GREMLIN Database
CAPPA - Phosphoenolpyruvate carboxylase
UniProt: Q97WG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 511 (477)
Sequences: 107 (92)
Seq/√Len: 4.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
416_Y422_D3.9670.84
7_T305_N3.7810.81
218_P227_A3.7420.81
46_H305_N3.6000.78
197_V295_D3.1790.68
246_N348_V3.1620.68
197_V238_L3.1520.67
159_E163_G3.1350.67
258_L509_S3.0890.66
507_R511_G2.9290.61
57_V362_I2.8540.59
229_L327_T2.7520.56
190_L237_E2.7330.56
194_N237_E2.6260.52
228_V416_Y2.5960.51
249_I412_F2.5870.51
352_L384_G2.5390.50
108_I214_A2.4120.46
215_R227_A2.4100.46
104_T220_M2.3230.43
45_V429_F2.2780.42
194_N244_S2.2720.42
135_T275_E2.2290.41
32_E35_E2.2200.40
127_V389_I2.1700.39
225_I240_K2.1590.39
227_A360_L2.1590.39
58_D65_L2.1560.39
270_E371_A2.1220.38
215_R218_P2.1180.38
106_E155_E2.1060.37
275_E394_E2.0370.35
199_G202_K2.0080.34
141_I243_E1.9980.34
329_L408_E1.9750.34
412_F456_I1.9360.33
82_L233_I1.9310.32
64_K99_K1.9220.32
52_A86_Y1.8800.31
301_I305_N1.8770.31
57_V61_V1.8690.31
84_L501_Y1.8320.30
9_S289_K1.8260.30
203_V284_I1.8200.30
218_P364_L1.8080.29
305_N374_V1.7970.29
101_F509_S1.7970.29
26_V357_A1.7870.29
220_M330_Y1.7860.29
311_P317_K1.7790.29
238_L408_E1.7730.28
57_V360_L1.7560.28
192_N195_N1.7530.28
213_L457_D1.7490.28
274_E385_S1.7170.27
213_L231_V1.7060.27
164_V412_F1.6870.26
221_N365_F1.6840.26
50_W58_D1.6800.26
152_V347_D1.6750.26
126_P297_V1.6650.26
180_V200_Y1.6500.26
202_K306_N1.6490.26
323_L411_I1.6330.25
250_Y384_G1.6320.25
165_K347_D1.6240.25
269_Y303_S1.6110.25
213_L510_L1.6010.24
193_I205_K1.5930.24
235_L251_P1.5880.24
65_L73_F1.5870.24
30_E97_D1.5770.24
116_E192_N1.5670.24
50_W355_R1.5590.24
229_L463_I1.5590.24
211_V389_I1.5580.24
58_D61_V1.5490.23
7_T304_I1.5480.23
306_N391_I1.5400.23
195_N249_I1.5390.23
50_W128_F1.5380.23
406_E412_F1.5360.23
500_L509_S1.5360.23
11_Q14_D1.5330.23
84_L379_A1.5240.23
58_D73_F1.5070.22
164_V456_I1.5050.22
84_L214_A1.5030.22
221_N364_L1.5000.22
245_L264_L1.4850.22
146_R186_D1.4810.22
298_K352_L1.4760.22
211_V238_L1.4750.22
72_Y274_E1.4740.22
64_K359_K1.4690.22
232_K275_E1.4690.22
80_K268_N1.4680.22
21_W206_P1.4680.22
58_D288_F1.4650.22
484_F503_M1.4620.22
63_R97_D1.4610.22
52_A104_T1.4530.21
299_S413_K1.4520.21
127_V345_I1.4140.21
72_Y264_L1.4120.21
284_I381_S1.4110.21
105_M145_A1.4110.21
192_N237_E1.4080.20
227_A362_I1.4080.20
65_L128_F1.4050.20
100_V263_H1.3990.20
310_S391_I1.3960.20
293_D418_N1.3950.20
236_S508_R1.3940.20
86_Y100_V1.3910.20
208_Y391_I1.3880.20
28_E220_M1.3820.20
296_K299_S1.3810.20
64_K221_N1.3760.20
50_W65_L1.3750.20
362_I502_E1.3750.20
476_K479_L1.3730.20
507_R510_L1.3690.20
46_H180_V1.3680.20
65_L288_F1.3670.20
97_D106_E1.3610.20
341_L349_S1.3610.20
220_M224_M1.3520.19
363_G368_S1.3470.19
58_D361_H1.3420.19
40_Y143_S1.3400.19
21_W98_R1.3370.19
348_V428_R1.3360.19
50_W288_F1.3290.19
109_P148_Y1.3290.19
282_Y289_K1.3200.19
91_P97_D1.3190.19
242_S348_V1.3080.19
82_L139_L1.3070.19
190_L213_L1.3070.19
224_M416_Y1.3030.19
237_E424_Q1.3010.18
187_R230_S1.3010.18
58_D355_R1.3010.18
263_H425_T1.2960.18
233_I362_I1.2940.18
152_V264_L1.2910.18
121_N391_I1.2880.18
45_V431_N1.2800.18
73_F361_H1.2750.18
141_I312_A1.2750.18
7_T46_H1.2740.18
249_I436_K1.2690.18
237_E509_S1.2680.18
9_S103_E1.2540.18
67_S385_S1.2460.18
374_V395_L1.2410.17
129_E367_Y1.2370.17
90_N132_L1.2360.17
29_G118_F1.2350.17
248_E332_E1.2350.17
135_T394_E1.2340.17
176_K372_G1.2330.17
264_L461_S1.2320.17
135_T382_F1.2300.17
62_V84_L1.2250.17
218_P221_N1.2240.17
4_I7_T1.2240.17
218_P376_L1.2200.17
78_L430_L1.2190.17
220_M510_L1.2160.17
73_F355_R1.2100.17
290_Y431_N1.2090.17
194_N311_P1.2040.17
61_V65_L1.2010.17
424_Q459_A1.1940.17
48_V110_I1.1920.17
16_A192_N1.1890.17
249_I461_S1.1880.17
65_L361_H1.1880.17
50_W73_F1.1860.17
39_A498_K1.1860.17
347_D354_R1.1850.16
119_Y504_A1.1800.16
115_A279_V1.1790.16
71_D461_S1.1780.16
50_W361_H1.1770.16
479_L503_M1.1750.16
195_N299_S1.1750.16
64_K360_L1.1750.16
91_P148_Y1.1710.16
52_A134_M1.1700.16
9_S126_P1.1690.16
504_A507_R1.1680.16
213_L238_L1.1620.16
165_K296_K1.1620.16
272_V282_Y1.1600.16
240_K321_D1.1590.16
348_V429_F1.1470.16
208_Y248_E1.1440.16
104_T209_M1.1430.16
7_T45_V1.1370.16
264_L284_I1.1360.16
231_V258_L1.1350.16
120_G191_Q1.1330.16
255_V360_L1.1320.16
73_F131_I1.1300.16
310_S352_L1.1260.16
316_E465_I1.1250.16
479_L499_Y1.1220.15
163_G389_I1.1210.15
99_K148_Y1.1210.15
62_V78_L1.1180.15
9_S359_K1.1160.15
152_V408_E1.1110.15
40_Y74_R1.1040.15
218_P365_F1.1040.15
382_F394_E1.0970.15
72_Y278_G1.0960.15
429_F454_E1.0950.15
80_K436_K1.0890.15
58_D126_P1.0830.15
248_E351_L1.0780.15
65_L355_R1.0760.15
8_M13_P1.0720.15
8_M11_Q1.0720.15
8_M12_H1.0720.15
8_M14_D1.0720.15
203_V466_K1.0550.14
191_Q436_K1.0530.14
138_S198_E1.0500.14
275_E422_D1.0500.14
391_I434_S1.0490.14
128_F232_K1.0460.14
134_M383_V1.0440.14
341_L416_Y1.0430.14
215_R477_H1.0410.14
19_P58_D1.0400.14
328_I453_K1.0390.14
99_K221_N1.0380.14
33_V381_S1.0370.14
49_M283_T1.0370.14
97_D359_K1.0360.14
39_A151_A1.0320.14
164_V343_N1.0310.14
164_V270_E1.0310.14
351_L429_F1.0290.14
63_R91_P1.0270.14
137_S184_V1.0230.14
100_V140_E1.0170.14
295_D461_S1.0160.14
33_V106_E1.0150.14
384_G503_M1.0120.14
275_E416_Y1.0110.14
101_F409_W1.0090.14
232_K361_H1.0090.14
268_N271_K1.0090.14
50_W148_Y1.0070.14
228_V423_L1.0050.14
129_E369_R1.0040.14
21_W56_D1.0030.14
412_F422_D1.0010.14
237_E315_L1.0000.14
37_F50_W0.9980.14
207_K246_N0.9970.14
148_Y360_L0.9950.14
4_I208_Y0.9930.14
90_N214_A0.9920.14
10_T13_P0.9880.14
10_T14_D0.9880.14
72_Y461_S0.9880.14
128_F288_F0.9880.14
354_R383_V0.9870.14
193_I339_E0.9870.14
355_R361_H0.9830.13
61_V275_E0.9820.13
58_D214_A0.9810.13
66_L84_L0.9810.13
504_A511_G0.9800.13
5_P8_M0.9800.13
304_I504_A0.9760.13
56_D134_M0.9710.13
199_G347_D0.9670.13
288_F361_H0.9670.13
58_D128_F0.9650.13
65_L266_P0.9650.13
289_K359_K0.9620.13
67_S264_L0.9600.13
33_V93_V0.9580.13
136_T161_Y0.9580.13
436_K508_R0.9570.13
4_I249_I0.9560.13
56_D98_R0.9550.13
96_A220_M0.9540.13
148_Y361_H0.9510.13
4_I181_I0.9490.13
195_N284_I0.9480.13
312_A329_L0.9480.13
65_L131_I0.9470.13
159_E199_G0.9460.13
39_A152_V0.9460.13
125_I159_E0.9450.13
77_I504_A0.9440.13
229_L385_S0.9430.13
97_D145_A0.9390.13
95_G383_V0.9380.13
140_E331_T0.9370.13
221_N342_A0.9330.13
52_A59_T0.9320.13
64_K365_F0.9280.13
151_A193_I0.9270.13
49_M212_F0.9270.13
37_F58_D0.9250.13
73_F288_F0.9160.13
298_K419_F0.9150.13
58_D131_I0.9140.13
184_V499_Y0.9140.13
328_I414_Q0.9120.12
45_V165_K0.9110.12
184_V193_I0.9090.12
64_K97_D0.9080.12
270_E307_S0.9070.12
107_S111_T0.9070.12
219_A353_P0.9050.12
353_P392_P0.9050.12
219_A392_P0.9050.12
19_P355_R0.9040.12
266_P366_G0.8950.12
241_L245_L0.8930.12
65_L76_H0.8930.12
40_Y302_S0.8920.12
38_L289_K0.8910.12
104_T119_Y0.8910.12
80_K198_E0.8890.12
21_W27_I0.8870.12
23_K323_L0.8870.12
423_L459_A0.8860.12
149_E427_A0.8860.12
141_I200_Y0.8860.12
65_L297_V0.8850.12
229_L260_F0.8840.12
161_Y506_I0.8840.12
46_H417_V0.8770.12
38_L43_Y0.8760.12
384_G510_L0.8740.12
152_V226_T0.8720.12
205_K412_F0.8710.12
3_I86_Y0.8690.12
102_A265_S0.8670.12
32_E36_A0.8670.12
27_I229_L0.8660.12
267_E296_K0.8650.12
71_D504_A0.8640.12
304_I502_E0.8640.12
242_S248_E0.8640.12
99_K175_P0.8620.12
68_N345_I0.8610.12
110_I289_K0.8610.12
371_A495_E0.8590.12
29_G103_E0.8580.12
228_V422_D0.8580.12
130_V180_V0.8510.12
33_V199_G0.8510.12
467_L500_L0.8500.12
383_V435_F0.8480.12
146_R383_V0.8480.12
225_I412_F0.8470.12
43_Y465_I0.8460.12
27_I504_A0.8460.12
141_I488_F0.8450.12
144_V293_D0.8440.12
103_E289_K0.8430.12
111_T226_T0.8420.12
227_A365_F0.8400.12
128_F364_L0.8400.12
72_Y155_E0.8390.12
48_V63_R0.8350.12
164_V332_E0.8310.11
111_T431_N0.8290.11
99_K369_R0.8270.11
362_I365_F0.8260.11
19_P65_L0.8260.11
249_I428_R0.8190.11
45_V226_T0.8180.11
190_L227_A0.8170.11
197_V395_L0.8170.11
190_L231_V0.8160.11
276_Y383_V0.8160.11
239_Y385_S0.8150.11
21_W339_E0.8130.11
335_Q422_D0.8120.11
249_I290_Y0.8110.11
313_R414_Q0.8110.11
174_Y428_R0.8100.11
193_I332_E0.8100.11
198_E454_E0.8080.11
475_R484_F0.8070.11
266_P355_R0.8030.11
284_I304_I0.8000.11
198_E314_I0.7970.11
107_S282_Y0.7950.11
16_A484_F0.7940.11
73_F128_F0.7920.11
74_R296_K0.7910.11
203_V206_P0.7910.11
24_S197_V0.7890.11
48_V98_R0.7880.11
283_T334_Y0.7870.11
209_M284_I0.7840.11
50_W214_A0.7840.11
346_N376_L0.7840.11
58_D64_K0.7840.11
148_Y288_F0.7840.11
16_A435_F0.7830.11
397_G401_L0.7790.11
19_P73_F0.7780.11
227_A255_V0.7760.11
37_F65_L0.7750.11
65_L113_D0.7750.11
222_Y282_Y0.7750.11
248_E385_S0.7740.11
176_K481_S0.7730.11
153_A163_G0.7730.11
299_S306_N0.7730.11
215_R226_T0.7700.11
62_V360_L0.7700.11
65_L126_P0.7690.11
225_I308_R0.7680.11
327_T412_F0.7680.11
142_I429_F0.7660.11
37_F287_A0.7640.11
225_I401_L0.7640.11
58_D148_Y0.7640.11
115_A200_Y0.7630.11
135_T338_I0.7630.11
211_V401_L0.7620.11
298_K349_S0.7610.11
193_I225_I0.7590.11
73_F266_P0.7590.11
272_V426_A0.7580.11
153_A428_R0.7570.11
224_M264_L0.7570.11
394_E416_Y0.7560.11
64_K175_P0.7550.11
19_P361_H0.7550.11
203_V209_M0.7540.11
80_K389_I0.7530.11
191_Q271_K0.7480.11
302_S310_S0.7430.10
266_P288_F0.7420.10
20_E134_M0.7420.10
64_K355_R0.7410.10
232_K363_G0.7390.10
64_K127_V0.7380.10
73_F232_K0.7370.10
20_E98_R0.7370.10
83_F452_I0.7360.10
128_F266_P0.7350.10
139_L302_S0.7340.10
72_Y349_S0.7340.10
37_F165_K0.7330.10
111_T258_L0.7310.10
208_Y250_Y0.7300.10
27_I141_I0.7260.10
63_R105_M0.7260.10
43_Y184_V0.7230.10
58_D297_V0.7230.10
324_R419_F0.7190.10
61_V128_F0.7170.10
34_K270_E0.7170.10
91_P99_K0.7170.10
19_P50_W0.7170.10
302_S368_S0.7160.10
245_L372_G0.7150.10
218_P346_N0.7140.10
429_F464_G0.7120.10
435_F477_H0.7120.10
29_G109_P0.7110.10
9_S15_N0.7090.10
288_F355_R0.7080.10
180_V374_V0.7060.10
331_T415_N0.7040.10
297_V355_R0.7010.10
117_K503_M0.7000.10
148_Y222_Y0.6990.10
113_D361_H0.6990.10
62_V214_A0.6980.10
428_R453_K0.6980.10
32_E366_G0.6970.10
209_M337_I0.6970.10
430_L467_L0.6950.10
348_V391_I0.6950.10
242_S450_A0.6940.10
80_K231_V0.6930.10
195_N296_K0.6890.10
225_I423_L0.6870.10
342_A365_F0.6860.10
457_D461_S0.6860.10
154_N282_Y0.6820.10
59_T112_Y0.6820.10
327_T426_A0.6760.10
477_H481_S0.6730.10
134_M158_L0.6720.10
148_Y355_R0.6720.10
209_M269_Y0.6720.10
215_R276_Y0.6700.10
277_K418_N0.6700.10
328_I457_D0.6700.10
211_V334_Y0.6700.10
160_L385_S0.6660.10
9_S136_T0.6640.10
179_E336_P0.6640.10
299_S312_A0.6640.10
193_I433_E0.6630.10
284_I427_A0.6620.10
228_V386_L0.6610.10
225_I451_K0.6610.10
3_I207_K0.6590.10
408_E466_K0.6580.10
22_A96_A0.6550.10
98_R289_K0.6530.09
270_E321_D0.6500.09
255_V268_N0.6500.09
270_E303_S0.6500.09
244_S407_K0.6490.09
65_L148_Y0.6490.09
52_A93_V0.6480.09
190_L282_Y0.6480.09
500_L504_A0.6450.09
253_I506_I0.6450.09
61_V113_D0.6440.09
72_Y78_L0.6410.09
73_F113_D0.6400.09
186_D189_S0.6400.09
253_I456_I0.6400.09
121_N264_L0.6390.09
93_V134_M0.6390.09
92_K140_E0.6390.09
310_S448_T0.6370.09
105_M412_F0.6360.09
331_T343_N0.6350.09
38_L154_N0.6350.09
64_K91_P0.6340.09
242_S452_I0.6340.09
237_E476_K0.6310.09
20_E111_T0.6270.09
424_Q456_I0.6270.09
28_E239_Y0.6270.09
15_N126_P0.6260.09
346_N364_L0.6250.09
456_I487_S0.6250.09
96_A330_Y0.6240.09
250_Y269_Y0.6240.09
50_W61_V0.6240.09
474_S500_L0.6240.09
301_I429_F0.6230.09
290_Y500_L0.6230.09
40_Y347_D0.6230.09
243_E247_F0.6210.09
357_A484_F0.6210.09
127_V449_I0.6210.09
83_F287_A0.6190.09
27_I184_V0.6180.09
221_N376_L0.6180.09
239_Y312_A0.6180.09
102_A127_V0.6180.09
102_A315_L0.6170.09
65_L214_A0.6160.09
334_Y510_L0.6160.09
144_V383_V0.6150.09
279_V312_A0.6150.09
31_D62_V0.6140.09
33_V337_I0.6130.09
83_F268_N0.6130.09
128_F214_A0.6120.09
248_E284_I0.6120.09
367_Y394_E0.6120.09
16_A204_I0.6100.09
228_V433_E0.6090.09
45_V327_T0.6060.09
146_R265_S0.6060.09
246_N433_E0.6050.09
165_K264_L0.6040.09
99_K288_F0.6030.09
333_R399_S0.6020.09
3_I202_K0.6020.09
263_H293_D0.6020.09
86_Y189_S0.6000.09
126_P289_K0.6000.09
92_K137_S0.5990.09
7_T336_P0.5980.09
45_V282_Y0.5980.09
326_I406_E0.5940.09
30_E111_T0.5940.09
360_L365_F0.5910.09
230_S263_H0.5910.09
379_A383_V0.5910.09
456_I510_L0.5900.09
93_V395_L0.5900.09
325_K344_A0.5890.09
150_K158_L0.5870.09
73_F126_P0.5860.09
128_F361_H0.5860.09
128_F208_Y0.5850.09
58_D76_H0.5850.09
88_L104_T0.5850.09
29_G175_P0.5840.09
151_A263_H0.5830.09
311_P504_A0.5820.09
36_A46_H0.5820.09
327_T496_S0.5810.09
68_N284_I0.5810.09
406_E453_K0.5810.09
40_Y46_H0.5790.09
312_A332_E0.5780.09
19_P288_F0.5780.09
326_I508_R0.5740.09
359_K365_F0.5730.09
113_D148_Y0.5720.09
50_W113_D0.5710.09
290_Y348_V0.5710.09
121_N421_H0.5710.09
160_L418_N0.5700.09
74_R482_S0.5690.09
186_D374_V0.5680.09
205_K465_I0.5680.09
325_K419_F0.5680.09
424_Q448_T0.5660.09
160_L384_G0.5640.09
50_W266_P0.5640.09
212_F366_G0.5620.09
74_R474_S0.5610.09
504_A510_L0.5610.09
207_K287_A0.5590.09
200_Y233_I0.5570.09
315_L424_Q0.5570.09
208_Y228_V0.5570.09
422_D506_I0.5560.09
34_K289_K0.5550.09
38_L235_L0.5530.09
64_K148_Y0.5520.09
139_L284_I0.5510.08
16_A323_L0.5510.08
330_Y400_S0.5510.08
239_Y389_I0.5490.08
394_E422_D0.5480.08
57_V65_L0.5480.08
134_M510_L0.5470.08
421_H497_K0.5470.08
115_A304_I0.5460.08
90_N101_F0.5460.08
263_H438_I0.5460.08
98_R102_A0.5450.08
63_R165_K0.5440.08
273_L452_I0.5420.08
435_F438_I0.5420.08
277_K295_D0.5420.08
186_D229_L0.5400.08
50_W232_K0.5400.08
67_S287_A0.5390.08
270_E295_D0.5390.08
430_L456_I0.5380.08
263_H406_E0.5380.08
76_H317_K0.5370.08
242_S500_L0.5350.08
240_K338_I0.5350.08
48_V173_I0.5350.08
274_E348_V0.5350.08
179_E192_N0.5340.08
355_R365_F0.5340.08
161_Y249_I0.5340.08
310_S326_I0.5320.08
78_L84_L0.5300.08
280_Y348_V0.5300.08
24_S139_L0.5290.08
58_D113_D0.5290.08
106_E145_A0.5270.08
21_W213_L0.5230.08
140_E293_D0.5220.08
317_K395_L0.5220.08
178_I244_S0.5220.08
73_F148_Y0.5210.08
57_V255_V0.5190.08
138_S193_I0.5190.08
45_V240_K0.5190.08
129_E394_E0.5190.08
249_I375_S0.5180.08
203_V240_K0.5180.08
180_V264_L0.5180.08
206_P339_E0.5140.08
86_Y383_V0.5140.08
367_Y397_G0.5140.08
159_E503_M0.5140.08
52_A146_R0.5130.08
84_L246_N0.5130.08
190_L215_R0.5120.08
95_G149_E0.5120.08
4_I250_Y0.5110.08
29_G376_L0.5110.08
33_V144_V0.5110.08
48_V56_D0.5110.08
96_A104_T0.5100.08
345_I482_S0.5090.08
152_V199_G0.5080.08
425_T501_Y0.5060.08
80_K121_N0.5060.08
9_S360_L0.5060.08
411_I429_F0.5050.08
86_Y134_M0.5040.08
373_K489_K0.5030.08
381_S452_I0.5010.08
25_E159_E0.5010.08
91_P359_K0.5010.08
149_E180_V0.5000.08
234_A376_L0.5000.08
59_T357_A0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3odmA 6 0.9315 100 0.439 Contact Map
4bxhA 3 0.8219 100 0.79 Contact Map
1jqnA 3 0.8395 100 0.792 Contact Map
3qllA 3 0.3953 97.3 0.965 Contact Map
4roqA 5 0.546 97.2 0.965 Contact Map
3r4iA 5 0.5616 97.1 0.966 Contact Map
3qz6A 5 0.4892 97.1 0.966 Contact Map
1u5hA 3 0.3973 96.9 0.967 Contact Map
4l9zA 5 0.5382 96.4 0.969 Contact Map
4mf4A 5 0.4423 96.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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