GREMLIN Database
Q97WG0 - Uncharacterized protein
UniProt: Q97WG0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (179)
Sequences: 55407 (40166)
Seq/√Len: 3002.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_E55_K4.2291.00
92_I116_G3.6331.00
45_T186_N2.7101.00
62_P78_F2.6781.00
181_D184_T2.4821.00
80_N106_F2.3981.00
121_G148_D2.3701.00
169_E188_K2.3371.00
141_L192_F2.2641.00
90_K115_S2.2431.00
92_I115_S2.2171.00
120_V185_F2.1541.00
171_V188_K2.0721.00
19_I37_A2.0611.00
15_K68_E1.9521.00
146_S170_I1.8291.00
106_F110_Y1.8161.00
80_N110_Y1.7641.00
80_N113_S1.7421.00
100_G122_A1.7321.00
53_G190_V1.7311.00
160_L166_A1.7201.00
17_H66_S1.7051.00
80_N84_N1.7031.00
93_L103_V1.6831.00
173_K181_D1.6721.00
48_S186_N1.6701.00
21_S58_S1.6541.00
26_L57_I1.6521.00
17_H37_A1.6431.00
20_E57_I1.6331.00
84_N113_S1.6331.00
18_Y82_F1.6291.00
26_L55_K1.6011.00
83_M91_A1.5981.00
140_L163_V1.5661.00
153_K170_I1.5551.00
92_I193_L1.5261.00
26_L88_I1.4791.00
105_E109_K1.4741.00
35_F39_T1.4491.00
188_K191_N1.4311.00
31_H61_L1.4301.00
92_I118_V1.4151.00
107_S117_L1.4051.00
30_F61_L1.3901.00
158_L162_K1.3881.00
25_S92_I1.3851.00
141_L169_E1.3841.00
12_K81_L1.3561.00
61_L102_A1.3561.00
54_Y92_I1.3471.00
77_E109_K1.3451.00
76_S105_E1.3301.00
31_H64_F1.3221.00
17_H60_D1.2991.00
73_I109_K1.2911.00
103_V117_L1.2691.00
184_T188_K1.2421.00
48_S190_V1.2421.00
25_S115_S1.2421.00
106_F114_V1.2401.00
110_Y113_S1.2221.00
79_I106_F1.2101.00
59_V79_I1.2061.00
96_A178_Y1.1861.00
187_E191_N1.1831.00
37_A60_D1.1751.00
106_F113_S1.1651.00
119_L122_A1.1611.00
105_E108_L1.1611.00
118_V189_I1.1611.00
14_R62_P1.1501.00
34_R64_F1.1421.00
104_L119_L1.1421.00
48_S51_S1.1401.00
37_A66_S1.1391.00
163_V166_A1.1371.00
29_L94_L1.1321.00
21_S46_V1.1311.00
30_F79_I1.1221.00
144_W156_Y1.1191.00
46_V58_S1.1161.00
30_F103_V1.1091.00
16_I78_F1.0951.00
82_F86_L1.0901.00
22_G55_K1.0891.00
184_T187_E1.0811.00
57_I82_F1.0751.00
153_K157_K1.0671.00
27_V54_Y1.0641.00
39_T178_Y1.0581.00
29_L56_A1.0371.00
34_R97_S1.0281.00
50_S53_G1.0251.00
84_N110_Y1.0231.00
118_V141_L1.0231.00
97_S175_H1.0201.00
94_L120_V1.0191.00
144_W170_I1.0091.00
157_K161_D1.0061.00
160_L168_L0.9931.00
144_W168_L0.9801.00
18_Y86_L0.9681.00
134_K162_K0.9671.00
48_S183_N0.9601.00
21_S50_S0.9541.00
167_K188_K0.9351.00
94_L189_I0.9331.00
171_V184_T0.9281.00
88_I91_A0.9201.00
174_N180_D0.9201.00
24_G55_K0.9191.00
91_A114_V0.9171.00
158_L161_D0.9161.00
144_W153_K0.9011.00
185_F189_I0.9001.00
146_S172_G0.8971.00
141_L167_K0.8961.00
32_G97_S0.8961.00
80_N109_K0.8961.00
116_G139_P0.8931.00
143_I171_V0.8851.00
37_A58_S0.8841.00
30_F93_L0.8781.00
95_G103_V0.8781.00
25_S90_K0.8751.00
14_R68_E0.8751.00
96_A176_A0.8731.00
173_K177_C0.8631.00
157_K168_L0.8491.00
54_Y193_L0.8451.00
169_E191_N0.8411.00
50_S56_A0.8381.00
120_V178_Y0.8331.00
41_V58_S0.8311.00
157_K160_L0.8301.00
183_N187_E0.8291.00
157_K170_I0.8251.00
143_I188_K0.8251.00
30_F59_V0.8241.00
59_V82_F0.8221.00
83_M88_I0.8171.00
76_S102_A0.8131.00
28_L83_M0.8121.00
173_K180_D0.8021.00
28_L91_A0.7921.00
81_L85_S0.7761.00
91_A113_S0.7701.00
33_A98_M0.7701.00
25_S54_Y0.7661.00
74_S77_E0.7641.00
73_I105_E0.7631.00
57_I86_L0.7601.00
47_D50_S0.7561.00
61_L98_M0.7521.00
137_K164_K0.7491.00
29_L40_W0.7361.00
147_R172_G0.7341.00
77_E81_L0.7331.00
16_I67_S0.7311.00
42_E47_D0.7291.00
60_D65_G0.7251.00
26_L54_Y0.7131.00
46_V56_A0.7111.00
27_V94_L0.7111.00
77_E80_N0.7101.00
27_V56_A0.7101.00
142_L166_A0.7101.00
93_L114_V0.7091.00
42_E45_T0.7091.00
19_I41_V0.7081.00
169_E184_T0.7071.00
117_L140_L0.7051.00
96_A121_G0.7051.00
81_L84_N0.7051.00
120_V177_C0.7011.00
76_S109_K0.7001.00
121_G177_C0.6911.00
107_S114_V0.6901.00
38_R41_V0.6851.00
26_L91_A0.6781.00
95_G100_G0.6751.00
75_L98_M0.6741.00
146_S153_K0.6731.00
108_L135_L0.6661.00
116_G192_F0.6601.00
156_Y168_L0.6591.00
155_N158_L0.6571.00
107_S138_I0.6571.00
54_Y190_V0.6531.00
186_N190_V0.6491.00
80_N83_M0.6491.00
101_K123_V0.6431.00
17_H67_S0.6431.00
83_M106_F0.6401.00
31_H59_V0.6361.00
21_S47_D0.6351.00
47_D51_S0.6341.00
116_G193_L0.6311.00
121_G144_W0.6311.00
172_G181_D0.6251.00
27_V193_L0.6251.00
25_S116_G0.6251.00
28_L79_I0.6231.00
61_L75_L0.6201.00
136_N140_L0.6201.00
94_L118_V0.6201.00
45_T185_F0.6141.00
51_S190_V0.6141.00
182_P186_N0.6131.00
37_A59_V0.6131.00
45_T48_S0.6091.00
28_L93_L0.6031.00
121_G145_G0.6011.00
187_E190_V0.6001.00
16_I62_P0.6001.00
96_A120_V0.5961.00
60_D66_S0.5941.00
87_G90_K0.5921.00
93_L106_F0.5921.00
171_V181_D0.5901.00
27_V92_I0.5861.00
154_R157_K0.5831.00
46_V50_S0.5811.00
53_G56_A0.5811.00
114_V138_I0.5811.00
61_L64_F0.5801.00
118_V192_F0.5771.00
118_V193_L0.5741.00
35_F176_A0.5731.00
104_L124_G0.5721.00
95_G99_G0.5711.00
23_D55_K0.5661.00
91_A115_S0.5651.00
42_E46_V0.5621.00
145_G177_C0.5551.00
20_E86_L0.5541.00
57_I88_I0.5521.00
73_I77_E0.5521.00
89_D113_S0.5501.00
41_V47_D0.5491.00
136_N163_V0.5451.00
12_K77_E0.5431.00
143_I185_F0.5421.00
62_P75_L0.5391.00
39_T96_A0.5381.00
76_S106_F0.5371.00
177_C185_F0.5351.00
97_S176_A0.5351.00
34_R98_M0.5341.00
119_L142_L0.5341.00
74_S78_F0.5331.00
19_I38_R0.5281.00
189_I193_L0.5211.00
12_K74_S0.5181.00
148_D175_H0.5171.00
24_G54_Y0.5171.00
19_I58_S0.5151.00
40_W46_V0.5121.00
167_K191_N0.5121.00
78_F81_L0.5121.00
33_A64_F0.5081.00
35_F179_L0.5051.00
156_Y160_L0.5051.00
29_L49_I0.5031.00
116_G141_L0.5031.00
27_V49_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4inzA 1 0.9543 100 0.134 Contact Map
3oosA 1 0.9594 100 0.152 Contact Map
1ehyA 1 0.9594 100 0.152 Contact Map
4lxhA 2 0.9797 100 0.171 Contact Map
2pujA 4 0.9898 100 0.172 Contact Map
3r40A 2 0.9492 100 0.18 Contact Map
2xuaA 2 0.9492 100 0.18 Contact Map
4opmA 2 0.9848 100 0.182 Contact Map
1iupA 2 0.9695 100 0.183 Contact Map
3om8A 4 0.9695 100 0.184 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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