GREMLIN Database
Q97WH5 - Ferric uptake regulation protein (Fur)
UniProt: Q97WH5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 136 (127)
Sequences: 6706 (4397)
Seq/√Len: 390.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_I118_K4.0181.00
92_D127_D3.7641.00
95_R130_K3.2961.00
116_D132_G3.1631.00
27_I67_L2.7311.00
114_G129_S2.3911.00
26_L41_E2.2941.00
117_I124_V2.2821.00
91_I125_Y2.1841.00
16_V21_I2.1831.00
62_K69_S2.0361.00
69_S76_T2.0181.00
91_I127_D1.9481.00
35_G58_L1.9431.00
62_K67_L1.8541.00
30_G41_E1.8111.00
39_Y51_L1.8011.00
93_S128_C1.7941.00
40_E43_K1.7881.00
59_E69_S1.7731.00
118_K127_D1.7641.00
88_V97_I1.7411.00
14_L64_S1.7351.00
7_N11_Q1.5921.00
86_V120_V1.5141.00
25_K29_R1.4851.00
23_I57_T1.4761.00
90_C93_S1.4271.00
22_A45_T1.4101.00
97_I115_L1.3911.00
24_L61_L1.3901.00
34_S37_Q1.3831.00
8_L12_R1.3761.00
115_L129_S1.3751.00
22_A25_K1.3731.00
41_E44_K1.3701.00
88_V115_L1.3691.00
21_I25_K1.3581.00
39_Y43_K1.3571.00
93_S131_L1.3451.00
26_L38_I1.3411.00
90_C128_C1.3051.00
109_N113_N1.2801.00
26_L42_L1.2391.00
32_H79_E1.1841.00
84_P120_V1.1831.00
19_Q53_T1.1711.00
30_G33_Y1.1281.00
32_H87_N1.1281.00
116_D127_D1.1271.00
128_C131_L1.1221.00
26_L30_G1.1051.00
8_L11_Q1.1051.00
105_N109_N1.0761.00
60_T64_S1.0661.00
36_E40_E1.0441.00
39_Y54_V1.0361.00
89_F125_Y1.0331.00
108_E112_K1.0261.00
57_T60_T1.0041.00
33_Y77_W1.0001.00
61_L66_I0.9971.00
31_G41_E0.9951.00
127_D132_G0.9771.00
42_L49_I0.9751.00
115_L126_A0.9671.00
85_H98_D0.9641.00
33_Y41_E0.9571.00
26_L45_T0.9471.00
88_V126_A0.9411.00
107_M120_V0.9321.00
119_N125_Y0.9311.00
20_R60_T0.9261.00
129_S133_K0.9211.00
24_L66_I0.9121.00
42_L46_E0.9111.00
86_V99_L0.9081.00
86_V101_I0.9071.00
70_F98_D0.9061.00
26_L33_Y0.9031.00
32_H96_I0.8921.00
31_G37_Q0.8911.00
14_L60_T0.8661.00
66_I80_I0.8611.00
91_I119_N0.8571.00
23_I38_I0.8501.00
19_Q49_I0.8471.00
32_H85_H0.8461.00
35_G54_V0.8431.00
18_P21_I0.8381.00
40_E44_K0.8351.00
27_I33_Y0.8241.00
104_D107_M0.8191.00
89_F123_I0.8181.00
89_F94_N0.8031.00
36_E75_I0.8031.00
32_H98_D0.8001.00
108_E111_T0.7981.00
33_Y38_I0.7941.00
59_E62_K0.7821.00
114_G132_G0.7791.00
90_C131_L0.7781.00
36_E51_L0.7681.00
27_I38_I0.7631.00
75_I78_F0.7621.00
43_K51_L0.7551.00
22_A46_E0.7511.00
20_R57_T0.7361.00
29_R41_E0.7191.00
101_I105_N0.7171.00
105_N108_E0.7161.00
18_P22_A0.7111.00
89_F96_I0.7111.00
58_L67_L0.7051.00
73_N77_W0.7051.00
86_V107_M0.7021.00
86_V122_I0.7001.00
34_S77_W0.6961.00
120_V124_V0.6941.00
109_N112_K0.6910.99
25_K45_T0.6850.99
59_E63_E0.6790.99
37_Q40_E0.6780.99
121_N125_Y0.6700.99
19_Q50_S0.6700.99
58_L62_K0.6630.99
35_G51_L0.6620.99
71_E76_T0.6600.99
36_E39_Y0.6590.99
10_R16_V0.6450.99
68_N81_N0.6440.99
39_Y49_I0.6420.99
70_F123_I0.6420.99
38_I67_L0.6370.99
16_V24_L0.6350.99
32_H50_S0.6330.99
94_N97_I0.6320.99
100_D113_N0.6310.99
53_T57_T0.6270.99
87_N98_D0.6250.99
23_I61_L0.6190.99
24_L28_M0.6160.99
26_L29_R0.6160.99
29_R45_T0.6150.99
9_L24_L0.6130.99
27_I34_S0.6070.99
86_V124_V0.6010.99
111_T132_G0.5980.99
23_I26_L0.5970.99
9_L16_V0.5960.98
130_K133_K0.5950.98
35_G75_I0.5950.98
24_L80_I0.5940.98
106_F111_T0.5830.98
120_V125_Y0.5810.98
22_A42_L0.5810.98
36_E69_S0.5730.98
102_E105_N0.5730.98
42_L47_P0.5630.98
19_Q57_T0.5610.98
35_G62_K0.5590.98
72_A121_N0.5570.98
28_M80_I0.5530.98
17_T53_T0.5500.97
35_G76_T0.5490.97
106_F109_N0.5470.97
90_C115_L0.5470.97
97_I130_K0.5440.97
126_A131_L0.5440.97
61_L67_L0.5440.97
79_E85_H0.5430.97
32_H36_E0.5430.97
84_P101_I0.5420.97
129_S132_G0.5370.97
8_L28_M0.5360.97
53_T56_N0.5320.97
78_F98_D0.5310.97
9_L14_L0.5300.97
37_Q41_E0.5300.97
118_K126_A0.5290.97
95_R129_S0.5290.97
34_S75_I0.5280.97
103_M106_F0.5230.97
9_L60_T0.5210.97
105_N130_K0.5150.96
107_M111_T0.5130.96
100_D106_F0.5090.96
111_T116_D0.5060.96
7_N10_R0.5020.96
14_L20_R0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fe3A 2 0.9853 100 0.186 Contact Map
2xigA 4 1 100 0.195 Contact Map
4mtdA 2 1 100 0.2 Contact Map
3eyyA 2 0.9485 100 0.203 Contact Map
4etsA 2 1 100 0.215 Contact Map
3mwmA 2 0.8897 100 0.223 Contact Map
2w57A 2 0.9191 100 0.232 Contact Map
4lmyA 2 1 100 0.251 Contact Map
2o03A 2 0.9118 100 0.256 Contact Map
1mzbA 4 0.9338 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.