GREMLIN Database
Q97WF1 - DNA polymerase phage SPO1 N-terminal domain homolog
UniProt: Q97WF1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (179)
Sequences: 3145 (2224)
Seq/√Len: 166.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_E53_K4.3841.00
36_E116_H3.7931.00
38_M110_I2.9111.00
39_F119_I2.6411.00
103_S107_T2.4161.00
11_V26_A2.2511.00
108_R111_E2.2051.00
38_M113_I2.2051.00
43_A84_V2.1351.00
66_L182_F2.1041.00
93_D124_H2.0831.00
20_W23_R2.0801.00
147_F160_F2.0521.00
46_E50_I1.9501.00
66_L178_L1.9371.00
23_R86_C1.8851.00
88_P98_E1.8601.00
147_F188_A1.8571.00
17_C102_C1.8491.00
69_E179_E1.8291.00
30_E75_R1.7711.00
15_Q20_W1.7301.00
69_E183_R1.6711.00
188_A191_S1.6551.00
11_V28_P1.6531.00
123_R127_S1.6431.00
120_T161_P1.6401.00
64_T75_R1.6281.00
149_T158_L1.6171.00
4_L33_S1.5841.00
8_A12_R1.5751.00
14_C17_C1.5731.00
39_F63_L1.5481.00
18_K97_D1.5001.00
38_M81_T1.4961.00
120_T159_V1.4911.00
151_N156_K1.4901.00
171_N174_I1.4791.00
141_G163_Y1.4661.00
114_R157_I1.4651.00
79_F109_Q1.4581.00
119_I185_V1.4121.00
149_T156_K1.4071.00
14_C86_C1.4001.00
14_C102_C1.3981.00
93_D127_S1.3981.00
86_C102_C1.3861.00
10_E108_R1.3841.00
160_F185_V1.3761.00
36_E77_D1.3731.00
118_I157_I1.3661.00
18_K21_K1.3561.00
144_R181_D1.3551.00
93_D123_R1.3541.00
7_I112_S1.3521.00
47_N50_I1.3301.00
71_L186_K1.3041.00
85_K109_Q1.2971.00
24_K50_I1.2931.00
39_F67_I1.2901.00
158_L188_A1.2651.00
110_I118_I1.2621.00
175_R179_E1.2551.00
117_I160_F1.2511.00
37_I185_V1.2341.00
186_K190_S1.2221.00
47_N51_E1.2051.00
67_I78_V1.2011.00
139_S142_K1.1941.00
160_F188_A1.1911.00
168_A178_L1.1861.00
99_I128_Y1.1741.00
48_E56_V1.1611.00
132_K138_E1.1591.00
147_F158_L1.1561.00
74_S77_D1.1531.00
126_T161_P1.1501.00
66_L179_E1.1401.00
120_T126_T1.1321.00
121_L162_T1.1301.00
179_E183_R1.1061.00
12_R26_A1.0981.00
150_W159_V1.0901.00
167_A170_Y1.0881.00
184_K187_E1.0871.00
92_R98_E1.0841.00
174_I177_V1.0771.00
27_V54_P1.0700.99
37_I119_I1.0670.99
83_L128_Y1.0610.99
119_I162_T1.0610.99
126_T138_E1.0600.99
81_T109_Q1.0590.99
167_A171_N1.0530.99
167_A174_I1.0390.99
16_K104_P1.0370.99
32_N35_A1.0290.99
138_E143_V1.0240.99
120_T129_L1.0170.99
32_N77_D1.0130.99
9_D13_K1.0110.99
39_F121_L1.0060.99
43_A88_P0.9980.99
96_E100_L0.9950.99
17_C86_C0.9860.99
40_I120_T0.9820.99
99_I124_H0.9610.99
119_I189_L0.9580.99
184_K188_A0.9580.99
6_L9_D0.9560.99
65_R69_E0.9260.99
41_G55_F0.9240.99
126_T143_V0.9230.99
132_K143_V0.9170.98
66_L71_L0.9110.98
45_G48_E0.9100.98
67_I71_L0.9020.98
8_A28_P0.9020.98
4_L112_S0.8910.98
37_I73_L0.8890.98
9_D12_R0.8860.98
19_L23_R0.8810.98
58_V170_Y0.8800.98
46_E87_R0.8740.98
14_C85_K0.8700.98
47_N58_V0.8680.98
130_F159_V0.8630.98
6_L10_E0.8600.98
38_M118_I0.8560.98
56_V82_N0.8540.98
108_R112_S0.8520.97
182_F185_V0.8480.97
103_S128_Y0.8390.97
61_K64_T0.8380.97
65_R175_R0.8350.97
37_I189_L0.8350.97
61_K65_R0.8310.97
140_I161_P0.8280.97
40_I106_L0.8260.97
62_L179_E0.8190.97
15_Q21_K0.8180.97
5_D9_D0.8170.97
51_E56_V0.8150.97
16_K105_Y0.8130.97
107_T111_E0.8130.97
117_I158_L0.8060.96
32_N79_F0.8060.96
187_E190_S0.8040.96
25_N49_D0.8030.96
117_I185_V0.8020.96
81_T106_L0.8010.96
176_K180_E0.7890.96
39_F78_V0.7810.96
18_K95_E0.7780.96
124_H127_S0.7760.96
104_P108_R0.7760.96
40_I129_L0.7740.96
120_T125_S0.7690.95
100_L131_K0.7600.95
163_Y177_V0.7590.95
45_G82_N0.7590.95
29_G79_F0.7550.95
110_I157_I0.7520.95
162_T178_L0.7510.95
20_W26_A0.7350.94
5_D33_S0.7290.94
143_V161_P0.7210.94
45_G54_P0.7130.93
143_V146_K0.7100.93
96_E127_S0.7090.93
37_I78_V0.7090.93
110_I129_L0.7090.93
8_A33_S0.7080.93
118_I129_L0.7030.93
12_R25_N0.7030.93
81_T85_K0.7020.93
71_L182_F0.6960.92
147_F184_K0.6920.92
46_E58_V0.6920.92
43_A91_N0.6910.92
82_N164_H0.6890.92
144_R162_T0.6780.91
24_K49_D0.6750.91
88_P91_N0.6680.91
45_G91_N0.6650.91
143_V148_Y0.6580.90
14_C23_R0.6500.90
7_I11_V0.6450.89
168_A175_R0.6440.89
64_T80_I0.6430.89
5_D8_A0.6430.89
82_N91_N0.6380.89
64_T67_I0.6370.89
163_Y167_A0.6350.88
45_G59_A0.6350.88
68_N74_S0.6350.88
160_F184_K0.6340.88
87_R92_R0.6320.88
54_P82_N0.6320.88
180_E184_K0.6300.88
20_W86_C0.6280.88
106_L110_I0.6270.88
41_G164_H0.6270.88
65_R68_N0.6250.88
130_F148_Y0.6230.87
55_F89_P0.6220.87
4_L7_I0.6170.87
28_P79_F0.6160.87
138_E161_P0.6150.87
29_G109_Q0.6130.87
138_E142_K0.6120.87
11_V105_Y0.6090.86
83_L99_I0.6070.86
104_P107_T0.6040.86
123_R139_S0.5990.85
23_R49_D0.5950.85
41_G82_N0.5880.84
115_P118_I0.5880.84
19_L49_D0.5870.84
62_L169_L0.5870.84
54_P59_A0.5860.84
180_E183_R0.5860.84
186_K189_L0.5840.84
42_E87_R0.5810.84
163_Y178_L0.5790.83
66_L168_A0.5770.83
26_A86_C0.5760.83
80_I91_N0.5750.83
29_G113_I0.5700.82
8_A26_A0.5680.82
25_N52_G0.5650.82
103_S131_K0.5650.82
175_R178_L0.5600.81
16_K101_A0.5600.81
178_L182_F0.5590.81
131_K137_M0.5580.81
178_L181_D0.5570.81
137_M142_K0.5570.81
97_D100_L0.5540.81
107_T150_W0.5540.81
127_S132_K0.5520.80
94_P98_E0.5510.80
83_L103_S0.5480.80
35_A81_T0.5460.80
43_A94_P0.5460.80
148_Y159_V0.5460.80
185_V189_L0.5460.80
97_D101_A0.5440.79
117_I188_A0.5440.79
35_A113_I0.5420.79
42_E48_E0.5420.79
65_R179_E0.5400.79
91_N98_E0.5370.79
59_A170_Y0.5320.78
145_G149_T0.5320.78
31_G35_A0.5300.78
120_T148_Y0.5290.78
181_D184_K0.5260.77
23_R26_A0.5260.77
107_T110_I0.5250.77
163_Y174_I0.5240.77
151_N157_I0.5230.77
62_L66_L0.5230.77
117_I189_L0.5210.76
120_T124_H0.5160.76
45_G170_Y0.5060.74
38_M115_P0.5040.74
42_E166_A0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vk2A 1 0.8472 100 0.266 Contact Map
1ui0A 1 0.8611 100 0.271 Contact Map
2d3yA 1 0.8657 100 0.328 Contact Map
3ikbA 1 0.838 100 0.348 Contact Map
1wywA 1 0.8843 100 0.474 Contact Map
1mugA 1 0.6991 100 0.563 Contact Map
1oe4A 2 0.8009 100 0.567 Contact Map
2c2qA 1 0.7824 99.9 0.638 Contact Map
2l3fA 1 0.6713 98.7 0.835 Contact Map
1yc5A 1 0.3333 44.7 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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