GREMLIN Database
Q97WH3 - Methyltransferase, putative
UniProt: Q97WH3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 223 (173)
Sequences: 12738 (9565)
Seq/√Len: 727.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_A124_F3.1791.00
113_A165_M2.9491.00
60_L78_A2.8141.00
64_L77_L2.7901.00
40_L90_F2.5661.00
43_G98_T2.5251.00
44_S59_A2.3921.00
85_F90_F2.3721.00
111_E114_R2.2501.00
67_L77_L2.2421.00
91_K117_K2.2261.00
104_D107_G2.2211.00
64_L68_K2.2201.00
93_V112_M2.1771.00
58_V90_F2.1571.00
56_R74_E2.0861.00
44_S50_H2.0861.00
70_S75_K2.0481.00
8_N63_S1.9811.00
105_V160_I1.9761.00
42_V112_M1.9641.00
67_L75_K1.9541.00
50_H57_I1.8981.00
14_K46_P1.8431.00
93_V116_T1.8281.00
42_V80_A1.7881.00
8_N65_L1.7591.00
106_K160_I1.7521.00
106_K110_R1.7341.00
102_I108_F1.7071.00
111_E115_I1.7041.00
78_A84_P1.7001.00
158_Y162_N1.6881.00
39_C53_I1.6771.00
153_S156_E1.6731.00
62_I79_D1.6371.00
116_T165_M1.5941.00
120_A123_C1.5321.00
61_D67_L1.5201.00
87_D114_R1.5101.00
58_V76_V1.5061.00
121_I124_F1.4211.00
39_C92_C1.4131.00
50_H59_A1.4021.00
65_L68_K1.3701.00
23_L26_N1.3691.00
59_A70_S1.3651.00
86_R89_S1.3511.00
83_L115_I1.3491.00
76_V85_F1.3281.00
107_G110_R1.3061.00
35_N38_D1.2931.00
125_I128_D1.2931.00
98_T102_I1.2871.00
38_D56_R1.2671.00
106_K163_D1.2611.00
95_S98_T1.2571.00
80_A98_T1.2541.00
50_H75_K1.2521.00
79_D82_H1.2291.00
24_Y27_E1.2241.00
43_G95_S1.2221.00
47_D75_K1.2111.00
83_L111_E1.2091.00
58_V74_E1.2081.00
58_V85_F1.1801.00
80_A102_I1.1731.00
112_M116_T1.1671.00
68_K71_K1.1571.00
21_S24_Y1.1561.00
159_V162_N1.1251.00
113_A163_D1.1231.00
26_N29_N1.0931.00
108_F112_M1.0921.00
158_Y170_I1.0921.00
154_R172_S1.0841.00
85_F115_I1.0771.00
46_P66_M1.0751.00
133_E136_E1.0741.00
59_A75_K1.0741.00
60_L76_V1.0721.00
29_N33_S1.0681.00
93_V115_I1.0541.00
11_K69_E1.0511.00
47_D70_S1.0381.00
109_I161_I1.0381.00
63_S66_M1.0301.00
40_L93_V1.0051.00
84_P111_E1.0041.00
129_S133_E1.0011.00
99_V102_I0.9931.00
135_Y138_L0.9911.00
7_F101_F0.9871.00
130_P134_Y0.9861.00
24_Y28_R0.9861.00
99_V109_I0.9831.00
44_S70_S0.9691.00
23_L27_E0.9691.00
116_T119_R0.9661.00
116_T120_A0.9661.00
112_M121_I0.9631.00
109_I163_D0.9471.00
99_V108_F0.9441.00
133_E137_N0.9381.00
97_V100_C0.9371.00
22_K25_E0.9261.00
130_P135_Y0.9251.00
50_H73_D0.9251.00
53_I94_F0.9211.00
41_D59_A0.9211.00
81_L104_D0.9171.00
25_E28_R0.9161.00
40_L115_I0.9071.00
87_D111_E0.9051.00
130_P133_E0.8981.00
7_F100_C0.8901.00
134_Y137_N0.8901.00
137_N141_S0.8891.00
39_C57_I0.8741.00
42_V93_V0.8731.00
82_H107_G0.8641.00
129_S132_G0.8621.00
41_D57_I0.8431.00
61_D66_M0.8431.00
97_V101_F0.8391.00
12_S15_R0.8381.00
49_F96_S0.8371.00
21_S25_E0.8351.00
27_E30_V0.8301.00
161_I165_M0.8251.00
26_N30_V0.8231.00
105_V109_I0.8211.00
33_S171_R0.8191.00
43_G102_I0.8141.00
134_Y138_L0.8131.00
112_M122_I0.8051.00
25_E29_N0.8041.00
132_G135_Y0.8031.00
133_E138_L0.7961.00
48_I52_E0.7961.00
42_V60_L0.7951.00
131_W134_Y0.7921.00
110_R163_D0.7791.00
21_S27_E0.7711.00
129_S134_Y0.7661.00
156_E159_V0.7621.00
29_N171_R0.7581.00
49_F94_F0.7471.00
29_N32_R0.7441.00
131_W135_Y0.7421.00
14_K69_E0.7381.00
26_N31_V0.7351.00
130_P138_L0.7331.00
51_E75_K0.7241.00
22_K26_N0.7231.00
132_G136_E0.7211.00
38_D117_K0.7171.00
89_S114_R0.7131.00
81_L102_I0.7121.00
107_G111_E0.7101.00
59_A73_D0.7051.00
44_S61_D0.7041.00
28_R52_E0.7021.00
31_V34_F0.7001.00
116_T122_I0.7001.00
41_D44_S0.7001.00
39_C94_F0.6991.00
131_W136_E0.6901.00
65_L69_E0.6831.00
41_D60_L0.6811.00
28_R32_R0.6801.00
54_G72_S0.6791.00
87_D115_I0.6671.00
90_F115_I0.6671.00
60_L83_L0.6641.00
8_N64_L0.6611.00
81_L103_E0.6581.00
82_H111_E0.6561.00
129_S136_E0.6531.00
109_I160_I0.6521.00
16_W19_L0.6481.00
89_S117_K0.6471.00
130_P137_N0.6461.00
138_L141_S0.6451.00
67_L70_S0.6441.00
137_N140_K0.6351.00
109_I157_F0.6311.00
17_Y101_F0.6201.00
62_I81_L0.6201.00
129_S137_N0.6131.00
106_K113_A0.6091.00
18_E48_I0.6081.00
129_S135_Y0.6081.00
89_S115_I0.6061.00
57_I73_D0.6051.00
85_F89_S0.6051.00
37_K55_G0.6031.00
138_L143_H0.6021.00
138_L142_G0.6021.00
145_Y148_H0.5991.00
54_G57_I0.5991.00
55_G72_S0.5981.00
38_D55_G0.5961.00
105_V152_I0.5941.00
132_G137_N0.5921.00
49_F52_E0.5911.00
26_N33_S0.5901.00
62_I77_L0.5891.00
49_F53_I0.5871.00
42_V108_F0.5851.00
113_A116_T0.5841.00
120_A126_A0.5821.00
17_Y20_H0.5811.00
109_I113_A0.5801.00
81_L108_F0.5771.00
136_E140_K0.5721.00
78_A83_L0.5721.00
88_N118_E0.5701.00
116_T121_I0.5661.00
137_N142_G0.5661.00
110_R114_R0.5661.00
44_S67_L0.5661.00
43_G62_I0.5641.00
99_V157_F0.5631.00
28_R33_S0.5621.00
24_Y30_V0.5621.00
30_V33_S0.5621.00
162_N167_I0.5611.00
84_P115_I0.5561.00
84_P114_R0.5511.00
136_E139_G0.5481.00
51_E73_D0.5481.00
40_L85_F0.5461.00
105_V108_F0.5431.00
14_K17_Y0.5431.00
27_E32_R0.5431.00
17_Y97_V0.5401.00
96_S101_F0.5391.00
23_L31_V0.5341.00
27_E34_F0.5331.00
135_Y139_G0.5331.00
39_C54_G0.5311.00
134_Y140_K0.5281.00
144_K147_S0.5271.00
38_D91_K0.5241.00
136_E141_S0.5241.00
80_A108_F0.5231.00
131_W137_N0.5221.00
98_T101_F0.5191.00
27_E31_V0.5181.00
155_R159_V0.5141.00
114_R118_E0.5131.00
81_L107_G0.5121.00
41_D94_F0.5111.00
29_N34_F0.5111.00
100_C147_S0.5101.00
33_S169_R0.5081.00
53_I57_I0.5040.99
88_N117_K0.5020.99
13_Y46_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ccfA 1 0.9238 100 0.456 Contact Map
2yqzA 1 0.9821 99.9 0.469 Contact Map
3b5iA 2 0.9103 99.9 0.47 Contact Map
2p35A 2 0.9417 99.9 0.476 Contact Map
2o57A 2 0.991 99.9 0.481 Contact Map
4pneA 2 0.9686 99.9 0.483 Contact Map
1vl5A 1 0.8969 99.9 0.488 Contact Map
1m6eX 2 1 99.9 0.492 Contact Map
4obxA 2 0.7982 99.9 0.496 Contact Map
4kdcA 1 0.8475 99.9 0.499 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.