GREMLIN Database
Q97WF3 - Uncharacterized protein
UniProt: Q97WF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (119)
Sequences: 2693 (1870)
Seq/√Len: 171.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_T78_N2.9541.00
88_E102_C2.9121.00
91_L108_F2.6821.00
19_L84_H2.5631.00
104_Y113_P2.5121.00
100_T115_E2.3821.00
82_K121_Y2.2981.00
14_E57_K2.2951.00
97_D100_T2.2161.00
13_R46_S2.2031.00
21_I60_V2.1911.00
61_K68_W2.0441.00
25_N74_T1.9651.00
89_I93_N1.9641.00
33_I47_V1.9061.00
119_K122_N1.8421.00
15_F110_Y1.8411.00
121_Y126_K1.8191.00
112_I117_I1.7861.00
79_Y114_E1.7611.00
92_V98_K1.6811.00
19_L106_K1.6561.00
23_R81_I1.6331.00
49_E53_H1.6301.00
42_I47_V1.6161.00
51_V60_V1.5821.00
59_L72_N1.5331.00
71_N74_T1.5131.00
87_I112_I1.4661.00
72_N75_R1.4541.00
122_N126_K1.4451.00
55_E62_K1.4441.00
107_Q111_L1.4431.00
20_T39_D1.4411.00
106_K110_Y1.3971.00
27_S39_D1.3951.00
90_L94_I1.3751.00
90_L123_Y1.3211.00
21_I31_A1.2691.00
35_R38_K1.2641.00
15_F109_D1.2551.00
12_R16_S1.2381.00
51_V67_V1.2241.00
23_R39_D1.2191.00
88_E92_V1.1761.00
84_H102_C1.1701.00
20_T36_I1.1561.00
11_S14_E1.1461.00
87_I120_L1.1381.00
124_L127_P1.1051.00
79_Y83_A1.1011.00
114_E118_D1.0921.00
25_N31_A1.0801.00
82_K86_V1.0791.00
106_K109_D1.0761.00
46_S50_E1.0751.00
22_K81_I1.0290.99
17_Y46_S1.0250.99
36_I51_V1.0240.99
24_Y31_A0.9620.99
104_Y116_I0.9570.99
75_R79_Y0.9520.99
16_S106_K0.9440.99
92_V101_A0.9360.99
97_D115_E0.9350.99
15_F80_L0.9160.99
40_L50_E0.9160.99
14_E50_E0.9150.99
36_I67_V0.9080.98
44_P50_E0.8970.98
115_E119_K0.8960.98
18_L22_K0.8950.98
25_N29_E0.8940.98
30_G66_G0.8890.98
22_K77_I0.8890.98
54_L59_L0.8820.98
48_F62_K0.8780.98
85_R88_E0.8640.98
18_L76_S0.8590.98
94_I119_K0.8500.98
96_I104_Y0.8500.98
96_I116_I0.8480.98
61_K70_T0.8410.98
33_I51_V0.8380.97
76_S79_Y0.8200.97
105_S111_L0.8160.97
60_V67_V0.8160.97
19_L109_D0.8090.97
25_N30_G0.8080.97
26_D85_R0.8060.97
83_A117_I0.8050.97
100_T104_Y0.7870.96
84_H106_K0.7860.96
10_L14_E0.7810.96
22_K26_D0.7730.96
87_I116_I0.7700.96
101_A106_K0.7650.96
34_N44_P0.7600.96
19_L23_R0.7540.95
16_S19_L0.7540.95
58_G72_N0.7530.95
83_A114_E0.7470.95
16_S111_L0.7430.95
28_G35_R0.7400.95
84_H88_E0.7390.95
33_I44_P0.7360.95
33_I48_F0.7270.94
52_S55_E0.7260.94
90_L124_L0.7220.94
71_N75_R0.7180.94
104_Y107_Q0.7160.94
16_S110_Y0.7140.94
36_I47_V0.7090.94
20_T23_R0.7080.93
50_E53_H0.7040.93
11_S64_E0.6970.93
17_Y47_V0.6890.93
43_A49_E0.6870.92
112_I116_I0.6820.92
104_Y112_I0.6730.92
42_I46_S0.6680.91
88_E98_K0.6590.91
19_L89_I0.6590.91
30_G68_W0.6580.91
118_D121_Y0.6480.90
72_N76_S0.6460.90
104_Y111_L0.6440.90
37_A42_I0.6430.90
32_K35_R0.6390.89
37_A46_S0.6360.89
14_E53_H0.6340.89
33_I62_K0.6340.89
14_E52_S0.6330.89
16_S109_D0.6300.89
10_L57_K0.6220.88
20_T40_L0.6190.88
21_I47_V0.6170.88
96_I100_T0.6160.88
12_R107_Q0.6150.88
95_G119_K0.6080.87
43_A48_F0.6040.87
14_E80_L0.6000.86
84_H109_D0.5960.86
52_S56_E0.5910.85
49_E52_S0.5820.85
22_K74_T0.5780.84
47_V51_V0.5750.84
22_K78_N0.5740.84
117_I121_Y0.5720.84
83_A113_P0.5720.84
19_L81_I0.5710.84
51_V62_K0.5670.83
81_I85_R0.5650.83
80_L83_A0.5650.83
93_N124_L0.5600.82
118_D122_N0.5580.82
42_I50_E0.5540.82
48_F64_E0.5470.81
45_S48_F0.5450.81
13_R16_S0.5440.80
78_N82_K0.5410.80
90_L120_L0.5410.80
52_S62_K0.5400.80
35_R39_D0.5390.80
86_V124_L0.5380.80
40_L44_P0.5350.79
86_V120_L0.5260.78
63_K68_W0.5260.78
15_F76_S0.5250.78
85_R127_P0.5230.78
16_S116_I0.5160.77
104_Y119_K0.5150.77
12_R31_A0.5090.76
113_P116_I0.5070.76
81_I88_E0.5070.76
77_I105_S0.5060.76
24_Y35_R0.5050.75
91_L101_A0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fx7A 4 0.9565 100 0.413 Contact Map
2qq9A 2 0.942 100 0.42 Contact Map
4o5vA 2 0.9348 99.9 0.43 Contact Map
3hrsA 2 0.9275 99.9 0.442 Contact Map
2x4hA 3 0.9493 99.9 0.533 Contact Map
1on2A 2 0.9348 99.8 0.579 Contact Map
2h09A 2 0.9058 99.7 0.622 Contact Map
2p8tA 1 0.8188 99.6 0.636 Contact Map
2fxaA 4 0.942 99 0.735 Contact Map
2nyxA 2 0.8261 98.8 0.754 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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