	0.77
171_A	261_V	0.527	0.76
186_W	190_E	0.527	0.76
225_T	234_S	0.527	0.76
151_F	187_E	0.526	0.76
255_S	275_W	0.525	0.76
10_T	49_T	0.525	0.76
195_L	218_N	0.525	0.76
113_E	142_K	0.519	0.75
12_T	79_H	0.518	0.75
75_V	79_H	0.518	0.75
106_L	109_S	0.517	0.75
262_E	274_D	0.516	0.75
256_L	282_K	0.515	0.75
32_I	62_L	0.515	0.75
216_N	219_K	0.514	0.75
14_D	17_A	0.513	0.75
27_L	58_V	0.513	0.75
17_A	121_I	0.512	0.74
83_G	86_N	0.510	0.74
202_Y	205_K	0.508	0.74
221_L	237_P	0.508	0.74
258_Y	279_H	0.508	0.74
25_F	119_L	0.508	0.74
27_L	55_K	0.507	0.74
13_D	17_A	0.507	0.74
219_K	223_E	0.507	0.74
93_N	139_K	0.505	0.73
98_K	139_K	0.504	0.73
128_A	173_I	0.504	0.73
10_T	122_S	0.503	0.73
4_V	245_A	0.502	0.73
214_F	304_L	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3t8iA	3	0.9935	100	0.047	Contact Map
4wr2A	4	0.9609	100	0.049	Contact Map
2masA	3	0.9935	100	0.052	Contact Map
3t8jA	3	0.9935	100	0.058	Contact Map
4kpoA	2	0.9935	100	0.063	Contact Map
4kpnA	2	0.9935	100	0.064	Contact Map
1q8fA	4	0.9902	100	0.067	Contact Map
3fz0A	3	0.9739	100	0.098	Contact Map
2c40A	2	0.9251	100	0.129	Contact Map
4i71A	2	0.9544	100	0.144	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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