GREMLIN Database
Q97WF4 - Uncharacterized protein
UniProt: Q97WF4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 293 (242)
Sequences: 7627 (5370)
Seq/√Len: 345.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_G175_F3.8441.00
28_F254_I3.3171.00
277_Y281_I3.1561.00
116_L179_F2.8721.00
83_I245_V2.7671.00
20_I243_G2.6881.00
79_L241_L2.6421.00
95_R206_R2.6121.00
83_I249_Y2.4741.00
89_F96_V2.3951.00
173_A195_G2.3671.00
137_A275_A2.3071.00
261_Q265_K2.2651.00
138_I142_R2.2101.00
22_S44_L2.1931.00
24_I246_V2.1761.00
103_T217_T2.1691.00
105_P171_I2.0871.00
262_T265_K2.0501.00
74_A222_A2.0401.00
23_G240_Y2.0061.00
99_G213_I1.9601.00
203_D206_R1.9181.00
276_I280_Y1.9051.00
253_T257_R1.9031.00
130_G275_A1.9001.00
111_V225_T1.8601.00
68_L71_G1.8501.00
272_I276_I1.8491.00
95_R98_E1.7591.00
175_F179_F1.7551.00
75_L237_S1.7531.00
98_E202_L1.7491.00
87_M252_S1.7461.00
72_T237_S1.7181.00
137_A272_I1.7071.00
82_Y216_G1.6881.00
45_L240_Y1.6881.00
259_P262_T1.6801.00
97_P100_I1.6581.00
52_A66_T1.6501.00
227_A234_I1.6381.00
88_H255_A1.6261.00
88_H93_N1.6181.00
238_L242_L1.6061.00
242_L246_V1.5751.00
265_K269_I1.5731.00
100_I104_I1.5641.00
20_I239_L1.5591.00
131_F135_A1.5221.00
134_I275_A1.5121.00
249_Y253_T1.4771.00
97_P101_I1.4701.00
100_I103_T1.4481.00
26_V40_L1.4451.00
68_L233_D1.4451.00
99_G210_T1.4431.00
137_A268_A1.4391.00
233_D236_I1.4371.00
16_Y239_L1.4371.00
85_S213_I1.4251.00
106_G218_F1.4241.00
168_T172_P1.4241.00
193_V207_A1.4231.00
28_F250_T1.4181.00
91_R256_S1.4181.00
115_Y119_L1.3981.00
21_I25_L1.3951.00
177_V191_L1.3931.00
132_L184_F1.3771.00
24_I247_G1.3481.00
107_V221_T1.3471.00
112_I175_F1.3351.00
17_L21_I1.3321.00
84_N248_G1.3311.00
235_V239_L1.3261.00
170_V200_T1.3131.00
23_G243_G1.3091.00
109_G179_F1.2971.00
70_L226_Y1.2911.00
140_M267_F1.2911.00
96_V100_I1.2831.00
224_I228_V1.2801.00
52_A68_L1.2791.00
197_L207_A1.2781.00
120_M183_Y1.2771.00
141_W268_A1.2741.00
110_D222_A1.2581.00
38_S182_G1.2561.00
111_V115_Y1.2511.00
145_C148_N1.2491.00
104_I108_I1.2401.00
225_T229_Y1.2331.00
109_G113_G1.2291.00
102_F196_L1.2271.00
130_G279_M1.2041.00
193_V211_S1.1971.00
114_A222_A1.1861.00
269_I273_V1.1841.00
89_F94_V1.1721.00
85_S89_F1.1571.00
192_V214_A1.1381.00
24_I250_T1.1381.00
24_I243_G1.1371.00
188_G192_V1.1231.00
78_G220_V1.1221.00
193_V208_V1.1191.00
205_L255_A1.1141.00
172_P176_L1.1061.00
88_H252_S1.1001.00
51_L236_I1.0991.00
96_V99_G1.0911.00
142_R145_C1.0791.00
247_G251_G1.0791.00
105_P109_G1.0711.00
20_I242_L1.0701.00
124_L128_L1.0671.00
105_P174_G1.0661.00
231_Y235_V1.0621.00
188_G194_P1.0401.00
88_H209_G1.0321.00
85_S216_G1.0311.00
215_V218_F1.0251.00
19_S240_Y1.0171.00
112_I115_Y1.0091.00
84_N212_L1.0061.00
26_V41_A1.0021.00
114_A225_T0.9931.00
87_M91_R0.9711.00
96_V213_I0.9631.00
18_L21_I0.9621.00
71_G232_V0.9581.00
85_S96_V0.9581.00
50_G69_T0.9551.00
127_F131_F0.9521.00
168_T171_I0.9511.00
122_G126_L0.9471.00
145_C149_R0.9471.00
94_V210_T0.9421.00
93_N209_G0.9371.00
105_P108_I0.9281.00
42_I73_T0.9141.00
78_G223_A0.9111.00
94_V99_G0.9051.00
253_T256_S0.9011.00
41_A240_Y0.8931.00
70_L117_S0.8921.00
273_V277_Y0.8901.00
166_K169_K0.8881.00
273_V276_I0.8811.00
46_L66_T0.8801.00
245_V249_Y0.8801.00
19_S236_I0.8781.00
75_L223_A0.8751.00
135_A139_R0.8751.00
174_G192_V0.8731.00
114_A221_T0.8701.00
238_L241_L0.8691.00
262_T266_L0.8691.00
87_M249_Y0.8641.00
86_Y90_R0.8611.00
117_S226_Y0.8561.00
73_T77_V0.8541.00
81_S185_G0.8531.00
223_A237_S0.8521.00
181_S218_F0.8521.00
106_G214_A0.8481.00
112_I179_F0.8471.00
31_G252_S0.8451.00
72_T232_V0.8381.00
106_G192_V0.8361.00
197_L204_M0.8351.00
169_K172_P0.8351.00
226_Y231_Y0.8341.00
18_L22_S0.8311.00
143_S264_R0.8311.00
30_L38_S0.8301.00
248_G252_S0.8281.00
80_N244_G0.8241.00
30_L181_S0.8231.00
177_V188_G0.8181.00
52_A67_H0.8161.00
20_I24_I0.8141.00
164_R167_V0.8121.00
123_A127_F0.8121.00
27_G37_G0.8121.00
77_V181_S0.8081.00
23_G236_I0.8011.00
26_V44_L0.8001.00
185_G188_G0.7981.00
204_M208_V0.7931.00
70_L74_A0.7901.00
268_A272_I0.7841.00
32_L263_L0.7831.00
31_G84_N0.7751.00
81_S215_V0.7741.00
77_V219_G0.7741.00
243_G247_G0.7741.00
258_M262_T0.7721.00
38_S77_V0.7701.00
99_G214_A0.7701.00
32_L251_G0.7631.00
87_M253_T0.7601.00
112_I116_L0.7571.00
83_I87_M0.7571.00
23_G27_G0.7571.00
267_F271_I0.7561.00
212_L215_V0.7521.00
121_S124_L0.7501.00
102_F214_A0.7481.00
115_Y118_H0.7471.00
124_L127_F0.7471.00
51_L68_L0.7451.00
255_A263_L0.7441.00
39_I133_M0.7391.00
74_A77_V0.7391.00
149_R153_Y0.7381.00
75_L241_L0.7300.99
188_G215_V0.7300.99
20_I246_V0.7280.99
51_L233_D0.7280.99
204_M267_F0.7250.99
181_S188_G0.7250.99
239_L243_G0.7240.99
126_L281_I0.7210.99
71_G223_A0.7200.99
89_F92_G0.7170.99
127_F130_G0.7140.99
70_L125_I0.7130.99
134_I272_I0.7120.99
110_D114_A0.7100.99
30_L40_L0.7080.99
76_A244_G0.7070.99
116_L119_L0.7030.99
67_H71_G0.7030.99
113_G179_F0.7020.99
164_R168_T0.7020.99
134_I138_I0.6990.99
72_T233_D0.6980.99
101_I104_I0.6960.99
20_I23_G0.6940.99
36_G78_G0.6930.99
27_G244_G0.6920.99
218_F244_G0.6910.99
115_Y225_T0.6900.99
172_P175_F0.6880.99
101_I167_V0.6870.99
97_P167_V0.6870.99
130_G134_I0.6870.99
30_L80_N0.6830.99
86_Y89_F0.6820.99
74_A219_G0.6810.99
30_L215_V0.6800.99
235_V238_L0.6790.99
93_N256_S0.6780.99
33_I248_G0.6780.99
46_L69_T0.6700.99
137_A141_W0.6680.99
108_I112_I0.6650.99
82_Y86_Y0.6630.99
23_G41_A0.6620.99
185_G211_S0.6590.99
275_A279_M0.6590.99
174_G178_G0.6510.99
192_V196_L0.6510.99
98_E206_R0.6500.99
130_G278_T0.6500.99
149_R152_L0.6490.99
143_S146_N0.6460.99
223_A227_A0.6440.99
16_Y20_I0.6430.99
213_I217_T0.6390.99
30_L77_V0.6350.99
259_P263_L0.6280.98
68_L72_T0.6270.98
211_S215_V0.6260.98
51_L69_T0.6210.98
74_A185_G0.6210.98
114_A182_G0.6200.98
30_L35_G0.6190.98
36_G43_P0.6190.98
189_G211_S0.6190.98
81_S248_G0.6160.98
38_S186_I0.6140.98
31_G248_G0.6140.98
24_I28_F0.6120.98
147_P150_S0.6080.98
195_G199_S0.6070.98
19_S182_G0.6070.98
78_G81_S0.6060.98
108_I111_V0.6060.98
77_V188_G0.6020.98
186_I190_F0.6000.98
147_P151_V0.5990.98
37_G186_I0.5970.98
74_A181_S0.5940.98
41_A77_V0.5920.98
148_N151_V0.5910.98
187_G215_V0.5860.97
32_L258_M0.5860.97
107_V217_T0.5830.97
137_A271_I0.5830.97
92_G95_R0.5810.97
277_Y280_Y0.5800.97
77_V81_S0.5780.97
141_W272_I0.5770.97
83_I248_G0.5720.97
227_A232_V0.5720.97
67_H70_L0.5680.97
250_T253_T0.5680.97
120_M124_L0.5680.97
181_S186_I0.5670.97
66_T122_G0.5610.97
129_F184_F0.5610.97
118_H229_Y0.5600.97
191_L194_P0.5600.97
254_I258_M0.5580.97
24_I27_G0.5580.97
32_L254_I0.5570.97
47_Y278_T0.5550.97
207_A211_S0.5530.96
42_I184_F0.5510.96
93_N206_R0.5500.96
87_M90_R0.5490.96
169_K195_G0.5460.96
185_G226_Y0.5440.96
18_L49_V0.5430.96
140_M194_P0.5400.96
66_T69_T0.5400.96
232_V237_S0.5400.96
37_G73_T0.5390.96
196_L210_T0.5380.96
38_S41_A0.5370.96
70_L208_V0.5340.96
42_I129_F0.5330.96
116_L120_M0.5330.96
66_T70_L0.5310.96
33_I208_V0.5300.95
133_M271_I0.5300.95
165_I169_K0.5280.95
258_M263_L0.5250.95
237_S241_L0.5250.95
34_G187_G0.5250.95
111_V228_V0.5230.95
79_L245_V0.5220.95
264_R268_A0.5210.95
205_L260_R0.5210.95
19_S49_V0.5180.95
81_S216_G0.5170.95
27_G32_L0.5170.95
91_R253_T0.5160.95
66_T125_I0.5160.95
196_L214_A0.5150.95
110_D221_T0.5150.95
204_M260_R0.5150.95
81_S188_G0.5120.95
125_I183_Y0.5110.95
85_S94_V0.5100.94
19_S239_L0.5070.94
218_F223_A0.5060.94
246_V250_T0.5050.94
188_G211_S0.5030.94
212_L216_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.8703 77.1 0.925 Contact Map
1pw4A 1 0.8805 73.4 0.928 Contact Map
3o7qA 1 0.8908 64.6 0.932 Contact Map
3wdoA 1 0.8874 60.8 0.934 Contact Map
4j05A 3 0.8567 45.9 0.939 Contact Map
3qe7A 2 0.4778 43.8 0.94 Contact Map
4pypA 1 0.8942 38.1 0.942 Contact Map
4m64A 1 0.8259 32.2 0.944 Contact Map
2cfqA 1 0.8498 31.7 0.944 Contact Map
3l1lA 2 0.4505 26.3 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.