GREMLIN Database
Q97WF2 - Dihydrodipicolinate synthase (DapA-1)
UniProt: Q97WF2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 289 (279)
Sequences: 10349 (6782)
Seq/√Len: 406.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_N228_R3.7341.00
28_D65_M3.3511.00
113_I147_K3.1071.00
13_D17_N3.0641.00
258_Y281_Y2.9791.00
24_Q65_M2.8521.00
20_T57_L2.7751.00
24_Q61_K2.6981.00
20_T61_K2.6491.00
90_Y124_D2.6041.00
56_I88_K2.6021.00
220_E228_R2.5061.00
74_V86_A2.4861.00
194_A199_T2.3671.00
86_A97_I2.2321.00
228_R231_E2.1081.00
215_T219_L2.0431.00
29_F33_K2.0191.00
146_E173_A2.0141.00
220_E225_N2.0041.00
109_E141_P1.9861.00
117_S151_E1.9851.00
219_L223_R1.9761.00
5_I37_D1.9701.00
195_L221_F1.9221.00
281_Y285_K1.9171.00
19_N22_A1.9041.00
57_L60_S1.9031.00
117_S121_N1.9031.00
109_E144_I1.8761.00
36_K219_L1.8671.00
52_Q81_N1.8621.00
121_N151_E1.8551.00
79_T115_Y1.8481.00
110_K114_S1.8421.00
213_L235_I1.8341.00
33_K212_E1.8281.00
139_N166_S1.8171.00
113_I117_S1.7961.00
27_L62_I1.7681.00
24_Q64_E1.7581.00
28_D32_K1.7541.00
110_K147_K1.7511.00
57_L61_K1.7141.00
23_L62_I1.6791.00
60_S64_E1.6721.00
63_R70_I1.6531.00
257_R264_G1.6511.00
128_F156_G1.6501.00
114_S117_S1.6381.00
6_S207_S1.6231.00
22_A25_Q1.6201.00
61_K65_M1.6001.00
145_I157_M1.5911.00
99_S119_L1.5711.00
40_V62_I1.5701.00
86_A123_I1.5421.00
141_P144_I1.5291.00
59_V72_V1.5001.00
278_G281_Y1.4861.00
231_E235_I1.4841.00
54_E267_R1.4801.00
23_L58_V1.4521.00
82_S119_L1.4241.00
90_Y125_L1.4121.00
90_Y123_I1.4011.00
114_S118_E1.3971.00
11_P23_L1.3941.00
245_L279_E1.3841.00
254_I258_Y1.3741.00
88_K91_D1.3631.00
216_N220_E1.3601.00
5_I39_W1.3561.00
61_K64_E1.3541.00
36_K215_T1.3521.00
275_R278_G1.3471.00
278_G282_N1.3441.00
9_V256_L1.3371.00
113_I151_E1.3251.00
76_E82_S1.3191.00
78_S81_N1.3171.00
52_Q84_I1.3141.00
216_N228_R1.3141.00
169_K173_A1.3111.00
29_F261_I1.2971.00
212_E216_N1.2951.00
274_S277_E1.2951.00
83_L118_E1.2901.00
56_I84_I1.2841.00
171_L183_V1.2811.00
52_Q88_K1.2701.00
221_F226_I1.2671.00
120_R151_E1.2651.00
128_F203_V1.2511.00
118_E268_K1.2451.00
4_N35_I1.2451.00
56_I60_S1.2431.00
257_R262_N1.2381.00
53_D57_L1.2321.00
182_K200_D1.2251.00
71_Y96_Y1.2171.00
27_L66_V1.2161.00
97_I123_I1.2141.00
226_I230_I1.2061.00
218_F222_D1.1881.00
59_V89_Y1.1711.00
120_R153_V1.1701.00
118_E122_A1.1511.00
46_E253_K1.1421.00
17_N80_R1.1411.00
60_S88_K1.1351.00
60_S92_L1.1311.00
192_L229_A1.1291.00
13_D19_N1.1291.00
41_L58_V1.1261.00
118_E121_N1.1111.00
147_K150_R1.1071.00
87_K91_D1.1061.00
255_G284_L1.1011.00
66_V70_I1.0971.00
56_I91_D1.0961.00
87_K122_A1.0941.00
20_T24_Q1.0871.00
216_N219_L1.0871.00
12_Y50_L1.0771.00
227_Q230_I1.0761.00
63_R95_D1.0711.00
71_Y128_F1.0641.00
282_N285_K1.0631.00
97_I125_L1.0611.00
169_K241_D1.0581.00
254_I257_R1.0581.00
254_I281_Y1.0581.00
31_I66_V1.0561.00
88_K92_L1.0531.00
196_I226_I1.0531.00
21_E24_Q1.0471.00
273_D280_I1.0451.00
83_L87_K1.0311.00
143_H173_A1.0301.00
27_L65_M1.0301.00
242_V283_V1.0281.00
14_D265_S1.0111.00
72_V94_V1.0101.00
110_K274_S1.0101.00
148_L154_L1.0091.00
167_F194_A1.0021.00
74_V89_Y1.0011.00
110_K113_I1.0011.00
52_Q85_L0.9981.00
273_D277_E0.9971.00
6_S30_L0.9951.00
279_E282_N0.9911.00
6_S35_I0.9881.00
84_I88_K0.9861.00
120_R127_L0.9801.00
228_R232_I0.9791.00
22_A263_V0.9781.00
97_I127_L0.9771.00
220_E232_I0.9771.00
114_S271_L0.9761.00
22_A262_N0.9701.00
4_N215_T0.9691.00
14_D263_V0.9621.00
83_L122_A0.9611.00
230_I234_R0.9541.00
206_I240_V0.9521.00
149_A181_F0.9451.00
113_I144_I0.9381.00
24_Q28_D0.9371.00
129_I145_I0.9341.00
195_L218_F0.9311.00
55_R85_L0.9301.00
196_I230_I0.9281.00
63_R94_V0.9281.00
101_P138_Y0.9281.00
112_L138_Y0.9231.00
109_E147_K0.9201.00
26_L256_L0.9171.00
16_E80_R0.9171.00
258_Y285_K0.9171.00
8_L30_L0.9051.00
131_N139_N0.9031.00
142_L173_A0.9021.00
76_E81_N0.9021.00
75_N100_V0.9021.00
28_D31_I0.9011.00
63_R92_L0.9001.00
36_K218_F0.9001.00
39_W98_F0.8971.00
53_D84_I0.8961.00
84_I87_K0.8951.00
146_E150_R0.8921.00
87_K90_Y0.8881.00
227_Q231_E0.8881.00
16_E268_K0.8841.00
196_I221_F0.8831.00
70_I94_V0.8821.00
257_R263_V0.8751.00
204_S207_S0.8641.00
74_V97_I0.8621.00
120_R154_L0.8571.00
276_A279_E0.8561.00
210_V239_L0.8501.00
12_Y267_R0.8481.00
79_T83_L0.8481.00
99_S127_L0.8471.00
35_I211_P0.8461.00
27_L61_K0.8451.00
184_F201_G0.8431.00
191_I202_A0.8341.00
217_L232_I0.8341.00
185_I194_A0.8321.00
237_N241_D0.8311.00
224_G227_Q0.8301.00
21_E25_Q0.8241.00
40_V58_V0.8201.00
216_N232_I0.8181.00
53_D56_I0.8171.00
8_L38_F0.8091.00
142_L169_K0.8081.00
33_K211_P0.8051.00
264_G272_E0.8001.00
233_Q237_N0.7971.00
50_L58_V0.7941.00
142_L146_E0.7921.00
25_Q261_I0.7921.00
114_S268_K0.7871.00
59_V92_L0.7861.00
142_L166_S0.7851.00
8_L23_L0.7831.00
245_L277_E0.7811.00
89_Y94_V0.7801.00
80_R84_I0.7741.00
210_V213_L0.7731.00
59_V94_V0.7671.00
41_L72_V0.7611.00
169_K172_K0.7591.00
210_V236_L0.7581.00
38_F66_V0.7541.00
4_N207_S0.7471.00
82_S99_S0.7451.00
23_L27_L0.7441.00
4_N202_A0.7411.00
213_L216_N0.7381.00
27_L38_F0.7331.00
265_S272_E0.7331.00
167_F183_V0.7291.00
147_K151_E0.7231.00
250_S273_D0.7191.00
165_V189_R0.7161.00
93_G125_L0.7151.00
37_D71_Y0.7151.00
193_S196_I0.7121.00
132_I136_T0.7101.00
217_L221_F0.7081.00
109_E143_H0.7081.00
151_E154_L0.7051.00
56_I85_L0.7041.00
79_T118_E0.7041.00
13_D265_S0.7041.00
266_V270_L0.7031.00
43_T104_Y0.7031.00
18_I23_L0.7021.00
16_E265_S0.7021.00
167_F171_L0.6991.00
31_I65_M0.6981.00
278_G285_K0.6961.00
111_G271_L0.6961.00
145_I170_Y0.6951.00
101_P140_V0.6951.00
30_L35_I0.6941.00
193_S197_L0.6931.00
41_L50_L0.6931.00
13_D21_E0.6921.00
168_L172_K0.6911.00
130_Y158_K0.6901.00
250_S266_V0.6891.00
52_Q56_I0.6871.00
256_L259_R0.6841.00
56_I92_L0.6811.00
192_L221_F0.6790.99
4_N218_F0.6780.99
19_N262_N0.6760.99
74_V99_S0.6740.99
139_N163_D0.6740.99
223_R228_R0.6700.99
129_I140_V0.6680.99
212_E259_R0.6670.99
140_V145_I0.6670.99
69_K95_D0.6650.99
168_L197_L0.6600.99
279_E283_V0.6580.99
18_I58_V0.6570.99
258_Y284_L0.6560.99
131_N159_Y0.6560.99
124_D153_V0.6560.99
178_N181_F0.6540.99
26_L30_L0.6530.99
117_S147_K0.6530.99
29_F259_R0.6500.99
56_I89_Y0.6490.99
60_S91_D0.6480.99
220_E223_R0.6450.99
155_D182_K0.6430.99
108_S250_S0.6430.99
168_L193_S0.6410.99
51_S80_R0.6410.99
172_K234_R0.6410.99
47_F73_G0.6370.99
192_L226_I0.6360.99
108_S111_G0.6360.99
40_V70_I0.6330.99
30_L33_K0.6320.99
246_G277_E0.6280.99
8_L62_I0.6270.99
254_I266_V0.6270.99
256_L261_I0.6260.99
191_I217_L0.6250.99
143_H169_K0.6240.99
108_S246_G0.6200.99
140_V144_I0.6170.99
143_H146_E0.6160.99
34_G215_T0.6150.99
5_I71_Y0.6110.99
59_V63_R0.6100.99
81_N84_I0.6100.99
150_R180_N0.6100.99
48_N105_H0.6090.99
232_I235_I0.6090.99
266_V271_L0.6090.99
166_S170_Y0.6060.99
219_L222_D0.6030.99
128_F155_D0.6030.99
195_L222_D0.6020.99
68_G95_D0.6020.99
110_K271_L0.6010.99
13_D16_E0.6010.99
172_K238_K0.5990.99
193_S233_Q0.5980.99
209_L255_G0.5980.99
12_Y54_E0.5980.99
63_R67_K0.5970.99
150_R178_N0.5970.99
246_G274_S0.5960.99
20_T65_M0.5940.99
144_I147_K0.5920.99
18_I61_K0.5920.99
192_L233_Q0.5900.99
242_V279_E0.5890.99
31_I68_G0.5880.99
171_L200_D0.5870.99
170_Y183_V0.5870.99
163_D166_S0.5870.99
94_V125_L0.5850.99
41_L55_R0.5820.98
159_Y167_F0.5800.98
191_I214_V0.5800.98
115_Y118_E0.5730.98
41_L59_V0.5710.98
168_L233_Q0.5680.98
156_G182_K0.5670.98
83_L119_L0.5650.98
187_E190_M0.5640.98
63_R68_G0.5610.98
121_N153_V0.5570.98
231_E234_R0.5570.98
53_D88_K0.5560.98
255_G280_I0.5530.98
255_G258_Y0.5530.98
71_Y98_F0.5510.98
63_R66_V0.5510.98
8_L27_L0.5500.98
28_D67_K0.5500.98
142_L170_Y0.5500.98
101_P116_F0.5490.98
254_I273_D0.5450.98
247_D251_G0.5440.98
39_W71_Y0.5430.98
192_L196_I0.5430.98
31_I67_K0.5390.97
64_E67_K0.5380.97
221_F229_A0.5370.97
7_A205_G0.5350.97
35_I215_T0.5350.97
99_S116_F0.5350.97
17_N57_L0.5330.97
128_F182_K0.5310.97
206_I214_V0.5310.97
86_A119_L0.5310.97
80_R118_E0.5290.97
243_V252_I0.5290.97
251_G273_D0.5270.97
191_I218_F0.5240.97
9_V252_I0.5240.97
26_L29_F0.5230.97
43_T130_Y0.5220.97
146_E178_N0.5210.97
213_L232_I0.5210.97
275_R281_Y0.5210.97
164_F190_M0.5210.97
85_L89_Y0.5190.97
51_S54_E0.5190.97
117_S150_R0.5180.97
209_L256_L0.5170.97
206_I210_V0.5160.97
14_D262_N0.5160.97
205_G252_I0.5160.97
156_G181_F0.5160.97
116_F154_L0.5140.97
171_L197_L0.5110.97
239_L243_V0.5070.96
90_Y122_A0.5050.96
29_F211_P0.5040.96
209_L252_I0.5030.96
83_L123_I0.5020.96
49_M79_T0.5000.96
62_I66_V0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oe7A 3 1 100 0.047 Contact Map
3qzeA 2 0.9896 100 0.052 Contact Map
3si9A 3 0.9896 100 0.052 Contact Map
2ojpA 2 0.9827 100 0.053 Contact Map
3na8A 3 0.9862 100 0.054 Contact Map
3cprA 3 0.9792 100 0.054 Contact Map
1o5kA 3 0.9931 100 0.054 Contact Map
3l21A 5 0.9792 100 0.054 Contact Map
4i7wA 3 0.9862 100 0.055 Contact Map
4pfmA 2 0.9862 100 0.056 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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