GREMLIN Database
Q97WH2 - Probable cation transport protein (CzcD)
UniProt: Q97WH2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (260)
Sequences: 10163 (7085)
Seq/√Len: 439.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_E165_V3.3941.00
176_A180_P3.1081.00
187_L192_G2.9531.00
212_H229_H2.8761.00
228_L263_V2.8481.00
201_M205_T2.6651.00
204_L228_L2.5991.00
194_S198_D2.4701.00
89_Y93_T2.4011.00
203_E256_Y2.3221.00
203_E255_K2.3151.00
16_I31_F2.3101.00
18_A109_S2.2921.00
58_E65_L2.2011.00
88_A168_I2.1861.00
207_I251_F2.1801.00
204_L248_I2.1541.00
113_A117_T2.1231.00
194_S197_I2.1011.00
250_D254_E2.0471.00
122_P131_K1.9841.00
77_L182_L1.9721.00
68_L190_M1.9681.00
199_H255_K1.9561.00
234_P239_A1.9421.00
237_T240_E1.9151.00
19_Y28_L1.9131.00
207_I248_I1.9031.00
183_K187_L1.8961.00
88_A171_V1.8241.00
108_V112_L1.8041.00
230_V248_I1.7801.00
203_E251_F1.7271.00
61_F65_L1.7251.00
17_V21_I1.7031.00
152_I156_I1.6861.00
67_R191_E1.6771.00
117_T120_A1.6651.00
242_D264_Q1.6601.00
107_I148_F1.6571.00
210_S231_K1.6381.00
238_I241_A1.6351.00
93_T97_K1.6351.00
243_K247_S1.6301.00
240_E243_K1.6141.00
104_F108_V1.5911.00
110_S117_T1.5901.00
179_I183_K1.5861.00
85_L89_Y1.5861.00
207_I247_S1.5511.00
42_A46_I1.5331.00
87_V167_A1.5251.00
16_I20_Y1.5241.00
172_I176_A1.5211.00
168_I172_I1.5111.00
202_E206_K1.4661.00
92_V96_F1.4651.00
241_A265_F1.4501.00
114_S117_T1.4421.00
131_K184_E1.4351.00
104_F155_F1.4321.00
63_Y227_T1.4161.00
121_S124_E1.4141.00
33_H136_H1.4011.00
110_S113_A1.3891.00
9_F38_F1.3741.00
251_F255_K1.3721.00
153_L157_S1.3681.00
91_S167_A1.3671.00
106_L113_A1.3641.00
199_H203_E1.3471.00
146_M166_G1.3341.00
247_S251_F1.3291.00
105_T108_V1.3221.00
152_I155_F1.3161.00
104_F107_I1.3151.00
216_V226_A1.3141.00
212_H266_E1.3071.00
161_E164_P1.3031.00
150_I166_G1.3011.00
180_P183_K1.2921.00
43_F72_V1.2721.00
107_I117_T1.2641.00
232_V238_I1.2581.00
86_A89_Y1.2491.00
106_L110_S1.2411.00
47_A72_V1.2401.00
121_S125_R1.2311.00
15_F34_A1.2141.00
58_E61_F1.2101.00
232_V244_I1.2051.00
7_L116_L1.1941.00
19_Y31_F1.1911.00
84_S175_F1.1881.00
245_R249_C1.1821.00
107_I155_F1.1771.00
25_P91_S1.1671.00
214_L228_L1.1641.00
205_T210_S1.1611.00
12_S35_L1.1611.00
50_F68_L1.1561.00
212_H231_K1.1561.00
203_E207_I1.1501.00
106_L117_T1.1401.00
191_E225_V1.1391.00
245_R264_Q1.1271.00
207_I244_I1.1211.00
95_L164_P1.1201.00
133_L136_H1.1051.00
229_H266_E1.1051.00
115_F119_F1.0961.00
61_F187_L1.0951.00
66_H223_V1.0941.00
81_I178_S1.0941.00
111_A115_F1.0861.00
239_A243_K1.0741.00
154_I157_S1.0731.00
199_H202_E1.0691.00
206_K251_F1.0671.00
226_A261_V1.0671.00
238_I265_F1.0641.00
60_R65_L1.0491.00
249_C264_Q1.0481.00
215_H260_H1.0461.00
12_S31_F1.0431.00
5_F38_F1.0361.00
107_I114_S1.0351.00
22_T106_L1.0341.00
249_C253_K1.0331.00
134_Y138_L1.0321.00
70_V188_I1.0311.00
199_H256_Y1.0291.00
153_L162_L1.0271.00
12_S16_I1.0261.00
226_A258_I1.0201.00
242_D267_T1.0181.00
90_T93_T1.0131.00
252_L258_I1.0131.00
95_L168_I1.0111.00
111_A114_S1.0101.00
11_T15_F1.0071.00
113_A120_A1.0071.00
88_A92_V0.9981.00
22_T105_T0.9961.00
6_V10_F0.9931.00
77_L181_L0.9891.00
195_V198_D0.9871.00
16_I28_L0.9831.00
107_I152_I0.9821.00
242_D245_R0.9811.00
107_I110_S0.9801.00
107_I111_A0.9771.00
5_F42_A0.9761.00
200_I216_V0.9731.00
25_P94_S0.9721.00
151_G155_F0.9701.00
118_Y138_L0.9661.00
7_L120_A0.9661.00
44_S129_G0.9661.00
46_I50_F0.9651.00
95_L161_E0.9621.00
203_E206_K0.9571.00
241_A245_R0.9551.00
30_E144_Y0.9541.00
44_S132_G0.9541.00
245_R265_F0.9521.00
200_I252_L0.9511.00
81_I179_I0.9501.00
145_I149_I0.9481.00
114_S118_Y0.9471.00
253_K259_S0.9391.00
30_E33_H0.9391.00
81_I85_L0.9351.00
211_V214_L0.9331.00
49_K52_G0.9321.00
25_P167_A0.9291.00
5_F45_I0.9211.00
50_F55_E0.9161.00
81_I175_F0.9141.00
110_S148_F0.9131.00
20_Y28_L0.9131.00
78_I82_L0.9101.00
90_T94_S0.9041.00
114_S148_F0.9011.00
60_R192_G0.8961.00
232_V265_F0.8951.00
219_I225_V0.8931.00
235_N239_A0.8901.00
92_V168_I0.8851.00
213_H260_H0.8821.00
106_L114_S0.8801.00
106_L109_S0.8791.00
159_I162_L0.8771.00
13_L17_V0.8761.00
202_E205_T0.8741.00
191_E219_I0.8731.00
165_V169_I0.8701.00
91_S168_I0.8681.00
232_V241_A0.8661.00
188_I218_S0.8651.00
62_S193_S0.8631.00
122_P134_Y0.8481.00
9_F13_L0.8451.00
25_P90_T0.8411.00
213_H229_H0.8401.00
211_V228_L0.8311.00
111_A148_F0.8261.00
120_A137_I0.8241.00
86_A90_T0.8231.00
246_G250_D0.8211.00
12_S38_F0.8201.00
245_R263_V0.8141.00
71_V186_F0.8101.00
104_F117_T0.8101.00
205_T211_V0.8081.00
116_L120_A0.8021.00
104_F114_S0.8011.00
246_G249_C0.8011.00
74_M78_I0.7971.00
71_V190_M0.7951.00
204_L211_V0.7831.00
191_E217_W0.7801.00
69_E127_D0.7791.00
251_F254_E0.7781.00
151_G154_I0.7771.00
93_T96_F0.7741.00
162_L166_G0.7721.00
82_L86_A0.7681.00
139_S177_L0.7651.00
8_M34_A0.7621.00
252_L261_V0.7621.00
122_P125_R0.7611.00
4_T120_A0.7591.00
48_I129_G0.7581.00
108_V111_A0.7471.00
201_M211_V0.7441.00
110_S114_S0.7441.00
16_I35_L0.7431.00
166_G170_L0.7431.00
99_T102_D0.7431.00
82_L89_Y0.7381.00
12_S34_A0.7371.00
241_A244_I0.7351.00
46_I49_K0.7341.00
135_M138_L0.7311.00
193_S216_V0.7291.00
74_M185_A0.7281.00
67_R217_W0.7271.00
132_G181_L0.7231.00
107_I151_G0.7221.00
33_H80_I0.7221.00
247_S250_D0.7201.00
36_I83_L0.7161.00
109_S117_T0.7161.00
209_P230_V0.7101.00
111_A117_T0.7101.00
11_T116_L0.7091.00
218_S224_K0.7071.00
63_Y217_W0.7071.00
105_T114_S0.7051.00
15_F31_F0.7021.00
33_H37_D0.6961.00
249_C261_V0.6951.00
243_K246_G0.6951.00
248_I263_V0.6941.00
106_L151_G0.6911.00
131_K135_M0.6871.00
150_I162_L0.6851.00
136_H140_D0.6841.00
20_Y31_F0.6821.00
17_V20_Y0.6771.00
112_L119_F0.6741.00
253_K261_V0.6741.00
4_T41_I0.6741.00
73_A129_G0.6741.00
51_I69_E0.6721.00
114_S119_F0.6701.00
91_S171_V0.6691.00
74_M182_L0.6681.00
215_H227_T0.6651.00
173_L177_L0.6651.00
14_S112_L0.6601.00
71_V75_I0.6581.00
85_L175_F0.6561.00
200_I256_Y0.6531.00
244_I248_I0.6490.99
26_L166_G0.6480.99
176_A179_I0.6480.99
100_T160_R0.6460.99
62_S215_H0.6450.99
39_L42_A0.6440.99
128_L188_I0.6360.99
264_Q267_T0.6310.99
8_M37_D0.6290.99
41_I133_L0.6270.99
93_T99_T0.6260.99
60_R187_L0.6240.99
200_I226_A0.6230.99
45_I49_K0.6180.99
198_D201_M0.6170.99
40_T44_S0.6170.99
77_L185_A0.6160.99
40_T79_I0.6140.99
241_A267_T0.6120.99
102_D105_T0.6100.99
18_A105_T0.6100.99
248_I251_F0.6100.99
128_L184_E0.6050.99
204_L230_V0.6050.99
227_T260_H0.6040.99
6_V9_F0.6030.99
153_L156_I0.6020.99
19_Y22_T0.6010.99
169_I173_L0.6000.99
4_T133_L0.6000.99
94_S99_T0.6000.99
198_D216_V0.6000.99
242_D246_G0.5990.99
154_I162_L0.5990.99
197_I224_K0.5990.99
193_S198_D0.5970.99
250_D253_K0.5930.99
24_S163_D0.5920.99
114_S120_A0.5910.99
15_F30_E0.5910.99
218_S221_D0.5880.99
113_A119_F0.5870.99
35_L39_L0.5870.99
138_L142_L0.5860.99
240_E247_S0.5830.99
105_T109_S0.5830.99
40_T136_H0.5810.99
245_R248_I0.5790.99
242_D266_E0.5790.99
110_S119_F0.5780.99
175_F179_I0.5770.99
73_A185_A0.5760.99
142_L145_I0.5750.99
143_G146_M0.5740.99
11_T120_A0.5720.99
73_A181_L0.5720.99
103_S155_F0.5680.99
107_I113_A0.5670.99
114_S145_I0.5650.99
61_F192_G0.5610.98
204_L207_I0.5600.98
43_F75_I0.5590.98
55_E65_L0.5580.98
166_G169_I0.5560.98
110_S120_A0.5550.98
109_S113_A0.5530.98
173_L176_A0.5520.98
258_I261_V0.5510.98
146_M170_L0.5500.98
84_S178_S0.5500.98
63_Y215_H0.5470.98
126_N131_K0.5450.98
230_V265_F0.5450.98
193_S218_S0.5420.98
82_L85_L0.5400.98
97_K100_T0.5360.98
68_L72_V0.5360.98
8_M38_F0.5350.98
157_S162_L0.5340.98
231_K266_E0.5340.98
5_F41_I0.5330.98
252_L263_V0.5320.98
25_P29_A0.5310.98
209_P244_I0.5300.98
109_S112_L0.5270.98
244_I247_S0.5220.98
15_F113_A0.5210.98
136_H139_S0.5210.98
112_L116_L0.5210.98
83_L86_A0.5190.98
80_I137_I0.5170.97
214_L226_A0.5150.97
144_Y147_G0.5130.97
235_N240_E0.5120.97
8_M137_I0.5110.97
98_E101_N0.5100.97
160_R164_P0.5090.97
186_F190_M0.5070.97
106_L120_A0.5070.97
131_K134_Y0.5060.97
4_T137_I0.5050.97
57_A65_L0.5040.97
123_K131_K0.5040.97
95_L165_V0.5010.97
109_S116_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3h90A 3 0.9852 100 0.136 Contact Map
3j1zP 8 0.9852 100 0.142 Contact Map
3bypA 2 0.2804 99.4 0.765 Contact Map
2zztA 2 0.2804 99.3 0.77 Contact Map
3w61A 2 0.2841 99.1 0.791 Contact Map
2jsxA 1 0.3026 42.8 0.942 Contact Map
3cq1A 2 0.2841 41.6 0.942 Contact Map
2pc6A 2 0.31 31.3 0.946 Contact Map
1zpvA 3 0.31 25.9 0.948 Contact Map
4k0jA 3 0.4022 25.2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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