Q97WF8 - SULSO - GREMLIN Contacts

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Q97WF8 - Uncharacterized protein

UniProt:	Q97WF8	Sequences: MLNNNLSKLIEEALNGNELAIARLLTKIEYMTDEGISALGTLSKRSGNAHVIGITGIPGSGKSTIIGGLIQEYVSRGHRVGVIVIDPSSPYTMGSFMGNRLRFQDKTMLKNVFVRSIGSRGYLGGISAEALMLTEALDGLGYDKIIIETVGAGQTDTEVEQSVHTILVVSIPGAGDDIQALKAGIMEIGDIYVLNKADRQDAELAFNTLKFAIDSAEISYRNGWKPLIVKTVAIKNEGIIELVNKIEDHLNYLKQKELFKKRIIDRRAKIVELIARRKIDEIISEIVKKNYNTIINEDITEAIPKVIHNVKELLR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	315 (305)
Sequences:	2203 (1386)
Seq/√Len:	79.4

ECOLI - ARGK
HALSA - Q9HRJ1
SULSO - Q97WF8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
74_V	109_L	4.620	1.00
14_L	45_R	3.898	1.00
298_D	303_I	3.815	1.00
21_I	136_A	3.794	1.00
12_E	17_N	3.431	1.00
193_V	242_L	3.138	1.00
165_T	249_H	3.009	1.00
194_L	206_F	2.944	1.00
81_G	137_L	2.815	1.00
13_A	24_L	2.779	1.00
83_I	133_L	2.712	1.00
245_K	248_D	2.689	1.00
250_L	254_K	2.670	1.00
275_A	279_I	2.555	1.00
70_I	82_V	2.511	1.00
9_L	20_A	2.485	1.00
74_V	111_N	2.462	1.00
282_I	313_L	2.460	1.00
231_T	242_L	2.420	1.00
71_Q	109_L	2.400	1.00
165_T	191_I	2.365	1.00
60_S	171_I	2.360	1.00
12_E	20_A	2.337	1.00
28_I	136_A	2.315	1.00
46_S	135_E	2.298	1.00
227_L	248_D	2.281	1.00
44_K	47_G	2.261	1.00
52_I	146_I	2.241	1.00
54_I	167_L	2.220	1.00
305_K	308_H	2.197	1.00
16_G	79_R	2.190	1.00
134_T	147_I	2.188	1.00
8_K	11_E	2.150	1.00
78_H	143_D	2.148	1.00
168_V	186_M	2.122	1.00
67_G	105_D	2.106	1.00
167_L	193_V	2.105	1.00
81_G	142_Y	2.084	1.00
206_F	230_K	1.954	1.00
72_E	76_R	1.920	1.00
65_I	242_L	1.920	1.00
70_I	112_V	1.900	1.00
71_Q	105_D	1.886	1.00
117_I	133_L	1.873	1.00
214_D	225_K	1.863	1.00
21_I	137_L	1.851	1.00
244_N	248_D	1.849	1.00
50_H	250_L	1.844	1.00
78_H	144_K	1.839	1.00
72_E	240_I	1.834	1.00
172_P	202_A	1.793	1.00
167_L	242_L	1.788	1.00
206_F	210_K	1.780	1.00
65_I	169_V	1.748	1.00
261_K	264_I	1.747	1.00
147_I	163_V	1.736	1.00
25_L	133_L	1.721	1.00
171_I	174_A	1.715	1.00
49_A	138_D	1.707	1.00
306_V	310_V	1.698	1.00
52_I	69_L	1.687	1.00
60_S	169_V	1.686	1.00
76_R	247_E	1.673	1.00
247_E	251_N	1.641	1.00
11_E	15_N	1.625	1.00
203_E	230_K	1.621	1.00
65_I	231_T	1.612	1.00
70_I	106_K	1.609	1.00
75_S	109_L	1.596	1.00
297_E	301_E	1.595	1.00
76_R	244_N	1.594	1.00
229_V	245_K	1.578	1.00
79_R	111_N	1.523	0.99
10_I	41_T	1.522	0.99
26_T	30_Y	1.520	0.99
76_R	243_V	1.513	0.99
295_I	309_N	1.491	0.99
52_I	246_I	1.483	0.99
39_L	44_K	1.474	0.99
71_Q	74_V	1.473	0.99
144_K	243_V	1.460	0.99
24_L	38_A	1.444	0.99
277_R	280_D	1.443	0.99
24_L	136_A	1.439	0.99
241_E	244_N	1.430	0.99
294_I	298_D	1.418	0.99
170_S	209_L	1.415	0.99
254_K	259_F	1.406	0.99
249_H	253_L	1.383	0.99
259_F	263_I	1.365	0.99
251_N	255_Q	1.352	0.99
195_N	233_A	1.342	0.98
96_F	181_L	1.330	0.98
73_Y	80_V	1.310	0.98
193_V	231_T	1.309	0.98
173_G	199_R	1.299	0.98
25_L	140_L	1.293	0.98
60_S	205_A	1.279	0.98
223_G	226_P	1.272	0.98
21_I	140_L	1.262	0.98
164_H	263_I	1.259	0.98
54_I	66_I	1.254	0.98
298_D	312_E	1.254	0.98
10_I	38_A	1.244	0.97
214_D	223_G	1.242	0.97
274_I	310_V	1.237	0.97
291_Y	312_E	1.220	0.97
214_D	226_P	1.210	0.97
126_I	162_S	1.206	0.97
224_W	249_H	1.204	0.97
72_E	239_I	1.191	0.97
291_Y	294_I	1.188	0.97
173_G	201_D	1.165	0.96
71_Q	75_S	1.159	0.96
90_P	121_G	1.155	0.96
42_L	136_A	1.145	0.96
298_D	301_E	1.143	0.96
17_N	20_A	1.141	0.96
191_I	245_K	1.123	0.95
57_I	171_I	1.122	0.95
21_I	142_Y	1.116	0.95
117_I	127_S	1.116	0.95
19_L	22_A	1.113	0.95
73_Y	243_V	1.103	0.95
43_S	145_I	1.095	0.95
101_L	178_I	1.094	0.95
26_T	29_E	1.093	0.95
294_I	297_E	1.090	0.95
37_S	41_T	1.089	0.95
42_L	46_S	1.079	0.94
304_P	312_E	1.078	0.94
13_A	140_L	1.072	0.94
114_V	152_A	1.071	0.94
47_G	138_D	1.066	0.94
167_L	246_I	1.049	0.93
170_S	194_L	1.048	0.93
74_V	80_V	1.038	0.93
253_L	258_L	1.028	0.93
10_I	14_L	1.024	0.93
249_H	252_Y	1.018	0.92
55_T	173_G	1.008	0.92
298_D	304_P	1.006	0.92
277_R	281_E	1.004	0.92
186_M	209_L	1.001	0.92
271_V	296_N	1.001	0.92
38_A	44_K	0.998	0.92
261_K	265_D	0.997	0.91
169_V	195_N	0.991	0.91
258_L	261_K	0.991	0.91
227_L	245_K	0.989	0.91
125_G	155_T	0.984	0.91
186_M	216_A	0.980	0.91
13_A	136_A	0.976	0.91
285_E	288_K	0.958	0.90
9_L	27_K	0.958	0.90
267_R	270_I	0.957	0.90
197_A	230_K	0.946	0.89
106_K	114_V	0.945	0.89
267_R	300_T	0.930	0.88
44_K	48_N	0.929	0.88
54_I	69_L	0.925	0.88
170_S	186_M	0.921	0.88
23_R	139_G	0.919	0.88
203_E	206_F	0.916	0.88
297_E	300_T	0.911	0.87
267_R	296_N	0.908	0.87
172_P	201_D	0.905	0.87
119_S	160_E	0.902	0.87
68_G	233_A	0.896	0.86
167_L	191_I	0.891	0.86
126_I	130_A	0.888	0.86
100_R	116_S	0.877	0.85
166_I	190_D	0.876	0.85
308_H	312_E	0.871	0.85
152_A	156_D	0.871	0.85
173_G	208_T	0.869	0.85
305_K	312_E	0.865	0.84
9_L	12_E	0.861	0.84
147_I	280_D	0.860	0.84
131_L	162_S	0.855	0.84
299_I	309_N	0.845	0.83
85_I	204_L	0.845	0.83
165_T	253_L	0.845	0.83
277_R	284_S	0.844	0.83
238_G	241_E	0.841	0.83
304_P	309_N	0.840	0.83
121_G	124_G	0.840	0.83
30_Y	155_T	0.837	0.82
49_A	249_H	0.834	0.82
85_I	155_T	0.832	0.82
81_G	118_G	0.831	0.82
26_T	155_T	0.831	0.82
123_L	155_T	0.826	0.82
204_L	208_T	0.822	0.81
119_S	155_T	0.820	0.81
72_E	236_N	0.820	0.81
271_V	283_I	0.816	0.81
263_I	266_R	0.814	0.81
39_L	43_S	0.807	0.80
304_P	308_H	0.806	0.80
47_G	141_G	0.806	0.80
74_V	110_K	0.801	0.80
294_I	311_K	0.801	0.80
170_S	205_A	0.794	0.79
221_R	226_P	0.792	0.79
177_D	181_L	0.791	0.79
260_K	264_I	0.791	0.79
66_I	146_I	0.789	0.79
83_I	134_T	0.788	0.78
50_H	247_E	0.785	0.78
260_K	301_E	0.784	0.78
17_N	311_K	0.781	0.78
106_K	112_V	0.780	0.78
64_T	197_A	0.777	0.78
39_L	42_L	0.776	0.77
10_I	24_L	0.774	0.77
251_N	294_I	0.773	0.77
256_K	284_S	0.771	0.77
270_I	279_I	0.767	0.77
135_E	269_K	0.763	0.76
257_E	260_K	0.761	0.76
90_P	157_T	0.760	0.76
272_E	275_A	0.758	0.76
99_N	156_D	0.754	0.75
88_S	119_S	0.753	0.75
72_E	75_S	0.752	0.75
119_S	152_A	0.751	0.75
170_S	208_T	0.749	0.75
64_T	232_V	0.748	0.75
18_E	26_T	0.746	0.75
122_Y	158_E	0.743	0.74
168_V	185_I	0.742	0.74
252_Y	256_K	0.742	0.74
52_I	144_K	0.741	0.74
184_G	188_I	0.739	0.74
32_T	35_G	0.737	0.74
123_L	130_A	0.737	0.74
75_S	236_N	0.736	0.74
300_T	304_P	0.736	0.74
168_V	215_S	0.735	0.74
250_L	259_F	0.732	0.73
221_R	258_L	0.731	0.73
57_I	174_A	0.726	0.73
50_H	249_H	0.724	0.72
83_I	137_L	0.720	0.72
92_T	194_L	0.718	0.72
194_L	205_A	0.717	0.72
258_L	262_R	0.715	0.71
186_M	192_Y	0.712	0.71
131_L	269_K	0.708	0.71
129_E	133_L	0.707	0.71
123_L	156_D	0.705	0.70
104_Q	186_M	0.702	0.70
209_L	228_I	0.701	0.70
149_T	159_V	0.698	0.70
29_E	117_I	0.696	0.69
80_V	146_I	0.694	0.69
8_K	12_E	0.694	0.69
105_D	108_M	0.694	0.69
251_N	254_K	0.694	0.69
287_V	290_N	0.691	0.69
113_F	142_Y	0.690	0.69
170_S	174_A	0.690	0.69
273_L	276_R	0.688	0.69
92_T	231_T	0.688	0.69
207_N	211_F	0.688	0.69
38_A	43_S	0.688	0.69
171_I	180_A	0.685	0.68
295_I	298_D	0.685	0.68
268_A	272_E	0.685	0.68
292_N	295_I	0.681	0.68
191_I	246_I	0.678	0.67
127_S	130_A	0.676	0.67
69_L	72_E	0.676	0.67
250_L	253_L	0.676	0.67
40_G	308_H	0.675	0.67
189_G	243_V	0.674	0.67
10_I	34_E	0.674	0.67
295_I	304_P	0.674	0.67
296_N	300_T	0.672	0.67
171_I	181_L	0.671	0.67
233_A	236_N	0.670	0.66
11_E	41_T	0.668	0.66
181_L	212_A	0.668	0.66
74_V	112_V	0.665	0.66
128_A	276_R	0.663	0.66
134_T	163_V	0.663	0.66
64_T	127_S	0.663	0.66
64_T	233_A	0.663	0.66
22_A	25_L	0.661	0.65
40_G	305_K	0.660	0.65
183_A	209_L	0.659	0.65
65_I	128_A	0.657	0.65
170_S	183_A	0.656	0.65
13_A	42_L	0.652	0.64
145_I	250_L	0.651	0.64
286_I	290_N	0.650	0.64
248_D	252_Y	0.650	0.64
79_R	142_Y	0.646	0.64
68_G	236_N	0.643	0.63
177_D	209_L	0.643	0.63
60_S	212_A	0.643	0.63
88_S	198_D	0.642	0.63
172_P	231_T	0.639	0.63
288_K	313_L	0.638	0.63
233_A	239_I	0.637	0.63
97_M	195_N	0.637	0.63
18_E	22_A	0.634	0.62
170_S	201_D	0.633	0.62
206_F	228_I	0.633	0.62
171_I	199_R	0.630	0.62
11_E	240_I	0.627	0.61
248_D	255_Q	0.625	0.61
299_I	305_K	0.625	0.61
183_A	216_A	0.625	0.61
29_E	155_T	0.624	0.61
309_N	312_E	0.619	0.60
166_I	188_I	0.618	0.60
132_M	135_E	0.618	0.60
103_F	189_G	0.617	0.60
27_K	30_Y	0.617	0.60
46_S	138_D	0.617	0.60
253_L	256_K	0.616	0.60
292_N	299_I	0.616	0.60
290_N	294_I	0.615	0.60
174_A	180_A	0.615	0.60
231_T	239_I	0.613	0.60
28_I	77_G	0.612	0.60
105_D	236_N	0.612	0.60
130_A	162_S	0.612	0.60
36_I	310_V	0.611	0.59
178_I	266_R	0.605	0.59
10_I	284_S	0.605	0.59
244_N	247_E	0.603	0.58
51_V	134_T	0.603	0.58
10_I	13_A	0.599	0.58
295_I	312_E	0.597	0.58
67_G	100_R	0.595	0.57
116_S	183_A	0.595	0.57
25_L	29_E	0.594	0.57
48_N	262_R	0.594	0.57
284_S	294_I	0.593	0.57
124_G	150_V	0.592	0.57
57_I	185_I	0.591	0.57
72_E	243_V	0.590	0.57
58_P	150_V	0.590	0.57
244_N	260_K	0.589	0.57
180_A	199_R	0.585	0.56
171_I	201_D	0.585	0.56
23_R	277_R	0.584	0.56
69_L	239_I	0.584	0.56
136_A	140_L	0.583	0.56
43_S	46_S	0.583	0.56
50_H	165_T	0.581	0.56
286_I	289_K	0.581	0.56
167_L	229_V	0.581	0.56
26_T	140_L	0.579	0.55
288_K	294_I	0.579	0.55
60_S	146_I	0.578	0.55
185_I	212_A	0.577	0.55
131_L	135_E	0.576	0.55
285_E	293_T	0.576	0.55
291_Y	295_I	0.575	0.55
39_L	92_T	0.575	0.55
276_R	284_S	0.573	0.55
21_I	132_M	0.572	0.54
90_P	119_S	0.571	0.54
100_R	169_V	0.569	0.54
122_Y	276_R	0.567	0.54
210_K	228_I	0.566	0.54
215_S	242_L	0.566	0.54
297_E	304_P	0.565	0.54
157_T	188_I	0.565	0.54
162_S	171_I	0.563	0.53
67_G	233_A	0.561	0.53
276_R	280_D	0.561	0.53
95_S	177_D	0.557	0.53
92_T	118_G	0.557	0.53
275_A	283_I	0.557	0.53
68_G	239_I	0.557	0.53
89_S	187_E	0.556	0.52
186_M	272_E	0.554	0.52
96_F	177_D	0.553	0.52
114_V	150_V	0.552	0.52
40_G	43_S	0.552	0.52
277_R	311_K	0.551	0.52
76_R	248_D	0.551	0.52
19_L	90_P	0.550	0.52
69_L	246_I	0.549	0.51
174_A	205_A	0.549	0.51
274_I	292_N	0.549	0.51
122_Y	132_M	0.547	0.51
26_T	164_H	0.542	0.51
23_R	208_T	0.542	0.51
14_L	79_R	0.542	0.51
155_T	199_R	0.542	0.51
37_S	145_I	0.541	0.50
73_Y	144_K	0.540	0.50
65_I	233_A	0.540	0.50
125_G	150_V	0.540	0.50
172_P	205_A	0.538	0.50
22_A	85_I	0.538	0.50
84_V	232_V	0.537	0.50
174_A	209_L	0.533	0.49
203_E	233_A	0.533	0.49
25_L	83_I	0.532	0.49
167_L	217_E	0.531	0.49
66_I	70_I	0.531	0.49
107_T	169_V	0.531	0.49
111_N	248_D	0.531	0.49
173_G	177_D	0.530	0.49
171_I	177_D	0.530	0.49
21_I	24_L	0.529	0.49
194_L	216_A	0.528	0.49
210_K	225_K	0.527	0.49
291_Y	297_E	0.527	0.49
177_D	270_I	0.527	0.49
41_T	113_F	0.526	0.49
12_E	57_I	0.526	0.49
270_I	274_I	0.524	0.48
92_T	212_A	0.524	0.48
30_Y	135_E	0.524	0.48
31_M	228_I	0.524	0.48
189_G	192_Y	0.523	0.48
11_E	261_K	0.522	0.48
224_W	253_L	0.520	0.48
174_A	201_D	0.520	0.48
168_V	173_G	0.520	0.48
30_Y	159_V	0.520	0.48
12_E	41_T	0.519	0.48
25_L	78_H	0.517	0.47
87_P	99_N	0.516	0.47
55_T	185_I	0.515	0.47
15_N	18_E	0.515	0.47
241_E	264_I	0.514	0.47
40_G	258_L	0.514	0.47
89_S	150_V	0.514	0.47
122_Y	189_G	0.513	0.47
235_K	240_I	0.512	0.47
40_G	297_E	0.512	0.47
253_L	262_R	0.511	0.47
263_I	299_I	0.511	0.47
160_E	217_E	0.510	0.46
50_H	246_I	0.510	0.46
229_V	242_L	0.510	0.46
111_N	127_S	0.510	0.46
137_L	145_I	0.509	0.46
210_K	227_L	0.509	0.46
134_T	145_I	0.506	0.46
295_I	299_I	0.505	0.46
41_T	44_K	0.505	0.46
20_A	93_M	0.504	0.46
77_G	143_D	0.503	0.46
49_A	139_G	0.503	0.46
222_N	258_L	0.501	0.45
100_R	183_A	0.501	0.45
123_L	152_A	0.501	0.45
250_L	280_D	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wwwA	2	0.9111	100	0.494	Contact Map
2qm8A	2	0.9937	100	0.551	Contact Map
2p67A	2	0.9143	100	0.578	Contact Map
3p32A	2	0.927	100	0.598	Contact Map
4xc8A	2	0.9937	100	0.658	Contact Map
2j69A	1	0.9587	100	0.743	Contact Map
2wsmA	2	0.6413	99.9	0.779	Contact Map
4hi0E	2	0.5873	99.9	0.79	Contact Map
2hf9A	2	0.6603	99.9	0.802	Contact Map
2akaB	1	0.8254	99.9	0.803	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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