Q97WH3 - SULSO - GREMLIN Contacts

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Q97WH3 - Methyltransferase, putative

UniProt:	Q97WH3	Sequences: MRAEDLFNDPKSYKRWYELHSKLYENERNVVRSFNLKDCLDVGSGPDIFHEEIGGRIVALDISLLMLKESKSDEKVLADALHLPFRDNSFKCVFSSVTVCFIEDVKGFIREMARITKERAIICFIARDSPWGEYYENLGKSGHKYYSHARFISRREFYVIINDFMKISRIRSTLKKMSETEIDGVYNDDSGSFICVEAIPMKPEPLSLSLNRHSGADPADPIS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	223 (173)
Sequences:	12738 (9565)
Seq/√Len:	727.2

ECOLI - BIOC YJHP TAM SMTA UBIE UBIG YAFE TEHB CMOA RLMA
BACSU - YCGJ YXBB YODH YBAJ YRRT YXJB MENG YRHH YQEM YDAC
HALSA - Q9HRX3 Q9HR63 Q9HMT2 Q9HND6 Q9HR81 ARSM Q9HSK6 Q9HQ85
SULSO - Q97WH3 Q7LXN7 Q97ZU8 Q97X57 Q97WT7 Q97YX4 Q97XD7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
120_A	124_F	3.179	1.00
113_A	165_M	2.949	1.00
60_L	78_A	2.814	1.00
64_L	77_L	2.790	1.00
40_L	90_F	2.566	1.00
43_G	98_T	2.525	1.00
44_S	59_A	2.392	1.00
85_F	90_F	2.372	1.00
111_E	114_R	2.250	1.00
67_L	77_L	2.242	1.00
91_K	117_K	2.226	1.00
104_D	107_G	2.221	1.00
64_L	68_K	2.220	1.00
93_V	112_M	2.177	1.00
58_V	90_F	2.157	1.00
56_R	74_E	2.086	1.00
44_S	50_H	2.086	1.00
70_S	75_K	2.048	1.00
8_N	63_S	1.981	1.00
105_V	160_I	1.976	1.00
42_V	112_M	1.964	1.00
67_L	75_K	1.954	1.00
50_H	57_I	1.898	1.00
14_K	46_P	1.843	1.00
93_V	116_T	1.828	1.00
42_V	80_A	1.788	1.00
8_N	65_L	1.759	1.00
106_K	160_I	1.752	1.00
106_K	110_R	1.734	1.00
102_I	108_F	1.707	1.00
111_E	115_I	1.704	1.00
78_A	84_P	1.700	1.00
158_Y	162_N	1.688	1.00
39_C	53_I	1.677	1.00
153_S	156_E	1.673	1.00
62_I	79_D	1.637	1.00
116_T	165_M	1.594	1.00
120_A	123_C	1.532	1.00
61_D	67_L	1.520	1.00
87_D	114_R	1.510	1.00
58_V	76_V	1.506	1.00
121_I	124_F	1.421	1.00
39_C	92_C	1.413	1.00
50_H	59_A	1.402	1.00
65_L	68_K	1.370	1.00
23_L	26_N	1.369	1.00
59_A	70_S	1.365	1.00
86_R	89_S	1.351	1.00
83_L	115_I	1.349	1.00
76_V	85_F	1.328	1.00
107_G	110_R	1.306	1.00
35_N	38_D	1.293	1.00
125_I	128_D	1.293	1.00
98_T	102_I	1.287	1.00
38_D	56_R	1.267	1.00
106_K	163_D	1.261	1.00
95_S	98_T	1.257	1.00
80_A	98_T	1.254	1.00
50_H	75_K	1.252	1.00
79_D	82_H	1.229	1.00
24_Y	27_E	1.224	1.00
43_G	95_S	1.222	1.00
47_D	75_K	1.211	1.00
83_L	111_E	1.209	1.00
58_V	74_E	1.208	1.00
58_V	85_F	1.180	1.00
80_A	102_I	1.173	1.00
112_M	116_T	1.167	1.00
68_K	71_K	1.157	1.00
21_S	24_Y	1.156	1.00
159_V	162_N	1.125	1.00
113_A	163_D	1.123	1.00
26_N	29_N	1.093	1.00
108_F	112_M	1.092	1.00
158_Y	170_I	1.092	1.00
154_R	172_S	1.084	1.00
85_F	115_I	1.077	1.00
46_P	66_M	1.075	1.00
133_E	136_E	1.074	1.00
59_A	75_K	1.074	1.00
60_L	76_V	1.072	1.00
29_N	33_S	1.068	1.00
93_V	115_I	1.054	1.00
11_K	69_E	1.051	1.00
47_D	70_S	1.038	1.00
109_I	161_I	1.038	1.00
63_S	66_M	1.030	1.00
40_L	93_V	1.005	1.00
84_P	111_E	1.004	1.00
129_S	133_E	1.001	1.00
99_V	102_I	0.993	1.00
135_Y	138_L	0.991	1.00
7_F	101_F	0.987	1.00
130_P	134_Y	0.986	1.00
24_Y	28_R	0.986	1.00
99_V	109_I	0.983	1.00
44_S	70_S	0.969	1.00
23_L	27_E	0.969	1.00
116_T	119_R	0.966	1.00
116_T	120_A	0.966	1.00
112_M	121_I	0.963	1.00
109_I	163_D	0.947	1.00
99_V	108_F	0.944	1.00
133_E	137_N	0.938	1.00
97_V	100_C	0.937	1.00
22_K	25_E	0.926	1.00
130_P	135_Y	0.925	1.00
50_H	73_D	0.925	1.00
53_I	94_F	0.921	1.00
41_D	59_A	0.921	1.00
81_L	104_D	0.917	1.00
25_E	28_R	0.916	1.00
40_L	115_I	0.907	1.00
87_D	111_E	0.905	1.00
130_P	133_E	0.898	1.00
7_F	100_C	0.890	1.00
134_Y	137_N	0.890	1.00
137_N	141_S	0.889	1.00
39_C	57_I	0.874	1.00
42_V	93_V	0.873	1.00
82_H	107_G	0.864	1.00
129_S	132_G	0.862	1.00
41_D	57_I	0.843	1.00
61_D	66_M	0.843	1.00
97_V	101_F	0.839	1.00
12_S	15_R	0.838	1.00
49_F	96_S	0.837	1.00
21_S	25_E	0.835	1.00
27_E	30_V	0.830	1.00
161_I	165_M	0.825	1.00
26_N	30_V	0.823	1.00
105_V	109_I	0.821	1.00
33_S	171_R	0.819	1.00
43_G	102_I	0.814	1.00
134_Y	138_L	0.813	1.00
112_M	122_I	0.805	1.00
25_E	29_N	0.804	1.00
132_G	135_Y	0.803	1.00
133_E	138_L	0.796	1.00
48_I	52_E	0.796	1.00
42_V	60_L	0.795	1.00
131_W	134_Y	0.792	1.00
110_R	163_D	0.779	1.00
21_S	27_E	0.771	1.00
129_S	134_Y	0.766	1.00
156_E	159_V	0.762	1.00
29_N	171_R	0.758	1.00
49_F	94_F	0.747	1.00
29_N	32_R	0.744	1.00
131_W	135_Y	0.742	1.00
14_K	69_E	0.738	1.00
26_N	31_V	0.735	1.00
130_P	138_L	0.733	1.00
51_E	75_K	0.724	1.00
22_K	26_N	0.723	1.00
132_G	136_E	0.721	1.00
38_D	117_K	0.717	1.00
89_S	114_R	0.713	1.00
81_L	102_I	0.712	1.00
107_G	111_E	0.710	1.00
59_A	73_D	0.705	1.00
44_S	61_D	0.704	1.00
28_R	52_E	0.702	1.00
31_V	34_F	0.700	1.00
116_T	122_I	0.700	1.00
41_D	44_S	0.700	1.00
39_C	94_F	0.699	1.00
131_W	136_E	0.690	1.00
65_L	69_E	0.683	1.00
41_D	60_L	0.681	1.00
28_R	32_R	0.680	1.00
54_G	72_S	0.679	1.00
87_D	115_I	0.667	1.00
90_F	115_I	0.667	1.00
60_L	83_L	0.664	1.00
8_N	64_L	0.661	1.00
81_L	103_E	0.658	1.00
82_H	111_E	0.656	1.00
129_S	136_E	0.653	1.00
109_I	160_I	0.652	1.00
16_W	19_L	0.648	1.00
89_S	117_K	0.647	1.00
130_P	137_N	0.646	1.00
138_L	141_S	0.645	1.00
67_L	70_S	0.644	1.00
137_N	140_K	0.635	1.00
109_I	157_F	0.631	1.00
17_Y	101_F	0.620	1.00
62_I	81_L	0.620	1.00
129_S	137_N	0.613	1.00
106_K	113_A	0.609	1.00
18_E	48_I	0.608	1.00
129_S	135_Y	0.608	1.00
89_S	115_I	0.606	1.00
57_I	73_D	0.605	1.00
85_F	89_S	0.605	1.00
37_K	55_G	0.603	1.00
138_L	143_H	0.602	1.00
138_L	142_G	0.602	1.00
145_Y	148_H	0.599	1.00
54_G	57_I	0.599	1.00
55_G	72_S	0.598	1.00
38_D	55_G	0.596	1.00
105_V	152_I	0.594	1.00
132_G	137_N	0.592	1.00
49_F	52_E	0.591	1.00
26_N	33_S	0.590	1.00
62_I	77_L	0.589	1.00
49_F	53_I	0.587	1.00
42_V	108_F	0.585	1.00
113_A	116_T	0.584	1.00
120_A	126_A	0.582	1.00
17_Y	20_H	0.581	1.00
109_I	113_A	0.580	1.00
81_L	108_F	0.577	1.00
136_E	140_K	0.572	1.00
78_A	83_L	0.572	1.00
88_N	118_E	0.570	1.00
116_T	121_I	0.566	1.00
137_N	142_G	0.566	1.00
110_R	114_R	0.566	1.00
44_S	67_L	0.566	1.00
43_G	62_I	0.564	1.00
99_V	157_F	0.563	1.00
28_R	33_S	0.562	1.00
24_Y	30_V	0.562	1.00
30_V	33_S	0.562	1.00
162_N	167_I	0.561	1.00
84_P	115_I	0.556	1.00
84_P	114_R	0.551	1.00
136_E	139_G	0.548	1.00
51_E	73_D	0.548	1.00
40_L	85_F	0.546	1.00
105_V	108_F	0.543	1.00
14_K	17_Y	0.543	1.00
27_E	32_R	0.543	1.00
17_Y	97_V	0.540	1.00
96_S	101_F	0.539	1.00
23_L	31_V	0.534	1.00
27_E	34_F	0.533	1.00
135_Y	139_G	0.533	1.00
39_C	54_G	0.531	1.00
134_Y	140_K	0.528	1.00
144_K	147_S	0.527	1.00
38_D	91_K	0.524	1.00
136_E	141_S	0.524	1.00
80_A	108_F	0.523	1.00
131_W	137_N	0.522	1.00
98_T	101_F	0.519	1.00
27_E	31_V	0.518	1.00
155_R	159_V	0.514	1.00
114_R	118_E	0.513	1.00
81_L	107_G	0.512	1.00
41_D	94_F	0.511	1.00
29_N	34_F	0.511	1.00
100_C	147_S	0.510	1.00
33_S	169_R	0.508	1.00
53_I	57_I	0.504	0.99
88_N	117_K	0.502	0.99
13_Y	46_P	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ccfA	1	0.9238	100	0.456	Contact Map
2yqzA	1	0.9821	99.9	0.469	Contact Map
3b5iA	2	0.9103	99.9	0.47	Contact Map
2p35A	2	0.9417	99.9	0.476	Contact Map
2o57A	2	0.991	99.9	0.481	Contact Map
4pneA	2	0.9686	99.9	0.483	Contact Map
1vl5A	1	0.8969	99.9	0.488	Contact Map
1m6eX	2	1	99.9	0.492	Contact Map
4obxA	2	0.7982	99.9	0.496	Contact Map
4kdcA	1	0.8475	99.9	0.499	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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