GREMLIN Database
Q97WG8 - Uncharacterized protein
UniProt: Q97WG8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 500 (431)
Sequences: 1907 (1529)
Seq/√Len: 73.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_G80_V5.6771.00
158_V390_V5.5581.00
178_H382_K5.2181.00
144_L388_T4.1301.00
151_G381_R4.0541.00
146_I158_V3.9211.00
157_T409_I3.8031.00
377_A387_L3.7171.00
145_A405_M3.6831.00
178_H379_E3.4571.00
378_R396_G3.4491.00
157_T460_I3.4291.00
179_G311_S3.2691.00
355_E390_V3.1581.00
122_R461_D3.1421.00
409_I447_I3.0631.00
409_I445_A3.0281.00
411_L445_A3.0221.00
328_L352_A2.9091.00
157_T411_L2.8021.00
441_D444_E2.7991.00
143_H150_T2.7321.00
162_S174_I2.7211.00
251_Q254_E2.6831.00
359_V379_E2.5841.00
255_L258_D2.5571.00
250_S254_E2.4841.00
122_R132_E2.4741.00
447_I458_V2.3381.00
160_V164_R2.2111.00
358_H394_P2.1991.00
198_P203_P2.1801.00
276_V279_K2.1141.00
229_K232_N2.0391.00
393_R404_Q1.9911.00
244_P247_T1.9811.00
30_V37_K1.9801.00
361_L373_A1.9691.00
255_L259_E1.9641.00
136_N139_S1.9341.00
244_P248_L1.9001.00
242_Q245_F1.8731.00
351_I388_T1.8661.00
143_H380_G1.8511.00
177_Y390_V1.8501.00
354_I373_A1.8311.00
260_L263_Q1.8221.00
164_R461_D1.8091.00
254_E258_D1.8011.00
443_G462_M1.7931.00
173_L310_V1.7841.00
135_L447_I1.7811.00
29_V40_G1.7371.00
156_N443_G1.7331.00
243_I247_T1.7131.00
179_G313_T1.7041.00
245_F248_L1.6601.00
417_T420_K1.6581.00
255_L262_T1.6441.00
380_G385_V1.6391.00
393_R449_G1.6220.99
163_Q465_G1.6120.99
331_I385_V1.6100.99
166_S307_V1.6080.99
246_S249_N1.6020.99
379_E382_K1.5960.99
29_V103_A1.5950.99
176_D382_K1.5790.99
394_P404_Q1.5700.99
374_S398_D1.5700.99
156_N463_F1.5560.99
253_Y263_Q1.5530.99
418_D455_P1.5480.99
126_L133_V1.5400.99
181_Y382_K1.5350.99
180_E382_K1.5350.99
178_H390_V1.5350.99
242_Q247_T1.5300.99
251_Q256_M1.5150.99
355_E396_G1.5080.99
178_H411_L1.5040.99
202_T205_E1.4990.99
410_I437_L1.4970.99
259_E263_Q1.4930.99
146_I157_T1.4820.99
200_Y204_R1.4790.99
159_A463_F1.4690.99
272_A275_E1.4560.99
396_G400_N1.4560.99
251_Q255_L1.4530.99
358_H379_E1.4430.99
408_K414_I1.4400.99
155_S180_E1.4310.99
252_F261_E1.4270.99
145_A402_L1.4220.99
244_P249_N1.4110.99
403_S418_D1.4040.99
153_G176_D1.4020.99
462_M466_K1.3950.98
250_S267_D1.3890.98
378_R391_S1.3750.98
376_I380_G1.3700.98
159_A180_E1.3600.98
104_R110_E1.3560.98
216_A219_Q1.3470.98
243_I246_S1.3420.98
149_A414_I1.3230.98
393_R418_D1.3170.98
164_R167_E1.3170.98
377_A401_I1.3060.98
380_G443_G1.3020.98
312_L315_L1.3020.98
148_A152_S1.3010.98
173_L350_I1.2990.98
84_C90_F1.2950.97
223_L227_F1.2930.97
175_F327_Y1.2930.97
82_M85_D1.2910.97
351_I386_G1.2890.97
270_S274_D1.2820.97
178_H383_F1.2810.97
256_M259_E1.2810.97
358_H378_R1.2780.97
142_R349_P1.2750.97
288_S293_L1.2740.97
375_R379_E1.2710.97
420_K424_E1.2630.97
179_G323_V1.2610.97
125_S132_E1.2570.97
374_S378_R1.2560.97
379_E403_S1.2530.97
431_E435_E1.2530.97
251_Q261_E1.2480.97
159_A467_L1.2410.97
229_K233_G1.2350.97
29_V186_I1.2330.97
162_S360_F1.2300.97
358_H404_Q1.2290.97
254_E263_Q1.2260.97
393_R403_S1.2250.96
254_E262_T1.2210.96
357_A389_I1.2160.96
272_A278_N1.2150.96
444_E459_K1.2140.96
32_E37_K1.2120.96
251_Q262_T1.2040.96
150_T404_Q1.2000.96
297_D300_E1.1920.96
275_E278_N1.1900.96
394_P418_D1.1840.96
392_Q404_Q1.1740.96
353_V388_T1.1740.96
147_L155_S1.1690.95
74_V78_A1.1690.95
215_N219_Q1.1690.95
325_S360_F1.1680.95
145_A355_E1.1640.95
149_A391_S1.1630.95
150_T406_T1.1470.95
199_L204_R1.1440.95
259_E262_T1.1430.95
145_A391_S1.1410.95
258_D262_T1.1390.95
225_R281_E1.1390.95
374_S400_N1.1330.95
413_I422_I1.1310.95
328_L373_A1.1230.94
333_D337_D1.1180.94
119_G136_N1.1180.94
165_I351_I1.1020.94
180_E358_H1.0980.94
73_P86_M1.0970.94
394_P413_I1.0890.93
181_Y355_E1.0870.93
255_L261_E1.0850.93
252_F258_D1.0840.93
223_L276_V1.0780.93
32_E35_N1.0760.93
250_S263_Q1.0690.93
150_T413_I1.0690.93
459_K462_M1.0690.93
108_D112_K1.0670.93
297_D301_K1.0640.93
172_V307_V1.0630.92
32_E104_R1.0600.92
252_F260_L1.0570.92
158_V177_Y1.0560.92
224_R228_I1.0530.92
182_Y189_L1.0470.92
180_E377_A1.0370.92
243_I248_L1.0360.91
355_E375_R1.0360.91
30_V104_R1.0340.91
269_K273_K1.0340.91
148_A427_D1.0300.91
155_S382_K1.0280.91
176_D391_S1.0170.91
64_R71_S1.0170.91
241_G246_S1.0130.91
226_A229_K1.0130.91
360_F396_G1.0110.90
275_E279_K1.0080.90
206_F210_L1.0040.90
142_R406_T1.0000.90
286_R289_N0.9990.90
404_Q418_D0.9970.90
358_H393_R0.9940.90
152_S157_T0.9730.89
241_G247_T0.9730.89
353_V357_A0.9710.89
359_V375_R0.9660.88
44_N79_K0.9650.88
249_N267_D0.9640.88
114_I454_L0.9630.88
77_K82_M0.9620.88
178_H358_H0.9600.88
252_F256_M0.9600.88
31_L40_G0.9580.88
251_Q267_D0.9550.88
243_I253_Y0.9550.88
358_H382_K0.9540.88
75_Y79_K0.9490.87
30_V33_Y0.9460.87
382_K392_Q0.9450.87
130_N292_D0.9430.87
253_Y260_L0.9430.87
374_S391_S0.9430.87
29_V42_I0.9420.87
360_F405_M0.9340.87
241_G245_F0.9330.87
171_S334_S0.9330.87
383_F387_L0.9300.86
178_H418_D0.9280.86
413_I418_D0.9270.86
214_E221_R0.9260.86
45_V108_D0.9230.86
251_Q259_E0.9200.86
269_K275_E0.9170.86
163_Q463_F0.9140.85
181_Y390_V0.9140.85
66_K69_N0.9110.85
242_Q246_S0.9090.85
436_Q440_L0.9070.85
177_Y407_N0.9040.85
216_A220_Y0.9040.85
150_T392_Q0.9000.85
463_F467_L0.9000.85
465_G468_L0.8970.84
152_S412_K0.8950.84
91_L161_L0.8930.84
202_T206_F0.8930.84
233_G251_Q0.8910.84
393_R400_N0.8900.84
382_K387_L0.8880.84
180_E404_Q0.8860.84
254_E259_E0.8860.84
144_L409_I0.8860.84
56_M62_V0.8850.84
144_L407_N0.8850.84
117_Q120_Q0.8830.83
173_L331_I0.8790.83
180_E413_I0.8780.83
379_E383_F0.8780.83
155_S159_A0.8760.83
380_G393_R0.8750.83
178_H449_G0.8740.83
294_T298_I0.8740.83
277_L281_E0.8740.83
160_V461_D0.8720.83
152_S411_L0.8700.82
36_V54_D0.8670.82
250_S259_E0.8660.82
118_D310_V0.8650.82
65_L69_N0.8610.82
324_V332_L0.8600.82
209_L276_V0.8590.82
30_V110_E0.8580.82
310_V322_A0.8570.81
21_R35_N0.8550.81
189_L300_E0.8530.81
115_Y158_V0.8490.81
272_A279_K0.8480.81
269_K272_A0.8470.81
215_N218_I0.8450.81
382_K418_D0.8450.81
84_C380_G0.8440.81
107_E110_E0.8430.80
382_K402_L0.8430.80
171_S348_F0.8390.80
64_R67_Q0.8390.80
39_L45_V0.8390.80
228_I247_T0.8390.80
276_V280_F0.8380.80
253_Y259_E0.8350.80
253_Y257_K0.8350.80
254_E261_E0.8350.80
257_K261_E0.8350.80
61_I65_L0.8320.80
376_I387_L0.8320.80
215_N222_I0.8300.79
273_K277_L0.8290.79
221_R228_I0.8290.79
310_V328_L0.8250.79
125_S130_N0.8250.79
225_R230_V0.8210.79
254_E257_K0.8180.78
241_G244_P0.8180.78
325_S332_L0.8160.78
148_A390_V0.8160.78
219_Q231_T0.8150.78
249_N254_E0.8120.78
365_E370_K0.8080.78
414_I426_S0.8070.77
178_H398_D0.8070.77
222_I225_R0.8060.77
358_H391_S0.8060.77
389_I393_R0.8040.77
144_L390_V0.8010.77
246_S250_S0.7990.77
157_T161_L0.7980.77
328_L376_I0.7960.76
429_L434_A0.7960.76
219_Q223_L0.7950.76
420_K423_L0.7920.76
74_V85_D0.7900.76
243_I249_N0.7890.76
24_R35_N0.7890.76
76_T86_M0.7880.76
154_K356_E0.7870.76
99_A180_E0.7870.76
246_S252_F0.7860.76
219_Q226_A0.7860.76
461_D464_E0.7830.75
384_G440_L0.7820.75
376_I393_R0.7800.75
379_E418_D0.7780.75
141_A150_T0.7760.75
21_R24_R0.7760.75
150_T379_E0.7750.75
213_R221_R0.7750.75
358_H396_G0.7730.74
201_M204_R0.7720.74
355_E388_T0.7700.74
44_N48_G0.7700.74
393_R401_I0.7680.74
414_I429_L0.7660.74
287_Y291_I0.7640.73
379_E412_K0.7640.73
46_T50_P0.7630.73
462_M465_G0.7630.73
68_F71_S0.7610.73
303_K327_Y0.7600.73
212_I218_I0.7600.73
294_T302_V0.7600.73
399_E421_Y0.7550.73
216_A230_V0.7550.73
359_V378_R0.7540.73
393_R412_K0.7540.73
379_E449_G0.7520.72
30_V41_L0.7510.72
288_S291_I0.7510.72
61_I66_K0.7500.72
138_N391_S0.7480.72
289_N354_I0.7470.72
379_E392_Q0.7470.72
394_P422_I0.7460.72
81_K86_M0.7460.72
157_T160_V0.7450.72
332_L380_G0.7450.72
404_Q414_I0.7450.72
251_Q257_K0.7440.72
143_H401_I0.7430.71
24_R32_E0.7420.71
298_I301_K0.7420.71
380_G391_S0.7420.71
387_L403_S0.7370.71
149_A444_E0.7360.71
376_I385_V0.7350.71
20_E23_V0.7320.70
146_I151_G0.7290.70
175_F424_E0.7280.70
76_T83_L0.7270.70
430_S433_L0.7270.70
294_T301_K0.7250.70
69_N74_V0.7240.69
382_K413_I0.7240.69
215_N221_R0.7240.69
178_H440_L0.7240.69
217_I226_A0.7230.69
192_I195_K0.7210.69
443_G463_F0.7210.69
258_D263_Q0.7210.69
324_V437_L0.7200.69
175_F407_N0.7170.69
133_V456_A0.7150.68
227_F231_T0.7140.68
279_K282_E0.7140.68
260_L267_D0.7140.68
400_N415_E0.7130.68
391_S404_Q0.7130.68
155_S391_S0.7120.68
287_Y290_V0.7120.68
404_Q438_S0.7110.68
214_E250_S0.7090.68
175_F324_V0.7060.68
433_L437_L0.7050.67
335_R432_D0.7010.67
332_L355_E0.7000.67
153_G391_S0.7000.67
363_K399_E0.6990.67
201_M205_E0.6990.67
67_Q87_N0.6970.67
171_S396_G0.6900.66
466_K469_G0.6900.66
423_L434_A0.6880.66
419_K428_N0.6870.65
390_V411_L0.6850.65
124_G151_G0.6830.65
208_T223_L0.6790.64
149_A412_K0.6780.64
367_T398_D0.6770.64
114_I399_E0.6760.64
416_P421_Y0.6750.64
181_Y418_D0.6720.64
403_S449_G0.6710.64
287_Y292_D0.6700.63
143_H381_R0.6690.63
383_F437_L0.6680.63
213_R217_I0.6670.63
185_D309_V0.6670.63
93_P383_F0.6670.63
75_Y86_M0.6650.63
42_I87_N0.6640.63
124_G443_G0.6620.63
395_K426_S0.6620.63
145_A375_R0.6610.62
127_I444_E0.6610.62
426_S429_L0.6610.62
175_F354_I0.6600.62
111_L145_A0.6600.62
164_R464_E0.6590.62
145_A357_A0.6590.62
56_M61_I0.6570.62
325_S329_R0.6550.62
463_F469_G0.6550.62
378_R383_F0.6540.62
81_K85_D0.6540.62
78_A82_M0.6540.62
268_K278_N0.6520.61
206_F216_A0.6520.61
253_Y256_M0.6510.61
143_H360_F0.6510.61
174_I181_Y0.6500.61
188_N367_T0.6470.61
97_P449_G0.6450.61
97_P101_T0.6430.60
376_I449_G0.6420.60
176_D357_A0.6410.60
49_S52_L0.6400.60
217_I275_E0.6390.60
76_T81_K0.6380.60
55_N302_V0.6370.60
245_F249_N0.6360.59
357_A394_P0.6300.59
185_D188_N0.6290.59
192_I308_N0.6290.59
215_N226_A0.6260.58
93_P96_P0.6260.58
143_H384_G0.6250.58
223_L226_A0.6240.58
50_P53_D0.6240.58
164_R291_I0.6230.58
192_I292_D0.6220.58
145_A176_D0.6220.58
217_I228_I0.6210.58
214_E220_Y0.6210.58
312_L399_E0.6210.58
208_T211_E0.6200.58
171_S305_G0.6190.57
295_S301_K0.6180.57
170_G349_P0.6170.57
245_F259_E0.6140.57
274_D287_Y0.6140.57
115_Y444_E0.6130.57
268_K279_K0.6120.57
256_M263_Q0.6110.56
214_E222_I0.6110.56
41_L48_G0.6100.56
444_E457_V0.6080.56
148_A396_G0.6070.56
287_Y293_L0.6070.56
162_S388_T0.6070.56
113_S290_V0.6060.56
38_A169_G0.6060.56
125_S461_D0.6040.56
170_G396_G0.6040.56
362_S365_E0.6040.56
61_I69_N0.6040.56
140_F144_L0.6030.55
209_L411_L0.6020.55
271_S279_K0.6020.55
181_Y449_G0.6010.55
180_E383_F0.6010.55
146_I282_E0.6000.55
254_E260_L0.6000.55
87_N130_N0.5990.55
418_D449_G0.5990.55
445_A460_I0.5980.55
161_L213_R0.5970.55
158_V181_Y0.5970.55
143_H412_K0.5970.55
419_K438_S0.5960.55
147_L405_M0.5960.55
146_I381_R0.5950.54
143_H406_T0.5950.54
402_L445_A0.5930.54
232_N250_S0.5900.54
259_E300_E0.5880.54
355_E370_K0.5870.53
377_A382_K0.5850.53
247_T250_S0.5840.53
181_Y358_H0.5840.53
384_G455_P0.5820.53
180_E418_D0.5820.53
214_E241_G0.5810.53
80_V280_F0.5810.53
221_R390_V0.5800.53
100_G426_S0.5800.53
376_I379_E0.5790.52
79_K113_S0.5790.52
147_L403_S0.5790.52
72_I87_N0.5790.52
271_S276_V0.5760.52
325_S411_L0.5750.52
161_L388_T0.5750.52
273_K281_E0.5730.52
140_F407_N0.5730.52
107_E113_S0.5730.52
147_L160_V0.5720.52
121_I464_E0.5710.51
146_I376_I0.5700.51
391_S396_G0.5690.51
77_K81_K0.5690.51
251_Q258_D0.5680.51
65_L73_P0.5670.51
156_N160_V0.5650.51
288_S292_D0.5650.51
148_A356_E0.5630.50
74_V82_M0.5630.50
357_A391_S0.5630.50
355_E394_P0.5630.50
132_E136_N0.5630.50
64_R68_F0.5620.50
244_P250_S0.5610.50
449_G454_L0.5610.50
252_F255_L0.5610.50
366_N447_I0.5600.50
274_D277_L0.5590.50
78_A83_L0.5590.50
134_K137_I0.5570.50
104_R107_E0.5570.50
153_G356_E0.5550.49
123_I161_L0.5550.49
189_L193_E0.5540.49
108_D130_N0.5540.49
358_H401_I0.5540.49
355_E439_S0.5540.49
213_R458_V0.5520.49
233_G250_S0.5490.49
377_A393_R0.5490.49
43_T80_V0.5480.49
143_H407_N0.5470.48
156_N411_L0.5460.48
29_V80_V0.5450.48
97_P402_L0.5450.48
331_I446_I0.5430.48
256_M261_E0.5430.48
181_Y378_R0.5420.48
393_R415_E0.5400.48
63_Q72_I0.5390.47
433_L455_P0.5390.47
160_V384_G0.5390.47
275_E291_I0.5390.47
207_S211_E0.5390.47
382_K403_S0.5380.47
361_L401_I0.5380.47
178_H391_S0.5370.47
247_T253_Y0.5360.47
169_G210_L0.5360.47
349_P384_G0.5350.47
174_I369_T0.5350.47
154_K381_R0.5350.47
228_I232_N0.5340.47
214_E217_I0.5320.47
325_S391_S0.5320.47
222_I231_T0.5320.47
62_V69_N0.5320.47
180_E373_A0.5320.47
142_R178_H0.5320.47
55_N72_I0.5320.47
325_S367_T0.5320.47
398_D437_L0.5310.46
393_R396_G0.5310.46
21_R27_T0.5310.46
358_H403_S0.5300.46
336_K379_E0.5290.46
49_S54_D0.5290.46
407_N422_I0.5280.46
155_S176_D0.5270.46
253_Y261_E0.5250.46
243_I256_M0.5240.46
52_L55_N0.5240.46
149_A396_G0.5230.46
94_D108_D0.5220.45
93_P97_P0.5220.45
383_F418_D0.5210.45
375_R398_D0.5200.45
23_V27_T0.5180.45
382_K404_Q0.5180.45
383_F404_Q0.5180.45
181_Y391_S0.5170.45
332_L336_K0.5150.45
375_R378_R0.5150.45
37_K110_E0.5140.44
302_V344_S0.5140.44
410_I442_V0.5140.44
178_H355_E0.5130.44
148_A335_R0.5120.44
31_L192_I0.5110.44
33_Y36_V0.5100.44
153_G357_A0.5100.44
203_P292_D0.5100.44
136_N146_I0.5100.44
400_N404_Q0.5090.44
152_S320_M0.5090.44
400_N403_S0.5090.44
155_S422_I0.5080.44
248_L346_L0.5060.43
65_L68_F0.5050.43
107_E187_K0.5040.43
227_F233_G0.5030.43
408_K427_D0.5030.43
261_E267_D0.5020.43
390_V456_A0.5010.43
323_V362_S0.5000.43
150_T383_F0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4d2iA 3 0.932 100 0.259 Contact Map
4ag6A 2 0.658 100 0.511 Contact Map
1e9rA 3 0.73 100 0.618 Contact Map
2iusA 1 0.744 99.9 0.773 Contact Map
2iutA 2 0.774 99.7 0.814 Contact Map
4lyaA 1 0.544 99.3 0.852 Contact Map
4nh0A 1 0.56 99.3 0.855 Contact Map
4kfuA 1 0.412 98.7 0.882 Contact Map
2r2aA 1 0.382 98.7 0.883 Contact Map
1jbkA 1 0.364 98.1 0.903 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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