GREMLIN Database
Q97WF7 - Methylmalonyl-CoA mutase, alpha-subunit, chain B (McmA2)
UniProt: Q97WF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 141 (129)
Sequences: 1785 (706)
Seq/√Len: 62.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_I59_A4.5761.00
75_I94_V4.3041.00
107_K113_E3.2661.00
81_I84_Q2.8571.00
104_K108_E2.8011.00
61_V93_I2.7621.00
115_F127_K2.5241.00
79_V92_L2.4901.00
12_V24_A2.2871.00
72_L105_K2.2831.00
52_R56_Q2.2831.00
52_R85_N2.2441.00
51_V81_I2.2141.00
87_L90_V2.2011.00
83_K88_N1.9341.00
15_L50_I1.9291.00
82_M87_L1.8511.00
48_E81_I1.8421.00
54_A62_I1.8251.00
77_K80_E1.8111.00
79_V111_V1.7270.99
80_E84_Q1.7130.99
64_I78_V1.6780.99
15_L64_I1.6300.99
27_V31_L1.6050.99
8_I36_M1.5550.99
55_L87_L1.5470.99
34_A125_V1.5450.99
81_I85_N1.4960.98
13_A50_I1.4610.98
105_K108_E1.4610.98
45_Q49_Q1.4370.98
91_G112_D1.4020.97
54_A90_V1.4010.97
39_V57_E1.3720.97
122_K126_E1.3020.96
126_E130_K1.2830.96
107_K114_V1.2810.96
105_K109_M1.2760.95
9_K39_V1.2720.95
79_V83_K1.2650.95
9_K37_E1.2560.95
103_I116_L1.2530.95
37_E57_E1.2310.94
31_L124_I1.1990.94
51_V85_N1.1870.93
55_L85_N1.1740.93
91_G131_V1.1440.92
41_T45_Q1.1440.92
61_V128_V1.1430.92
113_E127_K1.1050.90
71_H99_P1.1030.90
55_L90_V1.0920.90
6_K60_D1.0880.90
103_I114_V1.0640.89
76_P109_M1.0570.88
51_V82_M1.0490.88
92_L111_V1.0330.87
104_K107_K1.0140.86
115_F131_V0.9980.85
91_G127_K0.9850.85
9_K58_D0.9840.85
27_V124_I0.9830.85
16_G23_G0.9830.85
94_V111_V0.9770.84
82_M92_L0.9660.83
61_V132_A0.9560.83
61_V131_V0.9530.83
31_L128_V0.9500.82
11_I62_I0.9430.82
54_A59_A0.9310.81
21_D25_K0.9280.81
62_I79_V0.9230.81
10_V61_V0.9130.80
64_I75_I0.9010.79
91_G132_A0.8990.79
20_H23_G0.8940.78
51_V62_I0.8860.78
22_R70_A0.8730.77
91_G128_V0.8730.77
113_E131_V0.8680.76
30_A125_V0.8600.76
30_A118_G0.8500.75
50_I74_L0.8490.75
39_V58_D0.8410.74
75_I111_V0.8300.73
7_R60_D0.8220.72
36_M61_V0.8150.72
36_M129_K0.8130.71
21_D70_A0.8090.71
103_I107_K0.8090.71
17_L44_R0.8090.71
15_L78_V0.8070.71
94_V114_V0.8040.71
76_P80_E0.8000.70
119_S124_I0.8000.70
97_V117_P0.7990.70
112_D131_V0.7990.70
7_R39_V0.7860.69
93_I131_V0.7740.68
44_R73_E0.7710.67
107_K130_K0.7650.67
42_G50_I0.7620.67
72_L109_M0.7620.67
116_L119_S0.7580.66
48_E77_K0.7570.66
120_S123_E0.7490.65
66_I94_V0.7490.65
37_E59_A0.7340.64
76_P105_K0.7280.63
64_I111_V0.7220.62
71_H106_L0.7070.61
77_K81_I0.7020.60
92_L112_D0.6920.59
80_E109_M0.6900.59
127_K131_V0.6900.59
25_K28_A0.6850.58
66_I97_V0.6830.58
80_E83_K0.6830.58
19_G25_K0.6810.58
44_R127_K0.6810.58
123_E126_E0.6780.57
72_L76_P0.6770.57
10_V31_L0.6750.57
19_G71_H0.6550.55
27_V121_L0.6540.55
70_A118_G0.6510.54
27_V93_I0.6490.54
47_P74_L0.6460.54
26_V30_A0.6420.53
34_A126_E0.6420.53
70_A97_V0.6360.53
21_D71_H0.6330.52
14_K99_P0.6310.52
88_N108_E0.6270.52
32_K40_Y0.6200.51
7_R37_E0.6190.51
21_D43_L0.6190.51
19_G46_T0.6170.51
37_E49_Q0.6020.49
44_R68_S0.6010.49
62_I78_V0.6010.49
76_P117_P0.5960.48
62_I86_G0.5950.48
37_E58_D0.5900.47
13_A43_L0.5900.47
24_A41_T0.5880.47
49_Q90_V0.5800.46
97_V116_L0.5780.46
88_N91_G0.5770.46
128_V132_A0.5700.45
32_K39_V0.5700.45
61_V91_G0.5660.45
39_V53_A0.5640.45
83_K112_D0.5630.44
42_G57_E0.5630.44
79_V103_I0.5590.44
12_V41_T0.5560.44
79_V109_M0.5540.43
83_K111_V0.5530.43
32_K57_E0.5530.43
130_K133_R0.5510.43
126_E129_K0.5510.43
36_M132_A0.5470.43
27_V63_G0.5460.43
46_T49_Q0.5440.42
94_V109_M0.5410.42
53_A57_E0.5410.42
40_Y57_E0.5400.42
12_V28_A0.5400.42
27_V106_L0.5360.41
51_V55_L0.5350.41
19_G44_R0.5320.41
47_P78_V0.5310.41
72_L111_V0.5280.41
17_L40_Y0.5210.40
22_R99_P0.5210.40
10_V36_M0.5210.40
28_A63_G0.5200.40
112_D126_E0.5120.39
25_K46_T0.5110.39
45_Q125_V0.5110.39
108_E133_R0.5100.39
22_R25_K0.5090.38
48_E52_R0.5080.38
42_G53_A0.5060.38
41_T50_I0.5060.38
43_L73_E0.5060.38
41_T44_R0.5040.38
14_K19_G0.5020.38
48_E85_N0.5010.38
7_R52_R0.5000.37
65_S95_G0.5000.37
97_V114_V0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xijA 2 0.9504 100 0.409 Contact Map
1reqA 1 0.9787 100 0.415 Contact Map
1reqB 1 0.9362 100 0.498 Contact Map
4xc8A 2 0.9858 100 0.498 Contact Map
3kp1A 2 0.9504 100 0.5 Contact Map
1xrsB 2 0.9574 99.9 0.548 Contact Map
4r3uC 1 0.9291 99.9 0.577 Contact Map
3bulA 1 0.9716 99.9 0.583 Contact Map
3ezxA 2 0.8794 99.8 0.628 Contact Map
2i2xB 1 0.9433 99.8 0.63 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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