GREMLIN Database
Q97WE7 - MutT-like protein
UniProt: Q97WE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 164 (129)
Sequences: 4613 (3283)
Seq/√Len: 289.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_R83_E4.5081.00
45_Q124_K2.9861.00
93_V148_M2.9401.00
33_C72_L2.5881.00
62_V71_A2.5861.00
143_Y147_S2.5061.00
68_L94_Q2.4391.00
40_K129_P2.3851.00
66_E74_R2.2711.00
67_T70_E2.2121.00
49_P52_A1.9491.00
129_P132_K1.9221.00
45_Q123_V1.9141.00
89_I92_I1.8931.00
42_L127_Y1.8021.00
85_A110_K1.7841.00
55_W128_V1.7391.00
69_E107_F1.6791.00
130_F150_F1.6381.00
68_L105_L1.6301.00
91_S148_M1.6221.00
29_V103_V1.5751.00
92_I105_L1.5541.00
70_E73_K1.5161.00
76_M84_V1.5001.00
68_L107_F1.4901.00
88_N152_G1.4551.00
89_I105_L1.4511.00
67_T94_Q1.4471.00
75_E79_E1.4251.00
35_I76_M1.4241.00
128_V134_N1.4131.00
86_V110_K1.4071.00
43_L128_V1.4051.00
33_C76_M1.3841.00
87_G110_K1.3741.00
62_V68_L1.3461.00
47_K123_V1.3411.00
36_V108_E1.3361.00
75_E78_E1.3351.00
31_V71_A1.3341.00
95_V144_D1.2931.00
44_V122_A1.2771.00
37_E40_K1.2661.00
51_N54_L1.2621.00
33_C109_C1.2191.00
36_V149_Y1.2181.00
45_Q55_W1.2081.00
111_P114_G1.2061.00
29_V62_V1.2001.00
53_G123_V1.1941.00
25_D64_Y1.1871.00
82_L111_P1.1851.00
44_V125_V1.1741.00
55_W126_E1.1621.00
90_I152_G1.1471.00
144_D148_M1.1301.00
118_A121_D1.1231.00
67_T95_V1.1171.00
41_V146_L1.1151.00
73_K77_R1.1091.00
88_N108_E1.1011.00
27_P64_Y1.0881.00
118_A125_V1.0811.00
118_A122_A1.0791.00
85_A112_I1.0721.00
32_G104_I1.0681.00
34_L149_Y1.0531.00
119_S122_A1.0311.00
73_K84_V1.0221.00
46_R50_P1.0131.00
81_G117_R0.9881.00
147_S151_R0.9801.00
75_E121_D0.9741.00
66_E71_A0.9721.00
32_G106_D0.9561.00
44_V56_A0.9541.00
73_K87_G0.9411.00
60_G75_E0.9321.00
30_A102_Y0.9191.00
25_D28_L0.9121.00
144_D147_S0.9031.00
40_K127_Y0.9031.00
65_G101_H0.9021.00
30_A104_I0.8941.00
29_V105_L0.8881.00
32_G59_G0.8821.00
28_L61_K0.8801.00
50_P53_G0.8801.00
24_M61_K0.8751.00
28_L100_F0.8541.00
77_R81_G0.8521.00
106_D145_M0.8281.00
45_Q53_G0.8271.00
64_Y101_H0.8251.00
60_G79_E0.8211.00
61_K102_Y0.8191.00
34_L41_V0.8161.00
32_G142_T0.8151.00
104_I142_T0.8151.00
98_E141_T0.8141.00
43_L138_T0.8111.00
46_R56_A0.8050.99
68_L92_I0.8040.99
74_R78_E0.7940.99
122_A125_V0.7890.99
143_Y146_L0.7810.99
69_E94_Q0.7770.99
54_L139_T0.7760.99
55_W124_K0.7760.99
24_M27_P0.7720.99
36_V110_K0.7690.99
90_I108_E0.7680.99
88_N110_K0.7600.99
44_V58_P0.7450.99
28_L102_Y0.7370.99
86_V109_C0.7320.99
39_N130_F0.7270.99
32_G61_K0.7120.99
89_I107_F0.7100.99
54_L135_I0.7100.99
51_N139_T0.6980.99
39_N129_P0.6980.99
139_T142_T0.6950.98
62_V103_V0.6930.98
83_E113_G0.6930.98
57_I145_M0.6860.98
56_A139_T0.6850.98
31_V94_Q0.6790.98
117_R120_T0.6740.98
79_E121_D0.6730.98
23_F26_R0.6720.98
84_V109_C0.6720.98
67_T96_I0.6600.98
71_A74_R0.6550.98
73_K86_V0.6450.98
148_M151_R0.6440.98
147_S150_F0.6350.97
47_K52_A0.6340.97
31_V105_L0.6340.97
96_I101_H0.6340.97
37_E113_G0.6330.97
142_T145_M0.6310.97
126_E132_K0.6240.97
33_C84_V0.6240.97
71_A75_E0.6180.97
26_R29_V0.6070.96
73_K83_E0.6040.96
46_R53_G0.5930.96
146_L149_Y0.5920.96
46_R49_P0.5880.96
133_L143_Y0.5820.96
36_V130_F0.5710.95
73_K85_A0.5670.95
30_A61_K0.5640.95
72_L76_M0.5640.95
24_M28_L0.5620.95
26_R100_F0.5570.94
63_E79_E0.5570.94
43_L55_W0.5520.94
112_I115_N0.5490.94
32_G94_Q0.5440.94
93_V145_M0.5400.93
57_I106_D0.5390.93
80_T119_S0.5380.93
34_L90_I0.5370.93
26_R64_Y0.5350.93
76_M86_V0.5340.93
37_E127_Y0.5320.93
133_L146_L0.5320.93
31_V75_E0.5290.93
58_P76_M0.5270.93
87_G108_E0.5260.93
68_L103_V0.5260.93
45_Q126_E0.5210.92
77_R80_T0.5190.92
33_C86_V0.5170.92
111_P116_L0.5160.92
37_E114_G0.5160.92
31_V72_L0.5130.92
138_T142_T0.5120.92
75_E122_A0.5100.91
85_A115_N0.5090.91
82_L125_V0.5090.91
83_E86_V0.5090.91
28_L64_Y0.5080.91
44_V79_E0.5060.91
132_K135_I0.5050.91
80_T122_A0.5040.91
93_V141_T0.5030.91
59_G106_D0.5030.91
86_V108_E0.5010.91
133_L136_I0.5000.91
52_A123_V0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gz5A 2 0.8415 100 0.333 Contact Map
2fmlA 2 1 100 0.354 Contact Map
5bs6A 2 0.9085 100 0.375 Contact Map
2qjtB 2 0.939 100 0.409 Contact Map
3cngA 4 0.9878 100 0.42 Contact Map
1vk6A 2 0.9268 100 0.432 Contact Map
2qjoA 3 0.9329 100 0.435 Contact Map
3i9xA 2 0.8293 99.9 0.448 Contact Map
4ktbA 4 0.8354 99.9 0.457 Contact Map
3q1pA 2 0.9451 99.9 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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