GREMLIN Database
Q97WG6 - Uncharacterized protein
UniProt: Q97WG6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 501 (460)
Sequences: 3504 (2780)
Seq/√Len: 129.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_G123_A5.0331.00
398_L453_V4.5921.00
310_V432_T4.4791.00
310_V436_A3.9951.00
29_G62_V3.7411.00
133_P141_I3.2131.00
435_T452_G3.1681.00
234_V436_A3.0561.00
32_V154_I2.9841.00
381_D384_S2.8631.00
238_G247_P2.8311.00
26_E65_R2.7961.00
419_N461_T2.7401.00
50_Y144_F2.6831.00
417_T457_S2.5341.00
131_G134_R2.5151.00
341_I345_A2.4971.00
233_R263_Y2.4861.00
94_I99_Y2.4841.00
316_G344_D2.4551.00
192_N195_T2.4511.00
257_A434_I2.3231.00
39_R194_N2.3051.00
63_A154_I2.3001.00
347_K369_I2.2871.00
36_I152_V2.2451.00
142_K171_E2.2431.00
4_V163_D2.2411.00
31_S198_T2.2241.00
32_V63_A2.1971.00
257_A437_T2.1851.00
386_V405_I2.1691.00
48_Y117_A2.1451.00
21_T86_D2.1311.00
33_K63_A2.1241.00
144_F151_K2.1011.00
427_S476_I2.0841.00
151_K173_V2.0771.00
188_L192_N2.0701.00
61_L78_L2.0701.00
177_L196_V2.0481.00
12_I15_S2.0461.00
46_V118_D2.0391.00
359_V435_T2.0201.00
413_K450_Y2.0191.00
317_L347_K1.9671.00
422_M427_S1.9641.00
354_L358_A1.9391.00
161_N168_Y1.9341.00
144_F173_V1.8931.00
444_E447_I1.8821.00
124_M141_I1.8771.00
261_L425_G1.8771.00
79_L124_M1.8611.00
234_V259_A1.8431.00
388_T392_K1.8421.00
359_V439_M1.8421.00
37_V70_E1.8341.00
36_I119_I1.8081.00
178_V193_F1.8071.00
462_L483_V1.7931.00
51_V60_G1.7761.00
35_E196_V1.7751.00
249_L474_T1.7701.00
36_I121_I1.7691.00
251_A281_L1.7561.00
135_E139_S1.7481.00
367_F371_F1.7451.00
49_V64_A1.7361.00
389_Y397_V1.7231.00
150_F176_D1.7091.00
25_M58_G1.6981.00
47_A72_A1.6891.00
367_F389_Y1.6821.00
39_R177_L1.6691.00
123_A154_I1.6661.00
35_E177_L1.6651.00
125_L131_G1.6401.00
374_E377_K1.6241.00
152_V177_L1.6171.00
398_L435_T1.6091.00
446_F450_Y1.6011.00
64_A76_V1.5871.00
259_A262_V1.5781.00
35_E179_V1.5731.00
256_R475_D1.5631.00
415_N457_S1.5621.00
184_I197_V1.5621.00
226_S231_S1.5611.00
88_I92_N1.5591.00
179_V198_T1.5541.00
141_I145_N1.5501.00
253_G477_I1.5491.00
5_K9_A1.5471.00
125_L129_F1.5471.00
396_T449_A1.5441.00
422_M460_G1.5391.00
165_G187_G1.5351.00
184_I189_L1.5271.00
432_T436_A1.5081.00
434_I452_G1.5081.00
368_K378_N1.5031.00
9_A12_I1.4881.00
160_I172_Y1.4821.00
256_R472_T1.4751.00
184_I195_T1.4611.00
386_V407_S1.4591.00
311_I341_I1.4561.00
424_V473_P1.4551.00
434_I480_I1.4511.00
36_I63_A1.4491.00
49_V60_G1.4381.00
278_S281_L1.4331.00
3_S6_E1.4161.00
238_G313_P1.4051.00
466_R479_E1.4041.00
472_T475_D1.4041.00
442_K448_A1.4041.00
172_Y191_Y1.4001.00
234_V254_A1.3761.00
125_L158_S1.3761.00
389_Y393_C1.3761.00
463_A479_E1.3681.00
360_I397_V1.3671.00
4_V162_A1.3591.00
249_L430_T1.3481.00
220_R443_I1.3471.00
135_E138_R1.3431.00
138_R142_K1.3421.00
30_R34_D1.3391.00
138_R171_E1.3361.00
313_P432_T1.3361.00
222_R231_S1.3341.00
462_L479_E1.3321.00
308_V436_A1.3271.00
167_A191_Y1.3211.00
85_E88_I1.3081.00
340_V439_M1.3021.00
30_R66_H1.2981.00
182_H202_I1.2961.00
236_V247_P1.2951.00
340_V432_T1.2851.00
141_I158_S1.2821.00
234_V308_V1.2791.00
413_K446_F1.2771.00
251_A264_V1.2761.00
22_L89_L1.2751.00
421_G471_L1.2661.00
367_F399_L1.2621.00
354_L357_N1.2521.00
46_V73_K1.2521.00
53_H131_G1.2491.00
371_F389_Y1.2471.00
383_I412_F1.2461.00
359_V449_A1.2451.00
439_M445_P1.2421.00
46_V75_T1.2391.00
161_N164_T1.2361.00
32_V181_F1.2351.00
125_L134_R1.2351.00
48_Y77_I1.2331.00
2_I7_M1.2281.00
388_T391_K1.2261.00
252_L478_N1.2251.00
68_A99_Y1.2221.00
280_D474_T1.2100.99
9_A13_N1.2070.99
53_H80_G1.2060.99
405_I412_F1.2020.99
340_V452_G1.2000.99
211_G214_D1.1990.99
430_T477_I1.1930.99
389_Y395_C1.1850.99
387_I412_F1.1830.99
75_T102_T1.1800.99
62_V65_R1.1800.99
236_V250_A1.1760.99
244_S275_A1.1700.99
120_L144_F1.1690.99
263_Y282_I1.1690.99
209_Y416_K1.1680.99
2_I183_D1.1680.99
182_H199_K1.1630.99
91_L95_E1.1580.99
167_A172_Y1.1520.99
49_V63_A1.1520.99
463_A475_D1.1470.99
364_A382_R1.1370.99
318_A321_T1.1340.99
129_F168_Y1.1300.99
384_S388_T1.1300.99
252_L278_S1.1290.99
49_V123_A1.1250.99
360_I395_C1.1250.99
254_A262_V1.1230.99
460_G463_A1.1210.99
255_L472_T1.1110.99
11_E21_T1.1070.99
458_L461_T1.1030.99
23_L27_N1.1030.99
33_K70_E1.0980.99
317_L348_A1.0910.99
243_F282_I1.0890.99
68_A94_I1.0840.99
421_G461_T1.0830.99
13_N16_A1.0770.99
396_T408_D1.0750.99
454_F458_L1.0720.99
309_V332_L1.0720.99
75_T117_A1.0680.99
386_V390_A1.0630.99
247_P264_V1.0620.99
114_P117_A1.0600.99
32_V179_V1.0590.99
235_L265_A1.0590.99
132_K168_Y1.0560.99
424_V427_S1.0540.99
234_V440_A1.0540.99
390_A407_S1.0530.99
136_P139_S1.0510.99
317_L351_G1.0500.99
367_F385_Q1.0470.98
35_E38_K1.0430.98
364_A379_I1.0320.98
449_A452_G1.0300.98
160_I191_Y1.0290.98
63_A121_I1.0260.98
81_E84_H1.0230.98
229_G364_A1.0190.98
51_V61_L1.0140.98
203_P206_A1.0130.98
188_L195_T1.0130.98
79_L140_A1.0110.98
51_V123_A1.0110.98
37_V72_A1.0090.98
125_L137_F1.0080.98
317_L344_D1.0060.98
264_V274_I1.0060.98
235_L306_A1.0040.98
20_S23_L1.0040.98
266_S274_I0.9990.98
64_A74_V0.9970.98
2_I10_L0.9950.98
189_L195_T0.9940.98
61_L94_I0.9920.98
180_T188_L0.9910.98
347_K350_S0.9910.98
390_A408_D0.9850.98
466_R482_N0.9800.98
460_G464_Y0.9800.98
233_R261_L0.9790.98
415_N453_V0.9780.98
234_V310_V0.9770.98
411_R446_F0.9770.98
266_S270_T0.9760.98
189_L414_L0.9750.98
248_T277_Y0.9710.98
35_E39_R0.9690.97
355_Y358_A0.9680.97
7_M183_D0.9680.97
271_A275_A0.9680.97
425_G473_P0.9630.97
404_D453_V0.9580.97
90_N93_V0.9480.97
47_A119_I0.9420.97
167_A170_D0.9410.97
454_F457_S0.9330.97
235_L309_V0.9300.97
417_T454_F0.9290.97
40_F152_V0.9280.97
53_H84_H0.9260.97
41_N72_A0.9230.97
33_K67_L0.9230.97
350_S369_I0.9200.97
161_N166_E0.9170.97
317_L369_I0.9100.96
222_R421_G0.9100.96
174_K190_K0.9080.96
7_M11_E0.9070.96
443_I451_L0.9070.96
359_V396_T0.9040.96
418_G461_T0.9010.96
233_R307_D0.9000.96
398_L449_A0.8990.96
373_E377_K0.8970.96
386_V399_L0.8940.96
11_E14_S0.8920.96
259_A437_T0.8860.96
359_V398_L0.8830.96
119_I152_V0.8790.96
32_V36_I0.8770.95
76_V94_I0.8760.95
332_L337_K0.8750.95
455_I483_V0.8740.95
382_R399_L0.8720.95
22_L90_N0.8720.95
344_D347_K0.8710.95
438_L455_I0.8690.95
215_L451_L0.8690.95
145_N173_V0.8670.95
133_P168_Y0.8660.95
36_I39_R0.8640.95
437_T441_Q0.8640.95
415_N454_F0.8630.95
420_P469_A0.8610.95
61_L76_V0.8580.95
22_L62_V0.8570.95
422_M461_T0.8570.95
36_I40_F0.8560.95
93_V96_E0.8550.95
190_K223_P0.8540.95
479_E482_N0.8500.95
424_V472_T0.8500.95
257_A480_I0.8500.95
463_A471_L0.8500.95
141_I173_V0.8490.95
26_E90_N0.8490.95
367_F378_N0.8490.95
365_G368_K0.8470.95
181_F198_T0.8470.95
379_I382_R0.8460.95
22_L93_V0.8430.94
122_D158_S0.8380.94
151_K176_D0.8380.94
311_I345_A0.8370.94
156_V162_A0.8310.94
265_A286_L0.8310.94
345_A349_I0.8300.94
45_K118_D0.8260.94
133_P170_D0.8240.94
35_E198_T0.8240.94
271_A283_T0.8240.94
32_V152_V0.8230.94
250_A310_V0.8220.94
236_V262_V0.8200.94
177_L194_N0.8200.94
234_V262_V0.8200.94
33_K36_I0.8180.93
153_S175_P0.8160.93
153_S173_V0.8130.93
62_V90_N0.8090.93
407_S412_F0.8090.93
139_S142_K0.8070.93
371_F378_N0.8060.93
308_V439_M0.8050.93
174_K191_Y0.8050.93
261_L282_I0.8040.93
8_R163_D0.8040.93
33_K66_H0.8040.93
404_D449_A0.8010.93
271_A285_K0.7970.93
459_A463_A0.7950.93
443_I448_A0.7940.92
233_R305_R0.7940.92
61_L87_A0.7930.92
22_L86_D0.7930.92
180_T197_V0.7930.92
240_S318_A0.7920.92
186_P383_I0.7920.92
375_P379_I0.7920.92
160_I167_A0.7910.92
132_K138_R0.7900.92
273_I276_G0.7890.92
26_E62_V0.7870.92
339_A358_A0.7860.92
238_G250_A0.7850.92
382_R401_G0.7830.92
300_K303_I0.7820.92
406_I453_V0.7800.92
243_F261_L0.7760.92
407_S410_K0.7730.91
161_N187_G0.7710.91
338_L439_M0.7700.91
210_V450_Y0.7700.91
36_I72_A0.7690.91
341_I358_A0.7690.91
321_T348_A0.7670.91
430_T473_P0.7670.91
189_L209_Y0.7670.91
199_K203_P0.7660.91
53_H125_L0.7640.91
190_K225_Y0.7590.91
149_G176_D0.7570.91
458_L462_L0.7550.90
396_T445_P0.7550.90
27_N66_H0.7540.90
404_D456_N0.7500.90
87_A90_N0.7470.90
78_L91_L0.7440.90
387_I391_K0.7430.90
240_S267_P0.7420.90
386_V397_V0.7410.90
259_A440_A0.7410.90
65_R90_N0.7390.90
263_Y284_I0.7380.89
76_V99_Y0.7370.89
422_M476_I0.7370.89
11_E127_T0.7360.89
145_N174_K0.7350.89
252_L477_I0.7350.89
184_I209_Y0.7340.89
256_R478_N0.7340.89
459_A479_E0.7330.89
358_A395_C0.7330.89
233_R282_I0.7310.89
445_P448_A0.7300.89
8_R127_T0.7300.89
92_N95_E0.7290.89
368_K374_E0.7290.89
190_K224_Y0.7290.89
182_H200_I0.7280.89
252_L277_Y0.7270.89
124_M137_F0.7260.89
421_G464_Y0.7220.88
263_Y305_R0.7210.88
45_K72_A0.7200.88
119_I150_F0.7190.88
403_V414_L0.7190.88
368_K375_P0.7180.88
236_V310_V0.7180.88
131_G168_Y0.7170.88
248_T275_A0.7160.88
311_I315_M0.7150.88
461_T464_Y0.7130.88
79_L137_F0.7130.88
124_M133_P0.7090.87
364_A375_P0.7090.87
20_S89_L0.7070.87
460_G471_L0.7070.87
154_I181_F0.7060.87
382_R403_V0.7050.87
61_L82_N0.7050.87
371_F385_Q0.7040.87
470_H481_P0.7010.87
253_G434_I0.7010.87
38_K196_V0.7010.87
374_E378_N0.7000.87
150_F177_L0.6990.87
438_L448_A0.6990.87
13_N17_L0.6970.87
430_T434_I0.6940.86
381_D385_Q0.6930.86
417_T461_T0.6930.86
94_I97_M0.6900.86
226_S230_D0.6900.86
39_R152_V0.6890.86
307_D440_A0.6870.86
371_F393_C0.6860.86
405_I414_L0.6850.86
23_L93_V0.6850.86
418_G457_S0.6840.86
341_I349_I0.6840.86
244_S270_T0.6840.86
406_I413_K0.6830.85
264_V281_L0.6830.85
86_D89_L0.6790.85
425_G472_T0.6790.85
47_A67_L0.6780.85
61_L91_L0.6760.85
12_I16_A0.6730.85
445_P449_A0.6720.85
49_V121_I0.6720.85
31_S34_D0.6690.84
248_T278_S0.6670.84
419_N464_Y0.6600.83
212_P215_L0.6580.83
125_L133_P0.6560.83
2_I6_E0.6530.83
6_E9_A0.6530.83
447_I450_Y0.6530.83
327_L330_N0.6520.83
27_N30_R0.6510.83
5_K163_D0.6500.83
274_I278_S0.6470.82
36_I47_A0.6460.82
442_K449_A0.6460.82
417_T458_L0.6460.82
464_Y471_L0.6450.82
383_I414_L0.6450.82
476_I479_E0.6430.82
241_Y269_D0.6430.82
49_V74_V0.6410.82
89_L92_N0.6400.82
218_N447_I0.6390.81
386_V398_L0.6390.81
327_L331_Y0.6370.81
368_K373_E0.6370.81
14_S203_P0.6370.81
438_L452_G0.6360.81
301_L304_D0.6360.81
437_T440_A0.6350.81
383_I405_I0.6350.81
236_V436_A0.6330.81
365_G375_P0.6300.81
277_Y281_L0.6300.81
43_K118_D0.6300.81
383_I387_I0.6280.80
385_Q389_Y0.6280.80
269_D288_G0.6250.80
120_L149_G0.6240.80
373_E378_N0.6240.80
297_E301_L0.6220.80
22_L26_E0.6220.80
5_K8_R0.6210.80
462_L465_N0.6210.80
326_K352_F0.6210.80
310_V313_P0.6190.79
207_E412_F0.6170.79
435_T448_A0.6170.79
364_A401_G0.6160.79
69_D97_M0.6140.79
458_L483_V0.6130.79
179_V196_V0.6130.79
250_A432_T0.6130.79
266_S283_T0.6130.79
86_D90_N0.6120.79
48_Y114_P0.6120.79
396_T446_F0.6120.79
237_I315_M0.6110.79
462_L482_N0.6080.78
226_S423_T0.6080.78
237_I311_I0.6050.78
336_N354_L0.6050.78
263_Y306_A0.6050.78
15_S18_G0.6050.78
130_S161_N0.6040.78
378_N399_L0.6040.78
418_G422_M0.6010.77
114_P143_A0.6000.77
164_T187_G0.6000.77
91_L101_I0.6000.77
343_A347_K0.5990.77
8_R11_E0.5990.77
242_T282_I0.5970.77
253_G425_G0.5970.77
11_E20_S0.5970.77
224_Y420_P0.5950.77
82_N91_L0.5950.77
446_F449_A0.5920.76
210_V214_D0.5920.76
78_L87_A0.5910.76
367_F397_V0.5910.76
26_E93_V0.5900.76
157_P188_L0.5900.76
212_P454_F0.5900.76
455_I484_I0.5870.76
419_N422_M0.5850.76
51_V76_V0.5850.76
282_I425_G0.5850.76
308_V338_L0.5840.75
349_I360_I0.5840.75
297_E300_K0.5830.75
463_A477_I0.5820.75
32_V35_E0.5810.75
40_F177_L0.5800.75
262_V436_A0.5800.75
260_D456_N0.5790.75
240_S243_F0.5790.75
326_K330_N0.5780.75
48_Y120_L0.5770.75
93_V97_M0.5770.75
47_A63_A0.5760.74
255_L280_D0.5760.74
413_K447_I0.5750.74
4_V8_R0.5740.74
390_A394_K0.5740.74
212_P458_L0.5740.74
415_N461_T0.5730.74
311_I328_I0.5720.74
336_N357_N0.5720.74
19_V203_P0.5710.74
157_P175_P0.5700.74
58_G87_A0.5690.74
166_E380_R0.5690.74
80_G84_H0.5690.74
223_P226_S0.5660.73
233_R306_A0.5650.73
14_S202_I0.5640.73
68_A98_D0.5630.73
477_I480_I0.5630.73
255_L262_V0.5630.73
162_A187_G0.5610.72
15_S19_V0.5590.72
186_P207_E0.5590.72
396_T404_D0.5580.72
145_N151_K0.5580.72
390_A395_C0.5580.72
270_T275_A0.5570.72
375_P378_N0.5570.72
129_F170_D0.5570.72
11_E15_S0.5570.72
233_R243_F0.5550.72
208_I411_R0.5540.72
252_L474_T0.5530.71
244_S279_P0.5530.71
142_K146_N0.5520.71
8_R162_A0.5520.71
7_M200_I0.5520.71
302_W306_A0.5520.71
11_E23_L0.5520.71
210_V215_L0.5510.71
152_V179_V0.5500.71
424_V460_G0.5500.71
340_V359_V0.5490.71
66_H69_D0.5480.71
10_L202_I0.5470.71
34_D198_T0.5470.71
65_R93_V0.5470.71
40_F119_I0.5470.71
248_T252_L0.5460.70
425_G476_I0.5460.70
133_P138_R0.5440.70
235_L299_L0.5430.70
172_Y187_G0.5430.70
40_F72_A0.5410.70
39_R196_V0.5410.70
143_A147_S0.5410.70
39_R179_V0.5410.70
2_I182_H0.5400.70
398_L452_G0.5400.70
50_Y141_I0.5390.69
255_L282_I0.5370.69
120_L147_S0.5350.69
229_G233_R0.5340.69
250_A313_P0.5330.69
467_L478_N0.5330.69
326_K329_V0.5320.68
92_N96_E0.5310.68
336_N355_Y0.5310.68
471_L475_D0.5300.68
140_A143_A0.5300.68
280_D424_V0.5300.68
26_E66_H0.5300.68
125_L141_I0.5300.68
299_L303_I0.5290.68
33_K37_V0.5290.68
131_G135_E0.5280.68
438_L441_Q0.5280.68
129_F158_S0.5280.68
129_F133_P0.5270.68
261_L305_R0.5260.68
345_A348_A0.5260.68
149_G173_V0.5260.68
7_M182_H0.5260.68
21_T127_T0.5250.67
153_S158_S0.5250.67
135_E141_I0.5250.67
438_L442_K0.5240.67
218_N451_L0.5240.67
275_A279_P0.5240.67
357_N439_M0.5240.67
186_P405_I0.5240.67
189_L416_K0.5240.67
188_L367_F0.5220.67
178_V192_N0.5210.67
148_K151_K0.5210.67
260_D404_D0.5210.67
313_P420_P0.5210.67
11_E203_P0.5200.67
280_D473_P0.5200.67
455_I480_I0.5200.67
244_S273_I0.5190.67
141_I151_K0.5180.66
210_V413_K0.5180.66
82_N95_E0.5170.66
63_A152_V0.5150.66
137_F140_A0.5150.66
255_L281_L0.5150.66
262_V281_L0.5140.66
229_G261_L0.5130.66
457_S460_G0.5130.66
307_D337_K0.5130.66
98_D101_I0.5130.66
225_Y379_I0.5120.66
459_A483_V0.5110.65
269_D272_R0.5100.65
62_V66_H0.5090.65
58_G90_N0.5080.65
421_G424_V0.5080.65
463_A483_V0.5070.65
229_G425_G0.5070.65
175_P193_F0.5060.65
474_T477_I0.5050.65
367_F407_S0.5040.64
160_I192_N0.5040.64
218_N443_I0.5040.64
210_V406_I0.5020.64
378_N385_Q0.5020.64
10_L206_A0.5010.64
268_E285_K0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rssA 4 0.9521 100 0.289 Contact Map
3k5wA 4 0.8743 100 0.31 Contact Map
3bgkA 3 0.5409 100 0.639 Contact Map
1jztA 2 0.4471 100 0.66 Contact Map
2r3bA 3 0.5589 100 0.662 Contact Map
2o8nA 2 0.4331 100 0.662 Contact Map
3rpzA 3 0.5489 100 0.667 Contact Map
3d3kA 2 0.4172 100 0.679 Contact Map
3d3jA 2 0.4132 100 0.681 Contact Map
3nl6A 4 0.8643 100 0.779 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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