GREMLIN Database
Q97WF8 - Uncharacterized protein
UniProt: Q97WF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (305)
Sequences: 2203 (1386)
Seq/√Len: 79.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_V109_L4.6201.00
14_L45_R3.8981.00
298_D303_I3.8151.00
21_I136_A3.7941.00
12_E17_N3.4311.00
193_V242_L3.1381.00
165_T249_H3.0091.00
194_L206_F2.9441.00
81_G137_L2.8151.00
13_A24_L2.7791.00
83_I133_L2.7121.00
245_K248_D2.6891.00
250_L254_K2.6701.00
275_A279_I2.5551.00
70_I82_V2.5111.00
9_L20_A2.4851.00
74_V111_N2.4621.00
282_I313_L2.4601.00
231_T242_L2.4201.00
71_Q109_L2.4001.00
165_T191_I2.3651.00
60_S171_I2.3601.00
12_E20_A2.3371.00
28_I136_A2.3151.00
46_S135_E2.2981.00
227_L248_D2.2811.00
44_K47_G2.2611.00
52_I146_I2.2411.00
54_I167_L2.2201.00
305_K308_H2.1971.00
16_G79_R2.1901.00
134_T147_I2.1881.00
8_K11_E2.1501.00
78_H143_D2.1481.00
168_V186_M2.1221.00
67_G105_D2.1061.00
167_L193_V2.1051.00
81_G142_Y2.0841.00
206_F230_K1.9541.00
72_E76_R1.9201.00
65_I242_L1.9201.00
70_I112_V1.9001.00
71_Q105_D1.8861.00
117_I133_L1.8731.00
214_D225_K1.8631.00
21_I137_L1.8511.00
244_N248_D1.8491.00
50_H250_L1.8441.00
78_H144_K1.8391.00
72_E240_I1.8341.00
172_P202_A1.7931.00
167_L242_L1.7881.00
206_F210_K1.7801.00
65_I169_V1.7481.00
261_K264_I1.7471.00
147_I163_V1.7361.00
25_L133_L1.7211.00
171_I174_A1.7151.00
49_A138_D1.7071.00
306_V310_V1.6981.00
52_I69_L1.6871.00
60_S169_V1.6861.00
76_R247_E1.6731.00
247_E251_N1.6411.00
11_E15_N1.6251.00
203_E230_K1.6211.00
65_I231_T1.6121.00
70_I106_K1.6091.00
75_S109_L1.5961.00
297_E301_E1.5951.00
76_R244_N1.5941.00
229_V245_K1.5781.00
79_R111_N1.5230.99
10_I41_T1.5220.99
26_T30_Y1.5200.99
76_R243_V1.5130.99
295_I309_N1.4910.99
52_I246_I1.4830.99
39_L44_K1.4740.99
71_Q74_V1.4730.99
144_K243_V1.4600.99
24_L38_A1.4440.99
277_R280_D1.4430.99
24_L136_A1.4390.99
241_E244_N1.4300.99
294_I298_D1.4180.99
170_S209_L1.4150.99
254_K259_F1.4060.99
249_H253_L1.3830.99
259_F263_I1.3650.99
251_N255_Q1.3520.99
195_N233_A1.3420.98
96_F181_L1.3300.98
73_Y80_V1.3100.98
193_V231_T1.3090.98
173_G199_R1.2990.98
25_L140_L1.2930.98
60_S205_A1.2790.98
223_G226_P1.2720.98
21_I140_L1.2620.98
164_H263_I1.2590.98
54_I66_I1.2540.98
298_D312_E1.2540.98
10_I38_A1.2440.97
214_D223_G1.2420.97
274_I310_V1.2370.97
291_Y312_E1.2200.97
214_D226_P1.2100.97
126_I162_S1.2060.97
224_W249_H1.2040.97
72_E239_I1.1910.97
291_Y294_I1.1880.97
173_G201_D1.1650.96
71_Q75_S1.1590.96
90_P121_G1.1550.96
42_L136_A1.1450.96
298_D301_E1.1430.96
17_N20_A1.1410.96
191_I245_K1.1230.95
57_I171_I1.1220.95
21_I142_Y1.1160.95
117_I127_S1.1160.95
19_L22_A1.1130.95
73_Y243_V1.1030.95
43_S145_I1.0950.95
101_L178_I1.0940.95
26_T29_E1.0930.95
294_I297_E1.0900.95
37_S41_T1.0890.95
42_L46_S1.0790.94
304_P312_E1.0780.94
13_A140_L1.0720.94
114_V152_A1.0710.94
47_G138_D1.0660.94
167_L246_I1.0490.93
170_S194_L1.0480.93
74_V80_V1.0380.93
253_L258_L1.0280.93
10_I14_L1.0240.93
249_H252_Y1.0180.92
55_T173_G1.0080.92
298_D304_P1.0060.92
277_R281_E1.0040.92
186_M209_L1.0010.92
271_V296_N1.0010.92
38_A44_K0.9980.92
261_K265_D0.9970.91
169_V195_N0.9910.91
258_L261_K0.9910.91
227_L245_K0.9890.91
125_G155_T0.9840.91
186_M216_A0.9800.91
13_A136_A0.9760.91
285_E288_K0.9580.90
9_L27_K0.9580.90
267_R270_I0.9570.90
197_A230_K0.9460.89
106_K114_V0.9450.89
267_R300_T0.9300.88
44_K48_N0.9290.88
54_I69_L0.9250.88
170_S186_M0.9210.88
23_R139_G0.9190.88
203_E206_F0.9160.88
297_E300_T0.9110.87
267_R296_N0.9080.87
172_P201_D0.9050.87
119_S160_E0.9020.87
68_G233_A0.8960.86
167_L191_I0.8910.86
126_I130_A0.8880.86
100_R116_S0.8770.85
166_I190_D0.8760.85
308_H312_E0.8710.85
152_A156_D0.8710.85
173_G208_T0.8690.85
305_K312_E0.8650.84
9_L12_E0.8610.84
147_I280_D0.8600.84
131_L162_S0.8550.84
299_I309_N0.8450.83
85_I204_L0.8450.83
165_T253_L0.8450.83
277_R284_S0.8440.83
238_G241_E0.8410.83
304_P309_N0.8400.83
121_G124_G0.8400.83
30_Y155_T0.8370.82
49_A249_H0.8340.82
85_I155_T0.8320.82
81_G118_G0.8310.82
26_T155_T0.8310.82
123_L155_T0.8260.82
204_L208_T0.8220.81
119_S155_T0.8200.81
72_E236_N0.8200.81
271_V283_I0.8160.81
263_I266_R0.8140.81
39_L43_S0.8070.80
304_P308_H0.8060.80
47_G141_G0.8060.80
74_V110_K0.8010.80
294_I311_K0.8010.80
170_S205_A0.7940.79
221_R226_P0.7920.79
177_D181_L0.7910.79
260_K264_I0.7910.79
66_I146_I0.7890.79
83_I134_T0.7880.78
50_H247_E0.7850.78
260_K301_E0.7840.78
17_N311_K0.7810.78
106_K112_V0.7800.78
64_T197_A0.7770.78
39_L42_L0.7760.77
10_I24_L0.7740.77
251_N294_I0.7730.77
256_K284_S0.7710.77
270_I279_I0.7670.77
135_E269_K0.7630.76
257_E260_K0.7610.76
90_P157_T0.7600.76
272_E275_A0.7580.76
99_N156_D0.7540.75
88_S119_S0.7530.75
72_E75_S0.7520.75
119_S152_A0.7510.75
170_S208_T0.7490.75
64_T232_V0.7480.75
18_E26_T0.7460.75
122_Y158_E0.7430.74
168_V185_I0.7420.74
252_Y256_K0.7420.74
52_I144_K0.7410.74
184_G188_I0.7390.74
32_T35_G0.7370.74
123_L130_A0.7370.74
75_S236_N0.7360.74
300_T304_P0.7360.74
168_V215_S0.7350.74
250_L259_F0.7320.73
221_R258_L0.7310.73
57_I174_A0.7260.73
50_H249_H0.7240.72
83_I137_L0.7200.72
92_T194_L0.7180.72
194_L205_A0.7170.72
258_L262_R0.7150.71
186_M192_Y0.7120.71
131_L269_K0.7080.71
129_E133_L0.7070.71
123_L156_D0.7050.70
104_Q186_M0.7020.70
209_L228_I0.7010.70
149_T159_V0.6980.70
29_E117_I0.6960.69
80_V146_I0.6940.69
8_K12_E0.6940.69
105_D108_M0.6940.69
251_N254_K0.6940.69
287_V290_N0.6910.69
113_F142_Y0.6900.69
170_S174_A0.6900.69
273_L276_R0.6880.69
92_T231_T0.6880.69
207_N211_F0.6880.69
38_A43_S0.6880.69
171_I180_A0.6850.68
295_I298_D0.6850.68
268_A272_E0.6850.68
292_N295_I0.6810.68
191_I246_I0.6780.67
127_S130_A0.6760.67
69_L72_E0.6760.67
250_L253_L0.6760.67
40_G308_H0.6750.67
189_G243_V0.6740.67
10_I34_E0.6740.67
295_I304_P0.6740.67
296_N300_T0.6720.67
171_I181_L0.6710.67
233_A236_N0.6700.66
11_E41_T0.6680.66
181_L212_A0.6680.66
74_V112_V0.6650.66
128_A276_R0.6630.66
134_T163_V0.6630.66
64_T127_S0.6630.66
64_T233_A0.6630.66
22_A25_L0.6610.65
40_G305_K0.6600.65
183_A209_L0.6590.65
65_I128_A0.6570.65
170_S183_A0.6560.65
13_A42_L0.6520.64
145_I250_L0.6510.64
286_I290_N0.6500.64
248_D252_Y0.6500.64
79_R142_Y0.6460.64
68_G236_N0.6430.63
177_D209_L0.6430.63
60_S212_A0.6430.63
88_S198_D0.6420.63
172_P231_T0.6390.63
288_K313_L0.6380.63
233_A239_I0.6370.63
97_M195_N0.6370.63
18_E22_A0.6340.62
170_S201_D0.6330.62
206_F228_I0.6330.62
171_I199_R0.6300.62
11_E240_I0.6270.61
248_D255_Q0.6250.61
299_I305_K0.6250.61
183_A216_A0.6250.61
29_E155_T0.6240.61
309_N312_E0.6190.60
166_I188_I0.6180.60
132_M135_E0.6180.60
103_F189_G0.6170.60
27_K30_Y0.6170.60
46_S138_D0.6170.60
253_L256_K0.6160.60
292_N299_I0.6160.60
290_N294_I0.6150.60
174_A180_A0.6150.60
231_T239_I0.6130.60
28_I77_G0.6120.60
105_D236_N0.6120.60
130_A162_S0.6120.60
36_I310_V0.6110.59
178_I266_R0.6050.59
10_I284_S0.6050.59
244_N247_E0.6030.58
51_V134_T0.6030.58
10_I13_A0.5990.58
295_I312_E0.5970.58
67_G100_R0.5950.57
116_S183_A0.5950.57
25_L29_E0.5940.57
48_N262_R0.5940.57
284_S294_I0.5930.57
124_G150_V0.5920.57
57_I185_I0.5910.57
72_E243_V0.5900.57
58_P150_V0.5900.57
244_N260_K0.5890.57
180_A199_R0.5850.56
171_I201_D0.5850.56
23_R277_R0.5840.56
69_L239_I0.5840.56
136_A140_L0.5830.56
43_S46_S0.5830.56
50_H165_T0.5810.56
286_I289_K0.5810.56
167_L229_V0.5810.56
26_T140_L0.5790.55
288_K294_I0.5790.55
60_S146_I0.5780.55
185_I212_A0.5770.55
131_L135_E0.5760.55
285_E293_T0.5760.55
291_Y295_I0.5750.55
39_L92_T0.5750.55
276_R284_S0.5730.55
21_I132_M0.5720.54
90_P119_S0.5710.54
100_R169_V0.5690.54
122_Y276_R0.5670.54
210_K228_I0.5660.54
215_S242_L0.5660.54
297_E304_P0.5650.54
157_T188_I0.5650.54
162_S171_I0.5630.53
67_G233_A0.5610.53
276_R280_D0.5610.53
95_S177_D0.5570.53
92_T118_G0.5570.53
275_A283_I0.5570.53
68_G239_I0.5570.53
89_S187_E0.5560.52
186_M272_E0.5540.52
96_F177_D0.5530.52
114_V150_V0.5520.52
40_G43_S0.5520.52
277_R311_K0.5510.52
76_R248_D0.5510.52
19_L90_P0.5500.52
69_L246_I0.5490.51
174_A205_A0.5490.51
274_I292_N0.5490.51
122_Y132_M0.5470.51
26_T164_H0.5420.51
23_R208_T0.5420.51
14_L79_R0.5420.51
155_T199_R0.5420.51
37_S145_I0.5410.50
73_Y144_K0.5400.50
65_I233_A0.5400.50
125_G150_V0.5400.50
172_P205_A0.5380.50
22_A85_I0.5380.50
84_V232_V0.5370.50
174_A209_L0.5330.49
203_E233_A0.5330.49
25_L83_I0.5320.49
167_L217_E0.5310.49
66_I70_I0.5310.49
107_T169_V0.5310.49
111_N248_D0.5310.49
173_G177_D0.5300.49
171_I177_D0.5300.49
21_I24_L0.5290.49
194_L216_A0.5280.49
210_K225_K0.5270.49
291_Y297_E0.5270.49
177_D270_I0.5270.49
41_T113_F0.5260.49
12_E57_I0.5260.49
270_I274_I0.5240.48
92_T212_A0.5240.48
30_Y135_E0.5240.48
31_M228_I0.5240.48
189_G192_Y0.5230.48
11_E261_K0.5220.48
224_W253_L0.5200.48
174_A201_D0.5200.48
168_V173_G0.5200.48
30_Y159_V0.5200.48
12_E41_T0.5190.48
25_L78_H0.5170.47
87_P99_N0.5160.47
55_T185_I0.5150.47
15_N18_E0.5150.47
241_E264_I0.5140.47
40_G258_L0.5140.47
89_S150_V0.5140.47
122_Y189_G0.5130.47
235_K240_I0.5120.47
40_G297_E0.5120.47
253_L262_R0.5110.47
263_I299_I0.5110.47
160_E217_E0.5100.46
50_H246_I0.5100.46
229_V242_L0.5100.46
111_N127_S0.5100.46
137_L145_I0.5090.46
210_K227_L0.5090.46
134_T145_I0.5060.46
295_I299_I0.5050.46
41_T44_K0.5050.46
20_A93_M0.5040.46
77_G143_D0.5030.46
49_A139_G0.5030.46
222_N258_L0.5010.45
100_R183_A0.5010.45
123_L152_A0.5010.45
250_L280_D0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wwwA 2 0.9111 100 0.494 Contact Map
2qm8A 2 0.9937 100 0.551 Contact Map
2p67A 2 0.9143 100 0.578 Contact Map
3p32A 2 0.927 100 0.598 Contact Map
4xc8A 2 0.9937 100 0.658 Contact Map
2j69A 1 0.9587 100 0.743 Contact Map
2wsmA 2 0.6413 99.9 0.779 Contact Map
4hi0E 2 0.5873 99.9 0.79 Contact Map
2hf9A 2 0.6603 99.9 0.802 Contact Map
2akaB 1 0.8254 99.9 0.803 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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